Glycerate (BioDeep_00000001330)

 

Secondary id: BioDeep_00001868334

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


Metabolite Card


(2R)-2,3-dihydroxypropanoic acid

Formula: C3H6O4 (106.0266076)
Chinese Names: DL-甘油酸, 甘油酸
Spectrum Hits: Top Source Viridiplantae(plant) 0.32%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Glycerate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/glycerate (retrieved 2024-11-06) (BioDeep RN: BioDeep_00000001330). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Molecular Structure

SMILES: C(C(C(=O)O)O)O
InChI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)

Description

Glyceric acid is a colourless syrupy acid, obtained from oxidation of glycerol. It is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria, an inborn error of metabolism, and D-glycerate anemia. Deficiency of human glycerate kinase leads to D-glycerate acidemia/D-glyceric aciduria. Symptoms of the disease include progressive neurological impairment, hypotonia, seizures, failure to thrive, and metabolic acidosis. At sufficiently high levels, glyceric acid can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Glyceric acid is an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of untreated glyceric aciduria. Many affected children with organic acidemias experience intellectual disability or delayed development. In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures. Elevated values may also be due to microbial sources such as yeast (Aspergillus, Penicillium, probably Candida) or due to dietary sources containing glycerol (glycerine). Glyceric acid is isolated from various plants (e.g. brassicas, pulses, and Vicia faba).
A colorless syrupy acid, obtained from oxidation of glycerol. It is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria and D-glycerate anemia. Deficiency of human glycerate kinase leads to D-glycerate acidemia/D-glyceric aciduria. Symptoms of the disease include progressive neurological impairment, hypotonia, seizures, failure to thrive and metabolic acidosis.; Glyceric acid is a natural three-carbon sugar acid. Salts and esters of glyceric acid are known as glycerates. Glyceric acid is found in many foods, some of which are peanut, common grape, garden tomato (variety), and french plantain.

Glyceric acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=473-81-4 (retrieved 2024-06-29) (CAS RN: 473-81-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Synonyms

23 synonym names

DL-Glyceric Acid calcium Salt hydrate; D-(+)-Glyceric acid hemicalcium salt; (2R)-2,3-Dihydroxypropanoic acid; alpha,beta-Hydroxypropionic acid; (R)-2,3-Dihydroxypropanoic acid; D-2,3-Dihydroxypropanoic acid; 2,3-dihydroxy-propanoic acid; alpha,beta-Hydroxypropionate; a,b-Hydroxypropionic acid; a,b-Hydroxypropionate; DL-Glyceric acid sol; D-(+)-Glyceric acid; (R)-Glyceric acid; DL-GLYCERIC ACID; D-Glyceric acid; R-Glyceric acid; (R)-Glycerate; GLYCERIC ACID; R-Glycerate; D-Glycerate; Glycerate; D-GroA; Glyceric acid



Cross Reference

30 cross reference id

Classification Terms

Related Pathways

Reactome(0)

BioCyc(0)

PlantCyc(0)

Biological Process

296 related biological process reactions.

Reactome(12)

BioCyc(4)

WikiPathways(0)

Plant Reactome(234)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

27 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



Literature Reference

  • M Merlani, V Barbakadze, L Amiranashvili, L Gogilashvili, A Petrou, A Geronikaki, A Ćirić, J Glamočlija, M Soković. Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies. SAR and QSAR in environmental research. 2022 Apr; 33(4):307-321. doi: 10.1080/1062936x.2022.2066173. [PMID: 35532307]
  • Lili Cui, Chuanling Zhang, Zhichao Li, Tuxiu Xian, Limin Wang, Zhisheng Zhang, Guohui Zhu, Xinxiang Peng. Two plastidic glycolate/glycerate translocator 1 isoforms function together to transport photorespiratory glycolate and glycerate in rice chloroplasts. Journal of experimental botany. 2021 03; 72(7):2584-2599. doi: 10.1093/jxb/erab020. [PMID: 33483723]
  • Jörn Oliver Sass, Sidney Behringer, Malkanthi Fernando, Elisabetta Cesaroni, Ida Cursio, Alberto Volpini, Claudia Till. d-Glycerate kinase deficiency in a neuropediatric patient. Brain & development. 2020 Feb; 42(2):226-230. doi: 10.1016/j.braindev.2019.11.008. [PMID: 31837836]
  • Selçuk Aslan, Elad Noor, Sara Benito Vaquerizo, Steffen N Lindner, Arren Bar-Even. Design and engineering of E. coli metabolic sensor strains with a wide sensitivity range for glycerate. Metabolic engineering. 2020 01; 57(?):96-109. doi: 10.1016/j.ymben.2019.09.002. [PMID: 31491545]
  • Yoav Zehavi, Hanna Mandel, Ayelet Eran, Sarit Ravid, Muhammad Abu Rashid, Erwin E W Jansen, Mirjam M C Wamelink, Ann Saada, Avraham Shaag, Orly Elpeleg, Ronen Spiegel. Severe infantile epileptic encephalopathy associated with D-glyceric aciduria: report of a novel case and review. Metabolic brain disease. 2019 04; 34(2):557-563. doi: 10.1007/s11011-019-0384-x. [PMID: 30637540]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Liang Chi, Xiaoming Bian, Bei Gao, Pengcheng Tu, Yunjia Lai, Hongyu Ru, Kun Lu. Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice. Molecules (Basel, Switzerland). 2018 Feb; 23(2):. doi: 10.3390/molecules23020367. [PMID: 29425148]
  • Michael A Swanson, Stephanie M Garcia, Elaine Spector, Kathryn Kronquist, Geralyn Creadon-Swindell, Melanie Walter, Ernst Christensen, Johan L K Van Hove, Jörn Oliver Sass. d-Glyceric aciduria does not cause nonketotic hyperglycinemia: A historic co-occurrence. Molecular genetics and metabolism. 2017 06; 121(2):80-82. doi: 10.1016/j.ymgme.2017.04.009. [PMID: 28462797]
  • Emmanuel Richard, Jean-Marc Blouin, Jérome Harambat, Brigitte Llanas, Stéphane Bouchet, Cécile Acquaviva, Renaud de la Faille. Late diagnosis of primary hyperoxaluria type III. Annals of clinical biochemistry. 2017 May; 54(3):406-411. doi: 10.1177/0004563216677101. [PMID: 27742850]
  • Stéphanie Arrivault, Toshihiro Obata. Quantification of Photorespiratory Intermediates by Mass Spectrometry-Based Approaches. Methods in molecular biology (Clifton, N.J.). 2017; 1653(?):97-104. doi: 10.1007/978-1-4939-7225-8_7. [PMID: 28822128]
  • Leonardo Perez de Souza, Marek Szecówka, Alisdair R Fernie, Takayuki Tohge. 13CO2 Labeling and Mass Spectral Analysis of Photorespiration. Methods in molecular biology (Clifton, N.J.). 2017; 1653(?):157-166. doi: 10.1007/978-1-4939-7225-8_11. [PMID: 28822132]
  • Wei Zhang, Xin-An Zhang. A Novel Urinary Metabolite Signature for Non-invasive Post-stroke Depression Diagnosis. Cell biochemistry and biophysics. 2015 Jul; 72(3):661-7. doi: 10.1007/s12013-014-0472-9. [PMID: 27352185]
  • Jin Nakahara, Katsuaki Takechi, Fumiyoshi Myouga, Yasuko Moriyama, Hiroshi Sato, Susumu Takio, Hiroyoshi Takano. Bending of protonema cells in a plastid glycolate/glycerate transporter knockout line of Physcomitrella patens. PloS one. 2015; 10(3):e0118804. doi: 10.1371/journal.pone.0118804. [PMID: 25793376]
  • R Ros, B Cascales-Miñana, J Segura, A D Anoman, W Toujani, M Flores-Tornero, S Rosa-Tellez, J Muñoz-Bertomeu. Serine biosynthesis by photorespiratory and non-photorespiratory pathways: an interesting interplay with unknown regulatory networks. Plant biology (Stuttgart, Germany). 2013 Jul; 15(4):707-12. doi: 10.1111/j.1438-8677.2012.00682.x. [PMID: 23199004]
  • J Yang, T Chen, L Sun, Z Zhao, X Qi, K Zhou, Y Cao, X Wang, Y Qiu, M Su, A Zhao, P Wang, P Yang, J Wu, G Feng, L He, W Jia, C Wan. Potential metabolite markers of schizophrenia. Molecular psychiatry. 2013 Jan; 18(1):67-78. doi: 10.1038/mp.2011.131. [PMID: 22024767]
  • Richard C Sicher, Dennis Timlin, Bryan Bailey. Responses of growth and primary metabolism of water-stressed barley roots to rehydration. Journal of plant physiology. 2012 May; 169(7):686-95. doi: 10.1016/j.jplph.2012.01.002. [PMID: 22285575]
  • Jiayu Tu, Jiye A, Guangji Wang, Hongmei Wen, Aiyun Wang, Liuqing Di, Bei Cao, Linsheng Liu. [Plasma metabonomics study of ischemic cerebral apoplexy rats treated with Tongsaimai pellets]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Apr; 37(7):1028-33. doi: . [PMID: 22792811]
  • Markus Niessen, Katrin Krause, Ina Horst, Norma Staebler, Stephanie Klaus, Stefanie Gaertner, Rashad Kebeish, Wagner L Araujo, Alisdair R Fernie, Christoph Peterhansel. Two alanine aminotranferases link mitochondrial glycolate oxidation to the major photorespiratory pathway in Arabidopsis and rice. Journal of experimental botany. 2012 Apr; 63(7):2705-16. doi: 10.1093/jxb/err453. [PMID: 22268146]
  • Jean-Baptise Cazier, Pamela J Kaisaki, Karène Argoud, Benjamin J Blaise, Kirill Veselkov, Timothy M D Ebbels, Tsz Tsang, Yulan Wang, Marie-Thérèse Bihoreau, Steve C Mitchell, Elaine C Holmes, John C Lindon, James Scott, Jeremy K Nicholson, Marc-Emmanuel Dumas, Dominique Gauguier. Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase. Journal of proteome research. 2012 Feb; 11(2):631-42. doi: 10.1021/pr200566t. [PMID: 22029865]
  • Alexandra Maier, Holger Fahnenstich, Susanne von Caemmerer, Martin K M Engqvist, Andreas P M Weber, Ulf-Ingo Flügge, Veronica G Maurino. Transgenic Introduction of a Glycolate Oxidative Cycle into A. thaliana Chloroplasts Leads to Growth Improvement. Frontiers in plant science. 2012; 3(?):38. doi: 10.3389/fpls.2012.00038. [PMID: 22639647]
  • Hervé Colinet, David Renault, Blandine Charoy-Guével, Emmanuelle Com. Metabolic and proteomic profiling of diapause in the aphid parasitoid Praon volucre. PloS one. 2012; 7(2):e32606. doi: 10.1371/journal.pone.0032606. [PMID: 22389713]
  • David Toubiana, Yaniv Semel, Takayuki Tohge, Romina Beleggia, Luigi Cattivelli, Leah Rosental, Zoran Nikoloski, Dani Zamir, Alisdair R Fernie, Aaron Fait. Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. PLoS genetics. 2012; 8(3):e1002612. doi: 10.1371/journal.pgen.1002612. [PMID: 22479206]
  • Amy M Trowbridge, Dolores Asensio, Allyson S D Eller, Danielle A Way, Michael J Wilkinson, Jörg-Peter Schnitzler, Robert B Jackson, Russell K Monson. Contribution of various carbon sources toward isoprene biosynthesis in poplar leaves mediated by altered atmospheric CO2 concentrations. PloS one. 2012; 7(2):e32387. doi: 10.1371/journal.pone.0032387. [PMID: 22384238]
  • Josirley de F C Carvalho, Pippa J Madgwick, Stephen J Powers, Alfred J Keys, Peter J Lea, Martin A J Parry. An engineered pathway for glyoxylate metabolism in tobacco plants aimed to avoid the release of ammonia in photorespiration. BMC biotechnology. 2011 Nov; 11(?):111. doi: 10.1186/1472-6750-11-111. [PMID: 22104170]
  • Melissa J Morine, Audrey C Tierney, Ben van Ommen, Hannelore Daniel, Sinead Toomey, Ingrid M F Gjelstad, Isobel C Gormley, Pablo Pérez-Martinez, Christian A Drevon, Jose López-Miranda, Helen M Roche. Transcriptomic coordination in the human metabolic network reveals links between n-3 fat intake, adipose tissue gene expression and metabolic health. PLoS computational biology. 2011 Nov; 7(11):e1002223. doi: 10.1371/journal.pcbi.1002223. [PMID: 22072950]
  • Ehud Katz, Kyung Hwan Boo, Ho Youn Kim, Richard A Eigenheer, Brett S Phinney, Vladimir Shulaev, Florence Negre-Zakharov, Avi Sadka, Eduardo Blumwald. Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. Journal of experimental botany. 2011 Nov; 62(15):5367-84. doi: 10.1093/jxb/err197. [PMID: 21841177]
  • Asaph B Cousins, Berkley J Walker, Itsara Pracharoenwattana, Steven M Smith, Murray R Badger. Peroxisomal hydroxypyruvate reductase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release. Photosynthesis research. 2011 Sep; 108(2-3):91-100. doi: 10.1007/s11120-011-9651-3. [PMID: 21567290]
  • Ramona Kern, Hermann Bauwe, Martin Hagemann. Evolution of enzymes involved in the photorespiratory 2-phosphoglycolate cycle from cyanobacteria via algae toward plants. Photosynthesis research. 2011 Sep; 109(1-3):103-14. doi: 10.1007/s11120-010-9615-z. [PMID: 21222161]
  • Apaporn Boonmee, Chantragan Srisomsap, Daranee Chokchaichamnankit, Aphichart Karnchanatat, Polkit Sangvanich. A proteomic analysis of Curcuma comosa Roxb. rhizomes. Proteome science. 2011 Jul; 9(?):43. doi: 10.1186/1477-5956-9-43. [PMID: 21801377]
  • Qian Qiao, Tonghua Li, Jiangming Sun, Xiaoyan Liu, Jianke Ren, Jian Fei. Metabolomic analysis of normal (C57BL/6J, 129S1/SvImJ) mice by gas chromatography-mass spectrometry: detection of strain and gender differences. Talanta. 2011 Jul; 85(1):718-24. doi: 10.1016/j.talanta.2011.04.060. [PMID: 21645764]
  • Thomas P Howard, Julie C Lloyd, Christine A Raines. Inter-species variation in the oligomeric states of the higher plant Calvin cycle enzymes glyceraldehyde-3-phosphate dehydrogenase and phosphoribulokinase. Journal of experimental botany. 2011 Jul; 62(11):3799-805. doi: 10.1093/jxb/err057. [PMID: 21498632]
  • Paula Casati, Mabel Campi, Darren J Morrow, John F Fernandes, Virginia Walbot. Transcriptomic, proteomic and metabolomic analysis of UV-B signaling in maize. BMC genomics. 2011 Jun; 12(?):321. doi: 10.1186/1471-2164-12-321. [PMID: 21679461]
  • Peter E Larsen, Avinash Sreedasyam, Geetika Trivedi, Gopi K Podila, Leland J Cseke, Frank R Collart. Using next generation transcriptome sequencing to predict an ectomycorrhizal metabolome. BMC systems biology. 2011 May; 5(?):70. doi: 10.1186/1752-0509-5-70. [PMID: 21569493]
  • Baolei Jia, Le Thuy Linh, Sangmin Lee, Bang Phuong Pham, Jinliang Liu, Hongyu Pan, Shihong Zhang, Gang-Won Cheong. Biochemical characterization of glyceraldehyde-3-phosphate dehydrogenase from Thermococcus kodakarensis KOD1. Extremophiles : life under extreme conditions. 2011 May; 15(3):337-46. doi: 10.1007/s00792-011-0365-4. [PMID: 21409597]
  • Yasuhiro Yamamoto, Kenkichi Takase, Junji Kishino, Megumi Fujita, Noboru Okamura, Toshiyuki Sakaeda, Masafumi Fujimoto, Tatsurou Yagami. Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane. PloS one. 2011 Mar; 6(3):e17552. doi: 10.1371/journal.pone.0017552. [PMID: 21445266]
  • Stefan Timm, Alexandra Florian, Kathrin Jahnke, Adriano Nunes-Nesi, Alisdair R Fernie, Hermann Bauwe. The hydroxypyruvate-reducing system in Arabidopsis: multiple enzymes for the same end. Plant physiology. 2011 Feb; 155(2):694-705. doi: 10.1104/pp.110.166538. [PMID: 21205613]
  • Wagner L Araújo, Adriano Nunes-Nesi, Sonia Osorio, Björn Usadel, Daniela Fuentes, Réka Nagy, Ilse Balbo, Martin Lehmann, Claudia Studart-Witkowski, Takayuki Tohge, Enrico Martinoia, Xavier Jordana, Fábio M Damatta, Alisdair R Fernie. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. The Plant cell. 2011 Feb; 23(2):600-27. doi: 10.1105/tpc.110.081224. [PMID: 21307286]
  • Jan Huege, Jan Goetze, Doreen Schwarz, Hermann Bauwe, Martin Hagemann, Joachim Kopka. Modulation of the major paths of carbon in photorespiratory mutants of synechocystis. PloS one. 2011 Jan; 6(1):e16278. doi: 10.1371/journal.pone.0016278. [PMID: 21283704]
  • Lei Wang, Wei Chen, Yun Feng, Yan Ren, Zhennan Gu, Haiqin Chen, Hongchao Wang, Michael J Thomas, Baixi Zhang, Isabelle M Berquin, Yang Li, Jiansheng Wu, Huanxin Zhang, Yuanda Song, Xiang Liu, James S Norris, Suriguga Wang, Peng Du, Junguo Shen, Na Wang, Yanlin Yang, Wei Wang, Lu Feng, Colin Ratledge, Hao Zhang, Yong Q Chen. Genome characterization of the oleaginous fungus Mortierella alpina. PloS one. 2011; 6(12):e28319. doi: 10.1371/journal.pone.0028319. [PMID: 22174787]
  • Jérôme Harambat, Sonia Fargue, Justine Bacchetta, Cécile Acquaviva, Pierre Cochat. Primary hyperoxaluria. International journal of nephrology. 2011; 2011(?):864580. doi: 10.4061/2011/864580. [PMID: 21748001]
  • Penglin Li, Xiaoling Miao, Rongxiu Li, Jianjiang Zhong. In situ biodiesel production from fast-growing and high oil content Chlorella pyrenoidosa in rice straw hydrolysate. Journal of biomedicine & biotechnology. 2011; 2011(?):141207. doi: 10.1155/2011/141207. [PMID: 21318171]
  • Andrea Bräutigam, Kaisa Kajala, Julia Wullenweber, Manuel Sommer, David Gagneul, Katrin L Weber, Kevin M Carr, Udo Gowik, Janina Mass, Martin J Lercher, Peter Westhoff, Julian M Hibberd, Andreas P M Weber. An mRNA blueprint for C4 photosynthesis derived from comparative transcriptomics of closely related C3 and C4 species. Plant physiology. 2011 Jan; 155(1):142-56. doi: 10.1104/pp.110.159442. [PMID: 20543093]
  • Takayuki Tohge, Tabea Mettler, Stéphanie Arrivault, Adam James Carroll, Mark Stitt, Alisdair R Fernie. From models to crop species: caveats and solutions for translational metabolomics. Frontiers in plant science. 2011; 2(?):61. doi: 10.3389/fpls.2011.00061. [PMID: 22639601]
  • Rohit Ghai, Francisco Rodriguez-Valera, Katherine D McMahon, Danyelle Toyama, Raquel Rinke, Tereza Cristina Souza de Oliveira, José Wagner Garcia, Fernando Pellon de Miranda, Flavio Henrique-Silva. Metagenomics of the water column in the pristine upper course of the Amazon river. PloS one. 2011; 6(8):e23785. doi: 10.1371/journal.pone.0023785. [PMID: 21915244]
  • Oliver Fiehn, W Timothy Garvey, John W Newman, Kerry H Lok, Charles L Hoppel, Sean H Adams. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PloS one. 2010 Dec; 5(12):e15234. doi: 10.1371/journal.pone.0015234. [PMID: 21170321]
  • Yalin Liu, Huimin Gao, Zhimin Wang, Qiwei Zhang. [Trace analysis of aristolochic acid A]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Dec; 35(24):3314-7. doi: 10.4268/cjcmm20102419. [PMID: 21438398]
  • Tiago Tomaz, Matthieu Bagard, Itsara Pracharoenwattana, Pernilla Lindén, Chun Pong Lee, Adam J Carroll, Elke Ströher, Steven M Smith, Per Gardeström, A Harvey Millar. Mitochondrial malate dehydrogenase lowers leaf respiration and alters photorespiration and plant growth in Arabidopsis. Plant physiology. 2010 Nov; 154(3):1143-57. doi: 10.1104/pp.110.161612. [PMID: 20876337]
  • Phuc Thi Do, Marion Prudent, Ronan Sulpice, Mathilde Causse, Alisdair R Fernie. The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population. Plant physiology. 2010 Nov; 154(3):1128-42. doi: 10.1104/pp.110.163030. [PMID: 20841452]
  • Ronan Sulpice, Agata Sienkiewicz-Porzucek, Sonia Osorio, Ina Krahnert, Mark Stitt, Alisdair R Fernie, Adriano Nunes-Nesi. Mild reductions in cytosolic NADP-dependent isocitrate dehydrogenase activity result in lower amino acid contents and pigmentation without impacting growth. Amino acids. 2010 Oct; 39(4):1055-66. doi: 10.1007/s00726-010-0617-0. [PMID: 20473773]
  • Ajay P Sharma, Guido Filler. Epidemiology of pediatric urolithiasis. Indian journal of urology : IJU : journal of the Urological Society of India. 2010 Oct; 26(4):516-22. doi: 10.4103/0970-1591.74450. [PMID: 21369384]
  • Irène Hummel, Florent Pantin, Ronan Sulpice, Maria Piques, Gaëlle Rolland, Myriam Dauzat, Angélique Christophe, Marjorie Pervent, Marie Bouteillé, Mark Stitt, Yves Gibon, Bertrand Muller. Arabidopsis plants acclimate to water deficit at low cost through changes of carbon usage: an integrated perspective using growth, metabolite, enzyme, and gene expression analysis. Plant physiology. 2010 Sep; 154(1):357-72. doi: 10.1104/pp.110.157008. [PMID: 20631317]
  • Ronan Sulpice, Sandra Trenkamp, Matthias Steinfath, Bjorn Usadel, Yves Gibon, Hanna Witucka-Wall, Eva-Theresa Pyl, Hendrik Tschoep, Marie Caroline Steinhauser, Manuela Guenther, Melanie Hoehne, Johann M Rohwer, Thomas Altmann, Alisdair R Fernie, Mark Stitt. Network analysis of enzyme activities and metabolite levels and their relationship to biomass in a large panel of Arabidopsis accessions. The Plant cell. 2010 Aug; 22(8):2872-93. doi: 10.1105/tpc.110.076653. [PMID: 20699391]
  • Vakhtang Barbakadze, Lali Gogilashvili, Lela Amiranashvili, Maia Merlani, Karen Mulkijanyan, Manana Churadze, Antonio Salgado, Bezhan Chankvetadze. Poly[3-(3,4-dihydroxyphenyl)glyceric acid] from Anchusa italica roots. Natural product communications. 2010 Jul; 5(7):1091-5. doi: ". [PMID: 20734947]
  • Adam C English, Ketan S Patel, Ann E Loraine. Prevalence of alternative splicing choices in Arabidopsis thaliana. BMC plant biology. 2010 Jun; 10(?):102. doi: 10.1186/1471-2229-10-102. [PMID: 20525311]
  • Oliver Bartsch, Stefan Mikkat, Martin Hagemann, Hermann Bauwe. An autoinhibitory domain confers redox regulation to maize glycerate kinase. Plant physiology. 2010 Jun; 153(2):832-40. doi: 10.1104/pp.110.157719. [PMID: 20413649]
  • Margaretha J van der Merwe, Sonia Osorio, Wagner L Araújo, Ilse Balbo, Adriano Nunes-Nesi, Eugenia Maximova, Fernando Carrari, Victoria I Bunik, Staffan Persson, Alisdair R Fernie. Tricarboxylic acid cycle activity regulates tomato root growth via effects on secondary cell wall production. Plant physiology. 2010 Jun; 153(2):611-21. doi: 10.1104/pp.109.149047. [PMID: 20118274]
  • Osamu Morinaga, Takuhiro Uto, Chun-Su Yuan, Hiroyuki Tanaka, Yukihiro Shoyama. Evaluation of a new eastern blotting technique for the analysis of ginsenoside Re in American ginseng berry pulp extracts. Fitoterapia. 2010 Jun; 81(4):284-8. doi: 10.1016/j.fitote.2009.10.005. [PMID: 19850112]
  • Safiyh Taghavi, Daniel van der Lelie, Adam Hoffman, Yian-Biao Zhang, Michael D Walla, Jaco Vangronsveld, Lee Newman, Sébastien Monchy. Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638. PLoS genetics. 2010 May; 6(5):e1000943. doi: 10.1371/journal.pgen.1000943. [PMID: 20485560]
  • Wagner L Araújo, Kimitsune Ishizaki, Adriano Nunes-Nesi, Tony R Larson, Takayuki Tohge, Ina Krahnert, Sandra Witt, Toshihiro Obata, Nicolas Schauer, Ian A Graham, Christopher J Leaver, Alisdair R Fernie. Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. The Plant cell. 2010 May; 22(5):1549-63. doi: 10.1105/tpc.110.075630. [PMID: 20501910]
  • Ralph Kissen, Per Winge, Diem Hong Thi Tran, Tommy S Jørstad, Trond R Størseth, Tone Christensen, Atle M Bones. Transcriptional profiling of an Fd-GOGAT1/GLU1 mutant in Arabidopsis thaliana reveals a multiple stress response and extensive reprogramming of the transcriptome. BMC genomics. 2010 Mar; 11(?):190. doi: 10.1186/1471-2164-11-190. [PMID: 20307264]
  • Pierre Cochat, Valérie Pichault, Justine Bacchetta, Laurence Dubourg, Jean-François Sabot, Christine Saban, Michel Daudon, Aurélia Liutkus. Nephrolithiasis related to inborn metabolic diseases. Pediatric nephrology (Berlin, Germany). 2010 Mar; 25(3):415-24. doi: 10.1007/s00467-008-1085-6. [PMID: 19156444]
  • Snezana Djordjevic, Xiaoxuan Zhang, Mark Bartlam, Sheng Ye, Zihe Rao, Christopher J Danpure. Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting. Acta crystallographica. Section F, Structural biology and crystallization communications. 2010 Mar; 66(Pt 3):233-6. doi: 10.1107/s1744309109054645. [PMID: 20208150]
  • M Cristina Palmieri, Christian Lindermayr, Hermann Bauwe, Clara Steinhauser, Joerg Durner. Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation. Plant physiology. 2010 Mar; 152(3):1514-28. doi: 10.1104/pp.109.152579. [PMID: 20089767]
  • Giulia Friso, Wojciech Majeran, Mingshu Huang, Qi Sun, Klaas J van Wijk. Reconstruction of metabolic pathways, protein expression, and homeostasis machineries across maize bundle sheath and mesophyll chloroplasts: large-scale quantitative proteomics using the first maize genome assembly. Plant physiology. 2010 Mar; 152(3):1219-50. doi: 10.1104/pp.109.152694. [PMID: 20089766]
  • Lena Burri, G Hege Thoresen, Rolf K Berge. The Role of PPARα Activation in Liver and Muscle. PPAR research. 2010; 2010(?):. doi: 10.1155/2010/542359. [PMID: 20847941]
  • Agata Sienkiewicz-Porzucek, Ronan Sulpice, Sonia Osorio, Ina Krahnert, Andrea Leisse, Ewa Urbanczyk-Wochniak, Michael Hodges, Alisdair R Fernie, Adriano Nunes-Nesi. Mild reductions in mitochondrial NAD-dependent isocitrate dehydrogenase activity result in altered nitrate assimilation and pigmentation but do not impact growth. Molecular plant. 2010 Jan; 3(1):156-73. doi: 10.1093/mp/ssp101. [PMID: 20035036]
  • Veronika Turecková, Ondrej Novák, Miroslav Strnad. Profiling ABA metabolites in Nicotiana tabacum L. leaves by ultra-performance liquid chromatography-electrospray tandem mass spectrometry. Talanta. 2009 Nov; 80(1):390-9. doi: 10.1016/j.talanta.2009.06.027. [PMID: 19782241]
  • Mark M Aloysius, Abed M Zaitoun, Timothy E Bates, Abdulkader Albasri, Mohammad Ilyas, Brian J Rowlands, Dileep N Lobo. Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia. BMC cancer. 2009 Sep; 9(?):327. doi: 10.1186/1471-2407-9-327. [PMID: 19754967]
  • Wendy L Allan, Shawn M Clark, Gordon J Hoover, Barry J Shelp. Role of plant glyoxylate reductases during stress: a hypothesis. The Biochemical journal. 2009 Sep; 423(1):15-22. doi: 10.1042/bj20090826. [PMID: 19740079]
  • Martin Engqvist, María F Drincovich, Ulf-Ingo Flügge, Verónica G Maurino. Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways. The Journal of biological chemistry. 2009 Sep; 284(37):25026-37. doi: 10.1074/jbc.m109.021253. [PMID: 19586914]
  • Shou-Lei Yan, Qing-Zhang Wang, Guang-Hua Peng. Determination of catechin in lotus rhizomes by high-performance liquid chromatography. International journal of food sciences and nutrition. 2009 Aug; 60(5):432-8. doi: 10.1080/09637480701780062. [PMID: 22519678]
  • Irene Granlund, Michael Hall, Thomas Kieselbach, Wolfgang P Schröder. Light induced changes in protein expression and uniform regulation of transcription in the thylakoid lumen of Arabidopsis thaliana. PloS one. 2009 May; 4(5):e5649. doi: 10.1371/journal.pone.0005649. [PMID: 19461964]
  • Snezana Dordević, Vesna Kilibarda, Tomislav Stojanović. Determination of carbamazepine in serum and saliva samples by high performance liquid chromatography with ultraviolet detection. Vojnosanitetski pregled. 2009 May; 66(5):347-52. doi: 10.2298/vsp0905347d. [PMID: 19489468]
  • Nomy Levin-Iaina, Dganit Dinour, Lina Romero, Rotem Ron, R Leo Brady, Scott D Cramer, Eli J Holtzman. Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling. The Journal of urology. 2009 May; 181(5):2146-51. doi: 10.1016/j.juro.2009.01.045. [PMID: 19296982]
  • Que N Van, Timothy D Veenstra. How close is the bench to the bedside? Metabolic profiling in cancer research. Genome medicine. 2009 Jan; 1(1):5. doi: 10.1186/gm5. [PMID: 19348692]
  • Abhijit Karve, Brandon D Moore. Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth. Journal of experimental botany. 2009; 60(14):4137-49. doi: 10.1093/jxb/erp252. [PMID: 19706780]
  • Maria Piques, Waltraud X Schulze, Melanie Höhne, Björn Usadel, Yves Gibon, Johann Rohwer, Mark Stitt. Ribosome and transcript copy numbers, polysome occupancy and enzyme dynamics in Arabidopsis. Molecular systems biology. 2009; 5(?):314. doi: 10.1038/msb.2009.68. [PMID: 19888209]
  • Widodo, John H Patterson, Ed Newbigin, Mark Tester, Antony Bacic, Ute Roessner. Metabolic responses to salt stress of barley (Hordeum vulgare L.) cultivars, Sahara and Clipper, which differ in salinity tolerance. Journal of experimental botany. 2009; 60(14):4089-103. doi: 10.1093/jxb/erp243. [PMID: 19666960]
  • Geoffrey Fucile, Shannon Falconer, Dinesh Christendat. Evolutionary diversification of plant shikimate kinase gene duplicates. PLoS genetics. 2008 Dec; 4(12):e1000292. doi: 10.1371/journal.pgen.1000292. [PMID: 19057671]
  • Ki-Hong Jung, Christopher Dardick, Laura E Bartley, Peijian Cao, Jirapa Phetsom, Patrick Canlas, Young-Su Seo, Michael Shultz, Shu Ouyang, Qiaoping Yuan, Bryan C Frank, Eugene Ly, Li Zheng, Yi Jia, An-Ping Hsia, Kyungsook An, Hui-Hsien Chou, David Rocke, Geun Cheol Lee, Patrick S Schnable, Gynheung An, C Robin Buell, Pamela C Ronald. Refinement of light-responsive transcript lists using rice oligonucleotide arrays: evaluation of gene-redundancy. PloS one. 2008 Oct; 3(10):e3337. doi: 10.1371/journal.pone.0003337. [PMID: 18836531]
  • Asaph B Cousins, Itsara Pracharoenwattana, Wenxu Zhou, Steven M Smith, Murray R Badger. Peroxisomal malate dehydrogenase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release. Plant physiology. 2008 Oct; 148(2):786-95. doi: 10.1104/pp.108.122622. [PMID: 18685043]
  • Stefan Timm, Adriano Nunes-Nesi, Tiit Pärnik, Katja Morgenthal, Stefanie Wienkoop, Olav Keerberg, Wolfram Weckwerth, Leszek A Kleczkowski, Alisdair R Fernie, Hermann Bauwe. A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis. The Plant cell. 2008 Oct; 20(10):2848-59. doi: 10.1105/tpc.108.062265. [PMID: 18952776]
  • Oliver Bartsch, Martin Hagemann, Hermann Bauwe. Only plant-type (GLYK) glycerate kinases produce d-glycerate 3-phosphate. FEBS letters. 2008 Sep; 582(20):3025-8. doi: 10.1016/j.febslet.2008.07.038. [PMID: 18675808]
  • Ki-Hong Jung, Jinwon Lee, Chris Dardick, Young-Su Seo, Peijian Cao, Patrick Canlas, Jirapa Phetsom, Xia Xu, Shu Ouyang, Kyungsook An, Yun-Ja Cho, Geun-Cheol Lee, Yoosook Lee, Gynheung An, Pamela C Ronald. Identification and functional analysis of light-responsive unique genes and gene family members in rice. PLoS genetics. 2008 Aug; 4(8):e1000164. doi: 10.1371/journal.pgen.1000164. [PMID: 18725934]
  • Shigeru Sato, Masanori Arita, Tomoyoshi Soga, Takaaki Nishioka, Masaru Tomita. Time-resolved metabolomics reveals metabolic modulation in rice foliage. BMC systems biology. 2008 Jun; 2(?):51. doi: 10.1186/1752-0509-2-51. [PMID: 18564421]
  • Corrado Vitale, Emanuele Croppi, Martino Marangella. Biochemical evaluation in renal stone disease. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases. 2008 May; 5(2):127-30. doi: . [PMID: 22460994]
  • Jan Lisec, Rhonda C Meyer, Matthias Steinfath, Henning Redestig, Martina Becher, Hanna Witucka-Wall, Oliver Fiehn, Ottó Törjék, Joachim Selbig, Thomas Altmann, Lothar Willmitzer. Identification of metabolic and biomass QTL in Arabidopsis thaliana in a parallel analysis of RIL and IL populations. The Plant journal : for cell and molecular biology. 2008 Mar; 53(6):960-72. doi: 10.1111/j.1365-313x.2007.03383.x. [PMID: 18047556]
  • Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Serge Rezzi, Ziad Ramadan, Emma Peré-Trepat, Florence Rochat, Christine Cherbut, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. Molecular systems biology. 2008; 4(?):205. doi: 10.1038/msb.2008.40. [PMID: 18628745]
  • Delkin O Gonzalez, Lila O Vodkin. Specific elements of the glyoxylate pathway play a significant role in the functional transition of the soybean cotyledon during seedling development. BMC genomics. 2007 Dec; 8(?):468. doi: 10.1186/1471-2164-8-468. [PMID: 18093333]
  • Undurti N Das, Allam A Rao. Gene expression profile in obesity and type 2 diabetes mellitus. Lipids in health and disease. 2007 Dec; 6(?):35. doi: 10.1186/1476-511x-6-35. [PMID: 18078524]
  • Sushila Bhattarai, Van H Tran, Colin C Duke. Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids. Journal of pharmaceutical and biomedical analysis. 2007 Nov; 45(4):648-53. doi: 10.1016/j.jpba.2007.07.006. [PMID: 17706909]
  • Miyako Kusano, Atsushi Fukushima, Masanori Arita, Pär Jonsson, Thomas Moritz, Makoto Kobayashi, Naomi Hayashi, Takayuki Tohge, Kazuki Saito. Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana. BMC systems biology. 2007 Nov; 1(?):53. doi: 10.1186/1752-0509-1-53. [PMID: 18028551]
  • M E Poulsen, H B Christensen, M T Sørensen, H Leffers, J H Andersen. Determination of chlormequat in pig serum and sow milk by LC-MS/MS. Analytical and bioanalytical chemistry. 2007 Nov; 389(6):1799-804. doi: 10.1007/s00216-007-1457-y. [PMID: 17849106]
  • Muhammad Sarwar Khan. Engineering photorespiration in chloroplasts: a novel strategy for increasing biomass production. Trends in biotechnology. 2007 Oct; 25(10):437-40. doi: 10.1016/j.tibtech.2007.08.007. [PMID: 17870196]
  • Shunichi Takahashi, Hermann Bauwe, Murray Badger. Impairment of the photorespiratory pathway accelerates photoinhibition of photosystem II by suppression of repair but not acceleration of damage processes in Arabidopsis. Plant physiology. 2007 May; 144(1):487-94. doi: 10.1104/pp.107.097253. [PMID: 17400706]
  • Yuliya V Inyushkina, Victor P Bulgakov, Marina V Veselova, Valery M Bryukhanov, Yakov F Zverev, Vyacheslav V Lampatov, Olga V Azarova, Galina K Tchernoded, Sergey A Fedoreyev, Yury N Zhuravlev. High rabdosiin and rosmarinic acid production in Eritrichium sericeum callus cultures and the effect of the calli on masugi-nephritis in rats. Bioscience, biotechnology, and biochemistry. 2007 May; 71(5):1286-93. doi: 10.1271/bbb.60684. [PMID: 17485828]
  • Juane Dong, Xihan Ma. [Determination of geniposidic acid and chlorogenic acid in male flowers and related products of Eucommia ulmoides by reversed-phase high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2007 Mar; 25(2):217-20. doi: . [PMID: 17580690]
  • George B Lenon, Charlie C L Xue, David F Story, Frank C K Thien, Sarah McPhee, Chun G Li. Inhibition of release of inflammatory mediators in primary and cultured cells by a Chinese herbal medicine formula for allergic rhinitis. Chinese medicine. 2007 Feb; 2(?):2. doi: 10.1186/1749-8546-2-2. [PMID: 17302969]
  • Sigrun Reumann, Andreas P M Weber. Plant peroxisomes respire in the light: some gaps of the photorespiratory C2 cycle have become filled--others remain. Biochimica et biophysica acta. 2006 Dec; 1763(12):1496-510. doi: 10.1016/j.bbamcr.2006.09.008. [PMID: 17046077]