Sphinganine (BioDeep_00000405234)

Main id: BioDeep_00000001327

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


D-erythro-2-Amino-1,3-octadecanediol

化学式: C18H39NO2 (301.2981)
中文名称: D,L-赤型-二氢鞘氨醇, 鞘氨醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(C(CO)N)O
InChI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1

描述信息

A 2-aminooctadecane-1,3-diol having (2S,3R)-configuration.
D004791 - Enzyme Inhibitors
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
DL-erythro-Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2)[1][2].

同义名列表

10 个代谢物同义名

DL-erythro-Dihydrosphingosine; Sphinganine; D-erythro-2-Amino-1,3-octadecanediol; D-erythro-Sphinganine; Octadecasphinganine; Dihydrosphingosine; SPB 18:0;O2; Sphinganine (d18:0); D-Erythro-dihydrosphingosine; Sphinganine



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, CASP3, CD1D, SPHK1, SPHK2, TFPT
Peripheral membrane protein 2 CLTB, SPHK1
Endosome membrane 2 CD1D, SPHK1
Endoplasmic reticulum membrane 6 CD1D, CERS2, HSP90B1, SPTLC1, SPTLC2, SPTSSA
Nucleus 8 AKT1, ALB, CASP3, CERS2, HSP90B1, SPHK1, SPHK2, TFPT
cytosol 9 AKT1, ALB, CASP3, CLTB, GPT, HSP90B1, PRKCQ, SPHK1, SPHK2
trans-Golgi network 1 CLTB
centrosome 1 ALB
nucleoplasm 5 AKT1, CASP3, SPHK1, SPHK2, TFPT
Cell membrane 4 AKT1, CD1D, SMPD2, SPHK1
Cytoplasmic side 1 CLTB
lamellipodium 1 AKT1
Early endosome membrane 1 SPHK1
Multi-pass membrane protein 4 CERS2, SMPD2, SPTSSA, UGCG
Golgi apparatus membrane 1 UGCG
Synapse 1 SPHK1
cell cortex 1 AKT1
cell surface 1 CD1D
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 1 ALB
Golgi membrane 2 INS, UGCG
lysosomal membrane 2 CD1D, SPHK2
mitochondrial inner membrane 1 SPHK2
neuronal cell body 1 CASP3
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 2 CD1D, SMPD1
Presynapse 1 SPHK1
endosome 2 CD1D, SMPD1
plasma membrane 7 AKT1, CD1D, CLTB, PRKCQ, SMPD1, SMPD2, SPHK1
synaptic vesicle membrane 1 CLTB
Membrane 9 AKT1, CERS2, HSP90B1, SMPD1, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG
basolateral plasma membrane 1 CD1D
caveola 1 SMPD2
extracellular exosome 4 ALB, GPT, HSP90B1, SMPD1
Lysosome membrane 1 CD1D
endoplasmic reticulum 8 ALB, CD1D, CERS2, HSP90B1, SMPD2, SPHK2, SPTLC1, SPTSSA
extracellular space 5 ALB, CD1D, IL6, INS, SMPD1
lysosomal lumen 1 SMPD1
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 1 SPHK2
protein-containing complex 3 AKT1, ALB, HSP90B1
intracellular membrane-bounded organelle 3 CLTB, SPHK1, SPHK2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 CD1D
Secreted 4 ALB, IL6, INS, SMPD1
extracellular region 5 ALB, HSP90B1, IL6, INS, SMPD1
Single-pass membrane protein 2 SPTLC1, SPTLC2
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
ciliary membrane 1 CLTB
external side of plasma membrane 1 CD1D
microtubule cytoskeleton 1 AKT1
midbody 1 HSP90B1
Membrane, clathrin-coated pit 1 SPHK1
cell-cell junction 1 AKT1
clathrin-coated pit 1 SPHK1
vesicle 1 AKT1
Mitochondrion inner membrane 1 SPHK2
focal adhesion 1 HSP90B1
spindle 1 AKT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
ciliary basal body 2 AKT1, ALB
cell periphery 1 SMPD2
centriole 1 ALB
spindle pole 1 ALB
actin filament 1 TFPT
blood microparticle 1 ALB
Basolateral cell membrane 1 CD1D
endosome lumen 1 INS
Lipid droplet 1 SMPD1
Cytoplasmic vesicle membrane 1 CLTB
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, HSP90B1, IL6, INS
platelet alpha granule lumen 1 ALB
endocytic vesicle 1 SPHK1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle 1 CLTB
Sarcoplasmic reticulum lumen 1 HSP90B1
serine palmitoyltransferase complex 3 SPTLC1, SPTLC2, SPTSSA
death-inducing signaling complex 1 CASP3
nucleosome 1 SPHK2
clathrin coat of coated pit 1 CLTB
Membrane, coated pit 1 CLTB
[Isoform 2]: Lysosome membrane 1 SPHK2
clathrin vesicle coat 1 CLTB
clathrin coat of trans-Golgi network vesicle 1 CLTB
Ino80 complex 1 TFPT
endocytic vesicle lumen 1 HSP90B1
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
lamellar body 1 SMPD1
clathrin coat 1 CLTB
postsynaptic endocytic zone cytoplasmic component 1 CLTB
presynaptic endocytic zone membrane 1 CLTB
[Sphingomyelin phosphodiesterase, processed form]: Secreted, extracellular space 1 SMPD1
endolysosome 1 SMPD1
ciliary transition fiber 1 ALB


文献列表

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  • Hwang Eui Cho, Barry J Maurer, C Patrick Reynolds, Min H Kang. Hydrophilic interaction liquid chromatography-tandem mass spectrometric approach for simultaneous determination of safingol and D-erythro-sphinganine in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Apr; 1112(?):16-23. doi: 10.1016/j.jchromb.2019.02.023. [PMID: 30836314]
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