1-Methyladenine (BioDeep_00000001596)

 

Secondary id: BioDeep_00000737993

human metabolite Endogenous blood metabolite Volatile Flavor Compounds


代谢物信息卡片


1, 9-dihydro-1-Methyl-6H-purin-6-imine

化学式: C6H7N5 (149.07014220000002)
中文名称: 1-甲基腺嘌呤
谱图信息: 最多检出来源 Homo sapiens(blood) 0.06%

分子结构信息

SMILES: CN1C=NC2=C(C1=N)NC=N2
InChI: InChI=1S/C6H7N5/c1-11-3-10-6-4(5(11)7)8-2-9-6/h2-3H,7H2,1H3

描述信息

1-Methyladenine is the product of reaction between 1-methyladenosine and water which is catalyzed by 1-methyladenosine nucleosidase (EC:3.2.2.13). 1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation, a reaction requiring ferrous iron and 2-oxoglutarate as cofactor and co-substrate, respectively (PMID:15576352). 1-Methyladenine is found to be associated with adenosine deaminase (ADA) deficiency, which is an inborn error of metabolism.
1-Methyladenine is the product of reaction between 1-methyladenosine and water which is catalyzed by 1-methyladenosine nucleosidase. (EC:3.2.2.13)
KEIO_ID M074

同义名列表

8 个代谢物同义名

1, 9-dihydro-1-Methyl-6H-purin-6-imine; 1-Methyl-1H-purin-6-ylamine; 1-Methyl-1H-purin-6-amine; N1-Methyladenine; 1-Methyl-adenine; 1-Methyladenine; 1-Methyladenine; 1-Methyladenine



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kazuyoshi Chiba. Oocyte Maturation in Starfish. Cells. 2020 02; 9(2):. doi: 10.3390/cells9020476. [PMID: 32092921]
  • Jun Niu, Zifeng Pi, Hao Yue, Yang Wang, Qing Yu, Shuying Liu. Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Oct; 907(?):7-12. doi: 10.1016/j.jchromb.2012.08.012. [PMID: 22998979]
  • Chengqi Yi, Baoen Chen, Bo Qi, Wen Zhang, Guifang Jia, Liang Zhang, Charles J Li, Aaron R Dinner, Cai-Guang Yang, Chuan He. Duplex interrogation by a direct DNA repair protein in search of base damage. Nature structural & molecular biology. 2012 Jun; 19(7):671-6. doi: 10.1038/nsmb.2320. [PMID: 22659876]
  • Jong T Chun, Agostina Puppo, Filip Vasilev, Giovanni Gragnaniello, Ezio Garante, Luigia Santella. The biphasic increase of PIP2 in the fertilized eggs of starfish: new roles in actin polymerization and Ca2+ signaling. PloS one. 2010 Nov; 5(11):e14100. doi: 10.1371/journal.pone.0014100. [PMID: 21124897]
  • Keiichiro Kyozuka, Jong T Chun, Agostina Puppo, Gianni Gragnaniello, Ezio Garante, Luigia Santella. Actin cytoskeleton modulates calcium signaling during maturation of starfish oocytes. Developmental biology. 2008 Aug; 320(2):426-35. doi: 10.1016/j.ydbio.2008.05.549. [PMID: 18599031]
  • Troy A Roepke, Amro M Hamdoun, Gary N Cherr. Increase in multidrug transport activity is associated with oocyte maturation in sea stars. Development, growth & differentiation. 2006 Dec; 48(9):559-73. doi: 10.1111/j.1440-169x.2006.00893.x. [PMID: 17118011]
  • Elisabetta Tosti. Calcium ion currents mediating oocyte maturation events. Reproductive biology and endocrinology : RB&E. 2006 May; 4(?):26. doi: 10.1186/1477-7827-4-26. [PMID: 16684344]
  • Masatoshi Mita. Incapacity of response to disulfide-reducing agent in Triton X-100-treated oocytes of starfish, Asterina pectinifera. Annals of the New York Academy of Sciences. 2005 Apr; 1040(?):413-6. doi: 10.1196/annals.1327.077. [PMID: 15891076]
  • Maria Byrne. Viviparity in the sea star Cryptasterina hystera (Asterinidae)--conserved and modified features in reproduction and development. The Biological bulletin. 2005 Apr; 208(2):81-91. doi: 10.2307/3593116. [PMID: 15837957]
  • Marit S Bratlie, Finn Drabløs. Bioinformatic mapping of AlkB homology domains in viruses. BMC genomics. 2005 Jan; 6(?):1. doi: 10.1186/1471-2164-6-1. [PMID: 15627404]
  • N E Lamash, M G Eliseĭkina. [Effect of 1-methyladenine on localization of Galpha1-protein in starfish oocytes]. Ontogenez. 2002 Jul; 33(4):303-6. doi: NULL. [PMID: 12174576]
  • M Mita, M Yoshikuni, Y Nagahama, M Maekawa, M Saito, M Saneyoshi. Interaction of N1-substituted adenines with 1-methyladenine receptors of starfish oocytes in induction of maturation. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2001 Oct; 130(3):427-34. doi: 10.1016/s1096-4959(01)00457-2. [PMID: 11567906]
  • N E Lamash. [Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis]. Izvestiia Akademii nauk. Seriia biologicheskaia. 2001 Jan; ?(1):121-4. doi: . [PMID: 11236575]
  • L Santella, K Kyozuka, A A Genazzani, L De Riso, E Carafoli. Nicotinic acid adenine dinucleotide phosphate-induced Ca(2+) release. Interactions among distinct Ca(2+) mobilizing mechanisms in starfish oocytes. The Journal of biological chemistry. 2000 Mar; 275(12):8301-6. doi: 10.1074/jbc.275.12.8301. [PMID: 10722659]
  • T Nakano, K Kontani, H Kurosu, T Katada, M Hoshi, K Chiba. G-protein betagamma subunit-dependent phosphorylation of 62-kDa protein in the early signaling pathway of starfish oocyte maturation induced by 1-methyladenine. Developmental biology. 1999 May; 209(1):200-9. doi: 10.1006/dbio.1999.9248. [PMID: 10208753]
  • F J Longo, M Woerner, K Chiba, M Hoshi. Cortical changes in starfish (Asterina pectinifera) oocytes during 1-methyladenine-induced maturation and fertilisation/activation. Zygote (Cambridge, England). 1995 Aug; 3(3):225-39. doi: 10.1017/s0967199400002628. [PMID: 8903792]
  • K Chiba, K Kontani, H Tadenuma, T Katada, M Hoshi. Induction of starfish oocyte maturation by the beta gamma subunit of starfish G protein and possible existence of the subsequent effector in cytoplasm. Molecular biology of the cell. 1993 Oct; 4(10):1027-34. doi: 10.1091/mbc.4.10.1027. [PMID: 8298189]
  • G C Mills. 1-Methyladenine in urine of an adenosine deaminase-deficient adult without immunodeficiency. Biochemical medicine and metabolic biology. 1989 Dec; 42(3):240-7. doi: 10.1016/0885-4505(89)90062-5. [PMID: 2597438]
  • H G Mandel, J A Straw, P B Farmer, J Martin. Chromatographic detection of 7-methyladenine in urine of rats administered N-methylnitrosourea: a potential marker for monitoring exposure to methylating carcinogens. Carcinogenesis. 1989 Apr; 10(4):757-62. doi: 10.1093/carcin/10.4.757. [PMID: 2702723]
  • A Picard, J C Labbe, M Doree. The cell cycle can occur in starfish oocytes and embryos without the production of transferable MPF (maturation-promoting factor). Developmental biology. 1988 Jul; 128(1):129-35. doi: 10.1016/0012-1606(88)90274-6. [PMID: 2838346]
  • L Meijer, P Guerrier. Calmodulin in starfish oocytes. II. Trypsin treatment suppresses the trifluoperazine-sensitive step. Developmental biology. 1984 Jan; 101(1):257-62. doi: 10.1016/0012-1606(84)90139-8. [PMID: 6537928]
  • L Meijer, P Guerrier. Immobilized methylglyoxal-bis(guanylhydrazone) induces starfish oocyte maturation. Developmental biology. 1983 Dec; 100(2):308-17. doi: 10.1016/0012-1606(83)90225-7. [PMID: 6653875]
  • T E Schroeder, S A Stricker. Morphological changes during maturation of starfish oocytes: surface ultrastructure and cortical actin. Developmental biology. 1983 Aug; 98(2):373-84. doi: 10.1016/0012-1606(83)90366-4. [PMID: 6683686]
  • J G Cloud. Hydrostatic pressure inhibition of hormone-induced resumption of meiotic maturation in isolated oocytes. The Journal of experimental zoology. 1983 Aug; 227(2):265-70. doi: 10.1002/jez.1402270210. [PMID: 6604788]
  • A Picard, M Dorée. Is calcium the second messenger of 1-methyladenine in meiosis reinitiation of starfish oocytes?. Experimental cell research. 1983 May; 145(2):325-37. doi: 10.1016/0014-4827(83)90011-3. [PMID: 6407853]
  • B Dale, A de Santis, M Hoshi. Membrane response to 1-methyladenine requires the presence of the nucleus. Nature. 1979 Nov; 282(5734):89-90. doi: 10.1038/282089a0. [PMID: 503193]