Buprenorphine (BioDeep_00000001442)

 

Secondary id: BioDeep_00000398419

human metabolite blood metabolite natural product


代谢物信息卡片


(1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-3-azahexacyclo[13.2.2.1²,⁸.0¹,⁶.0⁶,¹⁴.0⁷,¹²]icosa-7,9,11-trien-11-ol

化学式: C29H41NO4 (467.3035)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 3.74%

分子结构信息

SMILES: CC(C)(C)C(C)(C1CC23CCC1(C4C25CCN(C3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O
InChI: InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1

描述信息

A derivative of the opioid alkaloid thebaine that is a more potent and longer lasting analgesic than morphine. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use. [PubChem]
N - Nervous system > N07 - Other nervous system drugs > N07B - Drugs used in addictive disorders > N07BC - Drugs used in opioid dependence
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AE - Oripavine derivatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
D002491 - Central Nervous System Agents > D000700 - Analgesics

同义名列表

39 个代谢物同义名

(1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-3-azahexacyclo[13.2.2.1²,⁸.0¹,⁶.0⁶,¹⁴.0⁷,¹²]icosa-7,9,11-trien-11-ol; 2-[3-Cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol; 17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol; 2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol; 17-Cyclopropylmethyl-4,5α-epoxy-7α-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol; 17-Cyclopropylmethyl-4,5a-epoxy-7a-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol; 2-(N-Cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6α-yl)-3,3-dimethyl-2-butanol; 2-(N-Cyclopropylmethyl-4,5a-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6a-yl)-3,3-dimethyl-2-butanol; 21-Cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 21-Cyclopropyl-7α-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 21-Cyclopropyl-7a-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; Reckitt and colman brand 2 OF buprenorphine hydrochloride; Reckitt and colman brand 1 OF buprenorphine hydrochloride; Reckitt benckiser brand OF buprenorphine hydrochloride; Schering-plough brand OF buprenorphine hydrochloride; Schering plough brand OF buprenorphine hydrochloride; Grünenthal brand OF buprenorphine hydrochloride; Reckitt brand OF buprenorphine hydrochloride; Essex brand OF buprenorphine hydrochloride; Key brand OF buprenorphine hydrochloride; Grünenthal brand OF buprenorphine; Buprenorphine grünenthal brand; Hydrochloride, buprenorphine; Buprenorphine hydrochloride; (-)-Buprenorphine; Buprenorphinum; buprenorphine; Buprenorfina; Buprenophine; RX 6029 m; RX-6029-m; RX 6029M; Temgesic; Temgésic; Buprenex; Subutex; Buprex; Prefin; Buprenorphine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, BDNF, CYP2B6, CYP2C19, CYP2D6, POMC
Peripheral membrane protein 2 CYP1B1, CYP2B6
Endoplasmic reticulum membrane 5 CYP1B1, CYP2B6, CYP2C19, CYP2D6, UGT2B7
Nucleus 1 OTP
cytosol 3 GPT, SCLY, SLC22A16
dendrite 3 BDNF, PDYN, PNOC
nuclear body 1 OTP
nucleoplasm 1 OTP
Cell membrane 4 ABCB1, OPRD1, SLC22A16, TNF
Multi-pass membrane protein 3 ABCB1, OPRD1, SLC22A16
Synapse 2 PDYN, PNOC
cell surface 3 ABCB1, TNF, TNR
glutamatergic synapse 1 TNR
Golgi apparatus 1 SCLY
neuronal cell body 3 PDYN, PNOC, TNF
presynaptic membrane 1 OPRD1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 SCLY
plasma membrane 8 ABCB1, CYP2C19, INSRR, OPRD1, PDYN, PNOC, SLC22A16, TNF
synaptic vesicle membrane 1 OPRD1
Membrane 8 ABCB1, BDNF, CYP1B1, CYP2D6, INSRR, OPRD1, SLC22A16, UGT2B7
apical plasma membrane 1 ABCB1
axon 2 BDNF, INSRR
extracellular exosome 2 ABCB1, GPT
endoplasmic reticulum 1 CYP2D6
extracellular space 6 BDNF, CCL2, IL6, POMC, TNF, TNR
perinuclear region of cytoplasm 1 BDNF
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 2 CYP1B1, CYP2D6
intracellular membrane-bounded organelle 4 CYP1B1, CYP2B6, CYP2C19, CYP2D6
Microsome membrane 3 CYP1B1, CYP2B6, CYP2D6
Single-pass type I membrane protein 1 INSRR
Secreted 6 BDNF, CCL2, IL6, PDYN, PNOC, POMC
extracellular region 8 BDNF, CCL2, IL6, PDYN, PNOC, POMC, TNF, TNR
Single-pass membrane protein 2 CYP2D6, UGT2B7
hippocampal mossy fiber to CA3 synapse 1 PDYN
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 TNR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 2 TNF, TNR
collagen-containing extracellular matrix 1 TNR
secretory granule 1 POMC
receptor complex 1 INSRR
neuron projection 1 OPRD1
chromatin 1 OTP
phagocytic cup 1 TNF
fibrillar center 1 OTP
synaptic membrane 1 PNOC
secretory granule lumen 1 POMC
endoplasmic reticulum lumen 2 BDNF, IL6
axon terminus 3 OPRD1, PDYN, PNOC
postsynaptic density membrane 1 OPRD1
perineuronal net 1 TNR
neuronal dense core vesicle 2 OPRD1, PDYN
external side of apical plasma membrane 1 ABCB1
dendrite membrane 1 OPRD1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalytic complex 1 SCLY
interleukin-6 receptor complex 1 IL6
insulin receptor complex 1 INSRR
tenascin complex 1 TNR
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
spine apparatus 1 OPRD1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Ethan B Niebergall, Daron Weekley, Anna Mazur, Nathan A Olszewski, Kayla M DeSchepper, N Radant, Aishwarya S Vijay, W Christopher Risher. Abnormal Morphology and Synaptogenic Signaling in Astrocytes Following Prenatal Opioid Exposure. Cells. 2024 May; 13(10):. doi: 10.3390/cells13100837. [PMID: 38786059]
  • Davene Lynch, Lyndsey Chitty, Brittany Johnson, Amie L Hoefnagel. Suspected Buprenorphine-Precipitated Opioid Withdrawal following Intercourse: A Case Report. Journal of pain & palliative care pharmacotherapy. 2023 Dec; 37(4):314-316. doi: 10.1080/15360288.2023.2250344. [PMID: 37640398]
  • Hilton Klein, Barry L Levinson, Steven L Leary, Glenn Dobson. A pharmacokinetic study of extended-release buprenorphine in cynomolgus monkeys (Macaca fasicularis). Journal of medical primatology. 2023 12; 52(6):369-373. doi: 10.1111/jmp.12661. [PMID: 37432036]
  • Aleaya R Bowie, Katherine N Gibson-Corley, Erin Nz Yu. Pharmacokinetics of Extended-release Buprenorphine in Mongolian Gerbils (Meriones unguiculatus). Journal of the American Association for Laboratory Animal Science : JAALAS. 2023 11; 62(6):538-544. doi: 10.30802/aalas-jaalas-23-000048. [PMID: 37813575]
  • Soraya Babaie, Mohammad Charkhpour, Maryam Kouhsoltani, Hamed Hamishehkar, Ana Cláudia Paiva-Santos. Nano-invasomes for simultaneous topical delivery of buprenorphine and bupivacaine for dermal analgesia. Experimental dermatology. 2023 Jun; ?(?):. doi: 10.1111/exd.14850. [PMID: 37283479]
  • Krista R Noam, Timothy J Schmutte, Sandrine Pirard, Carol Bourdon, Daniel Langless, Robert Plant. Associations Between Inpatient Induction on Medications for Opioid Use Disorder and Postdischarge Medications for Opioid Use Disorder Adherence, Overdose, and Service Use. Journal of addiction medicine. 2023 May; 17(3):e199-e201. doi: 10.1097/adm.0000000000001092. [PMID: 37267183]
  • Elham Khodaverdi, Farzin Hadizadeh, Nilofarsadat Hoseini, Farhad Eisvand, Mohadeseh Tayebi, Hossein Kamali, Fatemeh Oroojalian. In-vitro and in-vivo evaluation of sustained-release buprenorphine using in-situ forming lipid-liquid crystal gels. Life sciences. 2023 Feb; 314(?):121324. doi: 10.1016/j.lfs.2022.121324. [PMID: 36574944]
  • Guan-Yu Zhuo, Ming-Chi Chen, Tzu-Yu Lin, Shih-Ting Lin, Daniel Tzu-Li Chen, Cynthia Wei-Sheng Lee. Opioid-Modulated Receptor Localization and Erk1/2 Phosphorylation in Cells Coexpressing μ-Opioid and Nociceptin Receptors. International journal of molecular sciences. 2023 Jan; 24(2):. doi: 10.3390/ijms24021048. [PMID: 36674576]
  • Gholamreza Kheirabadi, Masoud Asadi, Mohammad Niroumand Sarvandani, Alireza Jamshidi, Faezeh Mahdavi. Risk and Protective Factors Affecting Drug Craving among Patients with Substance Use Disorders Undergoing Opioid Agonists Maintenance Therapy. Substance use & misuse. 2023; 58(13):1742-1750. doi: 10.1080/10826084.2023.2247068. [PMID: 37602742]
  • Josiah Perez. Kratom and opioid use disorder in the perioperative period: A case report on the expanding role of buprenorphine. Journal of opioid management. 2023 Jan; 19(1):91-93. doi: 10.5055/jom.2023.0762. [PMID: 36683304]
  • Yi Zhou, Xihua Lu, Yunfei Zhang, Changsheng Li, Yu Bai, Zhen Zhang. Investigation of the effects of opioids on microglial nitrite and nitric oxide synthase (iNOS) production and phagocytosis during inflammation. Combinatorial chemistry & high throughput screening. 2022 Nov; ?(?):. doi: 10.2174/1386207326666221111093915. [PMID: 36372918]
  • Marta Tikhomirov, Paweł Jajor, Tomasz Śniegocki, Błażej Poźniak. Predicting the efficacy of opioid sequestration by intravenous lipid emulsion using biologically relevant in vitro models of drug distribution. Scientific reports. 2022 11; 12(1):18683. doi: 10.1038/s41598-022-21790-4. [PMID: 36333363]
  • Kristin M Mattocks, David T Moore, Dora Lendvai Wischik, Christina M Lazar, Marc I Rosen. Understanding opportunities and challenges with telemedicine-delivered buprenorphine during the COVID-19 pandemic. Journal of substance abuse treatment. 2022 Aug; 139(?):108777. doi: 10.1016/j.jsat.2022.108777. [PMID: 35346533]
  • Anna Beth Parlier-Ahmad, Mickeal Pugh, Caitlin E Martin. Treatment Outcomes Among Black Adults Receiving Medication for Opioid Use Disorder. Journal of racial and ethnic health disparities. 2022 Aug; 9(4):1557-1567. doi: 10.1007/s40615-021-01095-4. [PMID: 34254271]
  • Barrot H Lambdin, Ricky N Bluthenthal, Hansel E Tookes, Lynn Wenger, Terry Morris, Paul LaKosky, Alex H Kral. Buprenorphine implementation at syringe service programs following waiver of the Ryan Haight Act in the United States. Drug and alcohol dependence. 2022 Aug; 237(?):109504. doi: 10.1016/j.drugalcdep.2022.109504. [PMID: 35688052]
  • Judith I Tsui, Aimee N C Campbell, Martina Pavlicova, Tse-Hwei Choo, Joshua D Lee, Ryan R Cook, Matisyahu Shulman, Edward V Nunes, John Rotrosen. Methamphetamine/amphetamine use over time among persons with opioid use disorders treated with buprenorphine/naloxone versus extended-release naltrexone. Drug and alcohol dependence. 2022 Jul; 236(?):109469. doi: 10.1016/j.drugalcdep.2022.109469. [PMID: 35605529]
  • Nicholas Lintzeris, Rachel M Deacon, Victoria Hayes, Tracy Cowan, Llewellyn Mills, Laila Parvaresh, Lucy Harvey Dodds, Louisa Jansen, Raelene Dojcinovic, Man Cho Leung, Apo Demirkol, Therese Finch, Kristie Mammen. Opioid agonist treatment and patient outcomes during the COVID-19 pandemic in south east Sydney, Australia. Drug and alcohol review. 2022 Jul; 41(5):1009-1019. doi: 10.1111/dar.13382. [PMID: 34520592]
  • Hiroko Enomoto, Lydia Love, Melanie Madsen, Amber Wallace, Kristen M Messenger. Pharmacokinetics of intravenous, oral transmucosal, and intranasal buprenorphine in healthy male dogs. Journal of veterinary pharmacology and therapeutics. 2022 Jul; 45(4):358-365. doi: 10.1111/jvp.13056. [PMID: 35445748]
  • Kevin J Freise, Craig Reinemeyer, Katherine Warren, Ting-Li Lin, Terrence P Clark. Single-dose pharmacokinetics and bioavailability of a novel extended duration transdermal buprenorphine solution in cats. Journal of veterinary pharmacology and therapeutics. 2022 Jul; 45 Suppl 1(?):S31-S39. doi: 10.1111/jvp.13044. [PMID: 35790014]
  • Lauren Textor, Daniel Ventricelli, Shoshana V Aronowitz. 'Red Flags' and 'Red Tape': Telehealth and pharmacy-level barriers to buprenorphine in the United States. The International journal on drug policy. 2022 Jul; 105(?):103703. doi: 10.1016/j.drugpo.2022.103703. [PMID: 35561484]
  • Ria Garg, Sophie A Kitchen, Siyu Men, Tonya J Campbell, Nikki Bozinoff, Mina Tadrous, Tony Antoniou, Jennifer Wyman, Dan Werb, Charlotte Munro, Tara Gomes. Impact of the COVID-19 pandemic on the prevalence of opioid agonist therapy discontinuation in Ontario, Canada: A population-based time series analysis. Drug and alcohol dependence. 2022 Jul; 236(?):109459. doi: 10.1016/j.drugalcdep.2022.109459. [PMID: 35489179]
  • Terrence P Clark, Deborah D Linton, Kevin J Freise, Craig Reinemeyer, Kim M Newkirk, Adam Aulbach, Ting-Li Lin. Margin of safety of extended-duration transdermal buprenorphine solution following multiple-dose administrations to cats. Journal of veterinary pharmacology and therapeutics. 2022 Jul; 45 Suppl 1(?):S67-S84. doi: 10.1111/jvp.13051. [PMID: 35790012]
  • David Dadiomov, Maria Bolshakova, Melania Mikhaeilyan, Rebecca Trotzky-Sirr. Buprenorphine and naloxone access in pharmacies within high overdose areas of Los Angeles during the COVID-19 pandemic. Harm reduction journal. 2022 Jun; 19(1):69. doi: 10.1186/s12954-022-00651-3. [PMID: 35768817]
  • Noa Krawczyk, Sachini Bandara, Sydney Merritt, Hridika Shah, Alexandra Duncan, Brendan McEntee, Maria Schiff, N Jia Ahmad, Sara Whaley, Amanda Latimore, Brendan Saloner. Jail-based treatment for opioid use disorder in the era of bail reform: a qualitative study of barriers and facilitators to implementation of a state-wide medication treatment initiative. Addiction science & clinical practice. 2022 Jun; 17(1):30. doi: 10.1186/s13722-022-00313-6. [PMID: 35655293]
  • Aileen G Guillen, Minal Reddy, Soheil Saadat, Bharath Chakravarthy. Utilization of Telehealth Solutions for Patients with Opioid Use Disorder Using Buprenorphine: A Scoping Review. Telemedicine journal and e-health : the official journal of the American Telemedicine Association. 2022 06; 28(6):761-767. doi: 10.1089/tmj.2021.0308. [PMID: 34714172]
  • Elizabeth D Nesoff, Megan E Marziali, Silvia S Martins. The estimated impact of state-level support for expanded delivery of substance use disorder treatment during the COVID-19 pandemic. Addiction (Abingdon, England). 2022 Jun; 117(6):1781-1786. doi: 10.1111/add.15778. [PMID: 34873783]
  • Thuy Nguyen, Engy Ziedan, Kosali Simon, Jennifer Miles, Stephen Crystal, Hillary Samples, Sumedha Gupta. Racial and Ethnic Disparities in Buprenorphine and Extended-Release Naltrexone Filled Prescriptions During the COVID-19 Pandemic. JAMA network open. 2022 06; 5(6):e2214765. doi: 10.1001/jamanetworkopen.2022.14765. [PMID: 35648400]
  • Sara N Edmond, Sophia Currie, Amanda Gehrke, Caroline G Falker, Minhee Sung, Audrey Abelleira, Ellen L Edens, William C Becker. Optimizing Interdisciplinary Virtual Pain Care and Buprenorphine Initiation During COVID-19: A Quality Improvement Study. Pain medicine (Malden, Mass.). 2022 05; 23(6):1043-1046. doi: 10.1093/pm/pnab348. [PMID: 34940877]
  • Erik Olofsen, Marijke Hyke Algera, Laurence Moss, Robert L Dobbins, Geert J Groeneveld, Monique van Velzen, Marieke Niesters, Albert Dahan, Celine M Laffont. Modeling buprenorphine reduction of fentanyl-induced respiratory depression. JCI insight. 2022 05; 7(9):. doi: 10.1172/jci.insight.156973. [PMID: 35316224]
  • Joanne Spetz, Laurie Hailer, Caryl Gay, Matthew Tierney, Laura Schmidt, Bethany Phoenix, Susan Chapman. Changes in US Clinician Waivers to Prescribe Buprenorphine Management for Opioid Use Disorder During the COVID-19 Pandemic and After Relaxation of Training Requirements. JAMA network open. 2022 05; 5(5):e225996. doi: 10.1001/jamanetworkopen.2022.5996. [PMID: 35552728]
  • Sophie A Kitchen, Tonya J Campbell, Siyu Men, Nikki Bozinoff, Mina Tadrous, Tony Antoniou, Jennifer Wyman, Dan Werb, Charlotte Munro, Tara Gomes. Impact of the COVID-19 pandemic on the provision of take-home doses of opioid agonist therapy in Ontario, Canada: A population-based time-series analysis. The International journal on drug policy. 2022 05; 103(?):103644. doi: 10.1016/j.drugpo.2022.103644. [PMID: 35272107]
  • John R Brooklyn, Marne Stothart, Mallory Stunell, Vanessa Melamede Berman, Danielle Rylant, Melanie Hanson. Characterizing the Clinical use of a Novel Video-assisted Dosing Protocol With Secure Medication Dispensers to Reduce Barriers to Opioid Treatment. Journal of addiction medicine. 2022 May; 16(3):310-316. doi: 10.1097/adm.0000000000000895. [PMID: 34282084]
  • Moosa Javdani, Abolfazl Barzegar, Pegah Khosravian, Mohammad Hashemnia. Evaluation of Inflammatory Response Due to Use of Controlled Release Drug Delivery System of Chitosan Hydrogel Loaded with Buprenorphine and Ketorolac in Rat with Experimental Proximal Tibial Epiphysis Defect. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2022 May; 35(5):996-1011. doi: 10.1080/08941939.2021.1989728. [PMID: 34666588]
  • Bradley D Stein, Brendan Saloner, Rose Kerber, Mark Sorbero, Adam J Gordon. Subsequent Buprenorphine Treatment Following Emergency Physician Buprenorphine Prescription Fills: A National Assessment 2019 to 2020. Annals of emergency medicine. 2022 05; 79(5):441-450. doi: 10.1016/j.annemergmed.2022.01.042. [PMID: 35305851]
  • Raka Jain, Siddharth Sarkar, Nizamuddin Saifi, Shayani Ghosh. Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre. Asian journal of psychiatry. 2022 May; 71(?):103080. doi: 10.1016/j.ajp.2022.103080. [PMID: 35305452]
  • Sarah M Allen, Taylor A Nichols, Janet Fawcett, Show Lin. Outcomes associated with once-daily versus multiple-daily dosing of buprenorphine/naloxone for opioid use disorder. The American journal on addictions. 2022 05; 31(3):173-179. doi: 10.1111/ajad.13267. [PMID: 35226393]
  • Treah Haggerty, Maryam Khodaverdi, Patricia Dekeseredy, Nathan Wood, Brian Hendricks, Jason Peklinsky, Cara L Sedney. Assessing the impact of social distancing measures implemented during COVID-19 pandemic on medications for opioid use disorder in West Virginia. Journal of substance abuse treatment. 2022 05; 136(?):108687. doi: 10.1016/j.jsat.2021.108687. [PMID: 34903397]
  • Mahmoud Abdelwahab, Michelle Petrich, Heather Wang, Erin Walker, Erin M Cleary, Kara M Rood. Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder. American journal of obstetrics & gynecology MFM. 2022 05; 4(3):100582. doi: 10.1016/j.ajogmf.2022.100582. [PMID: 35123110]
  • Valerie S Ganetsky, Jessica Heil, Brianna Yates, Iris Jones, Krystal Hunter, Brandon Rivera, Lindsay Wilson, Matthew Salzman, Kaitlan E Baston. A Low-threshold Comprehensive Shared Medical Appointment Program for Perinatal Substance Use in an Underserved Population. Journal of addiction medicine. 2022 May; 16(3):e203-e209. doi: 10.1097/adm.0000000000000912. [PMID: 34510086]
  • Kim Corace, Kelly Suschinsky, Jennifer Wyman, Pamela Leece, Sue Cragg, Sarah Konefal, Priscille Pana, Susan Barrass, Amy Porath, Brian Hutton. Evaluating how has care been affected by the Ontario COVID-19 Opioid Agonist Treatment Guidance: Patients' and prescribers' experiences with changes in unsupervised dosing. The International journal on drug policy. 2022 04; 102(?):103573. doi: 10.1016/j.drugpo.2021.103573. [PMID: 35123246]
  • Chinazo O Cunningham, Laila Khalid, Yuting Deng, Kristine Torres-Lockhart, Mariya Masyukova, Shenell Thomas, Chenshu Zhang, Tiffany Lu. A comparison of office-based buprenorphine treatment outcomes in Bronx community clinics before versus during the COVID-19 pandemic. Journal of substance abuse treatment. 2022 04; 135(?):108641. doi: 10.1016/j.jsat.2021.108641. [PMID: 34863608]
  • Elizabeth A Samuels, Utsha G Khatri, Hannah Snyder, Rachel S Wightman, Babak Tofighi, Noa Krawczyk. Buprenorphine Telehealth Treatment Initiation and Follow-Up During COVID-19. Journal of general internal medicine. 2022 Apr; 37(5):1331-1333. doi: 10.1007/s11606-021-07249-8. [PMID: 34981357]
  • Paul J Joudrey, Marynia Kolak, Qinyun Lin, Susan Paykin, Vidal Anguiano, Emily A Wang. Assessment of Community-Level Vulnerability and Access to Medications for Opioid Use Disorder. JAMA network open. 2022 04; 5(4):e227028. doi: 10.1001/jamanetworkopen.2022.7028. [PMID: 35438757]
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