Bepridil (BioDeep_00000001663)

 

Secondary id: BioDeep_00000408894

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline

化学式: C24H34N2O (366.2670994)
中文名称: 苄普地尔
谱图信息: 最多检出来源 Homo sapiens(blood) 52.63%

分子结构信息

SMILES: CC(C)COCC(CN(CC1=CC=CC=C1)C1=CC=CC=C1)N1CCCC1
InChI: InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3

描述信息

Bepridil is only found in individuals that have used or taken this drug. It is a long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. [PubChem]Bepridil has inhibitory effects on both the slow calcium (L-type) and fast sodium inward currents in myocardial and vascular smooth muscle, interferes with calcium binding to calmodulin, and blocks both voltage and receptor operated calcium channels. Bepridil inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. This has been demonstrated in isolated myocardial and vascular smooth muscle preparations in which both the slope of the calcium dose response curve and the maximum calcium-induced inotropic response were significantly reduced by bepridil. In cardiac myocytes in vitro, bepridil was shown to be tightly bound to actin. Bepridil regularly reduces heart rate and arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing total peripheral resistance (afterload) against which the heart works.
C - Cardiovascular system > C08 - Calcium channel blockers > C08E - Non-selective calcium channel blockers > C08EA - Phenylalkylamine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

26 个代谢物同义名

N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline; Nourypharma brand OF bepridil hydrochloride; Bepridil monohydrochloride, alpha isomer; Monohydrochloride, alpha-isomer bepridil; Bepridil monohydrochloride, alpha-isomer; Wallace brand OF bepridil hydrochloride; Bepridil monohydrochloride, monohydrate; Riom brand OF bepridil hydrochloride; BEPRIDIL HYDROCHLORIDE MONOHYDRATE; Monohydrochloride, bepridil; Bepridil monohydrochloride; Bepridil, alpha isomer; Bepridil, alpha-isomer; Bepridil, (+-)-isomer; Bepridil, (+)-isomer; Bepridil, (-)-isomer; Unicordium; 1978-CERM; CERM 1978; CERM-1978; 1978 CERM; bepridil; Bepadin; Bedapin; Cordium; Vascor



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sheng Han, Heng Li, Weixiong Chen, Li Yang, Xiankun Tong, Jianping Zuo, Youhong Hu. Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold. European journal of medicinal chemistry. 2022 Oct; 240(?):114608. doi: 10.1016/j.ejmech.2022.114608. [PMID: 35872393]
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  • Kazuki Matsui, Yutaro Mukai, Kota Sakakura, Kyoichi Wada, Tsutomu Nakamura, Atsufumi Kawabata, Nobue Terakawa, Naoki Hayakawa, Kengo Kusano, Kouichi Hosomi, Satoshi Yokoyama, Mitsutaka Takada. Relationship between serum bepridil concentration and corrected QT interval. International journal of clinical pharmacology and therapeutics. 2021 Jan; 59(1):63-70. doi: 10.5414/cp203843. [PMID: 33026317]
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  • Bhavesh D Patel, Nageswararao Palakundam, Rajesh Alamanda, Ajit R Gadekar, Amol A Raje, Rakshit Ameta. A simple and sensitive LC-MS/MS method for quantification of Bepridil in rat plasma and its application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2019 Aug; 172(?):113-119. doi: 10.1016/j.jpba.2019.04.038. [PMID: 31029800]
  • Kjell De Vriese, Ellie Himschoot, Kai Dünser, Long Nguyen, Andrzej Drozdzecki, Alex Costa, Moritz K Nowack, Jürgen Kleine-Vehn, Dominique Audenaert, Tom Beeckman, Steffen Vanneste. Identification of Novel Inhibitors of Auxin-Induced Ca2+ Signaling via a Plant-Based Chemical Screen. Plant physiology. 2019 05; 180(1):480-496. doi: 10.1104/pp.18.01393. [PMID: 30737267]
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