Phenacetin (BioDeep_00000001600)

 

Secondary id: BioDeep_00000399091

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


N-(4-ethoxyphenyl)acetamide

化学式: C10H13NO2 (179.09462380000002)
中文名称: N-(4-乙氧基-D5-苯基)乙酰胺, 非那西丁
谱图信息: 最多检出来源 Homo sapiens(blood) 1.03%

分子结构信息

SMILES: CCOc(c1)ccc(NC(C)=O)c1
InChI: InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 800; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7488; ORIGINAL_PRECURSOR_SCAN_NO 7485
CONFIDENCE standard compound; INTERNAL_ID 800; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7488; ORIGINAL_PRECURSOR_SCAN_NO 7486
CONFIDENCE standard compound; INTERNAL_ID 800; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7450; ORIGINAL_PRECURSOR_SCAN_NO 7449
CONFIDENCE standard compound; INTERNAL_ID 800; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7440; ORIGINAL_PRECURSOR_SCAN_NO 7439
CONFIDENCE standard compound; INTERNAL_ID 800; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7504; ORIGINAL_PRECURSOR_SCAN_NO 7499
CONFIDENCE standard compound; INTERNAL_ID 800; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7480; ORIGINAL_PRECURSOR_SCAN_NO 7478
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BE - Anilides
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
[Raw Data] CBA18_Phenacetin_pos_40eV_1-10_01_709.txt
[Raw Data] CBA18_Phenacetin_pos_20eV_1-10_01_707.txt
[Raw Data] CBA18_Phenacetin_pos_10eV_1-10_01_706.txt
[Raw Data] CBA18_Phenacetin_pos_50eV_1-10_01_710.txt
[Raw Data] CBA18_Phenacetin_pos_30eV_1-10_01_708.txt

同义名列表

19 个代谢物同义名

N-(4-ethoxyphenyl)acetamide; 1-Acetamido-4-ethoxybenzene; 4-Ethoxyacetanilide; Acetophenetidine; Acetophenetidin; Acetphenetidin; Contradouleur; Phenacetin-d5; Acetophenetin; Phenacetinum; Commotional; Phenacetine; Achrocidin; Fenacetina; phenacetin; Codempiral; Contradol; Phenacetin; Phenacetin



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

33 个相关的代谢反应过程信息。

Reactome(33)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jiangjing Wang, Shunyi Wei, Yingfang Ao, Yuping Yang. [Comparison of the early analgesic efficacy of three different drugs after anterior cruciate ligament reconstruction]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2024 Apr; 56(2):293-298. doi: ". [PMID: 38595247]
  • Junxue Wu, Bin Wang, Han Qu, Fang Wang, Lei Duan, Gang Yu. Acid-washed zero-valent aluminum as a highly efficient persulfate activator for degradation of phenacetin. Environmental science and pollution research international. 2023 Feb; 30(7):19439-19449. doi: 10.1007/s11356-022-23473-z. [PMID: 36229732]
  • Hirohiko Ohtsuka, Kazuaki Takahashi, Harumi Kitaura, Hitoshi Kandori, Kenta Danbayashi, Tomoaki Higuchi, Fumihiro Jinno, Shin-Ichiro Nitta, Kanae Mori, Atsushi Iwai, Keiko Nakai, Kosuke Saito, Yoshiro Saito. No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity. The Journal of toxicological sciences. 2022; 47(5):193-199. doi: 10.2131/jts.47.193. [PMID: 35527007]
  • Maki Mizogami, Hironori Tsuchiya. Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could Be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2022; 31(2):111-117. doi: 10.1159/000524210. [PMID: 35316804]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yao Fu, Xiaoxiao Tian, Lingling Han, Yilin Li, Ying Peng, Jiang Zheng. Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol. Chemico-biological interactions. 2020 May; 322(?):109053. doi: 10.1016/j.cbi.2020.109053. [PMID: 32198085]
  • Mei-Ling Wu, Yi-Ping Lin, Yan-Li Wei, Hong-Jian Du, Xiao-Qian Ying, Wen-Zhuang Tan, Bi-E Tang. Calycosin Influences the Metabolism of Five Probe Drugs in Rats. Drug design, development and therapy. 2020; 14(?):429-434. doi: 10.2147/dddt.s236221. [PMID: 32099327]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Adarsh Sahu, Debashree Das, Ram Kishore Agrawal, Asmita Gajbhiye. Bio-isosteric replacement of amide group with 1,2,3-triazole in phenacetin improves the toxicology and efficacy of phenacetin-triazole conjugates (PhTCs). Life sciences. 2019 Jul; 228(?):176-188. doi: 10.1016/j.lfs.2019.05.004. [PMID: 31059688]
  • Camille Fuselier, Christine Terryn, Alexandre Berquand, Jean-Marc Crowet, Arnaud Bonnomet, Michael Molinari, Manuel Dauchez, Laurent Martiny, Christophe Schneider. Low-diluted Phenacetinum disrupted the melanoma cancer cell migration. Scientific reports. 2019 06; 9(1):9109. doi: 10.1038/s41598-019-45578-1. [PMID: 31235855]
  • Pedro Rafael da Silva, Laís Cristina Santana Sena, Rubens Pedro Lorena Silva, Danielle Cristine Almeida Silva de Santana, Fernando José Malagueño de Santana. Determination of cocaine adulterants in human urine by dispersive liquid-liquid microextraction and high-performance liquid chromatography. Analytical and bioanalytical chemistry. 2019 Jun; 411(16):3447-3461. doi: 10.1007/s00216-019-01797-z. [PMID: 31123783]
  • Zhe Wang, Wei Sun, Zheng-Feng Lin, Rui Sun, Cheng-Ke Huang, Wei-Jian Ye, Yao-Yao Dong, Xiao-Dan Zhang, Rui-Jie Chen. A UHPLC-MS/MS method coupled with liquid-liquid extraction for the quantitation of phenacetin, omeprazole, metoprolol, midazolam and their metabolites in rat plasma and its application to the study of four CYP450 activities. Journal of pharmaceutical and biomedical analysis. 2019 Jan; 163(?):204-210. doi: 10.1016/j.jpba.2018.10.012. [PMID: 30317077]
  • Cecilia Scorza, Claudia Piccini, Marcela Martínez Busi, Juan Andrés Abin Carriquiry, Pablo Zunino. Alterations in the Gut Microbiota of Rats Chronically Exposed to Volatilized Cocaine and Its Active Adulterants Caffeine and Phenacetin. Neurotoxicity research. 2019 Jan; 35(1):111-121. doi: 10.1007/s12640-018-9936-9. [PMID: 30066173]
  • Chen Cheng, Jianchang Qian, Zhe Wang, Wanshu Li, Chengke Huang, Mengchun Chen, Yaoyao Dong, Lejing Lian, Wei Sun. Influences of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach. BioMed research international. 2019; 2019(?):9614781. doi: 10.1155/2019/9614781. [PMID: 30800683]
  • Juan Andrés Abin-Carriquiry, Marcela Martínez-Busi, Martín Galvalisi, Manuel Minteguiaga, José Pedro Prieto, María Cecilia Scorza. Identification and Quantification of Cocaine and Active Adulterants in Coca-Paste Seized Samples: Useful Scientific Support to Health Care. Neurotoxicity research. 2018 08; 34(2):295-304. doi: 10.1007/s12640-018-9887-1. [PMID: 29536266]
  • Sang-Bum Kim, Kyu-Sang Kim, Heon-Min Ryu, Seong-Ho Hong, Bo-Kyoung Kim, Dae-Duk Kim, Jin Woo Park, In-Soo Yoon. Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo. Molecules (Basel, Switzerland). 2018 06; 23(6):. doi: 10.3390/molecules23061470. [PMID: 29914211]
  • Madhuri Vaghela, Niteshkumar Sahu, Prashant Kharkar, Nancy Pandita. In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats. Chemico-biological interactions. 2017 Dec; 278(?):141-151. doi: 10.1016/j.cbi.2017.10.015. [PMID: 29042257]
  • Snehasis Jana, Himanshu Rastogi. Effects of Caffeic Acid and Quercetin on In Vitro Permeability, Metabolism and In Vivo Pharmacokinetics of Melatonin in Rats: Potential for Herb-Drug Interaction. European journal of drug metabolism and pharmacokinetics. 2017 Oct; 42(5):781-791. doi: 10.1007/s13318-016-0393-7. [PMID: 28070878]
  • Nan Hu, Yanjuan Huang, Xuejiao Gao, Sai Li, Zhixiang Yan, Bin Wei, Ru Yan. Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine. Chemico-biological interactions. 2017 Jun; 271(?):48-58. doi: 10.1016/j.cbi.2017.04.018. [PMID: 28438436]
  • Per-Uno Malmström. Drugs and risk of cancer. Scandinavian journal of urology. 2017 Jun; 51(3):212-218. doi: 10.1080/21681805.2017.1329905. [PMID: 28657390]
  • Xiaohua Pan, Xiaodong Li, Liqing Cui, Qianwei Wang. Preoperative Phenacetin Metabolism Test in the Prediction of Postoperative Liver Dysfunction of Patients with Hepatocellular Carcinoma. Medical science monitor : international medical journal of experimental and clinical research. 2017 May; 23(?):2607-2611. doi: 10.12659/msm.905228. [PMID: 28553832]
  • Marcin Lukasik, Anna Malkowska, Magdalena Bamburowicz-Klimkowska, Piotr Polak, Miroslaw M Szutowski. THE EFFECT OF METHANOL USED AS VEHICULUM ON SERUM PHENACETIN CONCENTRATION IN THE RAT. Acta poloniae pharmaceutica. 2016 Sep; 73(5):1129-1137. doi: . [PMID: 29638053]
  • C W Locuson, P Williams, J M Adcock, J S Daniels. Evaluation of tizanidine as a marker of canine CYP1A2 activity. Journal of veterinary pharmacology and therapeutics. 2016 Apr; 39(2):122-30. doi: 10.1111/jvp.12256. [PMID: 26228837]
  • Suresh Ponnayyan Sulochana, Vishnuvardh Ravichandiran, Ramesh Mullangi, Sathesh Kumar Sukumaran. Highly Sensitive LC-MS-MS Method for the Determination of Tacrine in Rat Plasma: Application to Pharmacokinetic Studies in Rats. Journal of chromatographic science. 2016 Mar; 54(3):397-404. doi: 10.1093/chromsci/bmv155. [PMID: 26561498]
  • Wiriyaporn Sumsakul, Wiratchanee Mahavorasirikul, Kesara Na-Bangchang. Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450. Phytotherapy research : PTR. 2015 Dec; 29(12):1926-33. doi: 10.1002/ptr.5485. [PMID: 26490449]
  • Xin-Yue Jing, Yun-Ru Peng, Xin-Min Wang, Jin-Ao Duan. Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats. Chinese journal of natural medicines. 2015 Aug; 13(8):588-94. doi: 10.1016/s1875-5364(15)30054-6. [PMID: 26253491]
  • Jianshe Ma, Shuanghu Wang, Meiling Zhang, Qingwei Zhang, Yunfang Zhou, Chongliang Lin, Guanyang Lin, Xianqin Wang. Simultaneous determination of bupropion, metroprolol, midazolam, phenacetin, omeprazole and tolbutamide in rat plasma by UPLC-MS/MS and its application to cytochrome P450 activity study in rats. Biomedical chromatography : BMC. 2015 Aug; 29(8):1203-12. doi: 10.1002/bmc.3409. [PMID: 25582505]
  • Evelyn Pawlik, Hellmut Mahler, Benno Hartung, Gerd Plässer, Thomas Daldrup. Drug-related death: adulterants from cocaine preparations in lung tissue and blood. Forensic science international. 2015 Apr; 249(?):294-303. doi: 10.1016/j.forsciint.2015.02.006. [PMID: 25747329]
  • Xin-shuai Wang, Xiao-chen Hu, Gui-ling Chen, Xiang Yuan, Rui-na Yang, Shuo Liang, Jing Ren, Jia-chun Sun, Guo-qiang Kong, She-gan Gao, Xiao-shan Feng. Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. Phytotherapy research : PTR. 2015 Mar; 29(3):366-72. doi: 10.1002/ptr.5260. [PMID: 25447838]
  • V G N V Prasad, Ch Vivek, P Anand Kumar, P Ravi Kumar, G S Rao. Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats. European journal of drug metabolism and pharmacokinetics. 2015 Mar; 40(1):23-8. doi: 10.1007/s13318-013-0172-7. [PMID: 24356809]
  • Li-Ya Liu, Yong-Long Han, Jin-Hui Zhu, Qi Yu, Quan-Jun Yang, Jin Lu, Cheng Guo. A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates. Biomedical chromatography : BMC. 2015 Mar; 29(3):437-44. doi: 10.1002/bmc.3294. [PMID: 25098274]
  • Hui-dan Zhu, Ni Gu, Meng Wang, Hong-ru Kong, Meng-tao Zhou. Effects of capsicine on rat cytochrome P450 isoforms CYP1A2, CYP2C19, and CYP3A4. Drug development and industrial pharmacy. 2015; 41(11):1824-8. doi: 10.3109/03639045.2015.1011166. [PMID: 25678312]
  • Kezhi Lin, Qingwei Zhang, Zezheng Liu, Suping Yang, Yingying Lin, Congcong Wen, Yuancai Zheng. Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities. International journal of clinical and experimental pathology. 2015; 8(5):5584-90. doi: . [PMID: 26191268]
  • Yuji Kawamura, Hiroyuki Hayashi, Kenichi Masumura, Satoshi Numazawa, Takehiko Nohmi. Genotoxicity of phenacetin in the kidney and liver of Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week repeated-dose studies. Toxicology. 2014 Oct; 324(?):10-7. doi: 10.1016/j.tox.2014.07.003. [PMID: 25047350]
  • Sebastien Antoni, Isabelle Soerjomataram, Suzanne Moore, Jacques Ferlay, Freddy Sitas, David P Smith, David Forman. The ban on phenacetin is associated with changes in the incidence trends of upper-urinary tract cancers in Australia. Australian and New Zealand journal of public health. 2014 Oct; 38(5):455-8. doi: 10.1111/1753-6405.12252. [PMID: 25169832]
  • Yujing Pan, Luxia Zhang, Fang Wang, Xiaomei Li, Haiyan Wang. Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: a cross-sectional survey in China. Nephrology (Carlton, Vic.). 2014 Oct; 19(10):655-60. doi: 10.1111/nep.12318. [PMID: 25196389]
  • Y Huang, S-L Zheng, Z-S Xu, Y Hou. Effects of unprocessed vs. cooked-processed Gastrodia elata on cytochrome P450 enzymes in rats. Drug research. 2014 Aug; 64(8):424-8. doi: 10.1055/s-0033-1361107. [PMID: 24285404]
  • Dong-Lou Liang, Shuang-Li Zheng. Effects of icaritin on cytochrome P450 enzymes in rats. Die Pharmazie. 2014 Apr; 69(4):301-5. doi: NULL. [PMID: 24791596]
  • Yu-Jin Guo, Shuang-Li Zheng. Effect of myricetin on cytochrome P450 isoforms CYP1A2, CYP2C9 and CYP3A4 in rats. Die Pharmazie. 2014 Apr; 69(4):306-10. doi: . [PMID: 24791597]
  • Ren-Ai Xu, Zhi-Sheng Xu, Ren-Shan Ge. Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats. Journal of ethnopharmacology. 2014 Feb; 151(3):1141-1146. doi: 10.1016/j.jep.2013.12.025. [PMID: 24373810]
  • Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. The inhibitory activity of the extracts of popular medicinal herbs on CYP1A2, 2C9, 2C19 and 3A4 and the implications for herb-drug interaction. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2014; 11(4):54-61. doi: 10.4314/ajtcam.v11i4.9. [PMID: 25392581]
  • Sten Holmäng, Erik Holmberg, Sonny L Johansson. A population-based study of tumours of the renal pelvis and ureter: incidence, aetiology and histopathological findings. Scandinavian journal of urology. 2013 Dec; 47(6):491-6. doi: 10.3109/21681805.2013.795188. [PMID: 23634644]
  • Xiao-Mei Zhuang, Yu-Huan Zhong, Wei-Bin Xiao, Hua Li, Chuang Lu. Identification and characterization of psoralen and isopsoralen as potent CYP1A2 reversible and time-dependent inhibitors in human and rat preclinical studies. Drug metabolism and disposition: the biological fate of chemicals. 2013 Nov; 41(11):1914-22. doi: 10.1124/dmd.113.053199. [PMID: 23975028]
  • Jian-Long Chen, Yu-Ling Zhang, Yu Dong, Ji-Yu Gong, Han-Ming Cui. [CYP450 enzyme inhibition of berberine in pooled human liver microsomes by cocktail probe drugs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Jun; 38(12):2009-14. doi: . [PMID: 24066602]
  • Takeki Uehara, Chiaki Kondo, Yuji Morikawa, Hiroyuki Hanafusa, Seiko Ueda, Yohsuke Minowa, Noriyuki Nakatsu, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. Toxicogenomic biomarkers for renal papillary injury in rats. Toxicology. 2013 Jan; 303(?):1-8. doi: 10.1016/j.tox.2012.09.012. [PMID: 23142791]
  • Yan-Hui Zhang, You-Jin Zhang, Yan-Lei Guo, Wen-Juan Li, Chao Yu. Astragaloside IV inhibited the activity of CYP1A2 in liver microsomes and influenced theophylline pharmacokinetics in rats. The Journal of pharmacy and pharmacology. 2013 Jan; 65(1):149-55. doi: 10.1111/j.2042-7158.2012.01579.x. [PMID: 23215698]
  • Xianqin Wang, Xiaole Chen, Mengchun Chen, Guoxin Hu, Jianshe Ma, Jianchun Pan, Lufeng Hu, Guanyang Lin. Assessment of effects of chronic hydrogen sulfide poisoning on cytochrome P450 isoforms activity of rats by cocktail approach. Biological & pharmaceutical bulletin. 2013; 36(10):1627-33. doi: 10.1248/bpb.b13-00502. [PMID: 24088256]
  • Yuki Kobayashi, Tatsuki Fukami, Ryota Higuchi, Miki Nakajima, Tsuyoshi Yokoi. Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia. Biochemical pharmacology. 2012 Nov; 84(9):1196-206. doi: 10.1016/j.bcp.2012.08.015. [PMID: 22940574]
  • Ru Feng, Xuelin Zhou, Penelope M Y Or, Jing-Yi Ma, Xiang-Shan Tan, Jie Fu, Chao Ma, Jian-Gong Shi, Chun-Tao Che, Yan Wang, John H K Yeung. Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Sep; 19(12):1125-33. doi: 10.1016/j.phymed.2012.06.009. [PMID: 22819301]
  • Kuldeep Sharma, Anitha Police, Avinash Kumar, Gopal V Pawar, Sanjeev Giri, Sriram Rajagopal, Ramesh Mullangi. Development and validation of an LC-MS/MS-ESI method for the determination of lorglumide, a CCK-1 antagonist in mouse plasma: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2012 Jul; 26(7):833-8. doi: 10.1002/bmc.1737. [PMID: 22052726]
  • Sandip Gurav, Ravindra Punde, Junaid Farooqui, Mohd Zainuddin, Sriram Rajagopal, Ramesh Mullangi. Development and validation of a highly sensitive method for the determination of abiraterone in rat and human plasma by LC-MS/MS-ESI: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2012 Jun; 26(6):761-8. doi: 10.1002/bmc.1726. [PMID: 22002259]
  • Nitsupa Wattanachai, Wichittra Tassaneeyakul, Andrew Rowland, David J Elliot, Kushari Bowalgaha, Kathleen M Knights, John O Miners. Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance. Drug metabolism and disposition: the biological fate of chemicals. 2012 May; 40(5):982-9. doi: 10.1124/dmd.111.044057. [PMID: 22331994]
  • Yan Zhang, Yanyan Jia, Mengmeng Yang, Peng Yang, Yun Tian, Aiping Xiao, Aidong Wen. The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats. Environmental toxicology and pharmacology. 2012 May; 33(3):453-8. doi: 10.1016/j.etap.2012.01.002. [PMID: 22407168]
  • Zhigang Liu, Minyan Jiang, Xiumei Lu, Feng Qin, Yang Song, Jing Wen, Famei Li. Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 891-892(?):102-8. doi: 10.1016/j.jchromb.2012.02.022. [PMID: 22418072]
  • Yuki Kobayashi, Tatsuki Fukami, Akinori Nakajima, Akinobu Watanabe, Miki Nakajima, Tsuyoshi Yokoi. Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse. Drug metabolism and disposition: the biological fate of chemicals. 2012 Apr; 40(4):671-9. doi: 10.1124/dmd.111.043067. [PMID: 22207054]
  • Long Cheng, Lan Wang, Yanli Wang, Rixin Liang, Weipeng Yang, Wei Wang, Nan Hu, Xiaojie Yin, Xiaogang Weng, Yiwei Wang, Qing Yang. [Influence of jinlingzi powder with different compatibility on activity of cytochrome P1 A2 from rat liver microsomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(5):648-53. doi: 10.4268/cjcmm20120522. [PMID: 22693911]
  • Guan-Yang Lin, Jian-She Ma, Ren-Ai Xu, Lu-Feng Hu, Zhe Wang, Xian-Qin Wang. Effects of Ougan juice on P450 activities using a cocktail method. Die Pharmazie. 2012 Mar; 67(3):242-6. doi: NULL. [PMID: 22530306]
  • Xin Wang, John Hok-Keung Yeung. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Feb; 19(3-4):348-54. doi: 10.1016/j.phymed.2011.09.075. [PMID: 22056022]
  • Kuldeep Sharma, Murugesh Kandaswamy, Chandan Mithra, Ashok Kumar Meena, Sanjeev Giri, Sriram Rajagopal, Ramesh Mullangi. Highly sensitive LC-MS/MS-ESI method for simultaneous quantitation of albendazole and ricobendazole in rat plasma and its application to a rat pharmacokinetic study. Biomedical chromatography : BMC. 2012 Feb; 26(2):247-55. doi: 10.1002/bmc.1654. [PMID: 21633966]
  • Yong Zhao, Bent Håvard Hellum, Aihua Liang, Odd Georg Nilsen. The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine. Phytotherapy research : PTR. 2012 Feb; 26(2):277-83. doi: 10.1002/ptr.3554. [PMID: 21678521]
  • Valerie J Whiterock, Daniel G Morgan, Kimberley A Lentz, Tami L Orcutt, Michael W Sinz. Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs. Drug metabolism and disposition: the biological fate of chemicals. 2012 Feb; 40(2):228-31. doi: 10.1124/dmd.111.041848. [PMID: 22074769]
  • Longshan Zhao, Yunli Zhao, Qing Li, Xiaohui Chen, Feng Xiao, Bosai He, Jie Wang, Kaishun Bi. A fast, sensitive, and high throughput method for the determination of cefuroxime lysine in dog plasma by UPLC-MS/MS. Talanta. 2012 Jan; 89(?):84-90. doi: 10.1016/j.talanta.2011.11.063. [PMID: 22284463]
  • Ori Scott, Elaine Galicia-Connolly, Denise Adams, Soleil Surette, Sunita Vohra, Jerome Y Yager. The safety of cruciferous plants in humans: a systematic review. Journal of biomedicine & biotechnology. 2012; 2012(?):503241. doi: 10.1155/2012/503241. [PMID: 22500092]
  • Kuldeep Sharma, Radheraman Singh, Sanjeev Giri, Sriram Rajagopal, Ramesh Mullangi. Highly sensitive method for the determination of adenosine by LC-MS/MS-ESI: method validation and scope of application to a pharmacokinetic/pharmacodynamic study. Biomedical chromatography : BMC. 2012 Jan; 26(1):81-8. doi: 10.1002/bmc.1629. [PMID: 21491472]
  • Hua Cai, Jun Jiang, Qi Yang, Qingmei Chen, Yiqun Deng. Functional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49). PloS one. 2012; 7(6):e38395. doi: 10.1371/journal.pone.0038395. [PMID: 22675558]
  • Tomonori Kamei, Takahiko Aoyama, Chihiro Tanaka, Takafumi Nagashima, Yukio Aoyama, Hiroyuki Hayashi, Hiroki Nagase, Takahiro Ueno, Noboru Fukuda, Yoshiaki Matsumoto. Quantitation of pyrrole-imidazole polyamide in rat plasma by high-performance liquid chromatography coupled with UV detection. Journal of biomedicine & biotechnology. 2012; 2012(?):715928. doi: 10.1155/2012/715928. [PMID: 22778554]
  • Chong Shen, Guoliang Zhang, Qin Meng. Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PloS one. 2012; 7(4):e36110. doi: 10.1371/journal.pone.0036110. [PMID: 22558349]
  • Dinesh Kumar Dhull, Ankur Jindal, Rakesh K Dhull, Saurabh Aggarwal, Deepak Bhateja, Satyanarayana S V Padi. Neuroprotective effect of cyclooxygenase inhibitors in ICV-STZ induced sporadic Alzheimer's disease in rats. Journal of molecular neuroscience : MN. 2012 Jan; 46(1):223-35. doi: 10.1007/s12031-011-9583-6. [PMID: 21701788]
  • Michael A Tortorici, Melvin Toh, S V Rahavendran, Robert R Labadie, Christine W Alvey, Thomas Marbury, Ernesto Fuentes, Matthew Green, Grace Ni, Brian Hee, Yazdi K Pithavala. Influence of mild and moderate hepatic impairment on axitinib pharmacokinetics. Investigational new drugs. 2011 Dec; 29(6):1370-80. doi: 10.1007/s10637-010-9477-4. [PMID: 20596748]
  • Katsunori Yamaura, Maki Shimada, Noriyuki Nakayama, Koichi Ueno. Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats. Pharmacognosy research. 2011 Oct; 3(4):250-5. doi: 10.4103/0974-8490.89745. [PMID: 22224048]
  • Miroslav Dostalek, Jana Pistovcakova, Jan Jurica, Alexandra Sulcova, Josef Tomandl. The effect of St John's wort (hypericum perforatum) on cytochrome p450 1a2 activity in perfused rat liver. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2011 Sep; 155(3):253-7. doi: 10.5507/bp.2011.047. [PMID: 22286810]
  • J S Patil, Sarasija Suresh, A R Sureshbabu, M S Rajesh. Development and validation of liquid chromatography-mass spectrometry method for the estimation of rifampicin in plasma. Indian journal of pharmaceutical sciences. 2011 Sep; 73(5):558-63. doi: 10.4103/0250-474x.99014. [PMID: 22923869]
  • P S Suresh, Ravindra Ramachandra Punde, Manish Gupta, Abhishek Dixit, Sanjeev Giri, Sriram Rajagopal, Ramesh Mullangi. A highly sensitive LC-MS/MS method for the determination of S-raclopride in rat plasma: application to a pharmacokinetic study in rats. Biomedical chromatography : BMC. 2011 Aug; 25(8):930-7. doi: 10.1002/bmc.1547. [PMID: 21154642]
  • Sandip Dhondiram Gurav, Ravindranath Reddy Gilibili, Sherine Jeniffer, Sanjeev Giri, Nuggehally R Srinivas, Ramesh Mullangi. Highly sensitive method for the determination of a novel triple kinase inhibitor with anti-cancer activity, JI-101, in rat plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2011 Jul; 25(7):794-800. doi: 10.1002/bmc.1518. [PMID: 20872957]
  • Alan Wayne Jones. Early drug discovery and the rise of pharmaceutical chemistry. Drug testing and analysis. 2011 Jun; 3(6):337-44. doi: 10.1002/dta.301. [PMID: 21698778]
  • Loren Lipworth, Robert E Tarone, Joseph K McLaughlin. Renal cell cancer among African Americans: an epidemiologic review. BMC cancer. 2011 Apr; 11(?):133. doi: 10.1186/1471-2407-11-133. [PMID: 21486465]
  • Anna M Wobus, Peter Löser. Present state and future perspectives of using pluripotent stem cells in toxicology research. Archives of toxicology. 2011 Feb; 85(2):79-117. doi: 10.1007/s00204-010-0641-6. [PMID: 21225242]
  • Jin-Ki Kim, Jun-Pil Jee, Jeong-Sook Park, Hyung Tae Kim, Chong-Kook Kim. Reverse-phase liquid chromatography with electrospray ionization/mass spectrometry for the quantification of pseudoephedrine in human plasma and application to a bioequivalence study. Arzneimittel-Forschung. 2011; 61(5):276-81. doi: 10.1055/s-0031-1296199. [PMID: 21755810]
  • Xian Pan, Ping Wang, Nan Hu, Li Liu, Xiaodong Liu, Lin Xie, Guangji Wang. A physiologically based pharmacokinetic model characterizing mechanism-based inhibition of CYP1A2 for predicting theophylline/antofloxacin interaction in both rats and humans. Drug metabolism and pharmacokinetics. 2011; 26(4):387-98. doi: 10.2133/dmpk.dmpk-10-rg-126. [PMID: 21512260]
  • Wen Jian Xiong, Hui Jin, Shui Jun Li, Jia Chen Jin, Bei Na Ji, Chen Yu. Evaluating human liver reserve function by measuring serum concentrations of phenacetin and its metabolites. Journal of digestive diseases. 2010 Dec; 11(6):358-63. doi: 10.1111/j.1751-2980.2010.00463.x. [PMID: 21091898]
  • P S Suresh, Sanjeev Giri, Raghib Husain, Ramesh Mullangi. A highly sensitive LC-MS/MS method for the determination of S-citalopram in rat plasma: application to a pharmacokinetic study in rats. Biomedical chromatography : BMC. 2010 Oct; 24(10):1052-8. doi: 10.1002/bmc.1405. [PMID: 20352615]
  • John J Bissler, Brian J Siroky, Hong Yin. Glomerulocystic kidney disease. Pediatric nephrology (Berlin, Germany). 2010 Oct; 25(10):2049-56; quiz 2056. doi: 10.1007/s00467-009-1416-2. [PMID: 20091054]
  • Qinghao Zhang, Jinping Hu, Li Sheng, Yan Li. Simultaneous quantification of capsaicin and dihydrocapsaicin in rat plasma using HPLC coupled with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Aug; 878(24):2292-7. doi: 10.1016/j.jchromb.2010.06.040. [PMID: 20650692]
  • Yohannes Hagos, Natascha A Wolff. Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity. Toxins. 2010 08; 2(8):2055-82. doi: 10.3390/toxins2082055. [PMID: 22069672]
  • Liwei Hu, Wen Xu, Xi Zhang, Juan Su, Xinru Liu, Haiyun Li, Weidong Zhang. In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine. The Journal of pharmacy and pharmacology. 2010 May; 62(5):658-62. doi: 10.1211/jpp.62.05.0015. [PMID: 20609070]
  • Yu-xin Sheng, Ying-hao Zhang, Jin-lan Zhang, Jin Li, Hui Li, Hong-tao Jin. Determination and toxicokinetics comparison of ketamine and S(+)-ketamine in dog plasma by HPLC-MS method. Biomedical chromatography : BMC. 2010 Mar; 24(3):253-60. doi: 10.1002/bmc.1280. [PMID: 19634119]
  • Peter G Mantle, Cyrille Amerasinghe, Amy L Brown, Diana Herman, Thomas Horn, Thoger Krogh, Edward W Odell, Tomas Rosenbaum, Calin A Tatu. A pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology. Toxins. 2010 03; 2(3):326-40. doi: 10.3390/toxins2030326. [PMID: 22069587]
  • Toshiyuki Tsuchiya, Makoto Umeda, Noriho Tanaka, Ayako Sakai, Hiroshi Nishiyama, Isao Yoshimura, Syozo Ajimi, Shin Asada, Masumi Asakura, Hiroshi Baba, Yasuaki Dewa, Youji Ebe, Yuichi Fushiwaki, Yuji Hagiwara, Shuichi Hamada, Tetsuo Hamamura, Yumiko Iwase, Yoshitsugu Kajiwara, Yasushi Kasahara, Yukihiko Kato, Masayoshi Kawabata, Emiko Kitada, Kazuko Kaneko, Yuko Kizaki, Kinya Kubo, Daisaku Miura, Kaori Mashiko, Fukutaro Mizuhashi, Dai Muramatsu, Madoka Nakajima, Tetsu Nakamura, Hidetoshi Oishi, Toshiaki Sasaki, Sawako Shimada, Chitose Takahashi, Yuko Takeda, Sinobu Wakuri, Nobuhiro Yajima, Satoshi Yajima, Tomoko Yatsushiro. Application of the improved BALB/c 3T3 cell transformation assay to the examination of the initiating and promoting activities of chemicals: the second interlaboratory collaborative study by the non-genotoxic carcinogen study group of Japan. Alternatives to laboratory animals : ATLA. 2010 Mar; 38(1):11-27. doi: 10.1177/026119291003800111. [PMID: 20377301]
  • P Colin, P Koenig, C Ballereau, V Phé, N Berthon, A Villers, J Biserte, M Rouprêt. [Sporadic upper urinary tract urothelial cell carcinomas: identification of interaction between toxic carcinogens and individuals genetic susceptibility]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2010 Jan; 20(1):1-10. doi: 10.1016/j.purol.2009.10.010. [PMID: 20123521]
  • Chiaki Kondo, Yohsuke Minowa, Takeki Uehara, Yasushi Okuno, Noriyuki Nakatsu, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database. Toxicology. 2009 Nov; 265(1-2):15-26. doi: 10.1016/j.tox.2009.09.003. [PMID: 19761811]
  • Francisco Velázquez, Ricardo Manríquez, Leticia Maya, Lucia Barrientos, Fernando López-Dellamary. Phenacetin isolated from Bursera grandifolia, a herbal remedy with antipyretic properties. Natural product communications. 2009 Nov; 4(11):1575-6. doi: ". [PMID: 19967994]
  • Pierre Colin, Philippe Koenig, Adil Ouzzane, Nicolas Berthon, Arnauld Villers, Jacques Biserte, Morgan Rouprêt. Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract. BJU international. 2009 Nov; 104(10):1436-40. doi: 10.1111/j.1464-410x.2009.08838.x. [PMID: 19689473]
  • Loren Lipworth, Robert E Tarone, Lars Lund, Joseph K McLaughlin. Epidemiologic characteristics and risk factors for renal cell cancer. Clinical epidemiology. 2009 Aug; 1(?):33-43. doi: 10.2147/clep.s4759. [PMID: 20865085]
  • Xin Wang, Wayne Y W Lee, Penelope M Y Or, John H K Yeung. Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2009 Aug; 16(8):712-25. doi: 10.1016/j.phymed.2009.03.004. [PMID: 19403289]
  • Nikhil M Vad, Shashi K Kudugunti, Daniel Graber, Nathan Bailey, Kalkunte Srivenugopal, Majid Y Moridani. Efficacy of acetaminophen in skin B16-F0 melanoma tumor-bearing C57BL/6 mice. International journal of oncology. 2009 Jul; 35(1):193-204. doi: 10.3892/ijo_00000329. [PMID: 19513568]
  • Kuntheavy R Ing-Lorenzini, Jules A Desmeules, Marie Besson, Jean-Luc Veuthey, Pierre Dayer, Youssef Daali. Two-dimensional liquid chromatography-ion trap mass spectrometry for the simultaneous determination of ketorolac enantiomers and paracetamol in human plasma: application to a pharmacokinetic study. Journal of chromatography. A. 2009 May; 1216(18):3851-6. doi: 10.1016/j.chroma.2009.02.071. [PMID: 19281996]
  • Paul Michielsen, Lothar Heinemann, Michael Mihatsch, Peter Schnülle, Helmut Graf, Karl-Martin Koch. Non-phenacetin analgesics and analgesic nephropathy: clinical assessment of high users from a case-control study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 Apr; 24(4):1253-9. doi: 10.1093/ndt/gfn643. [PMID: 19037086]
  • Hongda Ma, Yongjun Wang, Tao Guo, Zhonggui He, Xinyu Chang, Xiaohui Pu. Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2009 Feb; 49(2):440-6. doi: 10.1016/j.jpba.2008.11.019. [PMID: 19121909]
  • Fengping Li, Mahendra D Chordia, Tao Huang, Timothy L Macdonald. In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: diiminoquinone formation and conjugation. Chemical research in toxicology. 2009 Jan; 22(1):72-80. doi: 10.1021/tx800152r. [PMID: 19053182]