Pregnenolone (BioDeep_00000001411)

 

Secondary id: BioDeep_00000398996, BioDeep_00000861171

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

化学式: C21H32O2 (316.24021719999996)
中文名称: 孕烯醇酮
谱图信息: 最多检出来源 Homo sapiens(blood) 0.02%

分子结构信息

SMILES: CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3

描述信息

Pregnenolone is a derivative of cholesterol, the product of cytochrome P450 side-chain cleavage (EC 1.14.15.6, CYP11A1. This reaction consists of three consecutive monooxygenations, a 22-hydroxylation, a 20-hydroxylation, and the cleavage of the C20-C22 bond, yielding pregnenolone. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. This reaction occurs in steroid hormone-producing tissues such as the adrenal cortex, corpus luteum, and placenta. The most notable difference between the placenta and other steroidogenic tissues is that electron supply to CYP11A1 limits the rate at which cholesterol is converted into pregnenolone in the placenta. The limiting component for electron delivery to CYP11A1 is the concentration of adrenodoxin reductase in the mitochondrial matrix which is insufficient to maintain the adrenodoxin pool in a fully reduced state. Pregnenolone is also a neurosteroid, and is produced in the spinal cord; CYP11A1 is the key enzyme catalyzing the conversion of cholesterol into pregnenolone, the rate-limiting step in the biosynthesis of all classes of steroids, and has been localized in sensory networks of the spinal cord dorsal horn. In the adrenal glomerulosa cell, angiotensin II, one of the major physiological regulators of mineralocorticoid synthesis, appears to affect most of the cholesterol transfer to the mitochondrial outer membrane and many steps in the transport to the inner membrane. Thus, it exerts a powerful control over the use of cholesterol for aldosterone production (PMID: 17222962, 15823613, 16632873, 15134809).
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
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Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

同义名列表

30 个代谢物同义名

1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone; 1-[(1S,2R,5S,10S,11S,14S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-14-yl]ethan-1-one; 1-[(1S,2R,5S,10S,11S,14S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-14-yl]ethanone; (3BETA)-3-HYDROXYPREGN-5-en-20-one; 3β-Hydroxy-5-pregnen-20-one; (3b)-3-hydroxy-Pregn-5-en-20-one; 3β-Hydroxypregn-5-en-20-one; (3Β)-3-hydroxypregn-5-en-20-one; (3b)-3-HYDROXYPREGN-5-en-20-one; 3beta-hydroxypregn-5-en-20-one; 5-Pregnen-3β-ol-20-one; 3Β-hydroxypregn-5-en-20-one; 3b-Hydroxypregn-5-en-20-one; 5-Pregnen-3-beta-ol-20-one; 3-Hydroxypregn-5-en-20-one; 5 Pregnen 3 beta ol 20 one; 5-Pregnen-3beta-ol-20-one; Pregn-5-ene-3b-ol-20-one; Pregn-5-en-3b-ol-20-one; 5-Pregnen-3β-ol-20-one; 5-Pregnen-3b-ol-20-one; Pregnenolone; Skinostelon; Pregnolon; Regnosone; Pregnetan; Pregneton; Prenolon; Natolone; 3β-Hydroxy-5-pregnen-20-one



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(16)

BioCyc(1)

PlantCyc(0)

代谢反应

152 个相关的代谢反应过程信息。

Reactome(141)

BioCyc(5)

WikiPathways(5)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ádám Horváth, Anita Steib, Andrea Nehr-Majoros, Boglárka Kántás, Ágnes Király, Márk Racskó, Balázs István Tóth, Eszter Szánti-Pintér, Eva Kudová, Rita Skoda-Földes, Zsuzsanna Helyes, Éva Szőke. Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094637. [PMID: 38731855]
  • Fu-Rong Xu, Zhen-Hong Wei, Xiao-Xia Xu, Xiao-Gang Zhang, Chao-Jun Wei, Xiao-Ming Qi, Yong-Hong Li, Xiao-Ling Gao, Yu Wu. The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice. Journal of neuroinflammation. 2023 Dec; 20(1):293. doi: 10.1186/s12974-023-02976-7. [PMID: 38062440]
  • Maritta Kunert, Chloe Langley, Rosalind Lucier, Kerstin Ploss, Carlos E Rodríguez López, Delia A Serna Guerrero, Eva Rothe, Sarah E O'Connor, Prashant D Sonawane. Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants. Nature plants. 2023 Sep; ?(?):. doi: 10.1038/s41477-023-01515-9. [PMID: 37723202]
  • Yiqin Lin, Yingle Chen, Jingyang Zeng, Shunyuan Li. Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway. Neuroimmunomodulation. 2022; 29(4):486-492. doi: 10.1159/000525690. [PMID: 35995035]
  • Alexander Becker, Claudia Götz, Mathias Montenarh, Stephan E Philipp. Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1. International journal of molecular sciences. 2021 Dec; 22(23):. doi: 10.3390/ijms222313133. [PMID: 34884938]
  • Cecilia Rustichelli, Emanuela Monari, Rossella Avallone, Elisa Bellei, Stefania Bergamini, Aldo Tomasi, Anna Ferrari. Dehydroepiandrosterone sulfate, dehydroepiandrosterone, 5α-dihydroprogesterone and pregnenolone in women with migraine: Analysis of serum levels and correlation with age, migraine years and frequency. Journal of pharmaceutical and biomedical analysis. 2021 Nov; 206(?):114388. doi: 10.1016/j.jpba.2021.114388. [PMID: 34597839]
  • Britton Trabert, Ashley M Geczik, Doug C Bauer, Diana S M Buist, Jane A Cauley, Roni T Falk, Gretchen L Gierach, Trisha F Hue, James V Lacey, Andrea Z LaCroix, Kara A Michels, Jeffrey A Tice, Xia Xu, Louise A Brinton, Cher M Dallal. Association of Endogenous Pregnenolone, Progesterone, and Related Metabolites with Risk of Endometrial and Ovarian Cancers in Postmenopausal Women: The B∼FIT Cohort. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 11; 30(11):2030-2037. doi: 10.1158/1055-9965.epi-21-0669. [PMID: 34465588]
  • K Rehm, A K Hankele, S E Ulbrich, L Bigler. Simultaneous quantification of progestogens in plasma and serum by UHPLC-HRMS employing multiplexed targeted single ion monitoring. Talanta. 2021 Sep; 232(?):122358. doi: 10.1016/j.talanta.2021.122358. [PMID: 34074386]
  • Johanna Ruhnau, Stephanie Hübner, Donna Sunny, Till Ittermann, Michaela F Hartmann, Jan De Lafollie, Stefan A Wudy, Matthias Heckmann. Impact of Gestational and Postmenstrual Age on Excretion of Fetal Zone Steroids in Preterm Infants Determined by Gas Chromatography-Mass Spectrometry. The Journal of clinical endocrinology and metabolism. 2021 08; 106(9):e3725-e3738. doi: 10.1210/clinem/dgab194. [PMID: 33822093]
  • Melanie H Jacobson, Cheryl R Stein, Mengling Liu, Marra G Ackerman, Jennifer K Blakemore, Sara E Long, Graziano Pinna, Raquel Romay-Tallon, Kurunthachalam Kannan, Hongkai Zhu, Leonardo Trasande. Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption. The Journal of clinical endocrinology and metabolism. 2021 06; 106(7):1887-1899. doi: 10.1210/clinem/dgab199. [PMID: 33792735]
  • Li Yu, Miao Liu, Zhenxin Wang, Te Liu, Suying Liu, Beili Wang, Baishen Pan, Xi Dong, Wei Guo. Correlation between steroid levels in follicular fluid and hormone synthesis related substances in its exosomes and embryo quality in patients with polycystic ovary syndrome. Reproductive biology and endocrinology : RB&E. 2021 May; 19(1):74. doi: 10.1186/s12958-021-00749-6. [PMID: 34001150]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Flavia Lo Castro, Carlo Baraldi, Aldo Tomasi, Anna Ferrari. Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study. The journal of headache and pain. 2021 Mar; 22(1):13. doi: 10.1186/s10194-021-01231-9. [PMID: 33757421]
  • Yilin Liu, Ilia G Denisov, Stephen G Sligar, James R Kincaid. Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5. Journal of the American Chemical Society. 2021 03; 143(10):3729-3733. doi: 10.1021/jacs.1c00581. [PMID: 33656879]
  • Melina A Pagotto, María L Roldán, Sara M Molinas, Trinidad Raices, Gerardo B Pisani, Omar P Pignataro, Liliana A Monasterolo. Impairment of renal steroidogenesis at the onset of diabetes. Molecular and cellular endocrinology. 2021 03; 524(?):111170. doi: 10.1016/j.mce.2021.111170. [PMID: 33482284]
  • Graziano Pinna. Sex and COVID-19: A Protective Role for Reproductive Steroids. Trends in endocrinology and metabolism: TEM. 2021 01; 32(1):3-6. doi: 10.1016/j.tem.2020.11.004. [PMID: 33229187]
  • Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Yanglan Tan, Michelle L Dubuke, Scott A Shaffer. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. Psychoneuroendocrinology. 2020 11; 121(?):104827. doi: 10.1016/j.psyneuen.2020.104827. [PMID: 32828068]
  • Y V Faletrov, K A Gilep, A S Falchevskaya, M S Horetski, J V Panada, E V Andrievskaya, E V Rudaya, N S Frolova, A Brzostek, R Plocinska, V M Shkumatov. [In silico modeling of izoniazid-steroid conjugates interactions with cytochromes P450 of mycobacteria and their bioconversion in vitro by the cells]. Biomeditsinskaia khimiia. 2020 Sep; 66(5):378-385. doi: 10.18097/pbmc20206605378. [PMID: 33140731]
  • Mathijs Drummen, Lea Tischmann, Blandine Gatta-Cherifi, Daniela Cota, Isabelle Matias, Anne Raben, Tanja Adam, Margriet Westerterp-Plantenga. Role of Endocannabinoids in Energy-Balance Regulation in Participants in the Postobese State-a PREVIEW Study. The Journal of clinical endocrinology and metabolism. 2020 07; 105(7):. doi: 10.1210/clinem/dgaa193. [PMID: 32333763]
  • Jeffrey M McManus, Nima Sharifi. Structure-dependent retention of steroid hormones by common laboratory materials. The Journal of steroid biochemistry and molecular biology. 2020 04; 198(?):105572. doi: 10.1016/j.jsbmb.2019.105572. [PMID: 31883923]
  • Wenqi Jin, Rui Ma, Lu Zhai, Xiaohao Xu, Tingting Lou, Qingxia Huang, Jing Wang, Daqing Zhao, Xiangyan Li, Liwei Sun. Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells. Life sciences. 2020 Mar; 245(?):117337. doi: 10.1016/j.lfs.2020.117337. [PMID: 31972205]
  • Natasja G J Costermans, Nicoline M Soede, Marco Blokland, Frederike van Tricht, Jaap Keijer, Bas Kemp, Katja J Teerds. Steroid profile of porcine follicular fluid and blood serum: Relation with follicular development. Physiological reports. 2019 12; 7(24):e14320. doi: 10.14814/phy2.14320. [PMID: 31883224]
  • Jingjing Jiang, Xue Liu, Xiaotian Liu, Zhongyan Tian, Haiqing Zhang, Xinling Qian, Zhicheng Luo, Dandan Wei, Shuna Jin, Chongjian Wang, Zhenxing Mao. The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort. European journal of endocrinology. 2019 Dec; 181(6):603-614. doi: 10.1530/eje-19-0352. [PMID: 31581126]
  • Jude Prah, Ali Winters, Kiran Chaudhari, Jessica Hersh, Ran Liu, Shao-Hua Yang. Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress. Brain research. 2019 11; 1723(?):146378. doi: 10.1016/j.brainres.2019.146378. [PMID: 31425677]
  • Bingyan Cao, Chunxiu Gong, Di Wu, Xuejun Liang, Wenjing Li, Min Liu, Chang Su, Miao Qin, Xi Meng, Liya Wei. A cross-sectional survey of adrenal steroid hormones among overweight/obese boys according to puberty stage. BMC pediatrics. 2019 11; 19(1):414. doi: 10.1186/s12887-019-1755-5. [PMID: 31690265]
  • Hiroshi Miura, Tatsuya Yamazaki, Motohiro Kikuchi, Minoru Sakaguchi. Plasma steroid hormone concentrations and their relationships in Suffolk ewes during gestation and parturition. Animal science journal = Nihon chikusan Gakkaiho. 2019 Nov; 90(11):1426-1431. doi: 10.1111/asj.13286. [PMID: 31486265]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ruben Vanholme, Lisa Sundin, Keletso Carol Seetso, Hoon Kim, Xinyu Liu, Jin Li, Barbara De Meester, Lennart Hoengenaert, Geert Goeminne, Kris Morreel, Jurgen Haustraete, Huei-Hsuan Tsai, Wolfgang Schmidt, Bartel Vanholme, John Ralph, Wout Boerjan. COSY catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins. Nature plants. 2019 10; 5(10):1066-1075. doi: 10.1038/s41477-019-0510-0. [PMID: 31501530]
  • L I Velikanova, Z R Shafigullina, N V Vorokhobina, E V Malevanaya. Gas Chromatography-Mass Spectrometry Analysis of Urinary Steroid Metabolomics for Detection of Early Signs of Adrenal Neoplasm Malignancy in Patients with Cushing's Syndrome. Bulletin of experimental biology and medicine. 2019 Sep; 167(5):676-680. doi: 10.1007/s10517-019-04597-8. [PMID: 31630306]
  • Monica Aleman, Patrick M McCue, Munashe Chigerwe, John E Madigan. Plasma concentrations of steroid precursors, steroids, neuroactive steroids, and neurosteroids in healthy neonatal foals from birth to 7 days of age. Journal of veterinary internal medicine. 2019 Sep; 33(5):2286-2293. doi: 10.1111/jvim.15618. [PMID: 31489708]
  • Marika Matousova, Radko Soucek, Eva Tloustova, Barbora Slavikova, Hana Chodounska, Helena Mertlikova-Kaiserova, Eva Kudova. Pregn-5-en-3β-ol and androst-5-en-3β-ol dicarboxylic acid esters as potential therapeutics for NMDA hypofunction: In vitro safety assessment and plasma stability. Steroids. 2019 07; 147(?):4-9. doi: 10.1016/j.steroids.2018.09.012. [PMID: 30296546]
  • Philippe Liere, Charlotte A Cornil, Marie Pierre de Bournonville, Antoine Pianos, Matthieu Keller, Michael Schumacher, Jacques Balthazart. Steroid profiles in quail brain and serum: Sex and regional differences and effects of castration with steroid replacement. Journal of neuroendocrinology. 2019 02; 31(2):e12681. doi: 10.1111/jne.12681. [PMID: 30585662]
  • Steven J Kleene, Brian J Siroky, Julio A Landero-Figueroa, Bradley P Dixon, Nolan W Pachciarz, Lu Lu, Nancy K Kleene. The TRPP2-dependent channel of renal primary cilia also requires TRPM3. PloS one. 2019; 14(3):e0214053. doi: 10.1371/journal.pone.0214053. [PMID: 30883612]
  • Jeffrey M McManus, Kelsey Bohn, Mohammad Alyamani, Yoon-Mi Chung, Eric A Klein, Nima Sharifi. Rapid and structure-specific cellular uptake of selected steroids. PloS one. 2019; 14(10):e0224081. doi: 10.1371/journal.pone.0224081. [PMID: 31622417]
  • Vitória Müller, Bruna R Curcio, Ramiro E Toribio, Lorena S Feijó, Luciana A Borba, Igor F Canisso, Carlos E W Nogueira. Cortisol, progesterone, 17αOHprogesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis. Theriogenology. 2019 Jan; 123(?):139-144. doi: 10.1016/j.theriogenology.2018.06.024. [PMID: 30308389]
  • K V Tugaeva, N N Sluchanko. Steroidogenic Acute Regulatory Protein: Structure, Functioning, and Regulation. Biochemistry. Biokhimiia. 2019 Jan; 84(Suppl 1):S233-S253. doi: 10.1134/s0006297919140141. [PMID: 31213205]
  • Jianguo Cui, Liping Pang, Meizhen Wei, Chunfang Gan, Dandan Liu, Haiyan Yuan, Yanmin Huang. Synthesis and antiproliferative activity of 17-[1',2',3']-selenadiazolylpregnenolone compounds. Steroids. 2018 12; 140(?):151-158. doi: 10.1016/j.steroids.2018.10.004. [PMID: 30296550]
  • Ying Sze, Andrew C Gill, Paula J Brunton. Sex-dependent changes in neuroactive steroid concentrations in the rat brain following acute swim stress. Journal of neuroendocrinology. 2018 11; 30(11):e12644. doi: 10.1111/jne.12644. [PMID: 30194779]
  • Dongdong Liang, Zhaofei Fan, Yuxia Zou, Xungang Tan, Zhihao Wu, Shuang Jiao, Jun Li, Peijun Zhang, Feng You. Characteristics of Cyp11a during Gonad Differentiation of the Olive Flounder Paralichthys olivaceus. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092641. [PMID: 30200601]
  • Abdelmoneim Khashana, Hoda Ahmed, Amal Ahmed, Amina Abdelwahab, Timo Saarela, Mika Rämet, Mikko Hallman. Cortisol precursors in neonates with vasopressor-resistant hypotension in relationship to demographic characteristics. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2018 Sep; 31(18):2473-2477. doi: 10.1080/14767058.2017.1344966. [PMID: 28629239]
  • Nadia Berkane, Philippe Liere, Guillaume Lefevre, Nadia Alfaidy, Roland Abi Nahed, Jessica Vincent, Jean-Paul Oudinet, Antoine Pianos, Annie Cambourg, Patrick Rozenberg, Pierre Galichon, Alexandra Rousseau, Tabassome Simon, Michael Schumacher, Nathalie Chabbert-Buffet, Alexandre Hertig. Abnormal steroidogenesis and aromatase activity in preeclampsia. Placenta. 2018 09; 69(?):40-49. doi: 10.1016/j.placenta.2018.07.004. [PMID: 30213483]
  • Martina I Boxler, Gabriel L Streun, Matthias E Liechti, Yasmin Schmid, Thomas Kraemer, Andrea E Steuer. Human Metabolome Changes after a Single Dose of 3,4-Methylenedioxymethamphetamine (MDMA) with Special Focus on Steroid Metabolism and Inflammation Processes. Journal of proteome research. 2018 08; 17(8):2900-2907. doi: 10.1021/acs.jproteome.8b00438. [PMID: 29947220]
  • Shamaila Fraz, Abigail H Lee, Joanna Y Wilson. Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 2018 May; 198(?):1-9. doi: 10.1016/j.aquatox.2018.02.006. [PMID: 29494825]
  • HuaLin Cai, Xiang Zhou, George G Dougherty, Ravinder D Reddy, Gretchen L Haas, Debra M Montrose, Matcheri Keshavan, Jeffrey K Yao. Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia. Psychoneuroendocrinology. 2018 04; 90(?):43-51. doi: 10.1016/j.psyneuen.2018.02.004. [PMID: 29433072]
  • S Caceres, B Monsalve, L Peña, P J de Andres, A Alonso-Diez, M J Illera, W A Woodward, J M Reuben, G Silvan, J C Illera. In vitro and in vivo effect of flutamide on steroid hormone secretion in canine and human inflammatory breast cancer cell lines. Veterinary and comparative oncology. 2018 Mar; 16(1):148-158. doi: 10.1111/vco.12324. [PMID: 28589573]
  • K Yoshida, Y Ohta, N Kawate, M Takahashi, T Inaba, S Hatoya, H Morii, K Takahashi, M Ito, H Tamada. Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. Andrologia. 2018 Feb; 50(1):. doi: 10.1111/and.12803. [PMID: 28295471]
  • Juilee Rege, Aya T Nanba, Richard J Auchus, Jianwei Ren, Hwei-Ming Peng, William E Rainey, Adina F Turcu. Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro. The Journal of clinical endocrinology and metabolism. 2018 01; 103(1):320-327. doi: 10.1210/jc.2017-01525. [PMID: 29126147]
  • Brittany L Mason, Erin Van Enkevort, Francesca Filbey, Christine E Marx, John Park, Alyson Nakamura, Prabha Sunderajan, E Sherwood Brown. Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders. Journal of clinical psychopharmacology. 2017 Dec; 37(6):684-688. doi: 10.1097/jcp.0000000000000793. [PMID: 29045302]
  • Yu-Chi Huang, Chi-Fa Hung, Pao-Yen Lin, Yu Lee, Chih-Ching Wu, Su-Ting Hsu, Chien-Chih Chen, Mian-Yoon Chong, Chieh-Hsin Lin, Liang-Jen Wang. Gender differences in susceptibility to schizophrenia: Potential implication of neurosteroids. Psychoneuroendocrinology. 2017 Oct; 84(?):87-93. doi: 10.1016/j.psyneuen.2017.06.017. [PMID: 28686904]
  • Erin L Legacki, Barry A Ball, C Jo Corbin, Shavahn C Loux, Kirsten E Scoggin, Scott D Stanley, Alan J Conley. Equine fetal adrenal, gonadal and placental steroidogenesis. Reproduction (Cambridge, England). 2017 10; 154(4):445-454. doi: 10.1530/rep-17-0239. [PMID: 28878092]
  • Philippe Liere, Antoine Pianos, Jean-Paul Oudinet, Michael Schumacher, Yvette Akwa. Differential effects of the 18-kDa translocator protein (TSPO) ligand etifoxine on steroidogenesis in rat brain, plasma and steroidogenic glands: Pharmacodynamic studies. Psychoneuroendocrinology. 2017 Sep; 83(?):122-134. doi: 10.1016/j.psyneuen.2017.05.022. [PMID: 28609670]
  • Guey-Shyang Hwang, Chih-Chieh Chen, Jou-Chun Chou, Ling-Ling Chang, Shu-Fen Kan, Wei-Ho Lai, Fu-Kong Lieu, Sindy Hu, Paulus S Wang, Shyi-Wu Wang. Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats. Scientific reports. 2017 08; 7(1):9035. doi: 10.1038/s41598-017-07054-6. [PMID: 28831034]
  • Shivani Daftary, Jung-Min Yon, Ehn-Kyoung Choi, Yun-Bae Kim, Collette Bice, Alexandra Kulikova, John Park, E Sherwood Brown. Microtubule associated protein 2 in bipolar depression: Impact of pregnenolone. Journal of affective disorders. 2017 08; 218(?):49-52. doi: 10.1016/j.jad.2017.04.024. [PMID: 28458115]
  • Tomoaki Tochitani, Akihito Yamashita, Izumi Matsumoto, Mami Kouchi, Yuta Fujii, Izuru Miyawaki, Toru Yamada, Kiyoko Bando. Usefulness of Simultaneous Measurement of Plasma Steroids, Including Precursors, for the Evaluation of Drug Effects on Adrenal Steroidogenesis in Rats. Toxicologic pathology. 2017 08; 45(6):756-763. doi: 10.1177/0192623317730416. [PMID: 29046138]
  • Mohammad Alyamani, Zhenfei Li, Michael Berk, Jianneng Li, Jingjie Tang, Sunil Upadhyay, Richard J Auchus, Nima Sharifi. Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities. Cell chemical biology. 2017 Jul; 24(7):825-832.e6. doi: 10.1016/j.chembiol.2017.05.020. [PMID: 28648378]
  • Barbara Costa, Chiara Cavallini, Eleonora Da Pozzo, Sabrina Taliani, Federico Da Settimo, Claudia Martini. The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity. ACS chemical neuroscience. 2017 07; 8(7):1448-1454. doi: 10.1021/acschemneuro.7b00027. [PMID: 28362078]
  • Juan Robles, Josep Marcos, Nuria Renau, Lorena Garrostas, Jordi Segura, Rosa Ventura, Bernardí Barceló, Antonia Barceló, Oscar J Pozo. Quantifying endogenous androgens, estrogens, pregnenolone and progesterone metabolites in human urine by gas chromatography tandem mass spectrometry. Talanta. 2017 Jul; 169(?):20-29. doi: 10.1016/j.talanta.2017.03.032. [PMID: 28411812]
  • Roberto Cosimo Melcangi, Daniele Santi, Roberto Spezzano, Maria Grimoldi, Tommaso Tabacchi, Maria Letizia Fusco, Silvia Diviccaro, Silvia Giatti, Giuseppe Carrà, Donatella Caruso, Manuela Simoni, Guido Cavaletti. Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients. The Journal of steroid biochemistry and molecular biology. 2017 07; 171(?):229-235. doi: 10.1016/j.jsbmb.2017.04.003. [PMID: 28408350]
  • Nadja Mannowetz, Melissa R Miller, Polina V Lishko. Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids. Proceedings of the National Academy of Sciences of the United States of America. 2017 05; 114(22):5743-5748. doi: 10.1073/pnas.1700367114. [PMID: 28507119]
  • Patrick J Trainor, Bradford G Hill, Samantha M Carlisle, Eric C Rouchka, Shesh N Rai, Aruni Bhatnagar, Andrew P DeFilippis. Systems characterization of differential plasma metabolome perturbations following thrombotic and non-thrombotic myocardial infarction. Journal of proteomics. 2017 05; 160(?):38-46. doi: 10.1016/j.jprot.2017.03.014. [PMID: 28341595]
  • Ute Krügel, Isabelle Straub, Holger Beckmann, Michael Schaefer. Primidone inhibits TRPM3 and attenuates thermal nociception in vivo. Pain. 2017 05; 158(5):856-867. doi: 10.1097/j.pain.0000000000000846. [PMID: 28106668]
  • Rachumallu Ramakrishna, Durgesh Kumar, Manisha Bhateria, Anil Nilkanth Gaikwad, Rabi Sankar Bhatta. 16-Dehydropregnenolone lowers serum cholesterol by up-regulation of CYP7A1 in hyperlipidemic male hamsters. The Journal of steroid biochemistry and molecular biology. 2017 04; 168(?):110-117. doi: 10.1016/j.jsbmb.2017.02.013. [PMID: 28232149]
  • Sheng-Yu Lee, Liang-Jen Wang, Cheng-Ho Chang, Chih-Ching Wu, Hsing-Ling Chen, Shih-Hsien Lin, Chin-Liang Chu, Ti Lu, Ru-Band Lu. Serum DHEA-S concentration correlates with clinical symptoms and neurocognitive function in patients with bipolar II disorder: A case-controlled study. Progress in neuro-psychopharmacology & biological psychiatry. 2017 03; 74(?):31-35. doi: 10.1016/j.pnpbp.2016.11.006. [PMID: 27914864]
  • Simone Romano, Nico Mitro, Silvia Diviccaro, Roberto Spezzano, Matteo Audano, Luis Miguel Garcia-Segura, Donatella Caruso, Roberto Cosimo Melcangi. Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus. The Journal of steroid biochemistry and molecular biology. 2017 03; 167(?):135-143. doi: 10.1016/j.jsbmb.2016.11.019. [PMID: 27890531]
  • Srividya Vasu, Mary K McGahon, R Charlotte Moffett, Tim M Curtis, J Michael Conlon, Yasser H A Abdel-Wahab, Peter R Flatt. Esculentin-2CHa(1-30) and its analogues: stability and mechanisms of insulinotropic action. The Journal of endocrinology. 2017 03; 232(3):423-435. doi: 10.1530/joe-16-0453. [PMID: 28115493]
  • Yangyang Sun, Lili Jia, Hui Zhou, Mengqian Mao, Xiaobo Wang, Lan Wei, Lixin Sun. Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration. Pharmaceutical development and technology. 2017 Mar; 22(2):218-228. doi: 10.1080/10837450.2016.1193192. [PMID: 27269370]
  • Ozgur Oktem, Nazli Akin, Gamze Bildik, Kayhan Yakin, Ebru Alper, Basak Balaban, Bulent Urman. FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization. Human reproduction (Oxford, England). 2017 03; 32(3):643-652. doi: 10.1093/humrep/dex010. [PMID: 28158500]
  • Yuyong Ke, Renaud Gonthier, Fernand Labrie. A sensitive and accurate LC-MS/MS assay with the derivatization of 1-Amino-4-methylpiperazine applied to serum allopregnanolone, pregnenolone and androsterone in pre- and postmenopausal women. Steroids. 2017 02; 118(?):25-31. doi: 10.1016/j.steroids.2016.11.007. [PMID: 27913096]
  • Patrizia Porcu, Todd K O'Buckley, Marcelo F Lopez, Howard C Becker, Michael F Miles, Robert W Williams, A Leslie Morrow. Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains. Alcohol (Fayetteville, N.Y.). 2017 Feb; 58(?):107-125. doi: 10.1016/j.alcohol.2016.07.011. [PMID: 27884493]
  • Sathvika Venugopal, Daniel Benjamin Martinez-Arguelles, Seimia Chebbi, Françoise Hullin-Matsuda, Toshihide Kobayashi, Vassilios Papadopoulos. Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. The Journal of biological chemistry. 2016 Dec; 291(50):26109-26125. doi: 10.1074/jbc.m116.740928. [PMID: 27815506]
  • Alberto Sánchez-Guijo, Jens Neunzig, Adrian Gerber, Vinzenz Oji, Michaela F Hartmann, Hans-Christian Schuppe, Heiko Traupe, Rita Bernhardt, Stefan A Wudy. Role of steroid sulfatase in steroid homeostasis and characterization of the sulfated steroid pathway: Evidence from steroid sulfatase deficiency. Molecular and cellular endocrinology. 2016 12; 437(?):142-153. doi: 10.1016/j.mce.2016.08.019. [PMID: 27531568]
  • Juilee Rege, Shigehiro Karashima, Antonio M Lerario, Joshua M Smith, Richard J Auchus, Josephine Z Kasa-Vubu, Hironobu Sasano, Yasuhiro Nakamura, Perrin C White, William E Rainey. Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate. The Journal of clinical endocrinology and metabolism. 2016 12; 101(12):4585-4593. doi: 10.1210/jc.2016-2864. [PMID: 27623070]
  • Rachumallu Ramakrishna, Manisha Bhateria, Rajbir Singh, Rabi Sankar Bhatta. Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes. The Journal of steroid biochemistry and molecular biology. 2016 10; 163(?):183-92. doi: 10.1016/j.jsbmb.2016.05.018. [PMID: 27224941]
  • Ana Belen Lopez-Rodriguez, Estefania Acaz-Fonseca, Roberto Spezzano, Silvia Giatti, Donatella Caruso, Maria-Paz Viveros, Roberto C Melcangi, Luis M Garcia-Segura. Profiling Neuroactive Steroid Levels After Traumatic Brain Injury in Male Mice. Endocrinology. 2016 Oct; 157(10):3983-3993. doi: 10.1210/en.2016-1316. [PMID: 27547849]
  • Shin Hye Kim, Su Hyeon Lee, Won-Yong Lee, Jeongae Lee, Bong Chul Chung, Mi-Jung Park, Man Ho Choi. Serum levels of cholesterol, pregnenolone, DHEA, and their sulfate conjugates based on sex and pubertal stage in adolescents. Clinica chimica acta; international journal of clinical chemistry. 2016 Oct; 461(?):47-52. doi: 10.1016/j.cca.2016.07.022. [PMID: 27475977]
  • Zhenxue Deng, Xiaobo Wang, Fang Wang, Zheng Qin, Yuqi Cui, Yangyang Sun, Lixin Sun. Pharmacokinetics and tissue distribution study of 16-dehydropregnenolone liposome in female mice after intravenous administration. Drug delivery. 2016 Oct; 23(8):2787-2795. doi: 10.3109/10717544.2015.1088596. [PMID: 26366505]
  • Hui Lin, Michael Travisano, Romas J Kazlauskas. The Fungus Trichoderma Regulates Submerged Conidiation Using the Steroid Pregnenolone. ACS chemical biology. 2016 09; 11(9):2568-75. doi: 10.1021/acschembio.6b00376. [PMID: 27413801]
  • Eun-Jin Kang, So-Hye Hong, Jae-Eon Lee, Seung Chul Kim, Hoe-Saeng Yang, Pyong In Yi, Sang-Myeong Lee, Beum-Soo An. Pregnenolone sulfate regulates prolactin production in the rat pituitary. The Journal of endocrinology. 2016 09; 230(3):339-46. doi: 10.1530/joe-16-0088. [PMID: 27507676]
  • Barbara Costa, Eleonora Da Pozzo, Chiara Cavallini, Sabrina Taliani, Federico Da Settimo, Claudia Martini. Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173. ACS chemical neuroscience. 2016 08; 7(8):1041-6. doi: 10.1021/acschemneuro.6b00149. [PMID: 27385308]
  • Lusine Demirkhanyan, Kunitoshi Uchida, Makoto Tominaga, Eleonora Zakharian. TRPM3 gating in planar lipid bilayers defines peculiar agonist specificity. Channels (Austin, Tex.). 2016 07; 10(4):258-60. doi: 10.1080/19336950.2016.1155900. [PMID: 26901668]
  • Yung-Hsing Yeh, Jou-Chun Chou, Ting-Chun Weng, Fu-Kong Lieu, Jou-Yu Lin, Chii-Chang Yeh, Sindy Hu, Paulus S Wang, Galina Idova, Shyi-Wu Wang. Effects of acrolein on the production of corticosterone in male rats. Steroids. 2016 07; 111(?):139-147. doi: 10.1016/j.steroids.2016.03.009. [PMID: 26996390]
  • Kai-Lee Wang, Wen-Ching Huang, Jou-Chun Chou, Ting-Chun Weng, Sindy Hu, Fu-Kong Lieu, Wei-Ho Lai, Galina Idova, Paulus S Wang, Shyi-Wu Wang. Effects of acrolein on aldosterone release from zona glomerulosa cells in male rats. Steroids. 2016 07; 111(?):89-94. doi: 10.1016/j.steroids.2016.03.008. [PMID: 26980145]
  • Benjamin Lemaire, Akira Kubota, Conor M O'Meara, David C Lamb, Robert L Tanguay, Jared V Goldstone, John J Stegeman. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicology and applied pharmacology. 2016 Apr; 296(?):73-84. doi: 10.1016/j.taap.2016.02.001. [PMID: 26853319]
  • Erin L Legacki, Elizabeth L Scholtz, Barry A Ball, Scott D Stanley, Trish Berger, Alan J Conley. The dynamic steroid landscape of equine pregnancy mapped by mass spectrometry. Reproduction (Cambridge, England). 2016 Apr; 151(4):421-30. doi: 10.1530/rep-15-0547. [PMID: 26814209]
  • Lucie Parésys, Kerstin Hoffmann, Nicolas Froger, Massimiliano Bianchi, Isabelle Villey, Etienne-Emile Baulieu, Eberhard Fuchs. Effects of the Synthetic Neurosteroid: 3β-Methoxypregnenolone (MAP4343) on Behavioral and Physiological Alterations Provoked by Chronic Psychosocial Stress in Tree Shrews. The international journal of neuropsychopharmacology. 2016 Apr; 19(4):. doi: 10.1093/ijnp/pyv119. [PMID: 26476437]
  • Kunitoshi Uchida, Lusine Demirkhanyan, Swapna Asuthkar, Alejandro Cohen, Makoto Tominaga, Eleonora Zakharian. Stimulation-dependent gating of TRPM3 channel in planar lipid bilayers. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Mar; 30(3):1306-16. doi: 10.1096/fj.15-281576. [PMID: 26655382]
  • Pedro E Martinez, David R Rubinow, Lynnette K Nieman, Deloris E Koziol, A Leslie Morrow, Crystal E Schiller, Dahima Cintron, Karla D Thompson, Khursheed K Khine, Peter J Schmidt. 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 Mar; 41(4):1093-102. doi: 10.1038/npp.2015.246. [PMID: 26272051]
  • Abdelmoneim Khashana, Marja Ojaniemi, Markku Leskinen, Timo Saarela, Mikko Hallman. Term neonates with infection and shock display high cortisol precursors despite low levels of normal cortisol. Acta paediatrica (Oslo, Norway : 1992). 2016 Feb; 105(2):154-8. doi: 10.1111/apa.13257. [PMID: 26537554]
  • Sandra Rubil, Oliver G Rössler, Gerald Thiel. CREB, AP-1, ternary complex factors and MAP kinases connect transient receptor potential melastatin-3 (TRPM3) channel stimulation with increased c-Fos expression. British journal of pharmacology. 2016 Jan; 173(2):305-18. doi: 10.1111/bph.13372. [PMID: 26493679]
  • N Ponce-Ruiz, A E Rojas-García, B S Barrón-Vivanco, G Elizondo, Y Y Bernal-Hernández, A Mejía-García, I M Medina-Díaz. Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells. Toxicology in vitro : an international journal published in association with BIBRA. 2015 Dec; 30(1 Pt B):348-54. doi: 10.1016/j.tiv.2015.09.031. [PMID: 26434531]
  • Divyan A Chopra, Daniel T Monaghan, Shashank M Dravid. Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu. Molecular pharmacology. 2015 Oct; 88(4):650-9. doi: 10.1124/mol.115.100396. [PMID: 26162866]
  • Rivka Ben Dor, Christine E Marx, Lawrence J Shampine, David R Rubinow, Peter J Schmidt. DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action. Psychopharmacology. 2015 Sep; 232(18):3375-83. doi: 10.1007/s00213-015-3991-1. [PMID: 26105109]
  • Josep Marcos, Marta Pol, Andreu Fabregat, Rosa Ventura, Nuria Renau, Felicia A Hanzu, Gregori Casals, Santi Marfà, Bernardí Barceló, Antonia Barceló, Juan Robles, Jordi Segura, Oscar J Pozo. Urinary cysteinyl progestogens: Occurrence and origin. The Journal of steroid biochemistry and molecular biology. 2015 Aug; 152(?):53-61. doi: 10.1016/j.jsbmb.2015.04.015. [PMID: 25913395]
  • Maximillian A Rogers, Jay Liu, Bao-Liang Song, Bo-Liang Li, Catherine C Y Chang, Ta-Yuan Chang. Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators. The Journal of steroid biochemistry and molecular biology. 2015 Jul; 151(?):102-7. doi: 10.1016/j.jsbmb.2014.09.008. [PMID: 25218443]
  • Balázs I Tóth, Maik Konrad, Debapriya Ghosh, Florian Mohr, Christian R Halaszovich, Michael G Leitner, Joris Vriens, Johannes Oberwinkler, Thomas Voets. Regulation of the transient receptor potential channel TRPM3 by phosphoinositides. The Journal of general physiology. 2015 Jul; 146(1):51-63. doi: 10.1085/jgp.201411339. [PMID: 26123194]
  • Alain Y Dury, Yuyong Ke, Renaud Gonthier, Maxim Isabelle, Jean-Nicolas Simard, Fernand Labrie. Validated LC-MS/MS simultaneous assay of five sex steroid/neurosteroid-related sulfates in human serum. The Journal of steroid biochemistry and molecular biology. 2015 May; 149(?):1-10. doi: 10.1016/j.jsbmb.2015.01.006. [PMID: 25595042]
  • P Wong, Y Sze, C C R Chang, J Lee, X Zhang. Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway. Translational psychiatry. 2015 Mar; 5(?):e528. doi: 10.1038/tp.2015.21. [PMID: 25781227]
  • G Y Son, Y M Yang, W S Park, I Chang, D M Shin. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. Journal of dental research. 2015 Mar; 94(3):473-81. doi: 10.1177/0022034514567196. [PMID: 25595364]
  • Donatella Caruso, Federico Abbiati, Silvia Giatti, Simone Romano, Letizia Fusco, Guido Cavaletti, Roberto Cosimo Melcangi. Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma. The Journal of steroid biochemistry and molecular biology. 2015 Feb; 146(?):74-9. doi: 10.1016/j.jsbmb.2014.03.012. [PMID: 24717976]