Sphinganine (BioDeep_00000001327)

 

Secondary id: BioDeep_00000171824, BioDeep_00000405234, BioDeep_00000406215, BioDeep_00000841079

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs Antitumor activity BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


D-Erythro-1,3-dihydroxy-2-aminooctadecane

化学式: C18H39NO2 (301.2980634)
中文名称: D-赤型二氢鞘氨醇, D,L-赤型-二氢鞘氨醇, 二氢神经鞘氨醇, DL-苏式-二氢鞘氨醇, DL-二氢鞘氨醇, 鞘氨醇
谱图信息: 最多检出来源 Homo sapiens(blood) 0.53%

Reviewed

Last reviewed on 2024-07-02.

Cite this Page

Sphinganine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/sphinganine (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000001327). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(C(CO)N)O
InChI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3

描述信息

Sphinganine, also known as c18-dihydrosphingosine or safingol, is a member of the class of compounds known as 1,2-aminoalcohols. 1,2-aminoalcohols are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Thus, sphinganine is considered to be a sphingoid base lipid molecule. Sphinganine is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Sphinganine can be found in a number of food items such as agar, biscuit, herbs and spices, and pasta, which makes sphinganine a potential biomarker for the consumption of these food products. Sphinganine can be found primarily in blood, feces, and urine, as well as throughout most human tissues. Sphinganine exists in all eukaryotes, ranging from yeast to humans. In humans, sphinganine is involved in few metabolic pathways, which include globoid cell leukodystrophy, metachromatic leukodystrophy (MLD), and sphingolipid metabolism. Sphinganine is also involved in few metabolic disorders, which include fabry disease, gaucher disease, and krabbe disease. Moreover, sphinganine is found to be associated with pregnancy. Sphinganine is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis. The administration of safingol alone has not been shown to exert a significant effect on tumor cell growth. However, preclinical and clinical studies have shown that combining safingol with conventional chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phase I clinical trials, it is believed to be safe to co-administer with cisplatin .
Sphinganine belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Thus, sphinganine is considered to be a sphingoid base lipid molecule. Sphinganine is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Sphinganine exists in all living species, ranging from bacteria to humans. Within humans, sphinganine participates in a number of enzymatic reactions. In particular, sphinganine can be converted into 3-dehydrosphinganine through its interaction with the enzyme 3-ketodihydrosphingosine reductase. In addition, sphinganine can be converted into sphinganine 1-phosphate; which is catalyzed by the enzyme sphingosine kinase 2. Outside of the human body, sphinganine has been detected, but not quantified in, several different foods, such as Mexican oregano, jostaberries, winter squash, angelica, and epazotes. This could make sphinganine a potential biomarker for the consumption of these foods. Sphinganine blocks postlysosomal cholesterol transport by inhibiting low-density lipoprotein-induced esterification of cholesterol and causing unesterified cholesterol to accumulate in perinuclear vesicles. It has been suggested that endogenous sphinganine may inhibit cholesterol transport in Niemann-Pick Type C (NPC) disease (PMID: 1817037).
D004791 - Enzyme Inhibitors
KEIO_ID D078
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

同义名列表

32 个代谢物同义名

D-Erythro-1,3-dihydroxy-2-aminooctadecane; (R-(R*,s*))-2-aminooctadecane-1,3-diol; [R-(R*,s*)]-2-amino-1,3-octadecanediol; D-erythro-2-Amino-1,3-octadecanediol; 2-Amino-D-erythro-1,3-octadecanediol; DL-1,3-DIHYDROXY-2-AMINO-OCTADECANE; (2S,3R)-2-Amino-1,3-octadecanediol; (2S,3R)-2-Aminooctadecane-1,3-diol; D-Erythro-C18-dihydrosphingosine; 2-Amino-1,3-dihydroxyoctadecane; DL-erythro-Dihydrosphingosine; D-Erythro-dihydrosphingosine; DL-THREO-DIHYDROSPHINGOSINE; 2-Aminooctadecane-1,3-diol; Threo-dihydrosphingosine; C18-Dihydro-sphingosine; Dihydro-C18-sphingosine; C18-Dihydrosphingosine; Erythro-D-sphinganine; D-erythro-Sphinganine; Erythro-sphinganine; Octadecasphinganine; (2S,3R)-Sphinganine; Dihydrosphingosine; C18-Sphinganine; Sphinganine; SP(D18:0); Safingol; D18:0; Sphinganine; Sphinganine (d18:0); Sphinganine



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(1)

PlantCyc(0)

代谢反应

272 个相关的代谢反应过程信息。

Reactome(15)

BioCyc(3)

WikiPathways(8)

Plant Reactome(219)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(27)

  • Biosynthesis of Unsaturated Fatty Acids: Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Biosynthesis of Unsaturated Fatty Acids (Tetracosanoyl-CoA): Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Biosynthesis of Unsaturated Fatty Acids (Docosanoyl-CoA): Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Biosynthesis of Unsaturated Fatty Acids (Icosanoyl-CoA): Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Biosynthesis of Unsaturated Fatty Acids (Stearoyl-CoA): Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Sphingolipid Metabolism: L-Serine + Palmityl-CoA ⟶ 3-Dehydrosphinganine + Carbon dioxide
  • Sphingolipid Metabolism: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Gaucher Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Globoid Cell Leukodystrophy: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Metachromatic Leukodystrophy (MLD): Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Fabry Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Krabbe Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Gaucher Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Globoid Cell Leukodystrophy: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Metachromatic Leukodystrophy (MLD): Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Fabry Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Krabbe Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Gaucher Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Globoid Cell Leukodystrophy: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Metachromatic Leukodystrophy (MLD): Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Fabry Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Krabbe Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sicong Ma, Roger Sandhoff, Xiu Luo, Fuwei Shang, Qiaozhen Shi, Zhaolong Li, Jingxia Wu, Yanan Ming, Frank Schwarz, Alaa Madi, Nina Weisshaar, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Xin Yan, Kerstin Mohr, Nora Ten Bosch, Zhe Li, Gernot Poschet, Hans-Reimer Rodewald, Nina Papavasiliou, Xi Wang, Pu Gao, Guoliang Cui. Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos. Science immunology. 2024 Apr; 9(94):eadg8817. doi: 10.1126/sciimmunol.adg8817. [PMID: 38640251]
  • Scotland Farley, Frank Stein, Per Haberkant, Fikadu G Tafesse, Carsten Schultz. Trifunctional Sphinganine: A New Tool to Dissect Sphingolipid Function. ACS chemical biology. 2024 Jan; ?(?):. doi: 10.1021/acschembio.3c00554. [PMID: 38284972]
  • Yongxian Bi, Jinjun Liu, Hao Li, Jinyue Sun, Wenyu Ding, Congfen He, Yan Jia. Lipidomics-based analysis of lipid differences between dry skin of women aged 22-28 years and 29-35 years. Journal of cosmetic dermatology. 2024 Jan; ?(?):. doi: 10.1111/jocd.16137. [PMID: 38214419]
  • Mohamed Ibrahim Madkour, Md Torikul Islam, Trevor S Tippetts, Kamrul H Chowdhury, Lisa A Lesniewski, Scott A Summers, Falak Zeb, Dana N Abdelrahim, Refat AlKurd, Husam M Khraiwesh, Katia H AbuShihab, Asma AlBakri, Khaled Obaideen, MoezAlIslam E Faris. Ramadan intermittent fasting is associated with ameliorated inflammatory markers and improved plasma sphingolipids/ceramides in subjects with obesity: lipidomics analysis. Scientific reports. 2023 Oct; 13(1):17322. doi: 10.1038/s41598-023-43862-9. [PMID: 37833312]
  • Eija Ahonen, Annelie Damerau, Kaisa M Linderborg. Antioxidative Effect of Dihydrosphingosine (d18:0) and α-Tocopherol on Tridocosahexaenoin (DHA-TAG). Journal of agricultural and food chemistry. 2023 Oct; 71(40):14769-14781. doi: 10.1021/acs.jafc.3c02668. [PMID: 37751317]
  • Haixia Wang, Yueqi Zhang, Jingrui Wang, Yun Chen, Tingjun Hou, Youfu Zhao, Zhonghua Ma. The sphinganine C4-hydroxylase FgSur2 regulates sensitivity to azole antifungal agents and virulence of Fusarium graminearum. Microbiological research. 2023 Mar; 271(?):127347. doi: 10.1016/j.micres.2023.127347. [PMID: 36907072]
  • Yudai Iino, Tatsuro Naganuma, Makoto Arita. Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1. Journal of lipid research. 2023 Feb; 64(2):100329. doi: 10.1016/j.jlr.2023.100329. [PMID: 36639058]
  • Aissa Miriam Röhrig, Katja Jakobi, Julia Dietz, Dominique Thomas, Eva Herrmann, Christoph Welsch, Christoph Sarrazin, Josef Pfeilschifter, Stefan Zeuzem, Georgios Grammatikos. The role of serum sphingolipids as potential biomarkers of non-response to direct acting antiviral therapy in chronic hepatitis C virus infection. Journal of viral hepatitis. 2023 Feb; 30(2):138-147. doi: 10.1111/jvh.13776. [PMID: 36463431]
  • Keqi Zeng, Xin Zhou, Wanyi Liu, Cong Nie, Yingfeng Zhang. Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC‒MS/MS. Lipids in health and disease. 2023 Jan; 22(1):13. doi: 10.1186/s12944-022-01762-3. [PMID: 36698123]
  • Fragoso-Vázquez Manuel Jonathan, Duclosel Darling, Rosales-Hernández Martha Cecilia, Estrada-Pérez Alan, Mendoza-Figueroa Humberto Lubriel, Olivares-Corichi Ivonne, Mendieta-Wejebe Jessica Elena, Reyes-López Cesar Augusto, Velasco-Quijano Jessica Sayuri, Gil-Ruiz Luis Angel, Correa-Basurto José. UHPLC-MS/MS Studies and Antiproliferative Effects in Breast Cancer Cells of Mexican Sargassum. Anti-cancer agents in medicinal chemistry. 2023; 23(1):76-86. doi: 10.2174/1871520622666220412125740. [PMID: 35418289]
  • Dev K Ranjit, Zachary D Moye, Fernanda G Rocha, Gregory Ottenberg, Frank C Nichols, Hey-Min Kim, Alejandro R Walker, Frank C Gibson, Mary E Davey. Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P. Microbiology spectrum. 2022 04; 10(2):e0000222. doi: 10.1128/spectrum.00002-22. [PMID: 35286133]
  • Einat B Vitner, Roy Avraham, Boaz Politi, Sharon Melamed, Tomer Israely. Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology. Life science alliance. 2022 01; 5(1):. doi: 10.26508/lsa.202101168. [PMID: 34764206]
  • Andrej Kováčik, Petra Pullmannová, Lukáš Opálka, Michaela Šilarová, Jaroslav Maixner, Kateřina Vávrová. Effects of (R)- and (S)-α-Hydroxylation of Acyl Chains in Sphingosine, Dihydrosphingosine, and Phytosphingosine Ceramides on Phase Behavior and Permeability of Skin Lipid Models. International journal of molecular sciences. 2021 Jul; 22(14):. doi: 10.3390/ijms22147468. [PMID: 34299088]
  • Li Wang, Xiaodong Suo, Yujie Liu, Chen Liu, Ming Luo. Sphingosine Promotes Embryo Biomass in Upland Cotton: A Biochemical and Transcriptomic Analysis. Biomolecules. 2021 04; 11(4):. doi: 10.3390/biom11040525. [PMID: 33915924]
  • Kevin Eade, Sarah Giles, Sarah Harkins-Perry, Martin Friedlander. Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery. Journal of visualized experiments : JoVE. 2021 03; ?(169):. doi: 10.3791/62269. [PMID: 33749682]
  • David R Adams, Susan Pyne, Nigel J Pyne. Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases. Cellular signalling. 2020 12; 76(?):109806. doi: 10.1016/j.cellsig.2020.109806. [PMID: 33035646]
  • Zhong-Xing Rao, Mike D Tokach, Jason C Woodworth, Joel M DeRouchey, Robert D Goodband, Hilda I Calderón, Steve S Dritz. Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs. Toxins. 2020 09; 12(9):. doi: 10.3390/toxins12090604. [PMID: 32961935]
  • Vincent Mignard, Nolwenn Dubois, Didier Lanoé, Marie-Pierre Joalland, Lisa Oliver, Claire Pecqueur, Dominique Heymann, François Paris, François M Vallette, Lisenn Lalier. Sphingolipid distribution at mitochondria-associated membranes (MAMs) upon induction of apoptosis. Journal of lipid research. 2020 07; 61(7):1025-1037. doi: 10.1194/jlr.ra120000628. [PMID: 32350079]
  • Ruzica Jurakic Toncic, Ivone Jakasa, Suzana Ljubojevic Hadzavdic, Susan Mi Goorden, Karen Jm Ghauharali-van der Vlugt, Femke S Stet, Anamaria Balic, Mikela Petkovic, Borna Pavicic, Kristina Zuzul, Branka Marinovic, Sanja Kezic. Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu. International journal of molecular sciences. 2020 Mar; 21(6):. doi: 10.3390/ijms21061958. [PMID: 32183011]
  • Ilaria Del Gaudio, Linda Sasset, Annarita Di Lorenzo, Christian Wadsack. Sphingolipid Signature of Human Feto-Placental Vasculature in Preeclampsia. International journal of molecular sciences. 2020 Feb; 21(3):. doi: 10.3390/ijms21031019. [PMID: 32033121]
  • Norihiro Isogai, Yuta Shiono, Tetsuya Kuramoto, Kenji Yoshioka, Hiroko Ishihama, Haruki Funao, Masaya Nakamura, Morio Matsumoto, Ken Ishii. Potential osteomyelitis biomarkers identified by plasma metabolome analysis in mice. Scientific reports. 2020 01; 10(1):839. doi: 10.1038/s41598-020-57619-1. [PMID: 31964942]
  • Vadim Dolgin, Rachel Straussberg, Ruijuan Xu, Izolda Mileva, Yuval Yogev, Raed Khoury, Osnat Konen, Yael Barhum, Alex Zvulunov, Cungui Mao, Ohad S Birk. DEGS1 variant causes neurological disorder. European journal of human genetics : EJHG. 2019 11; 27(11):1668-1676. doi: 10.1038/s41431-019-0444-z. [PMID: 31186544]
  • Marin L Gantner, Kevin Eade, Martina Wallace, Michal K Handzlik, Regis Fallon, Jennifer Trombley, Roberto Bonelli, Sarah Giles, Sarah Harkins-Perry, Tjebo F C Heeren, Lydia Sauer, Yoichiro Ideguchi, Michelle Baldini, Lea Scheppke, Michael I Dorrell, Maki Kitano, Barbara J Hart, Carolyn Cai, Takayuki Nagasaki, Mehmet G Badur, Mali Okada, Sasha M Woods, Catherine Egan, Mark Gillies, Robyn Guymer, Florian Eichler, Melanie Bahlo, Marcus Fruttiger, Rando Allikmets, Paul S Bernstein, Christian M Metallo, Martin Friedlander. Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy. The New England journal of medicine. 2019 10; 381(15):1422-1433. doi: 10.1056/nejmoa1815111. [PMID: 31509666]
  • Rachel S Kelly, Bo L Chawes, Feng Guo, Li Zhang, Kevin Blighe, Augusto A Litonjua, Benjamin A Raby, Bruce D Levy, Daniela Rago, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Xiaobo Zhou, Jessica A Lasky-Su, Scott T Weiss. The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D. The European respiratory journal. 2019 10; 54(4):. doi: 10.1183/13993003.00761-2019. [PMID: 31439681]
  • Graham Brogden, Diab M Husein, Pablo Steinberg, Hassan Y Naim. Isolation and Quantification of Sphingosine and Sphinganine from Rat Serum Revealed Gender Differences. Biomolecules. 2019 09; 9(9):. doi: 10.3390/biom9090459. [PMID: 31500283]
  • Walter Boiten, Richard Helder, Jeroen van Smeden, Joke Bouwstra. Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019 09; 1864(9):1206-1213. doi: 10.1016/j.bbalip.2019.05.003. [PMID: 31112754]
  • Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W Denning, Olaf Kniemeyer, Axel A Brakhage, David S Perlin. Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus. mBio. 2019 06; 10(3):. doi: 10.1128/mbio.00779-19. [PMID: 31164462]
  • Ruth Nabwire Wangia, David Peter Githanga, Kathy Siyu Xue, Lili Tang, Omu Aggrey Anzala, Jia-Sheng Wang. Validation of urinary sphingolipid metabolites as biomarker of effect for fumonisins exposure in Kenyan children. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2019 Jun; 24(4):379-388. doi: 10.1080/1354750x.2019.1587510. [PMID: 30821509]
  • Hwang Eui Cho, Barry J Maurer, C Patrick Reynolds, Min H Kang. Hydrophilic interaction liquid chromatography-tandem mass spectrometric approach for simultaneous determination of safingol and D-erythro-sphinganine in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Apr; 1112(?):16-23. doi: 10.1016/j.jchromb.2019.02.023. [PMID: 30836314]
  • Anders P E Backman, Josefin Halin, Matti A Kjellberg, Peter Mattjus. Indirect Lipid Transfer Protein Activity Measurements Using Quantification of Glycosphingolipid Production. Methods in molecular biology (Clifton, N.J.). 2019; 1949(?):105-114. doi: 10.1007/978-1-4939-9136-5_9. [PMID: 30790252]
  • Anna Małgorzata Chabowska, Barbara Boczkowska Radziwon, Bartlomiej Lukaszuk, Alina Lipska, Adrian Chabowski, Dorota Kaczerska, Piotr Siermontowski, Piotr Radziwon. Fatty acids and sphingolipids profile in the blood plasma of experienced divers in response to hyperbaric exposure. Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. 2018 Sep; 45(?):521-529. doi: . [PMID: 30428241]
  • Arvin B Tam, Lindsay S Roberts, Vivek Chandra, Io Guane Rivera, Daniel K Nomura, Douglass J Forbes, Maho Niwa. The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms. Developmental cell. 2018 08; 46(3):327-343.e7. doi: 10.1016/j.devcel.2018.04.023. [PMID: 30086303]
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