2'-Deoxyinosine triphosphate (BioDeep_00000001623)
Secondary id: BioDeep_00001869043
natural product human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C10H15N4O13P3 (491.9848)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(otcml) 31.86%
分子结构信息
SMILES: C1C(C(OC1N2C=NC3=C2N=CNC3=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
InChI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1
描述信息
2-Deoxyinosine triphosphate (dITP) is a deoxyribonucleotide that may be generated from dATP by slow, non-enzymatic hydrolysis or by reduction of ITP. Normally, the cellular dITP concentration is very low. The inability to demonstrate the synthesis of dITP in cellular preparations has been attributed to the presence in the cytoplasm of an inosine triphosphatase pyrophosphatase (ITPase, EC 3.6.1.19), an enzyme that does not permit accumulation of these nucleotides. dITP can be incorporated into DNA by polymerases. The deoxyribonucleotide dITP behaves as a dGTP analogue and is incorporated opposite cytosine with about 50\\% efficiency. Both isolated nuclei and purified DNA polymerases rapidly incorporated dITP into DNA. In the presence of ATP, dITP is stabilized in extracts of nuclei. dITP exist in all cells and is potentially mutagenic, and the levels of these nucleotides are controlled by ITPase. The function of this ubiquitous protein family is proposed to be the elimination of minor potentially mutagenic or clastogenic purine nucleoside triphosphates from the cell. (PMID: 11278832) [HMDB]
2-Deoxyinosine triphosphate (dITP) is a deoxyribonucleotide that may be generated from dATP by slow, non-enzymatic hydrolysis or by reduction of ITP. Normally, the cellular dITP concentration is very low. The inability to demonstrate the synthesis of dITP in cellular preparations has been attributed to the presence in the cytoplasm of an inosine triphosphatase pyrophosphatase (ITPase, EC 3.6.1.19), an enzyme that does not permit accumulation of these nucleotides. dITP can be incorporated into DNA by polymerases. The deoxyribonucleotide dITP behaves as a dGTP analogue and is incorporated opposite cytosine with about 50\\% efficiency. Both isolated nuclei and purified DNA polymerases rapidly incorporated dITP into DNA. In the presence of ATP, dITP is stabilized in extracts of nuclei. dITP exist in all cells and is potentially mutagenic, and the levels of these nucleotides are controlled by ITPase. The function of this ubiquitous protein family is proposed to be the elimination of minor potentially mutagenic or clastogenic purine nucleoside triphosphates from the cell. (PMID: 11278832).
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Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
17 个代谢物同义名
{[hydroxy({[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(6-oxo-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid; [hydroxy({hydroxy[(2R,3S,5R)-3-hydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphoryl}oxy)phosphoryl]oxyphosphonic acid; 2-Deoxy-inosine 5-(tetrahydrogen triphosphate); 2-DEOXYINOSINE-5-TRIPHOSPHATE TRISODIUM SALT; 2-Deoxyinosine triphosphate, trisodium salt; 2-Deoxyinosine 5-triphosphoric acid; 2-Deoxyinosine-5-triphosphoric acid; Deoxyinosine 5-triphosphoric acid; 2-Deoxyinosine triphosphoric acid; 2-Deoxyinosine-5-triphosphate; 2-Deoxyinosine 5-triphosphate; Deoxyinosine 5-triphosphate; 2-Deoxyinosine triphosphate; Deoxyinosine triphosphate; dITP - lyophilized; 2-Ditp; DITP
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:28807
- KEGG: C01345
- PubChem: 135402029
- PubChem: 135398616
- PubChem: 146302
- HMDB: HMDB0003537
- Metlin: METLIN58160
- foodb: FDB023190
- chemspider: 129052
- CAS: 16595-02-1
- MoNA: PS014909
- MoNA: PS014911
- MoNA: PS014907
- MoNA: PS014904
- MoNA: PS014908
- MoNA: PS014903
- PMhub: MS000000872
- PubChem: 4550
- PDB-CCD: Y43
- 3DMET: B01440
- NIKKAJI: J322.120B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
15 个相关的代谢反应过程信息。
Reactome(12)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Nucleotide metabolism:
H2O + XTP ⟶ PPi + XMP - Nucleobase catabolism:
H2O + XTP ⟶ PPi + XMP - Purine catabolism:
H2O + XTP ⟶ PPi + XMP - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Nucleotide metabolism:
H2O + XTP ⟶ PPi + XMP - Nucleobase catabolism:
H2O + XTP ⟶ PPi + XMP - Purine catabolism:
H2O + XTP ⟶ PPi + XMP - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Nucleotide metabolism:
H2O + XTP ⟶ PPi + XMP - Nucleobase catabolism:
H2O + XTP ⟶ PPi + XMP - Purine catabolism:
H2O + XTP ⟶ PPi + XMP
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(2)
- Purine nucleotides and Nucleosides metabolism ( Purine nucleotides and Nucleosides metabolism ):
H2O + XTP ⟶ Pyrophosphate + XMP - ATP + dIDP = ADP + dITP ( Purine nucleotides and Nucleosides metabolism ):
ATP + dIDP ⟶ ADP + dITP
PlantCyc(0)
COVID-19 Disease Map(1)
- @COVID-19 Disease
Map["name"]:
2-Methyl-3-acetoacetyl-CoA + Coenzyme A ⟶ Acetyl-CoA + Propanoyl-CoA
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3702 - Arabidopsis thaliana: 10.1111/TPJ.14594
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
