terbutaline (BioDeep_00000016564)

Main id: BioDeep_00000001518

 

PANOMIX_OTCML-2023


代谢物信息卡片


terbutaline

化学式: C12H19NO3 (225.1364864)
中文名称: 特布他林
谱图信息: 最多检出来源 Homo sapiens(urine) 90.91%

分子结构信息

SMILES: CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O
InChI: InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3

描述信息

R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
CONFIDENCE standard compound; INTERNAL_ID 1101
KEIO_ID T126; [MS3] KO009270
KEIO_ID T126; [MS2] KO009267
KEIO_ID T126
Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol[1]. Terbutaline can be used in asthma symptom research[2].
Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol[1]. Terbutaline can be used in asthma symptom research[2].

同义名列表

2 个代谢物同义名

terbutaline; KWD 2019



数据库引用编号

38 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Martha F Mallicote, Carolina I Medina, H Xie, Jose Zilberschtein, Stacie Atria, Megan Manzie, Jorge A Hernandez, Robert J MacKay. Efficacy of treatment of equine anhidrosis with acupuncture and Chinese herbs is low but higher in treated horses compared with placebo. Journal of the American Veterinary Medical Association. 2024 Mar; 262(3):1-6. doi: 10.2460/javma.23.08.0474. [PMID: 38056073]
  • Tran Thanh Tam Toan, Do Mai Nguyen, Doan Manh Dung, Dang Thi Ngoc Hoa, Le Thi Thanh Nhi, Nguyen Mau Thanh, Nguyen Nho Dung, Yasser Vasseghian, Nasrin Golzadeh. Electrochemical sensor to detect terbutaline in biological samples by a green agent. Chemosphere. 2022 Feb; 289(?):133171. doi: 10.1016/j.chemosphere.2021.133171. [PMID: 34875292]
  • Nasser Hadal Alotaibi, Muavia Sarwar, - Alamgeer, Zeeshan Jabbar, Muhammad Usman Munir, Hafiz Muhammad Irfan, Muhammad Akram, Syed Nasir Abbas Bukhari, Zahid Rasul Niazi, Abdul Qayyum Khan. Pharmacological exploration of anti-arthritic potential of terbutaline through in-vitro and in-vivo experimental models. Pakistan journal of pharmaceutical sciences. 2022 Jan; 35(1(Supplementary)):253-257. doi: NULL. [PMID: 35228185]
  • Joana A Loureiro, Stephanie Andrade, Maria João Ramalho, Nuno Oliveira, Maria Carmo Pereira. The interaction of a β2 adrenoceptor agonist drug with biomimetic cell membrane models: The case of terbutaline sulphate. Life sciences. 2021 Nov; 285(?):119992. doi: 10.1016/j.lfs.2021.119992. [PMID: 34592235]
  • Meghan Matheny, Noble Maleque, Natalie Channell, A Robin Eisch, Sara C Auld, Aleena Banerji, Kirk M Druey. Severe Exacerbations of Systemic Capillary Leak Syndrome After COVID-19 Vaccination: A Case Series. Annals of internal medicine. 2021 10; 174(10):1476-1478. doi: 10.7326/l21-0250. [PMID: 34125573]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Soha Mohamed, Mohamed Nasr, Abeer Salama, Hanan Refai. Novel lipid-polymer hybrid nanoparticles incorporated in thermosensitive in situ gel for intranasal delivery of terbutaline sulphate. Journal of microencapsulation. 2020 Dec; 37(8):577-594. doi: 10.1080/02652048.2020.1826590. [PMID: 32969722]
  • Makhala M Khammy, Cindy Kha Han Truong, Christine E Wright, James A Angus. The β2-adrenoceptor agonist bronchodilators terbutaline and orciprenaline are also weak α1-adrenoceptor antagonists. European journal of pharmacology. 2020 Sep; 882(?):173304. doi: 10.1016/j.ejphar.2020.173304. [PMID: 32592771]
  • Ronald A Strauss. Subcutaneous terbutaline as an alternative to aerosolized albuterol. The journal of allergy and clinical immunology. In practice. 2020 Jul; 8(7):2450. doi: 10.1016/j.jaip.2020.04.015. [PMID: 32336646]
  • Marcus S Shaker, John Oppenheimer, Mitchell Grayson, David Stukus, Nicholas Hartog, Elena W Y Hsieh, Nicholas Rider, Cullen M Dutmer, Timothy K Vander Leek, Harold Kim, Edmond S Chan, Doug Mack, Anne K Ellis, David Lang, Jay Lieberman, David Fleischer, David B K Golden, Dana Wallace, Jay Portnoy, Giselle Mosnaim, Matthew Greenhawt. Reply to 'Subcutaneous terbutaline as an alternative to aerosolized albuterol'. The journal of allergy and clinical immunology. In practice. 2020 Jul; 8(7):2450-2452. doi: 10.1016/j.jaip.2020.04.016. [PMID: 32340824]
  • Linlin Fang, Yanyan Zhao, Chao Wang, Changyuan Wang, Xu Han, Pengjun Chen, Lizhu Zhao, Jingping Wang, Shuang Li, Zhen Jiang. Preparation of a thiols β-cyclodextrin/gold nanoparticles-coated open tubular column for capillary electrochromatography enantioseparations. Journal of separation science. 2020 Jun; 43(11):2209-2216. doi: 10.1002/jssc.201901323. [PMID: 32160391]
  • Shahira F El Menshawe, Heba M Aboud, Mohammed H Elkomy, Rasha M Kharshoum, Amany M Abdeltwab. A novel nanogel loaded with chitosan decorated bilosomes for transdermal delivery of terbutaline sulfate: artificial neural network optimization, in vitro characterization and in vivo evaluation. Drug delivery and translational research. 2020 04; 10(2):471-485. doi: 10.1007/s13346-019-00688-1. [PMID: 31677149]
  • Cristina Travelli, Silvio Aprile, Daiana Mattoteia, Giorgia Colombo, Nausicaa Clemente, Eugenio Scanziani, Salvatore Terrazzino, Maria Alessandra Alisi, Lorenzo Polenzani, Giorgio Grosa, Armando A Genazzani, Gian Cesare Tron, Ubaldina Galli. Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group. European journal of medicinal chemistry. 2019 Nov; 181(?):111576. doi: 10.1016/j.ejmech.2019.111576. [PMID: 31400709]
  • Weiguo Xu, Junhua Wu, Yong Feng, Jing Zhu, Rong Cui. Comparison of the efficacy of aerosol inhalation between the ipratropium bromide and terbutaline on the patients with AECOPD. Pakistan journal of pharmaceutical sciences. 2019 Sep; 32(5(Special)):2489-2493. doi: . [PMID: 31894040]
  • Huimin Beng, Hao Su, Shanping Wang, Yihe Kuai, Junhua Hu, Rui Zhang, Fei Liu, Wen Tan. Differential effects of inhaled R- and S-terbutaline in ovalbumin-induced asthmatic mice. International immunopharmacology. 2019 Aug; 73(?):581-589. doi: 10.1016/j.intimp.2019.04.036. [PMID: 31234092]
  • John Molphy, John W Dickinson, Neil J Chester, Mike Loosemore, Gregory Whyte. The Effects of Inhaled Terbutaline on 3-km Running Time-Trial Performance. International journal of sports physiology and performance. 2019 07; 14(6):822–828. doi: 10.1123/ijspp.2018-0633. [PMID: 30569748]
  • Mohamed Magdy Khalil, Waleed M A El Rouby, Mohamed Ali Korany. Potentiometric sensor based on novel flowered-like Mg-Al layered double hydroxides/multiwalled carbon nanotubes nanocomposite for bambuterol hydrochloride determination. Materials science & engineering. C, Materials for biological applications. 2019 Jul; 100(?):186-195. doi: 10.1016/j.msec.2019.02.103. [PMID: 30948052]
  • Wei Wang, Qing-Bin Liu, Wei Jing. Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells. Chinese journal of natural medicines. 2019 Apr; 17(4):252-263. doi: 10.1016/s1875-5364(19)30029-9. [PMID: 31076129]
  • Zheng Ruihong, Wang Lu, Liu Xiaoli. Effect of terbutaline combined with budesonide in treatment of bronchial asthma and rehabilitation nursing. Pakistan journal of pharmaceutical sciences. 2018 Sep; 31(5(Special)):2249-2255. doi: . [PMID: 30463820]
  • Sule Doymaz, James Schneider. Safety of Terbutaline for Treatment of Acute Severe Pediatric Asthma. Pediatric emergency care. 2018 May; 34(5):299-302. doi: 10.1097/pec.0000000000000677. [PMID: 26959519]
  • Laust Frisenberg Buhl, Frederik Nørregaard Pedersen, Marianne Skovsager Andersen, Dorte Glintborg. Licorice-induced apparent mineralocorticoid excess compounded by excessive use of terbutaline and high water intake. BMJ case reports. 2018 Apr; 2018(?):. doi: 10.1136/bcr-2017-223918. [PMID: 29674401]
  • Glenn A Jacobson, Morten Hostrup. Terbutaline: level the playing field for inhaled β2-agonists by introducing a dosing and urine threshold. British journal of sports medicine. 2017 Sep; 51(18):1323-1324. doi: 10.1136/bjsports-2016-096453. [PMID: 27461883]
  • Trond-Eirik Strand, Hasse Z Khiabani, Alina Boico, Daniel Radiloff, Yulin Zhao, Karyn L Hamilton, Uwe Christians, Jelena Klawitter, Robert J Noveck, Claude A Piantadosi, Christopher Bell, David Irwin, Thies Schroeder. The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. Canadian journal of physiology and pharmacology. 2017 Sep; 95(9):1009-1018. doi: 10.1139/cjpp-2016-0635. [PMID: 28467859]
  • M Hostrup, S Jessen, J Onslev, T Clausen, C Porsbjerg. Two-week inhalation of budesonide increases muscle Na,K ATPase content but not endurance in response to terbutaline in men. Scandinavian journal of medicine & science in sports. 2017 Jul; 27(7):684-691. doi: 10.1111/sms.12677. [PMID: 27060857]
  • Ting Zhou, Jing Zeng, Ting Zhao, Qisheng Zhong, Yang Yang, Wen Tan. Enantioselective analysis of bambuterol in human plasma using microwave-assisted chiral derivatization coupled with ultra high performance liquid chromatography and tandem mass spectrometry. Journal of separation science. 2017 Jul; 40(13):2779-2790. doi: 10.1002/jssc.201700280. [PMID: 28493436]
  • M Kreiberg, V Becker, S Jessen, S Rzeppa, P Hemmersbach, V Backer, M Hostrup. Influence of exercise in normal and hot ambient conditions on the pharmacokinetics of inhaled terbutaline in trained men. Scandinavian journal of medicine & science in sports. 2017 Jul; 27(7):692-703. doi: 10.1111/sms.12697. [PMID: 27167471]
  • Nanna Krogh, Sebastian Rzeppa, Anders Dyreborg, Yvette Dehnes, Peter Hemmersbach, Vibeke Backer, Morten Hostrup. Terbutaline Accumulates in Blood and Urine after Daily Therapeutic Inhalation. Medicine and science in sports and exercise. 2017 06; 49(6):1236-1243. doi: 10.1249/mss.0000000000001199. [PMID: 28072631]
  • Shiru Liang, Hongyuan Yan, Jiankun Cao, Yehong Han, Shigang Shen, Ligai Bai. Molecularly imprinted phloroglucinol-formaldehyde-melamine resin prepared in a deep eutectic solvent for selective recognition of clorprenaline and bambuterol in urine. Analytica chimica acta. 2017 Jan; 951(?):68-77. doi: 10.1016/j.aca.2016.11.009. [PMID: 27998487]
  • Aysegul Kutluay Baytak, Tugce Teker, Sehriban Duzmen, Mehmet Aslanoglu. A sensitive determination of terbutaline in pharmaceuticals and urine samples using a composite electrode based on zirconium oxide nanoparticles. Materials science & engineering. C, Materials for biological applications. 2016 Oct; 67(?):125-131. doi: 10.1016/j.msec.2016.05.008. [PMID: 27287106]
  • Ting Zhou, Dan Zeng, Ting Zhao, Yang Yang, Shan Liu, Jie Wu, Ling Xu, Wen Tan. In vivo metabolism study of (R)-bambuterol in humans using ultra high performance liquid chromatography with tandem mass spectrometry. Journal of separation science. 2016 Aug; 39(15):2896-906. doi: 10.1002/jssc.201600424. [PMID: 27273913]
  • Florian Gueho, Sébastien Beaune, Philippe Devillier, Saik Urien, Christophe Faisy. Modeling the effectiveness of nebulized terbutaline for decompensated chronic obstructive pulmonary disease patients in the emergency department. Medicine. 2016 Aug; 95(32):e4553. doi: 10.1097/md.0000000000004553. [PMID: 27512880]
  • Mónica Moreira-Rodrigues, Priscila Mendes, Ana L Graça, Raquel Martinho, Paula Serrão, Daniel Moura. Low epinephrine levels and selective deficiency of β2-adrenoceptor vasodilation at birth. Life sciences. 2016 Jul; 156(?):1-6. doi: 10.1016/j.lfs.2016.05.029. [PMID: 27221021]
  • Fahima M Hashem, Mohamed Nasr, Gihan Fathy, Aliaa Ismail. Formulation and In Vitro and In Vivo Evaluation of Lipid-Based Terbutaline Sulphate Bi-layer Tablets for Once-Daily Administration. AAPS PharmSciTech. 2016 Jun; 17(3):727-34. doi: 10.1208/s12249-015-0404-z. [PMID: 26335420]
  • A J Simpson, J R Bood, S D Anderson, L M Romer, B Dahlén, S-E Dahlén, P Kippelen. A standard, single dose of inhaled terbutaline attenuates hyperpnea-induced bronchoconstriction and mast cell activation in athletes. Journal of applied physiology (Bethesda, Md. : 1985). 2016 05; 120(9):1011-7. doi: 10.1152/japplphysiol.00700.2015. [PMID: 26846550]
  • Yongjing Liu, Miaoduo Deng, Jia Yu, Zhen Jiang, Xingjie Guo. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism. Journal of separation science. 2016 May; 39(9):1766-75. doi: 10.1002/jssc.201501026. [PMID: 26935589]
  • Xiao Han, Ran Liu, Lifang Ji, Mei Hui, Qing Li, Liang Fang, Kaishun Bi. Determination of tulobuterol in rat plasma using a liquid chromatography-tandem mass spectrometry method and its application to a pharmacokinetic study of tulobuterol patch. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1008(?):108-114. doi: 10.1016/j.jchromb.2015.11.017. [PMID: 26638035]
  • Su Guan, Chun-Yun Hu, Meng-Ying He, Ying-Ying Yang, Yu-Xin Tang, Jie-di Chen, Li-Jie Huang, Wen Tan. Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs. European journal of drug metabolism and pharmacokinetics. 2015 Dec; 40(4):453-60. doi: 10.1007/s13318-014-0228-3. [PMID: 25281237]
  • Ting Zhou, Shan Liu, Ting Zhao, Jing Zeng, Mingzhi He, Beining Xu, Shanshan Qu, Ling Xu, Wen Tan. Chiral analysis of bambuterol, its intermediate and active drug in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Aug; 997(?):38-44. doi: 10.1016/j.jchromb.2015.05.024. [PMID: 26092775]
  • Yanrui Ye, Hang Xu, Lei Quan, Long Zhu, Jing Zeng, Ting Zhou, ChengJuan Zou, Qing Cheng, Shujie Bu, Wen Tan. The Lipid-lowering Effects of R-bambuterol in Healthy Chinese Volunteers: A Randomized Phase I Clinical Study. EBioMedicine. 2015 Apr; 2(4):356-64. doi: 10.1016/j.ebiom.2015.02.006. [PMID: 26137575]
  • Morten Hostrup, Anders Kalsen, Jens Bangsbo, Peter Hemmersbach, Sebastian Karlsson, Vibeke Backer. High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men. European journal of applied physiology. 2014 Dec; 114(12):2499-508. doi: 10.1007/s00421-014-2970-2. [PMID: 25113095]
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