Sphinganine (BioDeep_00000001327)

 

Secondary id: BioDeep_00000171824, BioDeep_00000405234, BioDeep_00000406215, BioDeep_00000841079

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs Antitumor activity BioNovoGene_Lab2019


代谢物信息卡片


D-Erythro-1,3-dihydroxy-2-aminooctadecane

化学式: C18H39NO2 (301.2981)
中文名称: D-赤型二氢鞘氨醇, D,L-赤型-二氢鞘氨醇, 二氢神经鞘氨醇, DL-苏式-二氢鞘氨醇, DL-二氢鞘氨醇, 鞘氨醇
谱图信息: 最多检出来源 Homo sapiens(blood) 15.23%

Reviewed

Last reviewed on 2024-07-02.

Cite this Page

Sphinganine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/sphinganine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001327). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(C(CO)N)O
InChI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3

描述信息

Sphinganine, also known as c18-dihydrosphingosine or safingol, is a member of the class of compounds known as 1,2-aminoalcohols. 1,2-aminoalcohols are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Thus, sphinganine is considered to be a sphingoid base lipid molecule. Sphinganine is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Sphinganine can be found in a number of food items such as agar, biscuit, herbs and spices, and pasta, which makes sphinganine a potential biomarker for the consumption of these food products. Sphinganine can be found primarily in blood, feces, and urine, as well as throughout most human tissues. Sphinganine exists in all eukaryotes, ranging from yeast to humans. In humans, sphinganine is involved in few metabolic pathways, which include globoid cell leukodystrophy, metachromatic leukodystrophy (MLD), and sphingolipid metabolism. Sphinganine is also involved in few metabolic disorders, which include fabry disease, gaucher disease, and krabbe disease. Moreover, sphinganine is found to be associated with pregnancy. Sphinganine is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis. The administration of safingol alone has not been shown to exert a significant effect on tumor cell growth. However, preclinical and clinical studies have shown that combining safingol with conventional chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phase I clinical trials, it is believed to be safe to co-administer with cisplatin .
Sphinganine belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Thus, sphinganine is considered to be a sphingoid base lipid molecule. Sphinganine is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Sphinganine exists in all living species, ranging from bacteria to humans. Within humans, sphinganine participates in a number of enzymatic reactions. In particular, sphinganine can be converted into 3-dehydrosphinganine through its interaction with the enzyme 3-ketodihydrosphingosine reductase. In addition, sphinganine can be converted into sphinganine 1-phosphate; which is catalyzed by the enzyme sphingosine kinase 2. Outside of the human body, sphinganine has been detected, but not quantified in, several different foods, such as Mexican oregano, jostaberries, winter squash, angelica, and epazotes. This could make sphinganine a potential biomarker for the consumption of these foods. Sphinganine blocks postlysosomal cholesterol transport by inhibiting low-density lipoprotein-induced esterification of cholesterol and causing unesterified cholesterol to accumulate in perinuclear vesicles. It has been suggested that endogenous sphinganine may inhibit cholesterol transport in Niemann-Pick Type C (NPC) disease (PMID: 1817037).
D004791 - Enzyme Inhibitors
KEIO_ID D078
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

同义名列表

32 个代谢物同义名

D-Erythro-1,3-dihydroxy-2-aminooctadecane; (R-(R*,s*))-2-aminooctadecane-1,3-diol; [R-(R*,s*)]-2-amino-1,3-octadecanediol; D-erythro-2-Amino-1,3-octadecanediol; 2-Amino-D-erythro-1,3-octadecanediol; DL-1,3-DIHYDROXY-2-AMINO-OCTADECANE; (2S,3R)-2-Amino-1,3-octadecanediol; (2S,3R)-2-Aminooctadecane-1,3-diol; D-Erythro-C18-dihydrosphingosine; 2-Amino-1,3-dihydroxyoctadecane; DL-erythro-Dihydrosphingosine; D-Erythro-dihydrosphingosine; DL-THREO-DIHYDROSPHINGOSINE; 2-Aminooctadecane-1,3-diol; Threo-dihydrosphingosine; C18-Dihydro-sphingosine; Dihydro-C18-sphingosine; C18-Dihydrosphingosine; Erythro-D-sphinganine; D-erythro-Sphinganine; Erythro-sphinganine; Octadecasphinganine; (2S,3R)-Sphinganine; Dihydrosphingosine; C18-Sphinganine; Sphinganine; SP(D18:0); Safingol; D18:0; Sphinganine; Sphinganine (d18:0); Sphinganine



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(1)

PlantCyc(0)

代谢反应

272 个相关的代谢反应过程信息。

Reactome(15)

BioCyc(3)

WikiPathways(8)

Plant Reactome(219)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(27)

  • Biosynthesis of Unsaturated Fatty Acids: Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Biosynthesis of Unsaturated Fatty Acids (Tetracosanoyl-CoA): Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Biosynthesis of Unsaturated Fatty Acids (Docosanoyl-CoA): Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Biosynthesis of Unsaturated Fatty Acids (Icosanoyl-CoA): Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Biosynthesis of Unsaturated Fatty Acids (Stearoyl-CoA): Adenosine triphosphate + Coenzyme A + Palmitic acid ⟶ Adenosine monophosphate + Palmityl-CoA + Pyrophosphate
  • Sphingolipid Metabolism: L-Serine + Palmityl-CoA ⟶ 3-Dehydrosphinganine + Carbon dioxide
  • Sphingolipid Metabolism: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Gaucher Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Globoid Cell Leukodystrophy: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Metachromatic Leukodystrophy (MLD): Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Fabry Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Krabbe Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Gaucher Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Globoid Cell Leukodystrophy: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Metachromatic Leukodystrophy (MLD): Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Fabry Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Krabbe Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Gaucher Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Globoid Cell Leukodystrophy: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Metachromatic Leukodystrophy (MLD): Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Fabry Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Krabbe Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, CASP3, CD1D, SPHK1, SPHK2, TFPT
Peripheral membrane protein 2 CLTB, SPHK1
Endosome membrane 2 CD1D, SPHK1
Endoplasmic reticulum membrane 6 CD1D, CERS2, HSP90B1, SPTLC1, SPTLC2, SPTSSA
Nucleus 8 AKT1, ALB, CASP3, CERS2, HSP90B1, SPHK1, SPHK2, TFPT
cytosol 9 AKT1, ALB, CASP3, CLTB, GPT, HSP90B1, PRKCQ, SPHK1, SPHK2
trans-Golgi network 1 CLTB
centrosome 1 ALB
nucleoplasm 5 AKT1, CASP3, SPHK1, SPHK2, TFPT
Cell membrane 4 AKT1, CD1D, SMPD2, SPHK1
Cytoplasmic side 1 CLTB
lamellipodium 1 AKT1
Early endosome membrane 1 SPHK1
Multi-pass membrane protein 4 CERS2, SMPD2, SPTSSA, UGCG
Golgi apparatus membrane 1 UGCG
Synapse 1 SPHK1
cell cortex 1 AKT1
cell surface 1 CD1D
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 1 ALB
Golgi membrane 2 INS, UGCG
lysosomal membrane 2 CD1D, SPHK2
mitochondrial inner membrane 1 SPHK2
neuronal cell body 1 CASP3
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 2 CD1D, SMPD1
Presynapse 1 SPHK1
endosome 2 CD1D, SMPD1
plasma membrane 7 AKT1, CD1D, CLTB, PRKCQ, SMPD1, SMPD2, SPHK1
synaptic vesicle membrane 1 CLTB
Membrane 9 AKT1, CERS2, HSP90B1, SMPD1, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG
basolateral plasma membrane 1 CD1D
caveola 1 SMPD2
extracellular exosome 4 ALB, GPT, HSP90B1, SMPD1
Lysosome membrane 1 CD1D
endoplasmic reticulum 8 ALB, CD1D, CERS2, HSP90B1, SMPD2, SPHK2, SPTLC1, SPTSSA
extracellular space 5 ALB, CD1D, IL6, INS, SMPD1
lysosomal lumen 1 SMPD1
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 1 SPHK2
protein-containing complex 3 AKT1, ALB, HSP90B1
intracellular membrane-bounded organelle 3 CLTB, SPHK1, SPHK2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 CD1D
Secreted 4 ALB, IL6, INS, SMPD1
extracellular region 5 ALB, HSP90B1, IL6, INS, SMPD1
Single-pass membrane protein 2 SPTLC1, SPTLC2
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
ciliary membrane 1 CLTB
external side of plasma membrane 1 CD1D
microtubule cytoskeleton 1 AKT1
midbody 1 HSP90B1
Membrane, clathrin-coated pit 1 SPHK1
cell-cell junction 1 AKT1
clathrin-coated pit 1 SPHK1
vesicle 1 AKT1
Mitochondrion inner membrane 1 SPHK2
focal adhesion 1 HSP90B1
spindle 1 AKT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
ciliary basal body 2 AKT1, ALB
cell periphery 1 SMPD2
centriole 1 ALB
spindle pole 1 ALB
actin filament 1 TFPT
blood microparticle 1 ALB
Basolateral cell membrane 1 CD1D
endosome lumen 1 INS
Lipid droplet 1 SMPD1
Cytoplasmic vesicle membrane 1 CLTB
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, HSP90B1, IL6, INS
platelet alpha granule lumen 1 ALB
endocytic vesicle 1 SPHK1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle 1 CLTB
Sarcoplasmic reticulum lumen 1 HSP90B1
serine palmitoyltransferase complex 3 SPTLC1, SPTLC2, SPTSSA
death-inducing signaling complex 1 CASP3
nucleosome 1 SPHK2
clathrin coat of coated pit 1 CLTB
Membrane, coated pit 1 CLTB
[Isoform 2]: Lysosome membrane 1 SPHK2
clathrin vesicle coat 1 CLTB
clathrin coat of trans-Golgi network vesicle 1 CLTB
Ino80 complex 1 TFPT
endocytic vesicle lumen 1 HSP90B1
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
lamellar body 1 SMPD1
clathrin coat 1 CLTB
postsynaptic endocytic zone cytoplasmic component 1 CLTB
presynaptic endocytic zone membrane 1 CLTB
[Sphingomyelin phosphodiesterase, processed form]: Secreted, extracellular space 1 SMPD1
endolysosome 1 SMPD1
ciliary transition fiber 1 ALB


文献列表

  • Sicong Ma, Roger Sandhoff, Xiu Luo, Fuwei Shang, Qiaozhen Shi, Zhaolong Li, Jingxia Wu, Yanan Ming, Frank Schwarz, Alaa Madi, Nina Weisshaar, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Xin Yan, Kerstin Mohr, Nora Ten Bosch, Zhe Li, Gernot Poschet, Hans-Reimer Rodewald, Nina Papavasiliou, Xi Wang, Pu Gao, Guoliang Cui. Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos. Science immunology. 2024 Apr; 9(94):eadg8817. doi: 10.1126/sciimmunol.adg8817. [PMID: 38640251]
  • Scotland Farley, Frank Stein, Per Haberkant, Fikadu G Tafesse, Carsten Schultz. Trifunctional Sphinganine: A New Tool to Dissect Sphingolipid Function. ACS chemical biology. 2024 Jan; ?(?):. doi: 10.1021/acschembio.3c00554. [PMID: 38284972]
  • Yongxian Bi, Jinjun Liu, Hao Li, Jinyue Sun, Wenyu Ding, Congfen He, Yan Jia. Lipidomics-based analysis of lipid differences between dry skin of women aged 22-28 years and 29-35 years. Journal of cosmetic dermatology. 2024 Jan; ?(?):. doi: 10.1111/jocd.16137. [PMID: 38214419]
  • Mohamed Ibrahim Madkour, Md Torikul Islam, Trevor S Tippetts, Kamrul H Chowdhury, Lisa A Lesniewski, Scott A Summers, Falak Zeb, Dana N Abdelrahim, Refat AlKurd, Husam M Khraiwesh, Katia H AbuShihab, Asma AlBakri, Khaled Obaideen, MoezAlIslam E Faris. Ramadan intermittent fasting is associated with ameliorated inflammatory markers and improved plasma sphingolipids/ceramides in subjects with obesity: lipidomics analysis. Scientific reports. 2023 Oct; 13(1):17322. doi: 10.1038/s41598-023-43862-9. [PMID: 37833312]
  • Eija Ahonen, Annelie Damerau, Kaisa M Linderborg. Antioxidative Effect of Dihydrosphingosine (d18:0) and α-Tocopherol on Tridocosahexaenoin (DHA-TAG). Journal of agricultural and food chemistry. 2023 Oct; 71(40):14769-14781. doi: 10.1021/acs.jafc.3c02668. [PMID: 37751317]
  • Haixia Wang, Yueqi Zhang, Jingrui Wang, Yun Chen, Tingjun Hou, Youfu Zhao, Zhonghua Ma. The sphinganine C4-hydroxylase FgSur2 regulates sensitivity to azole antifungal agents and virulence of Fusarium graminearum. Microbiological research. 2023 Mar; 271(?):127347. doi: 10.1016/j.micres.2023.127347. [PMID: 36907072]
  • Yudai Iino, Tatsuro Naganuma, Makoto Arita. Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1. Journal of lipid research. 2023 Feb; 64(2):100329. doi: 10.1016/j.jlr.2023.100329. [PMID: 36639058]
  • Aissa Miriam Röhrig, Katja Jakobi, Julia Dietz, Dominique Thomas, Eva Herrmann, Christoph Welsch, Christoph Sarrazin, Josef Pfeilschifter, Stefan Zeuzem, Georgios Grammatikos. The role of serum sphingolipids as potential biomarkers of non-response to direct acting antiviral therapy in chronic hepatitis C virus infection. Journal of viral hepatitis. 2023 Feb; 30(2):138-147. doi: 10.1111/jvh.13776. [PMID: 36463431]
  • Keqi Zeng, Xin Zhou, Wanyi Liu, Cong Nie, Yingfeng Zhang. Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC‒MS/MS. Lipids in health and disease. 2023 Jan; 22(1):13. doi: 10.1186/s12944-022-01762-3. [PMID: 36698123]
  • Fragoso-Vázquez Manuel Jonathan, Duclosel Darling, Rosales-Hernández Martha Cecilia, Estrada-Pérez Alan, Mendoza-Figueroa Humberto Lubriel, Olivares-Corichi Ivonne, Mendieta-Wejebe Jessica Elena, Reyes-López Cesar Augusto, Velasco-Quijano Jessica Sayuri, Gil-Ruiz Luis Angel, Correa-Basurto José. UHPLC-MS/MS Studies and Antiproliferative Effects in Breast Cancer Cells of Mexican Sargassum. Anti-cancer agents in medicinal chemistry. 2023; 23(1):76-86. doi: 10.2174/1871520622666220412125740. [PMID: 35418289]
  • Dev K Ranjit, Zachary D Moye, Fernanda G Rocha, Gregory Ottenberg, Frank C Nichols, Hey-Min Kim, Alejandro R Walker, Frank C Gibson, Mary E Davey. Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P. Microbiology spectrum. 2022 04; 10(2):e0000222. doi: 10.1128/spectrum.00002-22. [PMID: 35286133]
  • Einat B Vitner, Roy Avraham, Boaz Politi, Sharon Melamed, Tomer Israely. Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology. Life science alliance. 2022 01; 5(1):. doi: 10.26508/lsa.202101168. [PMID: 34764206]
  • Andrej Kováčik, Petra Pullmannová, Lukáš Opálka, Michaela Šilarová, Jaroslav Maixner, Kateřina Vávrová. Effects of (R)- and (S)-α-Hydroxylation of Acyl Chains in Sphingosine, Dihydrosphingosine, and Phytosphingosine Ceramides on Phase Behavior and Permeability of Skin Lipid Models. International journal of molecular sciences. 2021 Jul; 22(14):. doi: 10.3390/ijms22147468. [PMID: 34299088]
  • Li Wang, Xiaodong Suo, Yujie Liu, Chen Liu, Ming Luo. Sphingosine Promotes Embryo Biomass in Upland Cotton: A Biochemical and Transcriptomic Analysis. Biomolecules. 2021 04; 11(4):. doi: 10.3390/biom11040525. [PMID: 33915924]
  • Kevin Eade, Sarah Giles, Sarah Harkins-Perry, Martin Friedlander. Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery. Journal of visualized experiments : JoVE. 2021 03; ?(169):. doi: 10.3791/62269. [PMID: 33749682]
  • David R Adams, Susan Pyne, Nigel J Pyne. Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases. Cellular signalling. 2020 12; 76(?):109806. doi: 10.1016/j.cellsig.2020.109806. [PMID: 33035646]
  • Zhong-Xing Rao, Mike D Tokach, Jason C Woodworth, Joel M DeRouchey, Robert D Goodband, Hilda I Calderón, Steve S Dritz. Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs. Toxins. 2020 09; 12(9):. doi: 10.3390/toxins12090604. [PMID: 32961935]
  • Vincent Mignard, Nolwenn Dubois, Didier Lanoé, Marie-Pierre Joalland, Lisa Oliver, Claire Pecqueur, Dominique Heymann, François Paris, François M Vallette, Lisenn Lalier. Sphingolipid distribution at mitochondria-associated membranes (MAMs) upon induction of apoptosis. Journal of lipid research. 2020 07; 61(7):1025-1037. doi: 10.1194/jlr.ra120000628. [PMID: 32350079]
  • Ruzica Jurakic Toncic, Ivone Jakasa, Suzana Ljubojevic Hadzavdic, Susan Mi Goorden, Karen Jm Ghauharali-van der Vlugt, Femke S Stet, Anamaria Balic, Mikela Petkovic, Borna Pavicic, Kristina Zuzul, Branka Marinovic, Sanja Kezic. Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu. International journal of molecular sciences. 2020 Mar; 21(6):. doi: 10.3390/ijms21061958. [PMID: 32183011]
  • Ilaria Del Gaudio, Linda Sasset, Annarita Di Lorenzo, Christian Wadsack. Sphingolipid Signature of Human Feto-Placental Vasculature in Preeclampsia. International journal of molecular sciences. 2020 Feb; 21(3):. doi: 10.3390/ijms21031019. [PMID: 32033121]
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