Glycerate (BioDeep_00000001330)

 

Secondary id: BioDeep_00001868334

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(2R)-2,3-dihydroxypropanoic acid

化学式: C3H6O4 (106.0266076)
中文名称: DL-甘油酸, 甘油酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.39%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Glycerate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/glycerate (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000001330). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(=O)O)O)O
InChI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)

描述信息

Glyceric acid is a colourless syrupy acid, obtained from oxidation of glycerol. It is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria, an inborn error of metabolism, and D-glycerate anemia. Deficiency of human glycerate kinase leads to D-glycerate acidemia/D-glyceric aciduria. Symptoms of the disease include progressive neurological impairment, hypotonia, seizures, failure to thrive, and metabolic acidosis. At sufficiently high levels, glyceric acid can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Glyceric acid is an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of untreated glyceric aciduria. Many affected children with organic acidemias experience intellectual disability or delayed development. In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures. Elevated values may also be due to microbial sources such as yeast (Aspergillus, Penicillium, probably Candida) or due to dietary sources containing glycerol (glycerine). Glyceric acid is isolated from various plants (e.g. brassicas, pulses, and Vicia faba).
A colorless syrupy acid, obtained from oxidation of glycerol. It is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria and D-glycerate anemia. Deficiency of human glycerate kinase leads to D-glycerate acidemia/D-glyceric aciduria. Symptoms of the disease include progressive neurological impairment, hypotonia, seizures, failure to thrive and metabolic acidosis.; Glyceric acid is a natural three-carbon sugar acid. Salts and esters of glyceric acid are known as glycerates. Glyceric acid is found in many foods, some of which are peanut, common grape, garden tomato (variety), and french plantain.

Glyceric acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=473-81-4 (retrieved 2024-06-29) (CAS RN: 473-81-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

23 个代谢物同义名

DL-Glyceric Acid calcium Salt hydrate; D-(+)-Glyceric acid hemicalcium salt; (2R)-2,3-Dihydroxypropanoic acid; alpha,beta-Hydroxypropionic acid; (R)-2,3-Dihydroxypropanoic acid; D-2,3-Dihydroxypropanoic acid; 2,3-dihydroxy-propanoic acid; alpha,beta-Hydroxypropionate; a,b-Hydroxypropionic acid; a,b-Hydroxypropionate; DL-Glyceric acid sol; D-(+)-Glyceric acid; (R)-Glyceric acid; DL-GLYCERIC ACID; D-Glyceric acid; R-Glyceric acid; (R)-Glycerate; GLYCERIC ACID; R-Glycerate; D-Glycerate; Glycerate; D-GroA; Glyceric acid



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

296 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(4)

WikiPathways(0)

Plant Reactome(234)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

52 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

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  • Jörn Oliver Sass, Sidney Behringer, Malkanthi Fernando, Elisabetta Cesaroni, Ida Cursio, Alberto Volpini, Claudia Till. d-Glycerate kinase deficiency in a neuropediatric patient. Brain & development. 2020 Feb; 42(2):226-230. doi: 10.1016/j.braindev.2019.11.008. [PMID: 31837836]
  • Selçuk Aslan, Elad Noor, Sara Benito Vaquerizo, Steffen N Lindner, Arren Bar-Even. Design and engineering of E. coli metabolic sensor strains with a wide sensitivity range for glycerate. Metabolic engineering. 2020 01; 57(?):96-109. doi: 10.1016/j.ymben.2019.09.002. [PMID: 31491545]
  • Yoav Zehavi, Hanna Mandel, Ayelet Eran, Sarit Ravid, Muhammad Abu Rashid, Erwin E W Jansen, Mirjam M C Wamelink, Ann Saada, Avraham Shaag, Orly Elpeleg, Ronen Spiegel. Severe infantile epileptic encephalopathy associated with D-glyceric aciduria: report of a novel case and review. Metabolic brain disease. 2019 04; 34(2):557-563. doi: 10.1007/s11011-019-0384-x. [PMID: 30637540]
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