Diazepam (BioDeep_00000001458)

 

Secondary id: BioDeep_00000405800

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

化学式: C16H13ClN2O (284.0716358)
中文名称: 地西泮
谱图信息: 最多检出来源 Homo sapiens(blood) 16.9%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Diazepam. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/diazepam (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000001458). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
InChI: InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

描述信息

Diazepam is a benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589).
Diazepam, first marketed as Valium by Hoffmann-La Roche, is a benzodiazepine derivative drug. It is commonly used for treating anxiety, insomnia, seizures including status epilepticus, muscle spasms (such as in cases of tetanus), restless legs syndrome, alcohol withdrawal, benzodiazepine withdrawal and Ménières disease. Diazepam is found in potato and common wheat.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2626
CONFIDENCE standard compound; INTERNAL_ID 4084
CONFIDENCE standard compound; INTERNAL_ID 1608
CONFIDENCE standard compound; INTERNAL_ID 8560

同义名列表

14 个代谢物同义名

7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; Methyl diazepinone; Methyldiazepinone; Diazemuls; Stesolid; diazepam; Relanium; Faustan; Diastat; Seduxen; Apaurin; Sibazon; Valium



数据库引用编号

44 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ayokunmi Adebukola Akinduko, Sule Ola Salawu, Afolabi Clement Akinmoladun, Afolabi Akintunde Akindahunsi, Osarenkhoe Omorefosa Osemwegie. Assessment of the anxiolytic, antidepressant, and antioxidant potential of Parquetina nigrescens (Afzel.) Bullock in Wistar rats. Journal of ethnopharmacology. 2024 Mar; 322(?):117597. doi: 10.1016/j.jep.2023.117597. [PMID: 38128891]
  • Dayanne Terra Tenório Nonato, Gislei Frota Aragão, Raquel Magalhães Castelo Branco Craveiro, Maria Gonçalves Pereira, Silvânia Maria Mendes Vasconcelos, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Pedro Marcos Gomes Soares, Marcos Aurélio de Sousa Lima, Ana Maria Sampaio Assreuy, Edna Maria Camelo Chaves. Polysaccharide-rich extract of Genipa americana leaves protects seizures and oxidative stress in the mice model of pentylenetetrazole-induced epilepsy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116212. doi: 10.1016/j.biopha.2024.116212. [PMID: 38364734]
  • Natalie E Pinder, Isaac Y Ligocki, Brent M Horton, John E Hoover. Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice. Behavioural brain research. 2024 02; 457(?):114717. doi: 10.1016/j.bbr.2023.114717. [PMID: 37852540]
  • Robin Schürfeld, Ekaterine Baratashvili, Marleen Würfel, Matthias Blüher, Michael Stumvoll, Anke Tönjes, Thomas Ebert. Circulating acyl-CoA-binding protein/diazepam-binding inhibitor in gestational diabetes mellitus. Reproductive biology and endocrinology : RB&E. 2023 Oct; 21(1):96. doi: 10.1186/s12958-023-01152-z. [PMID: 37872629]
  • Colin Bouchard, Mathilde Monperrus, Stellia Sebihi, Cédric Tentelier, Valérie Bolliet. A psychiatric drug found in waste-water plant effluents alters the migratory behavior of critically endangered Anguilla anguilla juveniles. Ecotoxicology and environmental safety. 2023 Oct; 265(?):115496. doi: 10.1016/j.ecoenv.2023.115496. [PMID: 37742579]
  • Miao Ma, Hongfeng Quan, Shujuan Chen, Xueyan Fu, Lingling Zang, Lin Dong. The Anxiolytic Effect of Polysaccharides from Stellariae Radix through Monoamine Neurotransmitters, HPA Axis, and ECS/ERK/CREB/BDNF Signaling Pathway in Stress-induced Male Rats. Brain research bulletin. 2023 Sep; 203(?):110768. doi: 10.1016/j.brainresbull.2023.110768. [PMID: 37739234]
  • Cláudia Pina Costa, Laura Nižić Nodilo, Renata Silva, Eva Martins, Dijana Zadravec, Livije Kalogjera, João Nuno Moreira, José Manuel Sousa Lobo, Anita Hafner, Ana Catarina Silva. In situ hydrogel containing diazepam-loaded nanostructured lipid carriers (DZP-NLC) for nose-to-brain delivery: development, characterization and deposition studies in a 3D-printed human nasal cavity model. International journal of pharmaceutics. 2023 Aug; 644(?):123345. doi: 10.1016/j.ijpharm.2023.123345. [PMID: 37619806]
  • Maedeh Rahati Quchani, Elham Farmanesh, Asieh Esmaili, Ali Moghimi, Masoud Fereidoni, Saeed Rahati Quchani. Behavioral and electrophysiological (ECoG) effects of haplophyllum robustum and TRPA1 antagonist in adult male wistar rats. Toxicon : official journal of the International Society on Toxinology. 2023 Aug; ?(?):107233. doi: 10.1016/j.toxicon.2023.107233. [PMID: 37541601]
  • Constanza Meneses, Marisela Valdes-Gonzalez, Barbara B Garrido-Suárez, Gabino Garrido. Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020. Phytotherapy research : PTR. 2023 May; 37(5):2144-2167. doi: 10.1002/ptr.7830. [PMID: 37039741]
  • Kei Kawada, Tomoaki Ishida, Kohei Jobu, Shumpei Morisawa, Motoki Nishida, Naohisa Tamura, Saburo Yoshioka, Mitsuhiko Miyamura. Glycyrrhizae Radix suppresses lipopolysaccharide- and diazepam-induced nerve inflammation in the hippocampus, and contracts the duration of pentobarbital- induced loss of righting reflex in a mouse model. Journal of natural medicines. 2023 Apr; ?(?):. doi: 10.1007/s11418-023-01700-2. [PMID: 37115471]
  • Samson Sahile Salile, Hamin John Lee, Paul Sewes Frederick Alberts, Teferra Abula, Joseph Valentino Raimondo, Gary Ivan Stafford. In vitro and in vivo anti-seizure activity of hydromethanolic extract and fractions of Pterolobium stellatum. Journal of ethnopharmacology. 2023 Mar; 304(?):116073. doi: 10.1016/j.jep.2022.116073. [PMID: 36543277]
  • Stephanie Elise Muniz Tavares Branco, Marcos Paulo Antunes de Lima, Renata Andrade Silva, Marina Moller Nogueira, Raphael Rocha Wenceslau, José Eduardo Gonçalves, Suzane Lilian Beier, Rubens Antônio Carneiro, Marília Martins Melo. The clinical effect of intravenous lipid emulsion on rabbits medicated with diazepam. Research in veterinary science. 2023 Jan; 154(?):78-83. doi: 10.1016/j.rvsc.2022.11.006. [PMID: 36512977]
  • Masaru Matsuoka, Toru Imai, Sou Iwabuchi, Kosaku Kinoshita. Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion. The Journal of emergency medicine. 2023 Jan; 64(1):62-66. doi: 10.1016/j.jemermed.2022.10.016. [PMID: 36450616]
  • Robin Schürfeld, Benjamin Sandner, Annett Hoffmann, Nora Klöting, Ekaterine Baratashvili, Marcin Nowicki, Sabine Paeschke, Joanna Kosacka, Susan Kralisch, Anette Bachmann, Armin Frille, Anja Dietel, Jens-Uwe Stolzenburg, Matthias Blüher, Ming-Zhi Zhang, Raymond C Harris, Berend Isermann, Michael Stumvoll, Anke Tönjes, Thomas Ebert. Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor. Frontiers in endocrinology. 2023; 14(?):1152444. doi: 10.3389/fendo.2023.1152444. [PMID: 37288304]
  • Pushpa V H, Jayanthi M K, Rashmi H R, Veeresh Kumar N Shivamurthy, Shashank M Patil, Prithvi S Shirahatti, Ramith Ramu. New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca: an in vivo and in silico approach. Pharmaceutical biology. 2022 Dec; 60(1):1656-1668. doi: 10.1080/13880209.2022.2101669. [PMID: 36052952]
  • Duhyeon Kim, Minseok Yoon, Seonghui Kim, Min Young Um, Suengmok Cho. Effects of Green Kiwifruit Peel Extract on Sleep-Wake Profiles in Mice: A Polysomnographic Study Based on Electroencephalogram and Electromyogram Recordings. Nutrients. 2022 Nov; 14(22):. doi: 10.3390/nu14224732. [PMID: 36432419]
  • Lanlan Fan, Congwen Gu, Yu Jiang, Gang Cao, Li Sun, Rodney J Y Ho, Deling Wu, Yanquan Han, Yan Hong. Screening of different chemical components of sedative and hypnotic effects of Ziziphi Spinosae Semen before and after frying and determination of the Q-Marker. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Sep; 1207(?):123349. doi: 10.1016/j.jchromb.2022.123349. [PMID: 35849979]
  • Gregory D Cascino, Daniel Tarquinio, James W Wheless, Robert Edward Hogan, Michael R Sperling, Jay Desai, Blanca Vazquez, Emil Samara, Sunita N Misra, Enrique Carrazana, Adrian L Rabinowicz. Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis. Epilepsia. 2022 07; 63(7):1714-1723. doi: 10.1111/epi.17249. [PMID: 35377464]
  • Guillaume Drevin, Marie Briet, Severine Ferec, Chadi Abbara. Toxicity of designer benzodiazepines: A case of etizolam and cocaine intoxication. Forensic science international. 2022 Jul; 336(?):111324. doi: 10.1016/j.forsciint.2022.111324. [PMID: 35525006]
  • Kei Kawada, Tomoaki Ishida, Kohei Jobu, Shumpei Morisawa, Tetsushi Kawazoe, Motoki Nishida, Satomi Nishimura, Naohisa Tamura, Saburo Yoshioka, Mitsuhiko Miyamura. Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital. Journal of natural medicines. 2022 Jun; 76(3):634-644. doi: 10.1007/s11418-022-01612-7. [PMID: 35257304]
  • Xiaomeng Zhou, Liang Fang, Xuefei Tong, Ying Xu, Xue Wu. Clinical efficacy of clonazepam in the treatment of status epilepticus. Pakistan journal of pharmaceutical sciences. 2022 May; 35(3(Special)):891-895. doi: . [PMID: 35791584]
  • Valentin Yurievich Skryabin, Mikhail Zastrozhin, Marco Torrado, Elena Grishina, Kristina Ryzhikova, Valery Shipitsyn, Tatiana Galaktionova, Evgeny Bryun, Dmitry Sychev. Effects of CYP2C19*17 genetic polymorphisms on plasma and saliva concentrations of diazepam in patients with alcohol withdrawal syndrome. Psychiatric genetics. 2022 04; 32(2):67-73. doi: 10.1097/ypg.0000000000000306. [PMID: 35001019]
  • Priya Srihari, Alicia B Minns, Han T Gao, Allyson A Kreshak. Massive Nonfatal Hydroxychloroquine Ingestion in a Pediatric Patient. The Journal of emergency medicine. 2022 03; 62(3):332-336. doi: 10.1016/j.jemermed.2021.10.043. [PMID: 35065861]
  • Le-le Wang, Xin-Xin Ren, Yi He, Guan-Feng Cui, Jia-Jia Liu, Juan Jia, Jie Cao, Yao Liu, Bin Cong, Zhi-Wen Wei, Ke-Ming Yun. Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs in R&D. 2022 Mar; 22(1):43-50. doi: 10.1007/s40268-021-00375-y. [PMID: 35099786]
  • Benedict T Green, Clinton A Stonecipher, Kevin D Welch, Stephen T Lee, Daniel Cook. Evaluation of diazepam as a drug treatment for water hemlock (Cicuta species) poisoning in Spanish goats. Toxicon : official journal of the International Society on Toxinology. 2022 Jan; 205(?):79-83. doi: 10.1016/j.toxicon.2021.12.003. [PMID: 34871669]
  • Reza Jahani, Sahar Behzad, Maryam Saffariha, Niyusha Toufan Tabrizi, Mehrdad Faizi. Sedative-hypnotic, anxiolytic and possible side effects of Salvia limbata C. A. Mey. Extracts and the effects of phenological stage and altitude on the rosmarinic acid content. Journal of ethnopharmacology. 2022 Jan; 282(?):114630. doi: 10.1016/j.jep.2021.114630. [PMID: 34517061]
  • Ali Hasanvand, Azam Hosseinzadeh, Morteza Saeedavi, Mehdi Goudarzi, Zahra Basir, Saeed Mehrzadi. Neuroprotective effects of tannic acid against kainic acid-induced seizures in mice. Human & experimental toxicology. 2022 Jan; 41(?):9603271221093989. doi: 10.1177/09603271221093989. [PMID: 35544363]
  • Yu-Juan Li, Kun Yang, Xue-Ming Long, Gang Xiao, Si-Juan Huang, Zi-Yue Zeng, Zhao-Ying Liu, Zhi-Liang Sun. Toxicity assessment of gelsenicine and the search for effective antidotes. Human & experimental toxicology. 2022 Jan; 41(?):9603271211062857. doi: 10.1177/09603271211062857. [PMID: 35018838]
  • Anna Basińska-Szafrańska. Delayed crises following benzodiazepine withdrawal: deficient adaptive mechanisms or simple pharmacokinetics? Detoxification assisted by serum-benzodiazepine elimination tracking. European journal of clinical pharmacology. 2022 Jan; 78(1):101-110. doi: 10.1007/s00228-021-03205-x. [PMID: 34515812]
  • Yingze Liu, Chong Su, Yuyao Zhang, Di Zhang, Yaoshuang Li, Jingkai Gu, Ensi Wang, Dong Sun. High-throughput and trace analysis of diazepam in plasma using DART-MS/MS and its pharmacokinetic application. Analytical biochemistry. 2021 12; 635(?):114435. doi: 10.1016/j.ab.2021.114435. [PMID: 34715069]
  • Thamyres V N da Silva, Marcelo F Torres, Luís A Sampaio, Moisés Hamoy, José M Monserrat, Luis André L Barbas. Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum. Fish physiology and biochemistry. 2021 Dec; 47(6):1851-1864. doi: 10.1007/s10695-021-01010-y. [PMID: 34562200]
  • Gulsah Aynaoglu Yildiz, Duran Yildiz, Omer Erkan Yapca, Bahadir Suleyman, Yusuf Kemal Arslan, Nezahat Kurt, Halis Suleyman. Effect of diazepam, sertraline and melatonin on the stress-induced reproductive disorders and intrauterine growth restriction in female rats. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2021 Dec; 34(24):4103-4109. doi: 10.1080/14767058.2019.1706469. [PMID: 31875735]
  • Marta Díaz, Albert Blasco-Roset, Joan Villarroya, Abel López-Bermejo, Francis de Zegher, Francesc Villarroya, Lourdes Ibáñez. Circulating diazepam-binding inhibitor in infancy: Relation to markers of adiposity and metabolic health. Pediatric obesity. 2021 11; 16(11):e12802. doi: 10.1111/ijpo.12802. [PMID: 34014038]
  • Dmytro S Kulyk, Taghi Sahraeian, Suji Lee, Abraham K Badu-Tawiah. Microsampling with a Solid-Phase Extraction Cartridge: Storage and Online Mass Spectrometry Analysis. Analytical chemistry. 2021 10; 93(40):13632-13640. doi: 10.1021/acs.analchem.1c02960. [PMID: 34590821]
  • Antoine Kavaye Kandeda, Germain Sotoing Taiwe, Rigobert Espoir Mbomo Ayissi, Clémentine Moutchida. An aqueous extract of Canarium schweinfurthii attenuates seizures and potentiates sleep in mice: Evidence for involvement of GABA Pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):111973. doi: 10.1016/j.biopha.2021.111973. [PMID: 34343898]
  • Riccardo Maccioni, Filippo Cottiglia, Elias Maccioni, Giuseppe Talani, Enrico Sanna, Valentina Bassareo, Sanjay B Kasture, Elio Acquas. The biologically active compound of Withania somnifera (L.) Dunal, docosanyl ferulate, is endowed with potent anxiolytic properties but devoid of typical benzodiazepine-like side effects. Journal of psychopharmacology (Oxford, England). 2021 Oct; 35(10):1277-1284. doi: 10.1177/02698811211008588. [PMID: 33934670]
  • C P Costa, S Cunha, J N Moreira, R Silva, E Gil-Martins, V Silva, L Azevedo, A F Peixoto, J M Sousa Lobo, A C Silva. Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: Toxicological effect of surface charge on human neuronal cells. International journal of pharmaceutics. 2021 Sep; 607(?):120933. doi: 10.1016/j.ijpharm.2021.120933. [PMID: 34324988]
  • Monserrat Macías-Carballo, Sergio Rosas-Navarro, María Leonor López-Meraz, Luis Beltran-Parrazal, Consuelo Morgado-Valle. Anxiolytic effect of chronic intake of supplemental magnesium chloride in rat. Behavioural brain research. 2021 09; 413(?):113460. doi: 10.1016/j.bbr.2021.113460. [PMID: 34252502]
  • J J García-Peñas, A Gil Nagel-Rein, R Sánchez-Carpintero, V Villanueva-Haba. Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain. Revista de neurologia. 2021 09; 73(S01):S1-S8. doi: 10.33588/rn.73s01.2021250. [PMID: 34486101]
  • Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Masoumeh Askari, Alireza Amirabadizadeh, Mohsen Foadoddini, Omid Mehrpour. Effects of naloxone and diazepam on blood glucose levels in tramadol overdose using generalized estimating equation (GEE) model; (an experimental study). BMC endocrine disorders. 2021 Sep; 21(1):180. doi: 10.1186/s12902-021-00847-x. [PMID: 34488743]
  • Ina Schenk, Marc Machnik, Diane Broussou, Astrid Meuly, Béatrice B Roques, Elodie Lallemand, Michael Düe, Helma Röttgen, Henrike Lagershausen, Pierre-Louis Toutain, Mario Thevis. Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):733-744. doi: 10.1111/jvp.12991. [PMID: 34115414]
  • Syed Muzaffar Ali, Sumbul Shamim, Ishrat Younus, Laila Anwer, Sheikh Abdul Khaliq. Anxiolytic, antidepressant and inhibitory effect on MAO isoenzymes by Bougainvillea glabra flower extract in rats. Pakistan journal of pharmaceutical sciences. 2021 Sep; 34(5(Supplementary)):1963-1968. doi: ". [PMID: 34836867]
  • Shu-Hao Hsu, An-Chun Cheng, Tien-Yu Chang, Li-Heng Pao, Cheng-Huei Hsiong, Hong-Jaan Wang. Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111855. doi: 10.1016/j.biopha.2021.111855. [PMID: 34229248]
  • Heiter V M Boness, Milena S de Oliveira, Carine S C Batista, Leticia S Almeida, Elisangela F Boffo, Cristiane F Villarreal, Frederico G Cruz. Anti-Inflammatory and Antinociceptive Properties of Kielmeyerone A, a Chromenone Isolated from the Roots of Kielmeyera reticulata. Journal of natural products. 2021 08; 84(8):2157-2164. doi: 10.1021/acs.jnatprod.1c00157. [PMID: 34283606]
  • Jirair Gevorkyan, Juliet Kinyua, Sue Pearring, Luke N Rodda. A Case Series of Etizolam in Opioid-Related Deaths. Journal of analytical toxicology. 2021 Aug; 45(7):e4-e17. doi: 10.1093/jat/bkaa146. [PMID: 33031544]
  • Rodiya Manor, Ekkasit Kumarnsit, Nifareeda Samerphob, Thitima Rujiralai, Tidarat Puangpairote, Dania Cheaha. Characterization of pharmaco-EEG fingerprint and sleep-wake profiles of Lavandula angustifolia Mill. essential oil inhalation and diazepam administration in rats. Journal of ethnopharmacology. 2021 Aug; 276(?):114193. doi: 10.1016/j.jep.2021.114193. [PMID: 33971301]
  • Harumi Yoshinaga, Arturo Benitez, Shinichi Takeda, Martha Fournier, Alan R Kugler. A Phase 3 open-label study of the efficacy, safety and pharmacokinetics of buccally administered midazolam hydrochloride for the treatment of status epilepticus in pediatric Japanese subjects. Epilepsy research. 2021 08; 174(?):106651. doi: 10.1016/j.eplepsyres.2021.106651. [PMID: 34020149]
  • Valeria Ottaviano, Alessandro Mauro Tavone, Claudia Scipione, Saverio Potenza, Giulia Petroni, Gian Luca Marella. Drug detection in decomposed cadavers confirms testimonial evidence in a case of serial homicides. Forensic science international. 2021 Aug; 325(?):110893. doi: 10.1016/j.forsciint.2021.110893. [PMID: 34273605]
  • Ashima Saxena, Todd M Myers, Maurice L Sipos. Conjugates of human serum butyrylcholinesterase and nerve agents are behaviorally safe in rhesus macaques. Chemico-biological interactions. 2021 Aug; 344(?):109499. doi: 10.1016/j.cbi.2021.109499. [PMID: 33961835]
  • Leila Alba, Cristina Coll, Sonia Sáez, Lucía Alonso, Helena Pérez, Saray Palma, Virginia Vallés, Sonia Ortiz. New-onset psychosis: A case report of brief psychosis related to COVID-19 infection. Psychiatry research. 2021 07; 301(?):113975. doi: 10.1016/j.psychres.2021.113975. [PMID: 33990069]
  • Claudia Carelli, Francesca Freni, Matteo Moretti, Claudia Vignali, Marco Ballardini, Luca Morini. A case report on fatal intoxication by tapentadol: Study of distribution and metabolism. Forensic science international. 2021 Jul; 324(?):110825. doi: 10.1016/j.forsciint.2021.110825. [PMID: 34000617]
  • Min Young Um, Minseok Yoon, Jaekwang Lee, Jonghoon Jung, Suengmok Cho. A Novel Potent Sleep-Promoting Effect of Turmeric: Turmeric Increases Non-Rapid Eye Movement Sleep in Mice Via Histamine H1Receptor Blockade. Molecular nutrition & food research. 2021 07; 65(14):e2100100. doi: 10.1002/mnfr.202100100. [PMID: 34003596]
  • Arlindo César Matias Pereira, Brenda Lorena Sánchez-Ortíz, Ester Lopes de Melo, Lorane Izabel da Silva Hage-Melim, Raphaelle Sousa Borges, Xuebo Hu, José Carlos Tavares Carvalho. Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. Naunyn-Schmiedeberg's archives of pharmacology. 2021 06; 394(6):1177-1190. doi: 10.1007/s00210-021-02050-0. [PMID: 33515278]
  • Aliance Romain Fokoua, Magloire K Ndjenda, Adeline Kaptué Wuyt, Francis Desire Tatsinkou Bomba, Appolinaire Kene Dongmo, Rodolphe Chouna, Pepin Alango Nkeng-Efouet, Télesphore Benoît Nguelefack. Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. Journal of ethnopharmacology. 2021 May; 272(?):113955. doi: 10.1016/j.jep.2021.113955. [PMID: 33610704]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Laura J Hikin, Paul R Smith, Peter D Maskell, Hassan Kurimbokus, Emily Ashong, Lewis Couchman, Stephen R Morley. Femoral blood concentrations of the designer benzodiazepine etizolam in post-mortem cases. Medicine, science, and the law. 2021 Apr; 61(2):122-129. doi: 10.1177/0025802420973814. [PMID: 33236683]
  • Erin Johnson, Jasper van Heemst, Jeshurun Benavides, Bobby Gray. Metabolism and excretion of the benzodiazepine analogue etizolam in the horse. Drug testing and analysis. 2021 Mar; 13(3):583-594. doi: 10.1002/dta.2967. [PMID: 33169539]
  • Milad Ghani, Zahra Zayeri, Behrooz Maleki. Glutathione-stabilized Fe3 O4 nanoparticles as the sorbent for magnetic solid-phase extraction of diazepam and sertraline from urine samples through quantitation via high-performance liquid chromatography. Journal of separation science. 2021 Mar; 44(6):1195-1202. doi: 10.1002/jssc.202000938. [PMID: 33137222]
  • Keenan M Mahan, Bryan D Hayes, Crystal M North, Justin S Becker, Andrew Z Fenves, Guibenson Hyppolite, Sara Khosrowjerdi, Daniel Sinden, Dana A Stearns. Utility of Hypertonic Saline and Diazepam in COVID-19-Related Hydroxychloroquine Toxicity. The Journal of emergency medicine. 2021 03; 60(3):359-364. doi: 10.1016/j.jemermed.2020.10.048. [PMID: 33353811]
  • Ana Filipa Nogueira, Bruno Nunes. Acute and chronic effects of diazepam on the polychaete Hediste diversicolor: Antioxidant, metabolic, pharmacologic, neurotoxic and behavioural mechanistic traits. Environmental toxicology and pharmacology. 2021 Feb; 82(?):103538. doi: 10.1016/j.etap.2020.103538. [PMID: 33217557]
  • Isaac A Adedara, Babajide O Ajayi, Blessing A Afolabi, Ifeoluwa O Awogbindin, Joao B T Rocha, Ebenezer O Farombi. Toxicological outcome of exposure to psychoactive drugs carbamazepine and diazepam on non-target insect Nauphoeta cinerea. Chemosphere. 2021 Feb; 264(Pt 1):128449. doi: 10.1016/j.chemosphere.2020.128449. [PMID: 33032224]
  • David J Greenblatt, Jerold S Harmatz, Qingchen Zhang, Yuxi Chen, Richard I Shader. Slow Accumulation and Elimination of Diazepam and Its Active Metabolite With Extended Treatment in the Elderly. Journal of clinical pharmacology. 2021 02; 61(2):193-203. doi: 10.1002/jcph.1726. [PMID: 32856316]
  • Godfried Dougnon, Michiho Ito. Role of Ascaridole and p-Cymene in the Sleep-Promoting Effects of Dysphania ambrosioides Essential Oil via the GABAergic System in a ddY Mouse Inhalation Model. Journal of natural products. 2021 01; 84(1):91-100. doi: 10.1021/acs.jnatprod.0c01137. [PMID: 33325703]
  • Bruno Mégarbane, Azzurra Schicchi. Hydroxychloroquine Overdose: What Are the Exact Roles of Diazepam and Potassium Infusion?. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2021 01; 17(1):83-84. doi: 10.1007/s13181-020-00809-0. [PMID: 32926302]
  • Ernest Obese, Robert Peter Biney, Isaac Tabiri Henneh, Emmanuel Awintiig Adakudugu, Daniel Anokwah, Lovia Serwaa Agyemang, Eric Woode, Elvis Ofori Ameyaw. The Anticonvulsant Effect of Hydroethanolic Leaf Extract of Calotropis procera (Ait) R. Br. (Apocynaceae). Neural plasticity. 2021; 2021(?):5566890. doi: 10.1155/2021/5566890. [PMID: 34257639]
  • P R Chai, E G Ferro, J M Kirshenbaum, B D Hayes, S E Culbreth, E W Boyer, T B Erickson. In Reply to 'Hydroxychloroquine Overdose: What Are the Exact Roles of Diazepam and Potassium Infusion?'. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2021 01; 17(1):85-86. doi: 10.1007/s13181-020-00812-5. [PMID: 32926301]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Dyfrig A Hughes. Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam. British journal of pharmacology. 2020 11; 177(21):4975-4989. doi: 10.1111/bph.15101. [PMID: 32415690]
  • Szabolcs Sofalvi, Eric S Lavins, Claire K Kaspar, Haley M Michel, Christie L Mitchell-Mata, Marilyn A Huestis, Luigino G Apollonio. Development and Validation of an LC-MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction. Journal of analytical toxicology. 2020 Oct; 44(7):708-717. doi: 10.1093/jat/bkaa072. [PMID: 32808043]
  • V Kolbe, D Rentsch, D Boy, B Schmidt, R Kegler, A Büttner. The adulterated XANAX pill: a fatal intoxication with etizolam and caffeine. International journal of legal medicine. 2020 Sep; 134(5):1727-1731. doi: 10.1007/s00414-020-02352-7. [PMID: 32607751]
  • Fereshteh Farajdokht, Armin Vosoughi, Mojtaba Ziaee, Mostafa Araj-Khodaei, Javad Mahmoudi, Saeed Sadigh-Eteghad. The role of hippocampal GABAA receptors on anxiolytic effects of Echium amoenum extract in a mice model of restraint stress. Molecular biology reports. 2020 Sep; 47(9):6487-6496. doi: 10.1007/s11033-020-05699-7. [PMID: 32778988]
  • Said A Hassan, Norhan Badr ElDin, Hala E Zaazaa, Azza A Moustafa, Amr M Mahmoud. Point-of-care diagnostics for drugs of abuse in biological fluids: application of a microfabricated disposable copper potentiometric sensor. Mikrochimica acta. 2020 08; 187(9):491. doi: 10.1007/s00604-020-04445-x. [PMID: 32767121]
  • Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):389-396. doi: 10.1016/j.dmpk.2020.05.004. [PMID: 32690433]
  • Sarina Tanimoto, Luana Pesco Koplowitz, Richard E Lowenthal, Barry Koplowitz, Adrian L Rabinowicz, Enrique Carrazana. Evaluation of Pharmacokinetics and Dose Proportionality of Diazepam After Intranasal Administration of NRL-1 to Healthy Volunteers. Clinical pharmacology in drug development. 2020 08; 9(6):719-727. doi: 10.1002/cpdd.767. [PMID: 31916704]
  • Helia Aghamiri, Hamed Shafaroodi, Jinous Asgarpanah. Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABAA Neurotransmission and the Nitric Oxide Pathway. Clinical and translational science. 2020 07; 13(4):785-797. doi: 10.1111/cts.12767. [PMID: 32027449]
  • Zartashia Kazmi, Sara Zeeshan, Adnan Khan, Sumra Malik, Adeeb Shehzad, Eun Kyoung Seo, Salman Khan. Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling. Neurotoxicology. 2020 07; 79(?):150-163. doi: 10.1016/j.neuro.2020.05.005. [PMID: 32450180]
  • Peter R Chai, E G Ferro, J M Kirshenbaum, B D Hayes, S E Culbreth, E W Boyer, T B Erickson. Intentional Hydroxychloroquine Overdose Treated with High-Dose Diazepam: an Increasing Concern in the COVID-19 Pandemic. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2020 07; 16(3):314-320. doi: 10.1007/s13181-020-00790-8. [PMID: 32514696]
  • Muhammad Torequl Islam, Natália Martins, Muhammad Imran, Aneela Hameed, Shinawar Waseem Ali, Bahare Salehi, Ishtiaque Ahmad, Ahmad Hussain, Javad Sharifi-Rad. Anxiolytic-like effects of Moringa oleifera in Swiss mice. Cellular and molecular biology (Noisy-le-Grand, France). 2020 Jun; 66(4):73-77. doi: 10.14715/cmb/2020.66.4.12. [PMID: 32583774]
  • Xiao-Juan Ren, Guan-Ying Wang, Xing-Ping Zhang, Qing-Quan Wang, Zhi-Peng Peng. Sedative and Hypnotic Effects and Transcriptome Analysis of Polygala tenuifolia in Aged Insomnia Rats. Chinese journal of integrative medicine. 2020 Jun; 26(6):434-441. doi: 10.1007/s11655-020-3087-6. [PMID: 32240473]
  • Glauce C Nascimento, Bruno L Malzone, Daniela M Iyomasa, Yamba C L Pereira, João Paulo M Issa, Christie R A Leite-Panissi, Ii-Sei Watanabe, Mamie M Iyomasa, Ramon Fuentes, Elaine Del Bel, Fernando J Dias. Beneficial effects of benzodiazepine on masticatory muscle dysfunction induced by chronic stress and occlusal instability in an experimental animal study. Scientific reports. 2020 05; 10(1):8787. doi: 10.1038/s41598-020-65524-w. [PMID: 32472004]
  • Liang Jin, Yijun Pan, Natalie Lan Linh Tran, Leon N Polychronopoulos, Aparna Warrier, Kim L R Brouwer, Joseph A Nicolazzo. Intestinal Permeability and Oral Absorption of Selected Drugs Are Reduced in a Mouse Model of Familial Alzheimer's Disease. Molecular pharmaceutics. 2020 05; 17(5):1527-1537. doi: 10.1021/acs.molpharmaceut.9b01227. [PMID: 32212738]
  • Robert Edward Hogan, Daniel Tarquinio, Michael R Sperling, Pavel Klein, Ian Miller, Eric B Segal, Adrian L Rabinowicz, Enrique Carrazana. Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study. Epilepsia. 2020 05; 61(5):935-943. doi: 10.1111/epi.16506. [PMID: 32338380]
  • Ghazal Rahmani, Fereshteh Farajdokht, Gisou Mohaddes, Shirin Babri, Vida Ebrahimi, Hadi Ebrahimi. Garlic (Allium sativum) improves anxiety- and depressive-related behaviors and brain oxidative stress in diabetic rats. Archives of physiology and biochemistry. 2020 May; 126(2):95-100. doi: 10.1080/13813455.2018.1494746. [PMID: 30169970]
  • Chun-Yan Shen, Lin Wan, Jing-Jing Zhu, Jian-Guo Jiang. Targets and underlying mechanisms related to the sedative and hypnotic activities of saponin extracts from semen Ziziphus jujube. Food & function. 2020 May; 11(5):3895-3903. doi: 10.1039/d0fo00098a. [PMID: 32407431]
  • Junli Zhao, Yang Zheng, Keyue Liu, Junzi Chen, Nanxi Lai, Fan Fei, Jiaying Shi, Cenglin Xu, Shuang Wang, Masahiro Nishibori, Yi Wang, Zhong Chen. HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2020 04; 17(2):710-721. doi: 10.1007/s13311-019-00815-3. [PMID: 31802434]
  • R Edward Hogan, Barry E Gidal, Barry Koplowitz, Luana P Koplowitz, Richard E Lowenthal, Enrique Carrazana. Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers. Epilepsia. 2020 03; 61(3):455-464. doi: 10.1111/epi.16449. [PMID: 32065672]
  • Gergő Dargó, Dávid Bajusz, Kristóf Simon, Judit Müller, György T Balogh. Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design. Journal of medicinal chemistry. 2020 02; 63(4):1763-1774. doi: 10.1021/acs.jmedchem.0c00046. [PMID: 31995375]
  • Hiroshi Tsutsumi, Kosei Yonemitsu, Ako Sasao, Yuki Ohtsu, Shota Furukawa, Yoko Nishitani. Cerebrospinal fluid neurotransmitter levels and central nervous system depression in a rat drug overdose model. Toxicology mechanisms and methods. 2020 Feb; 30(2):139-145. doi: 10.1080/15376516.2019.1672122. [PMID: 31550965]
  • Dayse Karine Rodrigues Holanda, Nédio Jair Wurlitzer, Ana Paula Dionisio, Adriana Rolim Campos, Renato Azevedo Moreira, Paulo Henrique Machado de Sousa, Edy Sousa de Brito, Paulo Riceli Vasconcelos Ribeiro, Mayara Frade Iunes, Ana Maria Costa. Garlic passion fruit (Passiflora tenuifila Killip): Assessment of eventual acute toxicity, anxiolytic, sedative, and anticonvulsant effects using in vivo assays. Food research international (Ottawa, Ont.). 2020 02; 128(?):108813. doi: 10.1016/j.foodres.2019.108813. [PMID: 31955772]
  • José Ignacio Fortea, Marta Puerto, Carolina Fernández-Mena, Iris Asensio, María Arriba, Jorge Almagro, Juan Bañares, Cristina Ripoll, Rafael Bañares, Javier Vaquero. Sevoflurane versus ketamine+diazepam anesthesia for assessing systemic and hepatic hemodynamics in rats with non-cirrhotic portal hypertension. PloS one. 2020; 15(5):e0233778. doi: 10.1371/journal.pone.0233778. [PMID: 32469999]
  • Rowan Saloner, David J Grelotti, Griffin Tyree, Erin E Sundermann, Qing Ma, Scott Letendre, Robert K Heaton, Mariana Cherner. Benzodiazepine Use Is Associated With an Increased Risk of Neurocognitive Impairment in People Living With HIV. Journal of acquired immune deficiency syndromes (1999). 2019 12; 82(5):475-482. doi: 10.1097/qai.0000000000002183. [PMID: 31714426]
  • Michael A Rogawski, Allen H Heller. Diazepam buccal film for the treatment of acute seizures. Epilepsy & behavior : E&B. 2019 12; 101(Pt B):106537. doi: 10.1016/j.yebeh.2019.106537. [PMID: 31699662]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Gulraiz Ahmad, Nasir Rasool, Komal Rizwan, Imran Imran, Ameer Fawad Zahoor, Muhammad Zubair, Abdul Sadiq, Umer Rashid. Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogs. Bioorganic chemistry. 2019 11; 92(?):103216. doi: 10.1016/j.bioorg.2019.103216. [PMID: 31491567]
  • Rafael Fernández-Demeneghi, Juan-Francisco Rodríguez-Landa, Rosa-Isela Guzmán-Gerónimo, Héctor-Gabriel Acosta-Mesa, Enrique Meza-Alvarado, Isidro Vargas-Moreno, Socorro Herrera-Meza. Effect of blackberry juice (Rubus fruticosus L.) on anxiety-like behaviour in Wistar rats. International journal of food sciences and nutrition. 2019 Nov; 70(7):856-867. doi: 10.1080/09637486.2019.1580680. [PMID: 30892114]
  • Maëlle F Clabots, Elodie Gaillard, Marcel Aumann. Acute kidney injury, seizures, and hypertonic hyponatremia secondary to mannitol intoxication in a dog. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2019 Nov; 29(6):680-685. doi: 10.1111/vec.12902. [PMID: 31637833]
  • Zhipei Sang, Keren Wang, Pengfei Zhang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2019 Oct; 180(?):238-252. doi: 10.1016/j.ejmech.2019.07.021. [PMID: 31310916]
  • Sabrina Lehmann, Alissa Sczyslo, Judith Froch-Cortis, Markus Alexander Rothschild, Mario Thevis, Hilke Andresen-Streichert, Katja Mercer-Chalmers-Bender. Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine. Forensic science international. 2019 Oct; 303(?):109959. doi: 10.1016/j.forsciint.2019.109959. [PMID: 31546164]
  • Yun Li, Duanyi Song, Fanyan Bo, Min Deng, Xuefang Tang. Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABAA receptor α4-subunit. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Oct; 118(?):109239. doi: 10.1016/j.biopha.2019.109239. [PMID: 31351431]