Thymidine-5'-monophosphoric acid (BioDeep_00000001465)

 

Secondary id: BioDeep_00000399973

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid

化学式: C10H15N2O8P (322.0566)
中文名称: 胸苷-单磷酸, 脱氧胸苷酸, 胸腺嘧啶脱氧核苷酸
谱图信息: 最多检出来源 Homo sapiens(feces) 15.09%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Thymidine-5'-monophosphoric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/thymidine-5_-monophosphoric_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001465). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O
InChI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1

描述信息

5-Thymidylic acid (conjugate base thymidylate), also known as thymidine monophosphate (TMP), deoxythymidine monophosphate (dTMP), or deoxythymidylic acid (conjugate base deoxythymidylate), is a nucleotide that is used as a monomer in DNA. It is an ester of phosphoric acid with the nucleoside thymidine. dTMP consists of a phosphate group, the pentose sugar deoxyribose, and the nucleobase thymine. Unlike the other deoxyribonucleotides, thymidine monophosphate often does not contain the "deoxy" prefix in its name; nevertheless, its symbol often includes a "d" ("dTMP"). 5-Thymidylic acid belongs to the class of organic compounds known as pyrimidine 2-deoxyribonucleoside monophosphates. These are pyrimidine nucleotides with a monophosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. The neutral species of 5-Thymidylic acid (2-deoxythymidine 5-monophosphate). 5-Thymidylic acid exists in all living species, ranging from bacteria to humans. Within humans, 5-thymidylic acid participates in a number of enzymatic reactions. In particular, 5-thymidylic acid and dihydrofolic acid can be biosynthesized from dUMP and 5,10-methylene-THF by the enzyme thymidylate synthase. In addition, 5-thymidylic acid can be converted into dTDP; which is catalyzed by the enzyme thymidylate synthase. In humans, 5-thymidylic acid is involved in pyrimidine metabolism. Outside of the human body, 5-Thymidylic acid has been detected, but not quantified in several different foods, such as common buckwheats, corn salad, garden cress, squashberries, and star fruits.
5-thymidylic acid, also known as thymidylate or thymidine 5-phosphate, is a member of the class of compounds known as pyrimidine 2-deoxyribonucleoside monophosphates. Pyrimidine 2-deoxyribonucleoside monophosphates are pyrimidine nucleotides with a monophosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. 5-thymidylic acid is slightly soluble (in water) and a moderately acidic compound (based on its pKa). 5-thymidylic acid can be found in a number of food items such as burbot, enokitake, scarlet bean, and garland chrysanthemum, which makes 5-thymidylic acid a potential biomarker for the consumption of these food products. 5-thymidylic acid can be found primarily in feces, as well as in human fibroblasts tissue. 5-thymidylic acid exists in all living species, ranging from bacteria to humans. In humans, 5-thymidylic acid is involved in the pyrimidine metabolism. 5-thymidylic acid is also involved in few metabolic disorders, which include beta ureidopropionase deficiency, dihydropyrimidinase deficiency, MNGIE (mitochondrial neurogastrointestinal encephalopathy), and UMP synthase deficiency (orotic aciduria).
Acquisition and generation of the data is financially supported in part by CREST/JST.

同义名列表

48 个代谢物同义名

{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid; Thymidine 5-(dihydrogen phosphoric acid); Deoxyribosylthymine monophosphoric acid; Ribothymidine 5-monophosphoric acid; Thymidine 5-(dihydrogen phosphate); Deoxyribosylthymine monophosphate; 2-Deoxythymidine 5-monophosphate; Deoxythymidine 5-phosphoric acid; Thymidine-5-monophosphoric acid; Deoxythymidine 5-monophosphate; Thymidine monophosphoric acid; Ribothymidine 5-monophosphate; Deoxythymidine monophosphate; Thymidine 5-phosphoric acid; THYMIDINE-5-phosphoric acid; Thymidine-5-monophosphorate; Deoxythymidine 5-phosphate; THYMIDINE 5-MONOPHOSPHATE; Thymidine-5-monophosphate; monoPhosphate, thymidine; Thymidine mononucleotide; Thymidine 5-phosphorate; Thymidine monophosphate; THYMIDINE-5-phosphATE; Thymidine 5-phosphate; Deoxythymidylic acid; Deoxythymydilic acid; Thymidine phosphate; 5-Thymidylic acid; Acids, thymidylic; Deoxythymydilate; Deoxythymidylate; Acid, thymidylic; Thymidylic acids; Thymidylic acid; 5-Methyl-dUMP; 5-Thymidylate; Thymidine 5MP; Thymidylate; Deoxy TMP; 5-dTMP; (DT)1; 5-TMP; dTMP; TMP; Thymidine 5'-monophosphate; Thymideine-monophosphate(dTMP); dTMP



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(0)

代谢反应

60 个相关的代谢反应过程信息。

Reactome(15)

BioCyc(11)

WikiPathways(4)

Plant Reactome(0)

INOH(3)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(26)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 CMPK2, DCTD, DTYMK, MTHFD1, MTR, POLB, SHMT1, SHMT2, TK2, TP53, TYMS
Nucleus 9 DTYMK, DUT, POLB, SHMT1, SHMT2, TP53, TRIM33, TYMS, UNG
cytosol 11 CDA, DCTD, DTYMK, MTHFD1, MTHFR, MTR, NT5E, SHMT1, TP53, TYMP, TYMS
dendrite 1 THY1
centrosome 1 TP53
nucleoplasm 8 CMPK2, DUT, NT5E, POLB, SHMT1, TP53, TRIM33, UNG
Cell membrane 2 NT5E, THY1
cell surface 2 NT5E, THY1
glutamatergic synapse 1 THY1
growth cone 1 THY1
mitochondrial inner membrane 2 SHMT2, TYMS
postsynapse 1 THY1
Presynapse 1 THY1
plasma membrane 2 NT5E, THY1
Membrane 3 MTHFD1, NT5E, TP53
apical plasma membrane 1 THY1
extracellular exosome 6 DUT, MTHFD1, NT5E, SHMT1, SHMT2, THY1
endoplasmic reticulum 2 THY1, TP53
extracellular space 1 THPO
mitochondrion 10 CMPK2, DTYMK, DUT, MTHFD1, SHMT1, SHMT2, TK2, TP53, TYMS, UNG
protein-containing complex 2 POLB, TP53
Secreted 1 THPO
extracellular region 3 CDA, THPO, THY1
neuronal cell body membrane 1 THY1
Mitochondrion matrix 2 TP53, TYMS
mitochondrial matrix 5 DTYMK, SHMT2, TK2, TP53, TYMS
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 2 NT5E, THY1
microtubule cytoskeleton 1 SHMT2
nucleolus 1 TP53
Mitochondrion inner membrane 2 SHMT2, TYMS
Membrane raft 1 THY1
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 THY1
microtubule 1 POLB
axolemma 1 THY1
mitochondrial nucleoid 1 SHMT2
Nucleus, PML body 1 TP53
PML body 1 TP53
chromatin 2 TP53, TRIM33
Lipid-anchor, GPI-anchor 2 NT5E, THY1
site of double-strand break 1 TP53
side of membrane 2 NT5E, THY1
germ cell nucleus 1 TP53
replication fork 1 TP53
ficolin-1-rich granule lumen 1 CDA
secretory granule lumen 1 CDA
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
tertiary granule lumen 1 CDA
[Isoform 2]: Nucleus 1 DUT
[Isoform 1]: Nucleus 1 TP53
spindle microtubule 1 POLB
dendrite membrane 1 THY1
[Isoform 3]: Mitochondrion 1 DUT
Mitochondrion matrix, mitochondrion nucleoid 1 SHMT2
BRISC complex 1 SHMT2


文献列表

  • Marina Giralt, Sara Chocron, Roser Ferrer, Gema Ariceta. Plasma intact fibroblast growth factor 23 level is a useful tool for diagnostic approach of renal hypophosphatemia. Pediatric nephrology (Berlin, Germany). 2021 04; 36(4):1025-1028. doi: 10.1007/s00467-020-04906-8. [PMID: 33492457]
  • Morse Faria, Matthew S Halquist, Erick Kindt, Wenlin Li, H Thomas Karnes, Peter J O'Brien. Liquid chromatography-tandem mass spectrometry method for quantification of thymidine kinase activity in human serum by monitoring the conversion of 3'-deoxy-3'-fluorothymidine to 3'-deoxy-3'-fluorothymidine monophosphate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Oct; 907(?):13-20. doi: 10.1016/j.jchromb.2012.08.024. [PMID: 22995377]
  • Yan Ying Zheng, Ling Xie, Li Liu, Shu Peng Zhang, Xiao Bin Wu, Chang Le Zhu, Ren Sheng Lai. BAT-25 polymorphism in Chinese from Jiangsu province and its implication for locus microsatellite instability screening. The International journal of biological markers. 2012 Oct; 27(3):e227-31. doi: 10.5301/jbm.2012.9311. [PMID: 22653744]
  • A Tavani, S Malerba, C Pelucchi, L Dal Maso, A Zucchetto, D Serraino, F Levi, M Montella, S Franceschi, A Zambon, C La Vecchia. Dietary folates and cancer risk in a network of case-control studies. Annals of oncology : official journal of the European Society for Medical Oncology. 2012 Oct; 23(10):2737-2742. doi: 10.1093/annonc/mds212. [PMID: 22898036]
  • Fatih M Uckun, Pedro Cahn, Sanjive Qazi, Osmond D'Cruz. Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS. Expert opinion on investigational drugs. 2012 Apr; 21(4):489-500. doi: 10.1517/13543784.2012.664635. [PMID: 22360744]
  • Domenico Catalano, Domenico Pignone, Gabriella Sonnante, Mariella M Finetti-Sialer. In-silico and in-vivo analyses of EST databases unveil conserved miRNAs from Carthamus tinctorius and Cynara cardunculus. BMC bioinformatics. 2012 Mar; 13 Suppl 4(?):S12. doi: 10.1186/1471-2105-13-s4-s12. [PMID: 22536958]
  • Juan Wu, Toshihiro Okada, Toru Fukushima, Takahiko Tsudzuki, Masahiro Sugiura, Yasushi Yukawa. A novel hypoxic stress-responsive long non-coding RNA transcribed by RNA polymerase III in Arabidopsis. RNA biology. 2012 Mar; 9(3):302-13. doi: 10.4161/rna.19101. [PMID: 22336715]
  • Jacques Champier, Francine Claustrat, Nicolas Nazaret, Michelle Fèvre Montange, Bruno Claustrat. Folate depletion changes gene expression of fatty acid metabolism, DNA synthesis, and circadian cycle in male mice. Nutrition research (New York, N.Y.). 2012 Feb; 32(2):124-32. doi: 10.1016/j.nutres.2011.12.012. [PMID: 22348461]
  • Robert C Jackson. Pharmacodynamic modelling of biomarker data in oncology. ISRN pharmacology. 2012; 2012(?):590626. doi: 10.5402/2012/590626. [PMID: 22523699]
  • Zafar Rasheed, Hani A Al-Shobaili, Ahmad A Al Robaee, Abdullateef A Alzolibani, Walid I A Wadi, Muhammad Ismail Khan, Hamad A Al-Hamed. Preferential recognition of peroxynitrite damaged thymidine-monophosphate by anti-DNA autoantibodies in systemic lupus erythematosus. Nucleosides, nucleotides & nucleic acids. 2012; 31(10):736-51. doi: 10.1080/15257770.2012.724135. [PMID: 23067125]
  • Rui Shi, Ying-Husan Sun, Xing-Hai Zhang, Vincent L Chiang. Poly(T) adaptor RT-PCR. Methods in molecular biology (Clifton, N.J.). 2012; 822(?):53-66. doi: 10.1007/978-1-61779-427-8_4. [PMID: 22144191]
  • John P Burand, Woojin Kim, Claudio L Afonso, Edan R Tulman, Gerald F Kutish, Zhiqiang Lu, Daniel L Rock. Analysis of the genome of the sexually transmitted insect virus Helicoverpa zea nudivirus 2. Viruses. 2012 01; 4(1):28-61. doi: 10.3390/v4010028. [PMID: 22355451]
  • Ling-Ling Chen, Wan-Chia Chung, Chan-Pin Lin, Chih-Horng Kuo. Comparative analysis of gene content evolution in phytoplasmas and mycoplasmas. PloS one. 2012; 7(3):e34407. doi: 10.1371/journal.pone.0034407. [PMID: 22479625]
  • Susan M Wernimont, Andrew G Clark, Patrick J Stover, Martin T Wells, Augusto A Litonjua, Scott T Weiss, J Michael Gaziano, Katherine L Tucker, Andrea Baccarelli, Joel Schwartz, Valentina Bollati, Patricia A Cassano. Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. BMC medical genetics. 2011 Nov; 12(?):150. doi: 10.1186/1471-2350-12-150. [PMID: 22103680]
  • Thomas C Boothby, Stephen M Wolniak. Masked mRNA is stored with aggregated nuclear speckles and its asymmetric redistribution requires a homolog of Mago nashi. BMC cell biology. 2011 Oct; 12(?):45. doi: 10.1186/1471-2121-12-45. [PMID: 21995518]
  • Katherine Guild, Yang Zhang, Robin Stacy, Elizabeth Mundt, Sarah Benbow, Amanda Green, Peter J Myler. Wheat germ cell-free expression system as a pathway to improve protein yield and solubility for the SSGCID pipeline. Acta crystallographica. Section F, Structural biology and crystallization communications. 2011 Sep; 67(Pt 9):1027-31. doi: 10.1107/s1744309111032143. [PMID: 21904045]
  • Steffen G Jensen, Philippe Lamy, Mads H Rasmussen, Marie S Ostenfeld, Lars Dyrskjøt, Torben F Orntoft, Claus L Andersen. Evaluation of two commercial global miRNA expression profiling platforms for detection of less abundant miRNAs. BMC genomics. 2011 Aug; 12(?):435. doi: 10.1186/1471-2164-12-435. [PMID: 21867561]
  • Glenn Tisman, April Garcia. Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report. Journal of medical case reports. 2011 Aug; 5(?):413. doi: 10.1186/1752-1947-5-413. [PMID: 21867542]
  • Toshiro Sakaguchi, Kensuke Nakajima, Yusuke Matsuda. Identification of the UMP synthase gene by establishment of uracil auxotrophic mutants and the phenotypic complementation system in the marine diatom Phaeodactylum tricornutum. Plant physiology. 2011 May; 156(1):78-89. doi: 10.1104/pp.110.169631. [PMID: 21367966]
  • Marion Heller-Dohmen, Jens C Göpfert, Jens Pfannstiel, Otmar Spring. The nucleotide sequence and genome organization of Plasmopara halstedii virus. Virology journal. 2011 Mar; 8(?):123. doi: 10.1186/1743-422x-8-123. [PMID: 21410989]
  • Yasue Uchida, Saiko Sugiura, Fujiko Ando, Tsutomu Nakashima, Hiroshi Shimokata. Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study. BMC medical genetics. 2011 Mar; 12(?):35. doi: 10.1186/1471-2350-12-35. [PMID: 21385350]
  • Reason Wilken, Mysore S Veena, Marilene B Wang, Eri S Srivatsan. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Molecular cancer. 2011 Feb; 10(?):12. doi: 10.1186/1476-4598-10-12. [PMID: 21299897]
  • Juliana A Moura, Claudete J Valduga, Elaine R Tavares, Iara F Kretzer, Durvanei A Maria, Raul C Maranhão. Novel formulation of a methotrexate derivative with a lipid nanoemulsion. International journal of nanomedicine. 2011; 6(?):2285-95. doi: 10.2147/ijn.s18039. [PMID: 22072866]
  • Jesús Muñoz-Bertomeu, María Angeles Bermúdez, Juan Segura, Roc Ros. Arabidopsis plants deficient in plastidial glyceraldehyde-3-phosphate dehydrogenase show alterations in abscisic acid (ABA) signal transduction: interaction between ABA and primary metabolism. Journal of experimental botany. 2011 Jan; 62(3):1229-39. doi: 10.1093/jxb/erq353. [PMID: 21068209]
  • Nicole Stone, Faith Pangilinan, Anne M Molloy, Barry Shane, John M Scott, Per Magne Ueland, James L Mills, Peader N Kirke, Praveen Sethupathy, Lawrence C Brody. Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes. PloS one. 2011; 6(7):e21851. doi: 10.1371/journal.pone.0021851. [PMID: 21765920]
  • Linda M Liao, Paul Brennan, Dana M van Bemmel, David Zaridze, Vsevolod Matveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonila Szeszenia-Dabrowska, Dana Mates, Nathaniel Rothman, Paolo Boffetta, Wong-Ho Chow, Lee E Moore. LINE-1 methylation levels in leukocyte DNA and risk of renal cell cancer. PloS one. 2011; 6(11):e27361. doi: 10.1371/journal.pone.0027361. [PMID: 22076155]
  • Tomasz Wlodarski, Jan Kutner, Joanna Towpik, Lukasz Knizewski, Leszek Rychlewski, Andrzej Kudlicki, Maga Rowicka, Andrzej Dziembowski, Krzysztof Ginalski. Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome. PloS one. 2011; 6(8):e23168. doi: 10.1371/journal.pone.0023168. [PMID: 21858014]
  • Fabio Facchinelli, Andreas P M Weber. The metabolite transporters of the plastid envelope: an update. Frontiers in plant science. 2011; 2(?):50. doi: 10.3389/fpls.2011.00050. [PMID: 22645538]
  • Monika Hlavová, Mária Čížková, Milada Vítová, Kateřina Bišová, Vilém Zachleder. DNA damage during G2 phase does not affect cell cycle progression of the green alga Scenedesmus quadricauda. PloS one. 2011; 6(5):e19626. doi: 10.1371/journal.pone.0019626. [PMID: 21603605]
  • Claire M Payne, Cheray Crowley-Skillicorn, Carol Bernstein, Hana Holubec, Harris Bernstein. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clinical and experimental gastroenterology. 2011; 4(?):75-119. doi: 10.2147/ceg.s17114. [PMID: 21753893]
  • Angelo Verlotta, Vanessa De Simone, Anna M Mastrangelo, Luigi Cattivelli, Roberto Papa, Daniela Trono. Insight into durum wheat Lpx-B1: a small gene family coding for the lipoxygenase responsible for carotenoid bleaching in mature grains. BMC plant biology. 2010 Nov; 10(?):263. doi: 10.1186/1471-2229-10-263. [PMID: 21110856]
  • Jun Zhuang, Guiqin Cai, Qiying Lin, Zujian Wu, Lianhui Xie. A bacteriophage-related chimeric marine virus infecting abalone. PloS one. 2010 Nov; 5(11):e13850. doi: 10.1371/journal.pone.0013850. [PMID: 21079776]
  • Wei Cun See Too, Mun Teng Wong, Ling Ling Few, Manfred Konrad. Highly specific antibodies for co-detection of human choline kinase α1 and α2 isoforms. PloS one. 2010 Sep; 5(9):e12999. doi: 10.1371/journal.pone.0012999. [PMID: 20886003]
  • Vikki Ho, Thomas E Massey, Will D King. Influence of thymidylate synthase gene polymorphisms on total plasma homocysteine concentrations. Molecular genetics and metabolism. 2010 Sep; 101(1):18-24. doi: 10.1016/j.ymgme.2010.05.010. [PMID: 20580582]
  • Alagu Manickavelu, Kanako Kawaura, Kazuko Oishi, Tadasu Shin-I, Yuji Kohara, Nabila Yahiaoui, Beat Keller, Ayako Suzuki, Kentaro Yano, Yasunari Ogihara. Comparative gene expression analysis of susceptible and resistant near-isogenic lines in common wheat infected by Puccinia triticina. DNA research : an international journal for rapid publication of reports on genes and genomes. 2010 Aug; 17(4):211-22. doi: 10.1093/dnares/dsq009. [PMID: 20360266]
  • Shih-Chi Hsu, Mark F Belmonte, John J Harada, Kentaro Inoue. Indispensable Roles of Plastids in Arabidopsis thaliana Embryogenesis. Current genomics. 2010 Aug; 11(5):338-49. doi: 10.2174/138920210791616716. [PMID: 21286311]
  • Sally Hamour, Alan D Salama, Charles D Pusey. Management of ANCA-associated vasculitis: Current trends and future prospects. Therapeutics and clinical risk management. 2010 Jun; 6(?):253-64. doi: 10.2147/tcrm.s6112. [PMID: 20596502]
  • Changnian Song, Jinggui Fang, Chen Wang, Lei Guo, Kibet Korir Nicholas, Zhengqiang Ma. MiR-RACE, a new efficient approach to determine the precise sequences of computationally identified trifoliate orange (Poncirus trifoliata) microRNAs. PloS one. 2010 Jun; 5(6):e10861. doi: 10.1371/journal.pone.0010861. [PMID: 20539756]
  • E He, X H Xu, H Guan, Y Chen, Z H Chen, Z L Pan, L L Tang, G Z Hu, Y Li, M Zhang, J Zhou, S Eriksson, T Fornander, S Skog. Thymidine kinase 1 is a potential marker for prognosis and monitoring the response to treatment of patients with breast, lung, and esophageal cancer and non-Hodgkin's lymphoma. Nucleosides, nucleotides & nucleic acids. 2010 Jun; 29(4-6):352-8. doi: 10.1080/15257771003738535. [PMID: 20544519]
  • Carol Wagstaff, Irene Bramke, Emily Breeze, Sarah Thornber, Elizabeth Harrison, Brian Thomas, Vicky Buchanan-Wollaston, Tony Stead, Hilary Rogers. A specific group of genes respond to cold dehydration stress in cut Alstroemeria flowers whereas ambient dehydration stress accelerates developmental senescence expression patterns. Journal of experimental botany. 2010 Jun; 61(11):2905-21. doi: 10.1093/jxb/erq113. [PMID: 20457576]
  • Steven F Werder. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatric disease and treatment. 2010 May; 6(?):159-95. doi: 10.2147/ndt.s6564. [PMID: 20505848]
  • Hasmah Abdullah, Azimahtol Hawariah Lope Pihie, Judit Hohmann, Joseph Molnár. A natural compound from Hydnophytum formicarium induces apoptosis of MCF-7 cells via up-regulation of Bax. Cancer cell international. 2010 May; 10(?):14. doi: 10.1186/1475-2867-10-14. [PMID: 20441573]
  • Ofelia A Olivero, Irma L Vazquez, Catherine C Cooch, Jessica Ming, Emily Keller, Mia Yu, Jennifer P Borojerdi, Hannan M Braun, Edward McKee, Miriam C Poirier. Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells. Toxicological sciences : an official journal of the Society of Toxicology. 2010 May; 115(1):109-17. doi: 10.1093/toxsci/kfq023. [PMID: 20106944]
  • Chao Sun, Ying Li, Qiong Wu, Hongmei Luo, Yongzhen Sun, Jingyuan Song, Edmund M K Lui, Shilin Chen. De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. BMC genomics. 2010 Apr; 11(?):262. doi: 10.1186/1471-2164-11-262. [PMID: 20416102]
  • Anja Buhtz, Janin Pieritz, Franziska Springer, Julia Kehr. Phloem small RNAs, nutrient stress responses, and systemic mobility. BMC plant biology. 2010 Apr; 10(?):64. doi: 10.1186/1471-2229-10-64. [PMID: 20388194]
  • Nabil M Abdel-Hamid, Mohamed A Morsy. Novel biochemical pathways for 5-Fluorouracil in managing experimental hepatocellular carcinoma in rats. The Journal of membrane biology. 2010 Mar; 234(1):29-34. doi: 10.1007/s00232-010-9236-7. [PMID: 20177669]
  • Bradley L Urquhart, Jamie C Gregor, Nilesh Chande, Michael J Knauer, Rommel G Tirona, Richard B Kim. The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugs. American journal of physiology. Gastrointestinal and liver physiology. 2010 Feb; 298(2):G248-54. doi: 10.1152/ajpgi.00224.2009. [PMID: 19762432]
  • Koichi Murata, Hiroyuki Yoshitomi, Shimei Tanida, Masahiro Ishikawa, Kohei Nishitani, Hiromu Ito, Takashi Nakamura. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis research & therapy. 2010; 12(3):R86. doi: 10.1186/ar3013. [PMID: 20470394]
  • Juan Sun, Yanxin Hu, Shanping Cao, Guozhong Zhang, Lun-Quan Sun, Ming Wang. Acute, multiple-dose dermal and genetic toxicity of Nu-3: a novel antimicrobial agent. Journal of biomedicine & biotechnology. 2010; 2010(?):. doi: 10.1155/2010/362524. [PMID: 20706607]
  • Damian J Williams, Henry L Puhl, Stephen R Ikeda. A Simple, Highly Efficient Method for Heterologous Expression in Mammalian Primary Neurons Using Cationic Lipid-mediated mRNA Transfection. Frontiers in neuroscience. 2010; 4(?):181. doi: 10.3389/fnins.2010.00181. [PMID: 21267423]
  • Marco Vukich, Tommaso Giordani, Lucia Natali, Andrea Cavallini. Copia and Gypsy retrotransposons activity in sunflower (Helianthus annuus L.). BMC plant biology. 2009 Dec; 9(?):150. doi: 10.1186/1471-2229-9-150. [PMID: 20030800]
  • Davide Colavito, Giuseppe Cartei, Massimo Dal Bianco, Anna Stecca, Fable Zustovich, Maurizio Dalle Carbonare, Eugenio Ragazzi, Miriam Farina, Eva Colombrino, Alberta Leon. Thymidylate synthetase allelic imbalance in clear cell renal carcinoma. Cancer chemotherapy and pharmacology. 2009 Nov; 64(6):1195-200. doi: 10.1007/s00280-009-0986-9. [PMID: 19306093]
  • Regina S Baucom, James C Estill, Cristian Chaparro, Naadira Upshaw, Ansuya Jogi, Jean-Marc Deragon, Richard P Westerman, Phillip J Sanmiguel, Jeffrey L Bennetzen. Exceptional diversity, non-random distribution, and rapid evolution of retroelements in the B73 maize genome. PLoS genetics. 2009 Nov; 5(11):e1000732. doi: 10.1371/journal.pgen.1000732. [PMID: 19936065]
  • Joachim E M Jacob, Bartel Vanholme, Thomas Van Leeuwen, Godelieve Gheysen. A unique genetic code change in the mitochondrial genome of the parasitic nematode Radopholus similis. BMC research notes. 2009 Sep; 2(?):192. doi: 10.1186/1756-0500-2-192. [PMID: 19778425]
  • Marnix G E H Lam, Tjitske B Bosma, Peter P van Rijk, Bernard A Zonnenberg. (188)Re-HEDP combined with capecitabine in hormone-refractory prostate cancer patients with bone metastases: a phase I safety and toxicity study. European journal of nuclear medicine and molecular imaging. 2009 Sep; 36(9):1425-33. doi: 10.1007/s00259-009-1119-8. [PMID: 19319526]
  • Salim Khiati, Nathalie Pierre, Soahary Andriamanarivo, Mark W Grinstaff, Nessim Arazam, Frédéric Nallet, Laurence Navailles, Philippe Barthélémy. Anionic nucleotide--lipids for in vitro DNA transfection. Bioconjugate chemistry. 2009 Sep; 20(9):1765-72. doi: 10.1021/bc900163s. [PMID: 19711898]
  • Julio C Vega-Arreguín, Enrique Ibarra-Laclette, Beatriz Jiménez-Moraila, Octavio Martínez, Jean Philippe Vielle-Calzada, Luis Herrera-Estrella, Alfredo Herrera-Estrella. Deep sampling of the Palomero maize transcriptome by a high throughput strategy of pyrosequencing. BMC genomics. 2009 Jul; 10(?):299. doi: 10.1186/1471-2164-10-299. [PMID: 19580677]
  • Kim L Roberts, Adrien Breiman, Gemma C Carter, Helen A Ewles, Michael Hollinshead, Mansun Law, Geoffrey L Smith. Acidic residues in the membrane-proximal stalk region of vaccinia virus protein B5 are required for glycosaminoglycan-mediated disruption of the extracellular enveloped virus outer membrane. The Journal of general virology. 2009 Jul; 90(Pt 7):1582-1591. doi: 10.1099/vir.0.009092-0. [PMID: 19264647]
  • Rachel A Okrent, Matthew D Brooks, Mary C Wildermuth. Arabidopsis GH3.12 (PBS3) conjugates amino acids to 4-substituted benzoates and is inhibited by salicylate. The Journal of biological chemistry. 2009 Apr; 284(15):9742-54. doi: 10.1074/jbc.m806662200. [PMID: 19189963]
  • Salvatore Grosso, Raffaele Rocchi, Maria Margollicci, Giampaolo Vatti, Alice Luddi, Francesca Marchi, Paolo Balestri. Postictal serum nucleotidases activities in patients with epilepsy. Epilepsy research. 2009 Mar; 84(1):15-20. doi: 10.1016/j.eplepsyres.2008.11.020. [PMID: 19157784]
  • Wie-Hua Chen, Xiaomeng Ge, Weiwei Wang, Jun Yu, Songnian Hu. A gene catalogue for post-diapause development of an anhydrobiotic arthropod Artemia franciscana. BMC genomics. 2009 Jan; 10(?):52. doi: 10.1186/1471-2164-10-52. [PMID: 19173719]
  • Kevin J Cash, Alan J Heeger, Kevin W Plaxco, Yi Xiao. Optimization of a reusable, DNA pseudoknot-based electrochemical sensor for sequence-specific DNA detection in blood serum. Analytical chemistry. 2009 Jan; 81(2):656-61. doi: 10.1021/ac802011d. [PMID: 19093760]
  • Lena Carlsson, Anders Larsson, Henrik Lindman. Elevated levels of thymidine kinase 1 peptide in serum from patients with breast cancer. Upsala journal of medical sciences. 2009; 114(2):116-20. doi: 10.1080/03009730802688835. [PMID: 19396699]
  • Per Byström, Karin Björkegren, Anders Larsson, Linda Johansson, Ake Berglund. Serum vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer. Upsala journal of medical sciences. 2009; 114(3):160-4. doi: 10.1080/03009730903027172. [PMID: 19736606]
  • Karen Loizeau, Veerle De Brouwer, Bernadette Gambonnet, Agnès Yu, Jean-Pierre Renou, Dominique Van Der Straeten, Willy E Lambert, Fabrice Rébeillé, Stéphane Ravanel. A genome-wide and metabolic analysis determined the adaptive response of Arabidopsis cells to folate depletion induced by methotrexate. Plant physiology. 2008 Dec; 148(4):2083-95. doi: 10.1104/pp.108.130336. [PMID: 18931140]
  • S Mendelboum Raviv, A Horváth, J Aradi, Z Bagoly, F Fazakas, Z Batta, L Muszbek, J Hársfalvi. 4-thio-deoxyuridylate-modified thrombin aptamer and its inhibitory effect on fibrin clot formation, platelet aggregation and thrombus growth on subendothelial matrix. Journal of thrombosis and haemostasis : JTH. 2008 Oct; 6(10):1764-71. doi: 10.1111/j.1538-7836.2008.03106.x. [PMID: 18665927]
  • Shusei Sato, Yasukazu Nakamura, Takakazu Kaneko, Erika Asamizu, Tomohiko Kato, Mitsuteru Nakao, Shigemi Sasamoto, Akiko Watanabe, Akiko Ono, Kumiko Kawashima, Tsunakazu Fujishiro, Midori Katoh, Mitsuyo Kohara, Yoshie Kishida, Chiharu Minami, Shinobu Nakayama, Naomi Nakazaki, Yoshimi Shimizu, Sayaka Shinpo, Chika Takahashi, Tsuyuko Wada, Manabu Yamada, Nobuko Ohmido, Makoto Hayashi, Kiichi Fukui, Tomoya Baba, Tomoko Nakamichi, Hirotada Mori, Satoshi Tabata. Genome structure of the legume, Lotus japonicus. DNA research : an international journal for rapid publication of reports on genes and genomes. 2008 Aug; 15(4):227-39. doi: 10.1093/dnares/dsn008. [PMID: 18511435]
  • Bei Li, Lingling Ji, Yunfeng Wu, Xing'an Hao. [Isolation, prokaryotic expression and activity analysis of thymidylate kinase (tmk) gene from Phytoplasma of wheat blue dwarf]. Wei sheng wu xue bao = Acta microbiologica Sinica. 2008 Jun; 48(6):739-44. doi: . [PMID: 18720837]
  • W S Siegel-Lakhai, A S Zandvliet, A D R Huitema, M M Tibben, G Milano, V Girre, V Diéras, A King, E Richmond, J Wanders, J H Beijnen, J H M Schellens. A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours. British journal of cancer. 2008 Apr; 98(8):1320-6. doi: 10.1038/sj.bjc.6604300. [PMID: 18414469]
  • Su Li, Anxun Wang, Wenqi Jiang, Zhongzhen Guan. Pharmacokinetic characteristics and anticancer effects of 5-fluorouracil loaded nanoparticles. BMC cancer. 2008 Apr; 8(?):103. doi: 10.1186/1471-2407-8-103. [PMID: 18412945]
  • Janee Gelineau-van Waes, Joyce R Maddox, Lynette M Smith, Michael van Waes, Justin Wilberding, James D Eudy, Linda K Bauer, Richard H Finnell. Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex. BMC genomics. 2008 Apr; 9(?):156. doi: 10.1186/1471-2164-9-156. [PMID: 18400109]
  • Arnaud Ronceret, Jose Gadea-Vacas, Jocelyne Guilleminot, Frédéric Lincker, Valérie Delorme, Sylvie Lahmy, Georges Pelletier, Marie-Edith Chabouté, Martine Devic. The first zygotic division in Arabidopsis requires de novo transcription of thymidylate kinase. The Plant journal : for cell and molecular biology. 2008 Mar; 53(5):776-89. doi: 10.1111/j.1365-313x.2007.03372.x. [PMID: 18036198]
  • B G Le François, J A Maroun, H C Birnboim. Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F. British journal of cancer. 2007 Nov; 97(9):1242-50. doi: 10.1038/sj.bjc.6604020. [PMID: 17923872]
  • Peter J Little, Narin Osman, Stephanie T de Dios, Nelly Cemerlang, Mandy Ballinger, Julie Nigro. Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions. Cardiovascular diabetology. 2007 Oct; 6(?):33. doi: 10.1186/1475-2840-6-33. [PMID: 17963526]
  • Pratik Jaluria, Michael Betenbaugh, Konstantinos Konstantopoulos, Joseph Shiloach. Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog. BMC biotechnology. 2007 Oct; 7(?):71. doi: 10.1186/1472-6750-7-71. [PMID: 17945021]
  • Valérie de Crécy-Lagard, Basma El Yacoubi, Rocío Díaz de la Garza, Alexandre Noiriel, Andrew D Hanson. Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. BMC genomics. 2007 Jul; 8(?):245. doi: 10.1186/1471-2164-8-245. [PMID: 17645794]
  • Shankar R Chowdhury, Dale E King, Benjamin P Willing, Mark R Band, Jonathan E Beever, Adrienne B Lane, Juan J Loor, Juan C Marini, Laurie A Rund, Lawrence B Schook, Andrew G Van Kessel, H Rex Gaskins. Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets. BMC genomics. 2007 Jul; 8(?):215. doi: 10.1186/1471-2164-8-215. [PMID: 17615075]
  • Ping Wang, Qi Wang, Paul F G Sims, John E Hyde. Characterisation of exogenous folate transport in Plasmodium falciparum. Molecular and biochemical parasitology. 2007 Jul; 154(1):40-51. doi: 10.1016/j.molbiopara.2007.04.002. [PMID: 17509698]
  • Silke Besier, Albrecht Ludwig, Knut Ohlsen, Volker Brade, Thomas A Wichelhaus. Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus. International journal of medical microbiology : IJMM. 2007 Jul; 297(4):217-25. doi: 10.1016/j.ijmm.2007.02.003. [PMID: 17412637]
  • C Lee Elmore, Xuchu Wu, Daniel Leclerc, Erica D Watson, Teodoro Bottiglieri, Natalia I Krupenko, Sergey A Krupenko, James C Cross, Rima Rozen, Roy A Gravel, Rowena G Matthews. Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Molecular genetics and metabolism. 2007 May; 91(1):85-97. doi: 10.1016/j.ymgme.2007.02.001. [PMID: 17369066]
  • Y Basaki, F Hosoi, Y Oda, A Fotovati, Y Maruyama, S Oie, M Ono, H Izumi, K Kohno, K Sakai, T Shimoyama, K Nishio, M Kuwano. Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells. Oncogene. 2007 Apr; 26(19):2736-46. doi: 10.1038/sj.onc.1210084. [PMID: 17072343]
  • Simon Itou, Yasuyuki Goto, Takaaki Kondo, Kazuko Nishio, Sayo Kawai, Yoshiko Ishida, Mariko Naito, Nobuyuki Hamajima. No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese. International journal of medical sciences. 2007 Mar; 4(2):98-104. doi: 10.7150/ijms.4.98. [PMID: 17396161]
  • Henkjan Gellekink, Henk J Blom, Martin den Heijer. Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk. Clinical chemistry and laboratory medicine. 2007; 45(4):471-6. doi: 10.1515/cclm.2007.091. [PMID: 17439323]
  • Henkjan Gellekink, Henk J Blom, I J M van der Linden, Martin den Heijer. Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. European journal of human genetics : EJHG. 2007 Jan; 15(1):103-9. doi: 10.1038/sj.ejhg.5201713. [PMID: 16969375]
  • Young-Nam Kim, Ji-Young Lee, Judy A Driskell. Marginal folate inadequacy observed in a group of young children in Kwangju, Korea. Nutrition research and practice. 2007; 1(2):120-5. doi: 10.4162/nrp.2007.1.2.120. [PMID: 20535397]
  • Robert W Li, CongJun Li. Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells. BMC genomics. 2006 Sep; 7(?):234. doi: 10.1186/1471-2164-7-234. [PMID: 16972989]
  • Giovanna Pontarin, Paola Ferraro, Maria L Valentino, Michio Hirano, Peter Reichard, Vera Bianchi. Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy. The Journal of biological chemistry. 2006 Aug; 281(32):22720-8. doi: 10.1074/jbc.m604498200. [PMID: 16774911]
  • Lisa K Gilliam, Aimee D Kohn, Tasneem Lalani, Paul E Swanson, Vasyl Vasko, Aneeta Patel, Robert B Livingston, Cheryl A Pickett. Capecitabine therapy for refractory metastatic thyroid carcinoma: a case series. Thyroid : official journal of the American Thyroid Association. 2006 Aug; 16(8):801-10. doi: 10.1089/thy.2006.16.801. [PMID: 16910885]
  • Mario Houde, Mahdi Belcaid, François Ouellet, Jean Danyluk, Antonio F Monroy, Ani Dryanova, Patrick Gulick, Anne Bergeron, André Laroche, Matthew G Links, Luke MacCarthy, William L Crosby, Fathey Sarhan. Wheat EST resources for functional genomics of abiotic stress. BMC genomics. 2006 Jun; 7(?):149. doi: 10.1186/1471-2164-7-149. [PMID: 16772040]
  • Fatih M Uckun, Barbara Waurzyniak, Heather Tibbles, Taracad K Venkatachalam, Doug Erbeck. In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats. Arzneimittel-Forschung. 2006 Feb; 56(2A):176-92. doi: 10.1055/s-0031-1296805. [PMID: 16570826]
  • Rui Shi, Vincent L Chiang. Facile means for quantifying microRNA expression by real-time PCR. BioTechniques. 2005 Oct; 39(4):519-25. doi: 10.2144/000112010. [PMID: 16235564]
  • Lilah Rothem, Bluma Berman, Michal Stark, Gerrit Jansen, Yehuda G Assaraf. The reduced folate carrier gene is a novel selectable marker for recombinant protein overexpression. Molecular pharmacology. 2005 Sep; 68(3):616-24. doi: 10.1124/mol.105.013540. [PMID: 15939798]
  • Jeremy Kortmansky, Manish A Shah, Andreas Kaubisch, Amanda Weyerbacher, Sandy Yi, William Tong, Rebecca Sowers, Mithat Gonen, Eileen O'reilly, Nancy Kemeny, David I Ilson, Leonard B Saltz, Robert G Maki, David P Kelsen, Gary K Schwartz. Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2005 Mar; 23(9):1875-84. doi: 10.1200/jco.2005.03.116. [PMID: 15699481]
  • Herve Bercovier, Yolanta Fishman, Ronen Nahary, Sharon Sinai, Amir Zlotkin, Marina Eyngor, Oren Gilad, Avi Eldar, Ronald P Hedrick. Cloning of the koi herpesvirus (KHV) gene encoding thymidine kinase and its use for a highly sensitive PCR based diagnosis. BMC microbiology. 2005 Mar; 5(?):13. doi: 10.1186/1471-2180-5-13. [PMID: 15774009]
  • Uta Schurigt, Nadine Stopfel, Marion Hückel, Christina Pfirschke, Bernd Wiederanders, Rolf Bräuer. Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis. Arthritis research & therapy. 2005; 7(1):R174-88. doi: 10.1186/ar1466. [PMID: 15642138]
  • David M A Martin, Matthew Berriman, Geoffrey J Barton. GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes. BMC bioinformatics. 2004 Nov; 5(?):178. doi: 10.1186/1471-2105-5-178. [PMID: 15550167]
  • Michael Alifrangis, Inge T Christensen, Flemming S Jørgensen, Anita M Rønn, Jimmy E Weng, Ming Chen, Ib C Bygbjerg, Worachart Sirawaraporn, Yaseelan Palarasah, Claus Koch. Homology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparum. Malaria journal. 2004 Jun; 3(?):16. doi: 10.1186/1475-2875-3-16. [PMID: 15193156]
  • Osmond J D'Cruz, Peter Samuel, Barbara Waurzyniak, Fatih M Uckun. Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide. Biology of reproduction. 2003 Dec; 69(6):1843-51. doi: 10.1095/biolreprod.103.019182. [PMID: 12890726]
  • Miriam Vogel, Gudrun Bänfer, Ute Moog, Kurt Weising. Development and characterization of chloroplast microsatellite markers in Macaranga (Euphorbiaceae). Genome. 2003 Oct; 46(5):845-57. doi: 10.1139/g03-068. [PMID: 14608402]