Classification Term: 3425

Phenylbenzamines (ontology term: CHEMONTID:0004204)

Aromatic compounds consisting of a benzyl group that is N-linked to a benzamine." []

found 18 associated metabolites at category metabolite taxonomy ontology rank level.

Child Taxonomies: There is no child term of current ontology term.

Bepridil

N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline

Bepridil is only found in individuals that have used or taken this drug. It is a long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. [PubChem]Bepridil has inhibitory effects on both the slow calcium (L-type) and fast sodium inward currents in myocardial and vascular smooth muscle, interferes with calcium binding to calmodulin, and blocks both voltage and receptor operated calcium channels. Bepridil inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. This has been demonstrated in isolated myocardial and vascular smooth muscle preparations in which both the slope of the calcium dose response curve and the maximum calcium-induced inotropic response were significantly reduced by bepridil. In cardiac myocytes in vitro, bepridil was shown to be tightly bound to actin. Bepridil regularly reduces heart rate and arterial pressure at rest and at a given level of exercise by dilating peripheral arterioles and reducing total peripheral resistance (afterload) against which the heart works. C - Cardiovascular system > C08 - Calcium channel blockers > C08E - Non-selective calcium channel blockers > C08EA - Phenylalkylamine derivatives C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents D000077264 - Calcium-Regulating Hormones and Agents D049990 - Membrane Transport Modulators C93038 - Cation Channel Blocker

Retigabine

Ethyl N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamate hydrochloride

C16H18FN3O2 (303.138298)

C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics D049990 - Membrane Transport Modulators Same as: D09569

Flumetralin

N-[(2-chloro-6-fluorophenyl)methyl]-N-ethyl-2,6-dinitro-4-(trifluoromethyl)aniline

C16H12ClF4N3O4 (421.045243)

Antazoline

4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine

C17H19N3 (265.1578894)

Antazoline is only found in individuals that have used or taken this drug. It is a 1st generation antihistamine that also anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.Antazoline binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AC - Antiallergic agents, excl. corticosteroids R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist D018926 - Anti-Allergic Agents Antazoline (Phenazoline) is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect[1][2][3].

Fd&c blue no. 1, aluminum lake

2-[(4-{ethyl[(3-sulphophenyl)methyl]amino}phenyl)(4-{ethyl[(3-sulphophenyl)methyl]iminiumyl}cyclohexa-2,5-dien-1-ylidene)methyl]benzene-1-sulphonic acid

C37H36N2O9S3 (748.1582846)

Fd&c blue no. 1, aluminum lake is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]") D004396 - Coloring Agents

C.I. Acid Green 3

N-Ethyl-N-[4-[[4-ethyl[(3-sulfophenyl)methyl]amino]phenyl]phenylmethylene]-2,5-cyclohexadien-1-ylidene-3-sulfobenzenemethanaminium hydroxide inner salt, 9ci

C37H36N2O6S2 (668.2014676000001)

C.I. Acid Green 3 is formerly used for colouring foods. Delisted by FDA in 1970. Formerly used for colouring foods. Delisted by FDA in 1970 [DFC]. D004396 - Coloring Agents > D008086 - Lissamine Green Dyes

C.I. Acid Violet 49

N-[4-[[4-(dimethylamino)Phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium inner salt, 9ci

C39H41N3O6S2 (711.2436646000001)

Dye, use now prohibited in food. Dye, use now prohibited in food

C.I. Acid Green 5

N-Ethyl-N-[4-[[4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl](4-sulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-3-sulfobenzenemethanaminium hydroxide inner salt, 9ci

C37H36N2O9S3 (748.1582846)

D004396 - Coloring Agents > D008086 - Lissamine Green Dyes Dye. prohibited from use in food [DFC]. Dye. prohibited from use in food.

Erioglaucine A

N-Ethyl-N-[4-[[4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl](2-sulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-3-sulfobenzenemethanaminium(1+)

C37H37N2O9S3+ (749.1661091999999)

FDA permitted food colour for food and food contact paper or board (also as lakes) [DFC] FDA permitted food colour for food and food contact paper or board (also as lakes). D004396 - Coloring Agents

Fast green FCF

3-({[4-({3-[dihydroxy(oxo)-λ⁶-sulphanylidene]-4-oxocyclohexa-1,5-dien-1-yl}(4-{ethyl[(3-sulphophenyl)methyl]amino}phenyl)methylidene)cyclohexa-2,5-dien-1-ylidene](ethyl)azaniumyl}methyl)benzene-1-sulphonic acid

C37H36N2O10S3 (764.1531996)

FDA permitted food colourant used in beverages, desserts, candies, baking goods, dairy products and maraschino cherries Fast Green FCF, also called Food green 3, FD&C Green No. 3, Green 1724, Solid Green FCF, and C.I. 42053, is a sea green triarylmethane food dye. Its E number is E143. FDA permitted food colourant used in beverages, desserts, candies, baking goods, dairy products and maraschino cherries

Histapyrrodine

N-benzyl-N-[2-(pyrrolidin-1-yl)ethyl]aniline

C19H24N2 (280.1939384)

R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist Histapyrrodine is a first-generation ethylenediamine H1-antihistamine.

Phenbenzamine

N-Benzyl-N,N-dimethyl-N-phenylethylenediamine

C17H22N2 (254.1782892)

Promethazine is a first-generation ethylenediamine H1-antihistamine.

Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, methyl ester

C15H15NO4 (273.100103)

Adaphostin

adamantan-1-yl 4-{[(2,5-dihydroxyphenyl)methyl]amino}benzoate

C24H27NO4 (393.19399820000007)

Efonidipine

5-(5,5-Dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-(phenyl(phenylmethyl)amino) ethyl ester, p-oxide, hydrochloride

C34H38N3O7P (631.2447248)

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D000077264 - Calcium-Regulating Hormones and Agents D045283 - Natriuretic Agents > D004232 - Diuretics D049990 - Membrane Transport Modulators C93038 - Cation Channel Blocker

3-(4-((3-Phenoxybenzyl)amino)phenyl)propanoic acid

3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid

C22H21NO3 (347.15213560000007)

GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4].

Lavendustin A

5-{[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino}-2-hydroxybenzoic acid

C21H19NO6 (381.12123140000006)

C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor D004791 - Enzyme Inhibitors

lavendustin c

5-{[(2,5-dihydroxyphenyl)methyl]amino}-2-hydroxybenzoic acid

C14H13NO5 (275.0793688)

D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor