Mefenamic acid (BioDeep_00000001546)

 

Secondary id: BioDeep_00000399178

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-[(2,3-dimethylphenyl)amino]benzoic acid

化学式: C15H15NO2 (241.1103)
中文名称: 甲芬那酸
谱图信息: 最多检出来源 Homo sapiens(blood) 8.32%

分子结构信息

SMILES: c1(c(cccc1)C(O)=O)Nc1c(c(ccc1)C)C
InChI: InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)

描述信息

Mefenamic acid is only found in individuals that have used or taken this drug. It is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. [PubChem]Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10159; ORIGINAL_PRECURSOR_SCAN_NO 10158
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10220; ORIGINAL_PRECURSOR_SCAN_NO 10219
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10207; ORIGINAL_PRECURSOR_SCAN_NO 10204
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10231; ORIGINAL_PRECURSOR_SCAN_NO 10228
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10194; ORIGINAL_PRECURSOR_SCAN_NO 10192
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10244; ORIGINAL_PRECURSOR_SCAN_NO 10242
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5516; ORIGINAL_PRECURSOR_SCAN_NO 5514
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5591; ORIGINAL_PRECURSOR_SCAN_NO 5590
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5509; ORIGINAL_PRECURSOR_SCAN_NO 5507
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5490; ORIGINAL_PRECURSOR_SCAN_NO 5489
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5522; ORIGINAL_PRECURSOR_SCAN_NO 5520
CONFIDENCE standard compound; INTERNAL_ID 327; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5497; ORIGINAL_PRECURSOR_SCAN_NO 5493
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 208
EAWAG_UCHEM_ID 208; CONFIDENCE standard compound
CONFIDENCE standard compound; INTERNAL_ID 1151
CONFIDENCE standard compound; INTERNAL_ID 2351
CONFIDENCE standard compound; INTERNAL_ID 8570
CONFIDENCE standard compound; INTERNAL_ID 4094
D000893 - Anti-Inflammatory Agents
KEIO_ID M089; [MS2] KO009073
D004791 - Enzyme Inhibitors
KEIO_ID M089

同义名列表

69 个代谢物同义名

2-[(2,3-dimethylphenyl)amino]benzoic acid; Warner-lambert brand OF mefenamic acid; Warner lambert brand OF mefenamic acid; First horizon brand OF mefenamic acid; Pharmascience brand OF mefenamic acid; Farmasierra brand OF mefenamic acid; Parke davis brand OF mefenamic acid; N-(2,3-Xylyl)-2-aminobenzoic acid; Ashbourne brand OF mefenamic acid; Chemidex brand OF mefenamic acid; Nu pharm brand OF mefenamic acid; Pinewood brand OF mefenamic acid; Nu-pharm brand OF mefenamic acid; Gödecke brand OF mefenamic acid; Antigen brand OF mefenamic acid; Clonmel brand OF mefenamic acid; Pfizer brand OF mefenamic acid; Apotex brand OF mefenamic acid; N-(2,3-Xylyl)-2-aminobenzoate; Rowa brand OF mefenamic acid; Elan brand OF mefenamic acid; APS brand OF mefenamic acid; N-2,3-Xylylanthranilic acid; N-2,3-Xylylanthranilate; Acidum mefenamicum; PMS-Mefenamic acid; PMS Mefenamic acid; Mephenaminic acid; Acid, mefenaminic; Acide mefenamique; Acido mefenamico; Mefenaminic acid; Acid, mefenamic; Mephenamic acid; Methenamic acid; Mefenaminsaeure; Mefanamic acid; Forte, ponstan; mefenamic acid; Apo-mefenamic; Ponstan forte; Apo mefenamic; ApoMefenamic; Nu-mefenamic; Nu mefenamic; NuMefenamic; Pinalgesic; Mefenamate; Contraflam; Mefenacid; CN 35355; INF 3355; Ponalgic; Parkemed; INF-3355; CN-35355; Mefacit; Ponstan; Ponstel; Ponalar; Coslan; Dysman; Ponsyl; CI-473; Ponmel; Pontal; Mefac; Mefic; Mefenamic acid



数据库引用编号

86 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, BCL2, CYP2C9, KCNQ1, MEFV, PTGS1, PTGS2, SULT1A1, SULT1A3
Peripheral membrane protein 4 AP1S2, CYP1B1, PTGS1, PTGS2
Endoplasmic reticulum membrane 9 BCL2, CYP1A2, CYP1B1, CYP2C9, PTGS1, PTGS2, UGT1A1, UGT1A9, UGT2B7
Cytoplasmic vesicle, autophagosome 1 MEFV
Nucleus 3 ALB, BCL2, MEFV
autophagosome 1 MEFV
cytosol 6 ALB, AP1S2, BCL2, MEFV, SULT1A1, SULT1A3
centrosome 1 ALB
nucleoplasm 1 MEFV
Cell membrane 5 KCNE1, KCNQ1, TNF, TRPM2, TRPM3
Cytoplasmic side 1 AP1S2
lamellipodium 1 MEFV
Multi-pass membrane protein 4 KCNA3, KCNQ1, TRPM2, TRPM3
cell surface 2 KCNE1, TNF
glutamatergic synapse 1 KCNA3
Golgi apparatus 3 ALB, AP1S2, PTGS1
Golgi membrane 1 AP1S2
lysosomal membrane 2 AP1S2, TRPM2
neuronal cell body 2 KCNQ1, TNF
presynaptic membrane 1 KCNA3
Lysosome 3 KCNE1, KCNQ1, TRPM2
plasma membrane 8 CYP2C9, KCNA3, KCNE1, KCNQ1, TNF, TRPM2, TRPM3, UGT1A1
Membrane 9 BCL2, CYP1B1, KCNA3, KCNQ1, TRPM2, TRPM3, UGT1A1, UGT1A9, UGT2B7
apical plasma membrane 2 KCNE1, KCNQ1
axon 1 KCNA3
basolateral plasma membrane 1 KCNQ1
caveola 1 PTGS2
extracellular exosome 2 ALB, PTGS1
endoplasmic reticulum 6 ALB, BCL2, KCNQ1, PTGS2, UGT1A1, UGT1A9
extracellular space 2 ALB, TNF
perinuclear region of cytoplasm 2 KCNA3, UGT1A1
mitochondrion 2 BCL2, CYP1B1
protein-containing complex 3 ALB, BCL2, PTGS2
intracellular membrane-bounded organelle 5 AP1S2, CYP1A2, CYP1B1, CYP2C9, PTGS1
Microsome membrane 5 CYP1A2, CYP1B1, CYP2C9, PTGS1, PTGS2
Single-pass type I membrane protein 1 KCNE1
Secreted 1 ALB
extracellular region 2 ALB, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 4 BCL2, UGT1A1, UGT1A9, UGT2B7
mitochondrial outer membrane 1 BCL2
anchoring junction 1 ALB
photoreceptor outer segment 1 PTGS1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
perikaryon 1 TRPM2
Z disc 1 KCNE1
cytoplasmic vesicle 2 MEFV, TRPM2
Early endosome 2 AP1S2, KCNQ1
Membrane, clathrin-coated pit 1 AP1S2
clathrin-coated pit 1 AP1S2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 KCNA3
Apical cell membrane 2 KCNE1, KCNQ1
Cell projection, lamellipodium 1 MEFV
Cytoplasm, perinuclear region 1 UGT1A1
Membrane raft 4 KCNA3, KCNE1, KCNQ1, TNF
pore complex 1 BCL2
microtubule 1 MEFV
lateral plasma membrane 1 KCNQ1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 MEFV
Late endosome 1 KCNQ1
ruffle 1 MEFV
neuron projection 3 KCNQ1, PTGS1, PTGS2
ciliary basal body 1 ALB
ciliary base 1 KCNQ1
microtubule associated complex 1 MEFV
cell projection 1 TRPM2
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 KCNQ1
[Isoform 2]: Cell membrane 2 KCNA3, TRPM2
Endomembrane system 2 AP1S2, PTGS1
monoatomic ion channel complex 1 KCNQ1
Cytoplasmic vesicle membrane 3 AP1S2, KCNQ1, TRPM2
specific granule membrane 1 TRPM2
tertiary granule membrane 1 TRPM2
myelin sheath 1 BCL2
voltage-gated potassium channel complex 3 KCNA3, KCNE1, KCNQ1
trans-Golgi network membrane 1 AP1S2
endoplasmic reticulum lumen 2 ALB, PTGS2
platelet alpha granule lumen 1 ALB
transport vesicle 1 KCNQ1
calyx of Held 1 KCNA3
[Isoform 2]: Nucleus 1 MEFV
ficolin-1-rich granule membrane 1 TRPM2
[Isoform 1]: Cytoplasm, cytoskeleton 1 MEFV
canonical inflammasome complex 1 MEFV
[Isoform 1]: Cell membrane 2 KCNA3, TRPM2
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
AP-1 adaptor complex 1 AP1S2
[Isoform 3]: Cell membrane 1 TRPM2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endoplasmic reticulum chaperone complex 1 UGT1A1
BAD-BCL-2 complex 1 BCL2
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
cytochrome complex 1 UGT1A1
lumenal side of membrane 1 KCNQ1
ciliary transition fiber 1 ALB
basolateral part of cell 1 KCNQ1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jose Guzman-Esquivel, Hector R Galvan-Salazar, Hannah P Guzman-Solorzano, Andrea C Cuevas-Velazquez, Jose A Guzman-Solorzano, Karen A Mokay-Ramirez, Brenda A Paz-Michel, Efren Murillo-Zamora, Josuel Delgado-Enciso, Valery Melnikov, Osiris G Delgado-Enciso, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Fabian Rojas-Larios, Mireya Walle-Guillen, Citlaly B Cardenas-Aguilar, Oscar Beas-Guzman, Daniel Chaviano-Conesa, Hossana S Garcia-Garcia, Ivan Delgado-Enciso. Efficacy of the use of mefenamic acid combined with standard medical care vs. standard medical care alone for the treatment of COVID‑19: A randomized double‑blind placebo‑controlled trial. International journal of molecular medicine. 2022 Mar; 49(3):. doi: 10.3892/ijmm.2022.5084. [PMID: 35029292]
  • Dounia Sid, Milad Baitiche, Zineb Elbahri, Ferhat Djerboua, Mokhtar Boutahala, Zouhair Bouaziz, Marc Le Borgne. Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies. Journal of enzyme inhibition and medicinal chemistry. 2021 Dec; 36(1):605-617. doi: 10.1080/14756366.2020.1869225. [PMID: 33557644]
  • Yan Rong, Tony K L Kiang. Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification. Toxicology and applied pharmacology. 2021 08; 425(?):115553. doi: 10.1016/j.taap.2021.115553. [PMID: 33915121]
  • Rami Ayoub, Qais Jarrar, Dalia Ali, Said Moshawih, Yazun Jarrar, Muhammad Hakim, Zainul Zakaria. Synthesis of Novel Esters of Mefenamic Acid with Pronounced Anti-nociceptive Effects and a Proposed Activity on GABA, Opioid and Glutamate Receptors. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Aug; 163(?):105865. doi: 10.1016/j.ejps.2021.105865. [PMID: 33979659]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Fatemeh Darvishnejad, Jahan Bakhsh Raoof, Milad Ghani. In-situ synthesis of nanocubic cobalt oxide @ graphene oxide nanocomposite reinforced hollow fiber-solid phase microextraction for enrichment of non-steroidal anti-inflammatory drugs from human urine prior to their quantification via high-performance liquid chromatography-ultraviolet detection. Journal of chromatography. A. 2021 Mar; 1641(?):461984. doi: 10.1016/j.chroma.2021.461984. [PMID: 33611121]
  • Ernesto Callegari, Jian Lin, Susanna Tse, Theunis C Goosen, Vaishali Sahasrabudhe. Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid. CPT: pharmacometrics & systems pharmacology. 2021 02; 10(2):127-136. doi: 10.1002/psp4.12581. [PMID: 33314761]
  • Hadis Shahrahmani, Masumeh Ghazanfarpour, Nasim Shahrahmani, Fatemeh Abdi, Robert D E Sewell, Mahmoud Rafieian-Kopaei. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis. Journal of complementary & integrative medicine. 2021 Jan; 18(2):261-269. doi: 10.1515/jcim-2019-0212. [PMID: 34187122]
  • Zahra Jafari, Mohammad Reza Hadjmohammadi. A banana peel/silicon glue coated stir bar for extraction of aspirin, diclofenac, ibuprofen and mefenamic acid followed by high performance liquid chromatography-UV detection. Analytical methods : advancing methods and applications. 2020 09; 12(36):4429-4437. doi: 10.1039/d0ay01332c. [PMID: 32853301]
  • Michael R Duff, Scott A Gabel, Lars C Pedersen, Eugene F DeRose, Juno M Krahn, Elizabeth E Howell, Robert E London. The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. Journal of medicinal chemistry. 2020 08; 63(15):8314-8324. doi: 10.1021/acs.jmedchem.0c00546. [PMID: 32658475]
  • Milad Ghani. Nanocrystalline cellulose as a biotemplate for preparation of porous titania thin film as a sorbent for thin film microextraction of ketorolac, meloxicam, diclofenac and mefenamic acid. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1142(?):122039. doi: 10.1016/j.jchromb.2020.122039. [PMID: 32163902]
  • Qais Bashir Jarrar, Muhammad Nazrul Hakim, Zainul Amiruddin Zakaria, Manraj Singh Cheema, Said Moshawih. Renal ultrastructural alterations induced by various preparations of mefenamic acid. Ultrastructural pathology. 2020 Jan; 44(1):130-140. doi: 10.1080/01913123.2020.1717705. [PMID: 31967489]
  • Hmed Ben-Nasr, Kamilia Ksouda, Bahira Harrabi, Serria Turki Hammami, Khaled Zeghal, Hanen Affes. Pediatric liver failure following mefenamic acid associated to herbal auto-medication: A case report. Therapie. 2019 12; 74(6):677-680. doi: 10.1016/j.therap.2019.04.001. [PMID: 31635831]
  • Tianlang Zhang, Junlang Qiu, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. Uptake of pharmaceuticals acts as an abiotic stress and triggers variation of jasmonates in Malabar spinach (Basella alba. L). Chemosphere. 2019 Dec; 236(?):124711. doi: 10.1016/j.chemosphere.2019.124711. [PMID: 31549668]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram. Application of hydrophobic deep eutectic solvent as the carrier for ferrofluid: A novel strategy for pre-concentration and determination of mefenamic acid in human urine samples by high performance liquid chromatography under experimental design optimization. Talanta. 2019 Sep; 202(?):526-530. doi: 10.1016/j.talanta.2019.05.027. [PMID: 31171217]
  • Yang Li, Yingmin Liao, Youfang Huang, Ziwen Ye, Xiaojia Huang. Dual functional monomers modified magnetic adsorbent for the enrichment of non-steroidal anti-inflammatory drugs in water and urine samples. Talanta. 2019 Aug; 201(?):496-502. doi: 10.1016/j.talanta.2019.04.043. [PMID: 31122456]
  • Dong-Gyun Han, Hwayoung Yun, In-Soo Yoon. A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1122-1123(?):49-57. doi: 10.1016/j.jchromb.2019.05.023. [PMID: 31153131]
  • Z Raisi Dehkordi, M Rafieian-Kopaei, F S Hosseini-Baharanchi. A double-blind controlled crossover study to investigate the efficacy of salix extract on primary dysmenorrhea. Complementary therapies in medicine. 2019 Jun; 44(?):102-109. doi: 10.1016/j.ctim.2019.04.002. [PMID: 31126541]
  • Shahram Seidi, Sasan Eshghi Sanàti. Nickel-iron layered double hydroxide nanostructures for micro solid phase extraction of nonsteroidal anti-inflammatory drugs, followed by quantitation by HPLC-UV. Mikrochimica acta. 2019 04; 186(5):297. doi: 10.1007/s00604-019-3419-4. [PMID: 31016399]
  • Nagaraj P Shetti, Deepti S Nayak, Shweta J Malode, Raghava Reddy Kakarla, Shyam S Shukla, Tejraj M Aminabhavi. Sensors based on ruthenium-doped TiO2 nanoparticles loaded into multi-walled carbon nanotubes for the detection of flufenamic acid and mefenamic acid. Analytica chimica acta. 2019 Mar; 1051(?):58-72. doi: 10.1016/j.aca.2018.11.041. [PMID: 30661620]
  • Ian Cook, Ting Wang, Thomas S Leyh. Isoform-specific therapeutic control of sulfonation in humans. Biochemical pharmacology. 2019 01; 159(?):25-31. doi: 10.1016/j.bcp.2018.11.010. [PMID: 30423313]
  • Alketa Tarushi, George D Geromichalos, Dimitris P Kessissoglou, George Psomas. Manganese coordination compounds of mefenamic acid: In vitro screening and in silico prediction of biological activity. Journal of inorganic biochemistry. 2019 01; 190(?):1-14. doi: 10.1016/j.jinorgbio.2018.09.017. [PMID: 30312777]
  • Yazun Jarrar, Qais Jarrar, Mohammad Abu-Shalhoob, Abdulqader Abed, Esra'a Sha'ban. Relative Expression of Mouse Udp-glucuronosyl Transferase 2b1 Gene in the Livers, Kidneys, and Hearts: The Influence of Nonsteroidal Anti-inflammatory Drug Treatment. Current drug metabolism. 2019; 20(11):918-923. doi: 10.2174/1389200220666191115103310. [PMID: 31733637]
  • Mukesh Kumar, Dilpreet Singh, Neena Bedi. Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile. Therapeutic delivery. 2019 01; 10(1):21-36. doi: 10.4155/tde-2018-0053. [PMID: 30730824]
  • Hamid Asiabi, Yadollah Yamini, Maryam Shamsayei. Development of electrochemically controlled packed-in-tube solid phase microextraction method for sensitive analysis of acidic drugs in biological samples. Talanta. 2018 Aug; 185(?):80-88. doi: 10.1016/j.talanta.2018.03.058. [PMID: 29759253]
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