Fusidic Acid (BioDeep_00000000143)

   

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs


代谢物信息卡片


(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-4,8,10,14-tetramethyl-3,11-bis(oxidanyl)-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methyl-hept-5-enoic acid

化学式: C31H48O6 (516.3450708)
中文名称: 夫西地酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.61%

分子结构信息

SMILES: C1C[C@]2(C)[C@]3([H])[C@H](O)C[C@@]4([H])/C(=C(\CC/C=C(\C)/C)/C(=O)O)/[C@@H](OC(C)=O)C[C@]4(C)[C@@]3(C)CC[C@@]2([H])[C@H](C)[C@@H]1O
InChI: InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1

描述信息

Fusidic acid is a steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum. It has a role as a protein synthesis inhibitor, an EC 2.7.1.33 (pantothenate kinase) inhibitor and an Escherichia coli metabolite. It is a 3alpha-hydroxy steroid, an 11alpha-hydroxy steroid, a sterol ester, a steroid acid, an alpha,beta-unsaturated monocarboxylic acid and a steroid antibiotic. It is a conjugate acid of a fusidate. It derives from a hydride of a 5alpha-cholestane.
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. It is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections.
Fusidic acid is a natural product found in Epidermophyton floccosum, Stilbella aciculosa, and other organisms with data available.
Fusidic Acid is a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections. Fusidic acid acts as a bacterial protein synthesis inhibitor by preventing the turnover of elongation factor G (EF-G) from the ribosome. Fusidic acid is effective primarily on gram-positive bacteria.
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.
See also: Fusidate Sodium (active moiety of).
Fusidic Acid is only found in individuals that have used or taken this drug. It is an antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01X - Other antibacterials > J01XC - Steroid antibacterials
D - Dermatologicals > D09 - Medicated dressings > D09A - Medicated dressings > D09AA - Medicated dressings with antiinfectives
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06A - Antibiotics for topical use
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent
COVID info from PDB, Protein Data Bank
C784 - Protein Synthesis Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].

同义名列表

90 个代谢物同义名

(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-4,8,10,14-tetramethyl-3,11-bis(oxidanyl)-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methyl-hept-5-enoic acid; (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methyl-5-heptenoic acid; (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methyl-hept-5-enoic acid; (2E)-2-[(3R,4S,5S,8S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid; (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid; 2-[(1Z,2S,3aS,3bS,5aS,6S,7R,9aS,9bS,10R,11aR)-2-(acetyloxy)-7,10-dihydroxy-3a,3b,6,9a-tetramethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-[(3alpha,4alpha,5alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid; 2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-[(3beta,4beta,5alpha,8alpha,9beta,11beta,13alpha,16beta,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-[(17Z)-16beta-acetoxy-3alpha,11alpha-dihydroxy-4alpha,8alpha,10,14beta-tetramethyl-5alpha,9beta,13alpha-gonan-17-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-((17Z)-16beta-acetoxy-3alpha,11alpha-dihydroxy-4alpha,8alpha,10,14beta-tetramethyl-5alpha,9beta,13alpha-gonan-17-ylidene)-6-methylhept-5-enoic acid; 29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID, 16-(ACETYLOXY)-3,11-DIHYDROXY-, (3.ALPHA.,4.ALPHA.,8.ALPHA.,9.BETA.,11.ALPHA.,13.ALPHA.,14.BETA.,16.BETA.,17Z); 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3alpha,4alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-; 29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID, 16-(ACETYLOXY)-3,11-DIHYDROXY-, (3alpha,4alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z); (3alpha,4alpha,8alpha,9beta,11alpha,13alpha,147beta,167beta,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid; (3alpha,4alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid; 29-Nordammara-17(20), 16-(acetyloxy)-3,11-dihydroxy-, (3.alpha.,4.alpha.,8.alpha.,9.beta.,11.alpha.,13.alpha.,14.beta.,16.beta.,17Z)-; 29-Nor-8.alpha.,13.alpha.,14.beta.-dammara-17(20),24-dien-21-oic acid, 3.alpha.,11.alpha.,16.beta.-trihydroxy-, 16-acetate, (Z)-; 29-Nor-8alpha,9beta,13alpha,14beta-dammara-17(20),24-dien-21-oic acid, 3alpha,11alpha,16beta-trihydroxy-, 16-acetate, (Z)-; 3.alpha.,16.beta.-Trihydroxy-29-nor-8.alpha.,9.beta.,13.alpha.,14.beta.-dammara-17(20),24-dien-21-oic acid 16-acetate; 3alpha,11alpha,16beta-Trihydroxy-29-nor-8alpha,9beta,13alpha,14beta-dammara-17(20),24-dien-21-oic acid 16-acetate; 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-; Fusidic acid for peak identification, European Pharmacopoeia (EP) Reference Standard; (-)-16beta-acetoxy-3alpha,11alpha-dihydroxyfusida-17(20)Z,24-diene-21-oic acid; 16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid; Fusidic acid, European Pharmacopoeia (EP) Reference Standard; C.A.S. 62,602; Diethanolamine fusidate; Fusidic acid for peak identification; Acido fusidico (INN-Spanish); Acide fusidique (INN-French); Acido fusidico [INN-Spanish]; Acidum fusidicum [INN-Latin]; Acidum fusidicum (INN-Latin); Acide fusidique [INN-French]; FUSIDIC ACID [EP MONOGRAPH]; FUSIDIC ACID (EP MONOGRAPH); Fusidic acid [USAN:INN:BAN]; IECPWNUMDGFDKC-MZJAQBGESA-N; FUSIDIC ACID (EP IMPURITY); FUSIDIC ACID [EP IMPURITY]; Fusidic Acid, Sodium Salt; Fusidic acid (USAN/INN); Diethanolamine fusidate; Anhydrous Fusidic Acid; FUSIDIC ACID [WHO-DD]; FUSIDIC ACID [USAN]; FUSIDIC ACID [INN]; Prestwick2_000390; FUSIDIC ACID [MI]; (-)-Fusidic acid; Fusidate, Sodium; Acidum fusidicum; Fusidate, Silver; Sodium, Fusidate; Acide fusidique; UNII-59XE10C19C; Fusidate Sodium; Silver Fusidate; Sodium fusidate; Fusidinic Acid; Acido fusidico; C.A.S. 62,602; Acid, Fusidic; Fusidic Acid; fusidic-acid; Fucidic acid; Fucidin acid; (-)-Fusidate; FUSIDICACID; Fucithalmic; 59XE10C19C; SQ 16,603; Stanicide; Fusidine; Fusidate; Flucidin; Fucidate; Fusidin; D06AX01; Ramycin; S01AA13; FUCIDIN; J01XC01; Discoid; Taksta; 1qca; FA; MCULE-4654267035; SQ-16603



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Haeun Kwon, Bo-Ram Jin, Sori Yoo, Hyo-Jung Kim, Bang Yeon Hwang, Yuanqiang Guo, Joung Han Yim, Il-Chan Kim, Sang Hee Shim, Hyo Jin An, Dongho Lee. New fusidane-type nortriterpenoids from the Arctic marine-derived fungus Simplicillium lamellicola culture medium with their inhibitory effect on benign prostatic hyperplasia. Bioorganic chemistry. 2024 Feb; 143(?):107070. doi: 10.1016/j.bioorg.2023.107070. [PMID: 38190796]
  • Matthias Fellner, Annabel Walsh, Stephen Dela Ahator, Nadia Aftab, Ben Sutherland, Eng W Tan, Alexander T Bakker, Nathaniel I Martin, Mario van der Stelt, Christian S Lentz. Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response. ACS infectious diseases. 2023 Oct; ?(?):. doi: 10.1021/acsinfecdis.3c00246. [PMID: 37824340]
  • Pinar Ili, Fikret Sari. Egg yolk oil accelerates wound healing in streptozotocin induced diabetic rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023 Feb; 98(2):94-111. doi: 10.1080/10520295.2022.2115554. [PMID: 36040350]
  • Murugan Thulasi Meenu, Grace Kaul, Abdul Akhir, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance. Journal of natural products. 2022 10; 85(10):2413-2423. doi: 10.1021/acs.jnatprod.2c00621. [PMID: 36222797]
  • Jan Holmbäck, Vibhu Rinwa, Jenny Johansson, Joakim Håkansson, Puneet Rinwa, Anders Carlsson, Bengt Herslöf. Preclinical development of sodium fusidate antibiotic cutaneous spray based on water-free lipid formulation system. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2022 Sep; 176(?):106250. doi: 10.1016/j.ejps.2022.106250. [PMID: 35779822]
  • Mohammed Salih, Pavan Walvekar, Calvin A Omolo, Ahmed A Elrashedy, Nikita Devnarain, Victoria Fasiku, Ayman Y Waddad, Chunderika Mocktar, Thirumala Govender. A self-assembled polymer therapeutic for simultaneously enhancing solubility and antimicrobial activity and lowering serum albumin binding of fusidic acid. Journal of biomolecular structure & dynamics. 2021 10; 39(17):6567-6584. doi: 10.1080/07391102.2020.1803140. [PMID: 32772814]
  • Haider N Sultani, Ibrahim Morgan, Hidayat Hussain, Andreas H Roos, Haleh H Haeri, Goran N Kaluđerović, Dariush Hinderberger, Bernhard Westermann. Access to New Cytotoxic Triterpene and Steroidal Acid-TEMPO Conjugates by Ugi Multicomponent-Reactions. International journal of molecular sciences. 2021 Jul; 22(13):. doi: 10.3390/ijms22137125. [PMID: 34281176]
  • S Muralidharan, K Arun, V Ruckmani, B Devi. Scleredema adultorum of Buschke associated with hypothyroidism and liver cirrhosis. Journal of postgraduate medicine. 2021 Jul; 67(3):174-176. doi: 10.4103/jpgm.jpgm_1214_20. [PMID: 34380804]
  • Maria Michela Lauriola, Paolo Sena, Antonio De Bitonto, Monica Corazza. Allergic Contact Dermatitis Due to 'Therapeutic Uses' of Tea Tree Oil on the Lips and Toenails. Dermatitis : contact, atopic, occupational, drug. 2021 May; 32(3):e40-e41. doi: 10.1097/der.0000000000000649. [PMID: 33332860]
  • Zhi-Bin Zhang, Si-Yao Du, Bo Ji, Chang-Jiu Ji, Yi-Wen Xiao, Ri-Ming Yan, Du Zhu. New Helvolic Acid Derivatives with Antibacterial Activities from Sarocladium oryzae DX-THL3, an Endophytic Fungus from Dongxiang Wild Rice (Oryza rufipogon Griff.). Molecules (Basel, Switzerland). 2021 Mar; 26(7):. doi: 10.3390/molecules26071828. [PMID: 33805102]
  • W W Huang, X Y Ge, Y Huang, X T Chai, L Zhang, Y X Zhang, L N Deng, C Q Liu, H Xu, J Gao. High-yield strain of fusidic acid obtained by atmospheric and room temperature plasma mutagenesis and the transcriptional changes involved in improving its production in fungus Fusidium coccineum. Journal of applied microbiology. 2021 Feb; 130(2):405-415. doi: 10.1111/jam.14797. [PMID: 32734700]
  • Samuel K Kwofie, Emmanuel Broni, Seth O Asiedu, Gabriel B Kwarko, Bismark Dankwa, Kweku S Enninful, Elvis K Tiburu, Michael D Wilson. Cheminformatics-Based Identification of Potential Novel Anti-SARS-CoV-2 Natural Compounds of African Origin. Molecules (Basel, Switzerland). 2021 Jan; 26(2):. doi: 10.3390/molecules26020406. [PMID: 33466743]
  • Kaat José Peeters, Ashley Haeck, Lies Harinck, Oluwatoyin Oluwakemi Afolabi, Kristof Demeestere, Kris Audenaert, Monica Höfte. Morphological, Pathogenic and Toxigenic Variability in the Rice Sheath Rot Pathogen Sarocladium Oryzae. Toxins. 2020 02; 12(2):. doi: 10.3390/toxins12020109. [PMID: 32046323]
  • Zhi-Qin Cao, Jian-Ming Lv, Qiu Liu, Sheng-Ying Qin, Guo-Dong Chen, Ping Dai, Yue Zhong, Hao Gao, Xin-Sheng Yao, Dan Hu. Biosynthetic Study of Cephalosporin P1 Reveals a Multifunctional P450 Enzyme and a Site-Selective Acetyltransferase. ACS chemical biology. 2020 01; 15(1):44-51. doi: 10.1021/acschembio.9b00863. [PMID: 31860257]
  • Mathew Njoroge, Gurminder Kaur, Marlene Espinoza-Moraga, Antonina Wasuna, Godwin Akpeko Dziwornu, Ronnett Seldon, Dale Taylor, John Okombo, Digby F Warner, Kelly Chibale. Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture. ACS infectious diseases. 2019 09; 5(9):1634-1644. doi: 10.1021/acsinfecdis.9b00208. [PMID: 31309823]
  • Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, Om Prakash Katare. Nano-engineered lipid-polymer hybrid nanoparticles of fusidic acid: an investigative study on dermatokinetics profile and MRSA-infected burn wound model. Drug delivery and translational research. 2019 08; 9(4):748-763. doi: 10.1007/s13346-019-00616-3. [PMID: 30652257]
  • Francesco Miconi, Nicola Principi, Lorenzo Cassiani, Federica Celi, Roberta Crispoldi, Ada Russo, Susanna Esposito, Manuela Papini. A Cheek Nodule in a Child: Be Aware of Idiopathic Facial Aseptic Granuloma and Its Differential Diagnosis. International journal of environmental research and public health. 2019 07; 16(14):. doi: 10.3390/ijerph16142471. [PMID: 31336722]
  • Godwin Akpeko Dziwornu, Stephanie Kamunya, Tando Ntsabo, Kelly Chibale. Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin. MedChemComm. 2019 Jun; 10(6):961-969. doi: 10.1039/c9md00161a. [PMID: 31303994]
  • Maxime Bataillard, Marie-Noëlle Beyens, Geneviève Mounier, Delphine Vergnon-Miszczycha, Haleh Bagheri, Pascal Cathebras. Muscle Damage Due to Fusidic Acid-Statin Interaction: Review of 75 Cases From the French Pharmacovigilance Database and Literature Reports. American journal of therapeutics. 2019 May; 26(3):e375-e379. doi: 10.1097/mjt.0000000000000679. [PMID: 29189310]
  • Rita Pimenta, João Borges-Costa. Successful Treatment with Fusidic Acid in a Patient with Folliculitis Decalvans. Acta dermatovenerologica Croatica : ADC. 2019 Mar; 27(1):49-50. doi: . [PMID: 31032795]
  • Ahmad M Eid, Ibraheem Istateyeh, Noura Salhi, Thaer Istateyeh. Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel. International journal of nanomedicine. 2019; 14(?):9411-9421. doi: 10.2147/ijn.s229557. [PMID: 31819440]
  • Marco Adriano Chessa, Andrea Sechi, Carlotta Baraldi, Stefania Barruscotti, Miriam Leuzzi, Carlotta Gurioli, Annalucia Virdi, Francesco Savoia, Iria Neri. Zoon's plasma cell balanitis: clinical and dermoscopic features in pediatric patients. International journal of dermatology. 2018 11; 57(11):e142-e144. doi: 10.1111/ijd.14176. [PMID: 30117600]
  • Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, A B Patil, Om Prakash Katare. Chitosan-tailored lipidic nanoconstructs of Fusidic acid as promising vehicle for wound infections: An explorative study. International journal of biological macromolecules. 2018 Aug; 115(?):1012-1025. doi: 10.1016/j.ijbiomac.2018.04.092. [PMID: 29680503]
  • Jian-Ming Lv, Dan Hu, Hao Gao, Tetsuo Kushiro, Takayoshi Awakawa, Guo-Dong Chen, Chuan-Xi Wang, Ikuro Abe, Xin-Sheng Yao. Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis. Nature communications. 2017 11; 8(1):1644. doi: 10.1038/s41467-017-01813-9. [PMID: 29158519]
  • Xiaowei Luo, Xuefeng Zhou, Xiuping Lin, Xiaochu Qin, Tianyu Zhang, Junfeng Wang, Zhengchao Tu, Bin Yang, Shengrong Liao, Yongqi Tian, Xiaoyan Pang, Kumaravel Kaliyaperumal, Jian Lin Li, Huaming Tao, Yonghong Liu. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. Natural product research. 2017 Aug; 31(16):1958-1962. doi: 10.1080/14786419.2016.1266353. [PMID: 28068839]
  • Amélie Marsot, Amelie Ménard, Julien Dupouey, Cedric Muziotti, Romain Guilhaumou, Olivier Blin. Population pharmacokinetics of rifampicin in adult patients with osteoarticular infections: interaction with fusidic acid. British journal of clinical pharmacology. 2017 05; 83(5):1039-1047. doi: 10.1111/bcp.13178. [PMID: 27813241]
  • Manlu Zhu, Xiongfeng Dai, Yi-Ping Wang. Real time determination of bacterial in vivo ribosome translation elongation speed based on LacZα complementation system. Nucleic acids research. 2016 Nov; 44(20):e155. doi: 10.1093/nar/gkw698. [PMID: 27903884]
  • Anshul Gupta, Jennifer J Harris, Jianrong Lin, James P Bulgarelli, Bruce K Birmingham, Scott W Grimm. Fusidic Acid Inhibits Hepatic Transporters and Metabolic Enzymes: Potential Cause of Clinical Drug-Drug Interaction Observed with Statin Coadministration. Antimicrobial agents and chemotherapy. 2016 10; 60(10):5986-94. doi: 10.1128/aac.01335-16. [PMID: 27458210]
  • Ben Knippenberg, Madhu Page-Sharp, Sam Salman, Ben Clark, John Dyer, Kevin T Batty, Timothy M E Davis, Laurens Manning. Validation and Application of a Dried Blood Spot Assay for Biofilm-Active Antibiotics Commonly Used for Treatment of Prosthetic Implant Infections. Antimicrobial agents and chemotherapy. 2016 08; 60(8):4940-55. doi: 10.1128/aac.00756-16. [PMID: 27270283]
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