N-Acetylhistamine (BioDeep_00000001295)

 

Secondary id: BioDeep_00000406237

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


N-(2-(1H-Imidazol-4-yl)ethyl)acetamide (acd/name 4.0)

化学式: C7H11N3O (153.0902)
中文名称: N-乙酰组胺, N-ω-乙酰基组胺
谱图信息: 最多检出来源 Homo sapiens(feces) 28.43%

分子结构信息

SMILES: CC(=O)NCCC1=CN=CN1
InChI: InChI=1S/C7H11N3O/c1-6(11)9-3-2-7-4-8-5-10-7/h4-5H,2-3H2,1H3,(H,8,10)(H,9,11)

描述信息

N-Acetylhistamine is a 4-(beta-Acetylaminoethyl)imidazole that is an intermediate in Histidine metabolism. It is generated from Histamine via the enzyme Transferases (EC 2.3.1.-). Histamine is an amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Isolated from leaves of Spinacia oleracea (spinach). N-Acetylhistamine is found in green vegetables and spinach.
KEIO_ID A093
N-Acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.
N-Acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.

同义名列表

33 个代谢物同义名

N-(2-(1H-Imidazol-4-yl)ethyl)acetamide (acd/name 4.0); Acetamide, N-(2-(1H-imidazol-4-yl)ethyl)- (9ci); Acetamide, {n-[2-(1H-imidazol-4-yl)ethyl]-}; Acetamide, N-(2-imidazol-4-ylethyl)- (8ci); N-[2-(1H-Imidazol-4-yl)ethyl]-acetamide; N-[2-(1H-imidazol-5-yl)ethyl]acetamide; N-(2-(1H-Imidazol-4-yl)ethyl)acetamide; N-[2-(3H-Imidazol-4-yl)ethyl]acetamide; N-[2-(1H-IMIDAZOL-4-yl)ethyl]acetamide; N-(2-(Imidazol-4-yl)ethyl)acetamide; N-(2-Imidazol-4-ylethyl)-acetamide; 4-(beta-Acetylaminoethyl)imidazole; 4-(2-Acetylaminoethyl)imidazole; 4-(b-Acetylaminoethyl)imidazole; 4-(Β-acetylaminoethyl)imidazole; 4-(2-Acetamidoethyl)imidazole; Imidazole C-4(5) deriv. 1; N-.Omega.-acetylhistamine; N-Omega-acetyl-histamine; Omega-N-acetylhistamine; N-Omega-acetylhistamine; alpha-N-Acetylhistamine; Nalpha-acetylhistamine; Nomega-acetylhistamine; N-ω-Acetylhistamine; a-N-Acetylhistamine; Α-N-acetylhistamine; Nw-Acetylhistamine; N-acetylhistamine; N-Acetylhistamine; Acetylhistamine; AHN; N-Acetylhistamine



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AANAT, HDC, HNMT, MYD88, PIK3CA, TLR2
Endosome membrane 1 MYD88
Nucleus 3 HDC, MYD88, PCNA
cytosol 5 AANAT, HDC, HNMT, MYD88, PIK3CA
nuclear body 1 PCNA
centrosome 2 HNMT, PCNA
nucleoplasm 2 HNMT, PCNA
Cell membrane 3 CNTN3, PTPRC, TNF
lamellipodium 1 PIK3CA
Synapse 2 ACAN, PTPRC
cell surface 5 EPO, MYD88, PTPRC, TLR2, TNF
glutamatergic synapse 2 ACAN, CPNE4
Golgi apparatus 1 TLR2
Golgi membrane 1 INS
neuronal cell body 1 TNF
plasma membrane 7 CNTN3, CPNE4, MYD88, PIK3CA, PTPRC, TLR2, TNF
Membrane 3 HDC, PTPRC, TLR2
extracellular exosome 6 CPNE4, CXCL12, EPO, HNMT, PCNA, PTPRC
extracellular space 9 ACAN, CSF3, EPO, IL10, IL2, IL3, IL7, INS, TNF
lysosomal lumen 2 ACAN, CSF3
perinuclear region of cytoplasm 2 AANAT, PIK3CA
intercalated disc 1 PIK3CA
protein-containing complex 1 MYD88
Single-pass type I membrane protein 2 PTPRC, TLR2
Secreted 7 CSF3, EPO, IL10, IL2, IL3, IL7, INS
extracellular region 11 ACAN, CNTN3, CSF3, CXCL12, EPO, IL10, IL2, IL3, IL7, INS, TNF
cytoplasmic side of plasma membrane 1 PTPRC
external side of plasma membrane 3 CXCL12, PTPRC, TNF
Secreted, extracellular space, extracellular matrix 1 ACAN
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 3 PTPRC, TLR2, TNF
focal adhesion 1 PTPRC
GABA-ergic synapse 1 ACAN
basement membrane 1 ACAN
collagen-containing extracellular matrix 3 ACAN, CXCL12, IL7
receptor complex 1 TLR2
chromatin 1 PCNA
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 TLR2
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Lipid-anchor, GPI-anchor 1 CNTN3
endosome lumen 1 INS
cell body 2 EPO, TLR2
side of membrane 1 CNTN3
replication fork 1 PCNA
secretory granule lumen 2 EPO, INS
secretory granule membrane 2 PTPRC, TLR2
Golgi lumen 2 ACAN, INS
endoplasmic reticulum lumen 1 INS
male germ cell nucleus 1 PCNA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
perineuronal net 1 ACAN
nuclear lamina 1 PCNA
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
extrinsic component of plasma membrane 1 MYD88
membrane microdomain 1 PTPRC
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
bleb 1 PTPRC
endocytic vesicle lumen 1 CSF3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
perisynaptic extracellular matrix 1 ACAN
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Daniele Sanna, Linda Bíró, Péter Buglyó, Giovanni Micera, Eugenio Garribba. Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum. Journal of inorganic biochemistry. 2012 Oct; 115(?):87-99. doi: 10.1016/j.jinorgbio.2012.04.020. [PMID: 22926028]
  • Moses O Akiibinu, Omobola A Ogundahunsi, Ebenezer O Ogunyemi. Inter-relationship of plasma markers of oxidative stress and thyroid hormones in schizophrenics. BMC research notes. 2012 Mar; 5(?):169. doi: 10.1186/1756-0500-5-169. [PMID: 22463715]
  • H M ADAM, D C HARDWICK, K E SPENCER. A method of estimating histamine in plasma. British journal of pharmacology and chemotherapy. 1957 Dec; 12(4):397-405. doi: 10.1111/j.1476-5381.1957.tb00155.x. [PMID: 13489164]