METHIONINE SULFOXIMINE (BioDeep_00000015962)

 

Secondary id: BioDeep_00001870622

natural product BioNovoGene_Lab2019


代谢物信息卡片


(R-(R*,S*))-S-(3-Amino-3-carboxypropyl)-S-methylsulphoximide

化学式: C5H12N2O3S (180.0569)
中文名称: L-蛋氨酸磺酸盐, L-蛋氨酸砜亚胺
谱图信息: 最多检出来源 Homo sapiens(not specific) 2.44%

分子结构信息

SMILES: CS(=N)(=O)CCC(C(=O)O)N
InChI: InChI=1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)

描述信息

A non-proteinogenic alpha-amino acid that is the sulfoximine derivative of methionine .
KEIO_ID M114

同义名列表

6 个代谢物同义名

METHIONINE SULFOXIMINE; L-Methionine-DL-sulfoximine; (R-(R*,S*))-S-(3-Amino-3-carboxypropyl)-S-methylsulphoximide; 2S,5S-Methionine sulfoximine; 2S,5S-Methionine sulfoximine; L-Methionine sulfoximine



数据库引用编号

48 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 CA1, CRTC1, DHFR, GFAP, GLUL, GYG1, ODC1, PC, SOD1
Nucleus 5 CRTC1, FOS, GLUL, GYG1, SOD1
cytosol 13 CA1, CRTC1, DHFR, FOS, GCLM, GFAP, GLS, GLUL, GPT, GYG1, ODC1, PC, SOD1
nuclear body 1 CRTC1
nucleoplasm 5 ATP2B1, CRTC1, FOS, SLC3A2, SOD1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 6 ATP2B1, GLUL, SLC1A2, SLC1A3, SLC38A1, SLC3A2
Lipid-anchor 1 GLUL
Multi-pass membrane protein 4 ATP2B1, SLC1A2, SLC1A3, SLC38A1
Synapse 4 ATP2B1, GLS, SLC1A3, SLC3A2
cell junction 1 SLC3A2
cell surface 3 SLC1A2, SLC1A3, SLC3A2
glutamatergic synapse 2 ATP2B1, SLC1A2
Golgi membrane 1 INS
lysosomal membrane 1 SLC3A2
neuronal cell body 3 SLC1A3, SLC38A1, SOD1
presynaptic membrane 2 ATP2B1, SLC1A2
Cytoplasm, cytosol 2 GLS, GLUL
plasma membrane 7 ATP2B1, CRTC1, GLUL, SLC1A2, SLC1A3, SLC38A1, SLC3A2
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ATP2B1, GYG1, SLC1A2, SLC1A3, SLC38A1, SLC3A2
apical plasma membrane 1 SLC3A2
axon 1 SLC38A1
basolateral plasma membrane 3 ATP2B1, SLC38A1, SLC3A2
extracellular exosome 7 ATP2B1, CA1, GLUL, GPT, SLC38A1, SLC3A2, SOD1
Lysosome membrane 1 SLC3A2
endoplasmic reticulum 2 FOS, GLUL
extracellular space 3 CXCL8, INS, SOD1
lysosomal lumen 1 GYG1
perinuclear region of cytoplasm 1 SLC1A3
mitochondrion 5 DHFR, GLS, GLUL, PC, SOD1
protein-containing complex 1 SOD1
intracellular membrane-bounded organelle 1 ATP2B1
Secreted 2 CXCL8, INS
extracellular region 4 CXCL8, GYG1, INS, SOD1
astrocyte end-foot 1 GFAP
Mitochondrion matrix 1 PC
mitochondrial matrix 3 GLS, PC, SOD1
anchoring junction 1 SLC3A2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
cytoplasmic vesicle 2 SLC1A3, SOD1
axon cytoplasm 1 SOD1
Single-pass type II membrane protein 1 SLC3A2
vesicle 1 SLC1A2
Apical cell membrane 1 SLC3A2
Membrane raft 1 SLC1A2
axolemma 1 SLC1A2
Peroxisome 1 SOD1
mitochondrial intermembrane space 1 SOD1
intermediate filament 1 GFAP
lateral plasma membrane 1 ATP2B1
dendrite cytoplasm 1 SOD1
neuron projection 1 SLC1A3
chromatin 1 FOS
cell projection 2 ATP2B1, GFAP
[Isoform 1]: Mitochondrion 1 GLS
Basolateral cell membrane 2 ATP2B1, SLC3A2
endosome lumen 1 INS
Melanosome 1 SLC3A2
Presynaptic cell membrane 1 ATP2B1
cell body 3 GFAP, GLUL, SLC1A2
intermediate filament cytoskeleton 1 GFAP
basal plasma membrane 2 SLC1A3, SLC3A2
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 GYG1
secretory granule lumen 2 GYG1, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 FOS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
protein-DNA complex 1 FOS
external side of apical plasma membrane 1 SLC38A1
[Isoform 3]: Mitochondrion 1 GLS
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
astrocyte projection 1 SLC1A2
cytoplasmic side of lysosomal membrane 1 GFAP
glial cell projection 1 GLUL
transcription factor AP-1 complex 1 FOS
amino acid transport complex 1 SLC3A2
apical pole of neuron 1 SLC3A2
neuron projection terminus 1 SLC1A2
photoreceptor ribbon synapse 1 ATP2B1
membrane protein complex 2 SLC1A2, SLC1A3
glutamate-cysteine ligase complex 1 GCLM


文献列表

  • J Porter Hunt, R Jordan Barnett, Hannah Robinson, Mehran Soltani, J Andrew D Nelson, Bradley C Bundy. Rapid sensing of clinically relevant glutamine concentrations in human serum with metabolically engineered E. coli-based cell-free protein synthesis. Journal of biotechnology. 2021 Jan; 325(?):389-394. doi: 10.1016/j.jbiotec.2020.09.011. [PMID: 32961202]
  • Mei-Ya Liu, Dandan Tang, Yuanzhi Shi, Lifeng Ma, Yan Li, Qunfeng Zhang, Jianyun Ruan. Short-term inhibition of glutamine synthetase leads to reprogramming of amino acid and lipid metabolism in roots and leaves of tea plant (Camellia sinensis L.). BMC plant biology. 2019 Oct; 19(1):425. doi: 10.1186/s12870-019-2027-0. [PMID: 31615403]
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  • Meng-Yi Zhang, Dong Wei, Ran Li, Hong-Ting Jia, Yu-Wei Liu, Clauvis Nji Tizi Taning, Jin-Jun Wang, Guy Smagghe. Cytoplasmic glutamine synthetase gene expression regulates larval development in Bactrocera dorsalis (Hendel). Archives of insect biochemistry and physiology. 2018 Apr; 97(4):. doi: 10.1002/arch.21447. [PMID: 29359358]
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