5-Aminolevulinic acid (BioDeep_00000001259)

 

Secondary id: BioDeep_00000400275

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


Bertek brand OF aminolevulinic acid hydrochloride

化学式: C5H9NO3 (131.0582)
中文名称: 5-氨基酮戊酸, 5-氨基乙酰丙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 31.52%

分子结构信息

SMILES: C(CC(=O)O)C(=O)CN
InChI: InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)

描述信息

5-Aminolevulinic acid, also known as 5-aminolevulinate or 5-amino-4-oxopentanoate, belongs to the class of organic compounds known as delta amino acids and derivatives. Delta amino acids and derivatives are compounds containing a carboxylic acid group and an amino group at the C5 carbon atom. 5-Aminolevulinic acid is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. 5-Aminolevulinic acid exists in all living species, ranging from bacteria to humans. 5-aminolevulinic acid can be biosynthesized from glycine and succinyl-CoA by the enzyme 5-aminolevulinate synthase. The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. In humans, 5-aminolevulinic acid is involved in the metabolic disorder called the dimethylglycine dehydrogenase deficiency pathway. Outside of the human body, 5-Aminolevulinic acid has been detected, but not quantified in several different foods, such as american butterfish, vaccinium (blueberry, cranberry, huckleberry), amaranths, purple mangosteens, and garden cress. Used (in the form of the hydrochloride salt) in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin.
An intermediate in heme synthesis. This is the first compound in the porphyrin synthesis pathway. It is produced by the enzyme ALA synthase, from glycine and succinyl CoA. This reaction is known as the Shemin pathway. Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp. [HMDB]. 5-Aminolevulinic acid is found in many foods, some of which are fireweed, chia, sesbania flower, and taro.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XD - Sensitizers used in photodynamic/radiation therapy
Acquisition and generation of the data is financially supported in part by CREST/JST.
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
C1420 - Photosensitizing Agent
D003879 - Dermatologic Agents
KEIO_ID A052

同义名列表

40 个代谢物同义名

Bertek brand OF aminolevulinic acid hydrochloride; delta-Aminolevulinic acid hydrochloride; Hydrochloride, aminolevulinic acid; Acid hydrochloride, aminolevulinic; Aminolevulinic acid hydrochloride; 5-Amino-4-oxo-pentanoic acid; 5-Amino-4-oxopentanoic acid; Acid, Delta-aminolevulinic; Delta Aminolevulinic acid; 5-Amino-4-oxovaleric acid; delta-Aminolevulinic acid; 5(d)-Aminolevulinic Acid; 5-Amino-4-oxo-pentanoate; 5-Amino-4-oxopentanoate; 5-amino-levulinic acid; 5-Aminolaevulinic acid; 5-Aminolevulinic acid; Δ-aminolevulinic acid; 5-Amino-4-oxovalerate; delta-Aminolevulinate; Amino-levulinic acid; Acid, aminolevulinic; Aminolevulinic Acid; 5-Aminolaevulinate; 5 Aminolaevulinate; 5-Amino-levulinate; 5 Aminolevulinate; Δ-aminolevulinate; 5-Aminolevulinate; Aminolevulinate; delta-ALA; Kerastick; Aladerm; Levulan; 5-ALA; Δ-ala; DALA; 5-Aminolevulinic acid; 5-Aminolevulinic acid; 5-Aminolevulinate



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

62 个相关的代谢反应过程信息。

Reactome(10)

BioCyc(3)

WikiPathways(2)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(45)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKT1, BCL2, BFSP1, CASP9, CPOX, EGFR, HMBS, NFE2L2, TP53
Peripheral membrane protein 5 ALAS1, ALAS2, BFSP1, HSD17B6, PPOX
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 BCL2, CYP1A2, EGFR
Nucleus 6 AKT1, BCL2, CASP9, EGFR, NFE2L2, TP53
cytosol 9 AKT1, ALAS1, BCL2, CASP9, CPOX, HMBS, NFE2L2, TP53, UROD
mitochondrial membrane 1 PPOX
centrosome 2 NFE2L2, TP53
nucleoplasm 5 AKT1, ALAS1, NFE2L2, TP53, UROD
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 AKT1, BFSP1, CD8A, EGFR
Cytoplasmic side 1 BFSP1
lamellipodium 1 AKT1
ruffle membrane 1 EGFR
Early endosome membrane 2 EGFR, HSD17B6
Synapse 1 PPOX
cell cortex 2 AKT1, BFSP1
cell junction 1 EGFR
cell surface 2 EGFR, EPO
glutamatergic synapse 2 AKT1, EGFR
Golgi apparatus 1 NFE2L2
Golgi membrane 2 EGFR, INS
mitochondrial inner membrane 4 ALAS1, ALAS2, FECH, PPOX
postsynapse 2 AKT1, PPOX
synaptic vesicle 1 PPOX
Cytoplasm, cytosol 1 NFE2L2
endosome 1 EGFR
plasma membrane 5 AKT1, BFSP1, CD8A, EGFR, NFE2L2
Membrane 5 AKT1, BCL2, CPOX, EGFR, TP53
apical plasma membrane 1 EGFR
axon 1 CCK
basolateral plasma membrane 1 EGFR
extracellular exosome 1 EPO
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 BCL2, HSD17B6, TP53
extracellular space 4 CCK, EGFR, EPO, INS
perinuclear region of cytoplasm 2 EGFR, PPOX
mitochondrion 8 ALAS1, ALAS2, BCL2, CASP9, CPOX, FECH, PPOX, TP53
protein-containing complex 5 AKT1, BCL2, CASP9, EGFR, TP53
intracellular membrane-bounded organelle 2 CYP1A2, HSD17B6
Microsome membrane 2 CYP1A2, HSD17B6
Single-pass type I membrane protein 2 CD8A, EGFR
Secreted 3 CCK, EPO, INS
extracellular region 5 CCK, CD8A, EPO, INS, PPOX
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 TP53
mitochondrial matrix 4 ALAS1, ALAS2, FECH, TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 CD8A
neuronal dense core vesicle lumen 1 PPOX
cytoplasmic vesicle 1 PPOX
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
cell-cell junction 1 AKT1
vesicle 1 AKT1
Mitochondrion inner membrane 4 ALAS1, ALAS2, FECH, PPOX
Membrane raft 1 EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 BFSP1, TP53
focal adhesion 1 EGFR
spindle 1 AKT1
intracellular vesicle 1 EGFR
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 3 AKT1, CPOX, PPOX
intermediate filament 1 BFSP1
receptor complex 2 CD8A, EGFR
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, TP53
mediator complex 1 NFE2L2
Cytoplasm, cell cortex 1 BFSP1
site of double-strand break 1 TP53
endosome lumen 1 INS
cell body 1 EPO
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
plasma membrane raft 1 CD8A
secretory granule lumen 2 EPO, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 NFE2L2
[Isoform 1]: Cell membrane 1 CD8A
Rough endoplasmic reticulum 1 PPOX
Intermembrane side 1 PPOX
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
T cell receptor complex 1 CD8A
BAD-BCL-2 complex 1 BCL2
[Isoform 4]: Mitochondrion inner membrane 1 ALAS2
caspase complex 1 CASP9


文献列表

  • Peiyu Xu, Jing Liu, Ying Yi, Zhi Cai, Yihua Yin, Weiquan Cai, Jingli Zhang, Zhixia Gong, Yaqi Xiao. A dew-responsive pectin-based herbicide for enhanced photodynamic inactivation. Carbohydrate polymers. 2024 Jul; 336(?):122114. doi: 10.1016/j.carbpol.2024.122114. [PMID: 38670775]
  • Lu Chen, Yong Zhao, Qiandai Shi, Yu Du, Qiaohui Zeng, Haiquan Liu, Zhaohuan Zhang, Huaming Zheng, Jing Jing Wang. Preservation effects of photodynamic inactivation-mediated antibacterial film on storage quality of salmon fillets: Insights into protein quality. Food chemistry. 2024 Jun; 444(?):138685. doi: 10.1016/j.foodchem.2024.138685. [PMID: 38341917]
  • Qianyun Guo, Xiaoli Ji, Lei Zhang, Xingyun Liu, Yutian Wang, Zijian Liu, Jianqiu Jin, Ying Han, Hongwei Liu. Differences in the response of normal oral mucosa, oral leukoplakia, oral squamous cell carcinoma-derived mesenchymal stem cells, and epithelial cells to photodynamic therapy. Journal of photochemistry and photobiology. B, Biology. 2024 Jun; 255(?):112907. doi: 10.1016/j.jphotobiol.2024.112907. [PMID: 38677259]
  • Kai Chen, Yan-Yan Hu, Shan-Shan Qian, Jin-Zhao Wu, Li-Juan Cao, Lin-Lin Wang, Meng Li, Yu-Xin Xia, Qian Jiang, Hong-Ying Chen, Liu-Qing Chen, Dong-Sheng Li. A novel glycyrrhizic acid-based dressing effectively improved photodynamic therapy-caused skin barrier damage in port-wine stains. Journal of cosmetic dermatology. 2024 Jun; 23(6):2301-2303. doi: 10.1111/jocd.16250. [PMID: 38410871]
  • Isabela Santos Lopes, Jullio Kennedy Castro Soares, Lívia Soman de Medeiros, Lilia Coronato Courrol. Evaluation of ALA-capped silver, copper, and silver-copper nanoparticles for controlling fungal plant pathogens. Microbial pathogenesis. 2024 Jun; 191(?):106672. doi: 10.1016/j.micpath.2024.106672. [PMID: 38705219]
  • Zhengda Zhang, Jiao Dang, Luqiao Yuan, Yuhui Zhang, Fan Zhou, Tianlai Li, Xiaohui Hu. Exogenous 5-Aminolevulinic acid improved low-temperature tolerance tomato seedling by regulating starch content and phenylalanine metabolism. Plant physiology and biochemistry : PPB. 2024 May; 210(?):108083. doi: 10.1016/j.plaphy.2023.108083. [PMID: 38615441]
  • Xiaoli Chen, Min Li, Wen Li, Wenai Zheng, Weiwei Wu. Photodynamic therapy successfully treats refractory onychomycosis caused by Trichosporon asahii: a case report. Photodiagnosis and photodynamic therapy. 2024 Apr; 46(?):104045. doi: 10.1016/j.pdpdt.2024.104045. [PMID: 38479606]
  • Paulina Szczepanik-Kułak, Joanna Bartosińska, Dorota Kowalczuk, Agnieszka Gerkowicz, Iwona Bojar, Mirosław Kwaśny, Dorota Krasowska. Efficacy of photodynamic therapy using ALAHCl in gel with a lipid nanoemulsion and MALHCl in cream in superficial basal cell carcinoma. Annals of agricultural and environmental medicine : AAEM. 2024 Mar; 31(1):94-99. doi: 10.26444/aaem/183059. [PMID: 38549482]
  • Beata Čunderlíková, Kristína Klučková, Pavel Babál, Peter Mlkvý, Tibor Teplický. Modifications of DAMPs levels in extracellular environment induced by aminolevulinic acid-based photodynamic therapy of esophageal cancer cells. International journal of radiation biology. 2024 Feb; ?(?):1-15. doi: 10.1080/09553002.2024.2310002. [PMID: 38319688]
  • Fujun Huang, Qiang Fu, Lei Tang, Mingdan Zhao, Mengya Huang, Xun Zhou. Trends in photodynamic therapy for dermatology in recent 20 years: A scientometric review based on CiteSpace. Journal of cosmetic dermatology. 2024 Feb; 23(2):391-402. doi: 10.1111/jocd.16033. [PMID: 37815144]
  • Liuzi Zhang, Jiangting Zhang, Bo Wei, Yage Li, Xiang Fang, Yan Zhong, Liangju Wang. Transcription factor MdNAC33 is involved in ALA-induced anthocyanin accumulation in apples. Plant science : an international journal of experimental plant biology. 2024 Feb; 339(?):111949. doi: 10.1016/j.plantsci.2023.111949. [PMID: 38065304]
  • Juan Ji, Chu-Ting Liang, Jiao-Jiao Zhong, Xue Kong, Hao-Xiang Xu, Chang-Chun Xu, Mei-Hua Fu. 5-aminolevulinic acid-based photodynamic therapy in combination with antifungal agents for adult kerion and facial ulcer caused by Trichophyton rubrum. Photodiagnosis and photodynamic therapy. 2024 Feb; 45(?):103954. doi: 10.1016/j.pdpdt.2023.103954. [PMID: 38145772]
  • Weiming Zhang, Zhao Jin, Tingting Gao, Li Fan, Weizhen Wang, Xianyu Zeng, Li Qin. Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts. Photodiagnosis and photodynamic therapy. 2024 Feb; 45(?):103934. doi: 10.1016/j.pdpdt.2023.103934. [PMID: 38097120]
  • Josephine Herbst, Xiaoqing Pang, Lena Roling, Bernhard Grimm. The novel tetratricopeptide-repeat protein TTP1 forms complexes with GluTR and POR during tetrapyrrole biosynthesis. Journal of experimental botany. 2023 Dec; ?(?):. doi: 10.1093/jxb/erad491. [PMID: 38070484]
  • Hamid Mohammadi, Parviz Ezati, Saeid Hazrati, Mansour Ghorbanpour. Exogenously applied 5-aminolevulinic acid modulates growth, yield, and physiological parameters in lentil (Lens culinaris Medik.) under rain-fed and supplemental irrigation conditions. Scientific reports. 2023 12; 13(1):21312. doi: 10.1038/s41598-023-48732-y. [PMID: 38042953]
  • Huihui Liu, Qing Wang, Jingru Guo, Kai Feng, Yiling Ruan, Zhihao Zhang, Xin Ji, Jigang Wang, Tao Zhang, Xiaolian Sun. Prodrug-based strategy with a two-in-one liposome for Cerenkov-induced photodynamic therapy and chemotherapy. Journal of controlled release : official journal of the Controlled Release Society. 2023 12; 364(?):206-215. doi: 10.1016/j.jconrel.2023.10.036. [PMID: 37884209]
  • Weinan Zhang, Zhiqiang He, Yingyue Qin, Jie Gong, Wenjun Xie, Li Tong, Shulei Liu, Luoyingzi Xie. 5-aminolevulinic acid photodynamic therapy using 560-1200 nm followed by 420-1200 nm broadband light in the treatment of moderate-to-severe acne. Photodiagnosis and photodynamic therapy. 2023 Dec; 44(?):103902. doi: 10.1016/j.pdpdt.2023.103902. [PMID: 37984524]
  • Zhimin Duan, Jianbo Tong, Nana Zheng, Rong Zeng, Yuzhen Liu, Min Li. Effect of 5-Aminolevulinic Acid Photodynamic Therapy on Aspergillus fumigatus Biofilms in Vitro. Current microbiology. 2023 Sep; 80(10):334. doi: 10.1007/s00284-023-03351-8. [PMID: 37659001]
  • Xiaojie Liu, Jin Wang, Jipeng Yu, Weibin Xing, Junling Zhang. Experience analysis of a combined photodynamic/electrodesiccation therapy in the treatment of 11 cases of large patches of Bowen's disease. Photodiagnosis and photodynamic therapy. 2023 Sep; 43(?):103710. doi: 10.1016/j.pdpdt.2023.103710. [PMID: 37527695]
  • Xinru Xue, Minghui Xie, Li Zhu, Dong Wang, Zeping Xu, Le Liang, Jianwei Zhang, Linyu Xu, Peihan Zhou, Jianzhao Ran, Guofeng Yu, Yunsong Lai, Bo Sun, Yi Tang, Huanxiu Li. 5-ALA Improves the Low Temperature Tolerance of Common Bean Seedlings through a Combination of Hormone Transduction Pathways and Chlorophyll Metabolism. International journal of molecular sciences. 2023 Aug; 24(17):. doi: 10.3390/ijms241713189. [PMID: 37685996]
  • Oladayo A Oyebanji, Chad Brewer, Sharlo Bayless, Benjamin Schmeusser, Danielle A Corbin, Courtney E W Sulentic, Catherine M T Sherwin, Yanfang Chen, Christine M Rapp, Elizabeth E Cates, Yuhan Long, Jeffrey B Travers, Craig A Rohan. Topical Photodynamic Therapy Generates Bioactive Microvesicle Particles: Evidence for a Pathway Involved in Immunosuppressive Effects. The Journal of investigative dermatology. 2023 07; 143(7):1279-1288.e9. doi: 10.1016/j.jid.2022.12.018. [PMID: 36708950]
  • Zhen Kang, Yong Zhang, Xiongchun Cai, Zhengda Zhang, Zijian Xu, Xiangguang Meng, Xiaojing Li, Xiaohui Hu. Crosstalk between 5-Aminolevulinic Acid and Abscisic Acid Adjusted Leaf Iron Accumulation and Chlorophyll Synthesis to Enhance the Cold Tolerance in Solanum lycopersicum Seedlings. International journal of molecular sciences. 2023 Jun; 24(13):. doi: 10.3390/ijms241310781. [PMID: 37445959]
  • Daniel Wittmann, Peter Geigenberger, Bernhard Grimm. NTRC and TRX-f Coordinately Affect the Levels of Enzymes of Chlorophyll Biosynthesis in a Light-Dependent Manner. Cells. 2023 06; 12(12):. doi: 10.3390/cells12121670. [PMID: 37371140]
  • Shintaro Hamada, Yukari Mae, Tomoaki Takata, Hinako Hanada, Misaki Kubo, Sosuke Taniguchi, Takuji Iyama, Takaaki Sugihara, Hajime Isomoto. Five-Aminolevulinic Acid (5-ALA) Induces Heme Oxygenase-1 and Ameliorates Palmitic Acid-Induced Endoplasmic Reticulum Stress in Renal Tubules. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210151. [PMID: 37373300]
  • Jiheng Zhang, Lulu Liu, Xinying Li, Xiaoxiao Shen, Guihong Yang, Yumeng Deng, Zhengwei Hu, Junbo Zhang, Yuangang Lu. 5-ALA-PDT induced ferroptosis in keloid fibroblasts via ROS, accompanied by downregulation of xCT, GPX4. Photodiagnosis and photodynamic therapy. 2023 Jun; 42(?):103612. doi: 10.1016/j.pdpdt.2023.103612. [PMID: 37220842]
  • Peiru Wang, Fang Xie, Linglin Zhang, Shuang Zhao, Lude Zhu, Shuzhan Shen, Dongsheng Li, Zhou Chen, Rong Xiao, Yan Lu, Xia Lei, Yan Li, Guolong Zhang, Weihui Zeng, Xiuli Wang. Plum-blossom needle tapping enhances the efficacy of ALA photodynamic therapy for facial actinic keratosis in Chinese population: a randomized, multicenter, prospective, and observer-blind study. Photodiagnosis and photodynamic therapy. 2023 Jun; 42(?):103611. doi: 10.1016/j.pdpdt.2023.103611. [PMID: 37211296]
  • Xiaoqing Xiang, Yanliang Li, Yibo Tang, Runqun Liu, Tianming Ma, Xiguang Liu, Guozhang Ma. Efficacy of hematoporphyrin injection (HpD) photodynamic therapy in the treatment of widespread extramammary Paget's disease. Photodiagnosis and photodynamic therapy. 2023 Jun; 42(?):103649. doi: 10.1016/j.pdpdt.2023.103649. [PMID: 37302640]
  • Tingting Fan, Lena Roling, Boris Hedtke, Bernhard Grimm. FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway. The New phytologist. 2023 May; ?(?):. doi: 10.1111/nph.18952. [PMID: 37161708]
  • Cengiz Kaya, Muhammed Ashraf, Mohammed Nasser Alyemeni, Jörg Rinklebe, Parvaiz Ahmad. Alleviation of arsenic toxicity in pepper plants by aminolevulinic acid and heme through modulating its sequestration and distribution within cell organelles. Environmental pollution (Barking, Essex : 1987). 2023 May; ?(?):121747. doi: 10.1016/j.envpol.2023.121747. [PMID: 37146870]
  • Zishu Xu, Jianmin Pan, Najeeb Ullah, Yi Duan, Ruiyong Hao, Juanjuan Li, Qian Huang, Ling Xu. 5-Aminolevulinic acid mitigates the chromium-induced changes in Helianthus annuus L. as revealed by plant defense system enhancement. Plant physiology and biochemistry : PPB. 2023 May; 198(?):107701. doi: 10.1016/j.plaphy.2023.107701. [PMID: 37105019]
  • Huan Liu, Jingliang Sun, Jixiang Zou, Baisheng Li, Hua Jin. MeJA-mediated enhancement of salt-tolerance of Populus wutunensis by 5-aminolevulinic acid. BMC plant biology. 2023 Apr; 23(1):185. doi: 10.1186/s12870-023-04161-7. [PMID: 37024791]
  • Hang Zhao, Panxin Peng, Zhenkai Luo, Hailong Liu, Junwei Sun, Xuming Wang, Qiang Jia, Zhihao Yang. Comparison of hexaminolevulinate (HAL) -guided versus white light transurethral resection for NMIBC: A systematic review and meta-analysis of randomized controlled trials. Photodiagnosis and photodynamic therapy. 2023 Mar; 41(?):103220. doi: 10.1016/j.pdpdt.2022.103220. [PMID: 36462704]
  • Lu Chen, Qiandai Shi, Qingfeng Dong, Yu Du, Zhiyun Peng, Qiaohui Zeng, Zihao Lin, Jieer Qiu, Yong Zhao, Jing Jing Wang. Covalent Grafting of 5-Aminolevulinic Acid onto Polylactic Acid Films and Their Photodynamic Potency in Preserving Salmon. Journal of agricultural and food chemistry. 2023 Jan; 71(1):905-919. doi: 10.1021/acs.jafc.2c08340. [PMID: 36548110]
  • Guanghui Jin, Na Guo, Yasong Liu, Lele Zhang, Liang Chen, Tao Dong, Wei Liu, Xiaomei Zhang, Yong Jiang, Guo Lv, Fei Zhao, Wei Liu, Ziqing Hei, Yang Yang, Jingxing Ou. 5-aminolevulinate and CHIL3/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury. Theranostics. 2023; 13(14):4802-4820. doi: 10.7150/thno.83163. [PMID: 37771779]
  • Qianqian Li, Fei Zhang, Litao Zhang. Development of a 5-aminolevulinic acid feeding strategy capable of enhancing Haematococcus pluvialis biomass, astaxanthin, and fatty acid yields. Bioresource technology. 2023 Jan; 368(?):128319. doi: 10.1016/j.biortech.2022.128319. [PMID: 36375699]
  • Xiang Fang, Liuzi Zhang, Lingfei Shangguan, Liangju Wang. MdMYB110a, directly and indirectly, activates the structural genes for the ALA-induced accumulation of anthocyanin in apple. Plant science : an international journal of experimental plant biology. 2023 Jan; 326(?):111511. doi: 10.1016/j.plantsci.2022.111511. [PMID: 36377142]
  • NaiJia Bao, TianShu Gu, Jing Zeng, Yan Wu, Yan Sun, XingHua Gao, HongDuo Chen. Combined therapy of 5-aminolevulinic acid photodynamic therapy and intense pulsed light for rosacea. Lasers in medical science. 2022 Dec; 38(1):17. doi: 10.1007/s10103-022-03685-y. [PMID: 36562857]
  • Zheng Chen, Liangju Wang. ALA Upregulates MdPTPA Expression to Increase the PP2A Activity and Promote Stomatal Opening in Apple Leaves. Plant science : an international journal of experimental plant biology. 2022 Dec; 325(?):111490. doi: 10.1016/j.plantsci.2022.111490. [PMID: 36216297]
  • Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, Shouji Matsushima, Tomoko Koumura, Ken-Ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui. Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis. Science signaling. 2022 11; 15(758):eabn8017. doi: 10.1126/scisignal.abn8017. [PMID: 36318618]
  • Si Long, Bowen Liu, Jiongjiong Gong, Ruijia Wang, Shuanghong Gao, Tianqi Zhu, Huan Guo, Tieyuan Liu, Yuefei Xu. 5-Aminolevulinic acid promotes low-light tolerance by regulating chloroplast ultrastructure, photosynthesis, and antioxidant capacity in tall fescue. Plant physiology and biochemistry : PPB. 2022 Nov; 190(?):248-261. doi: 10.1016/j.plaphy.2022.09.010. [PMID: 36152510]
  • Neha Sinha, Jürgen Eirich, Iris Finkemeier, Bernhard Grimm. Glutamate 1-semialdehyde aminotransferase is connected to GluTR by GluTR-binding protein and contributes to the rate-limiting step of 5-aminolevulinic acid synthesis. The Plant cell. 2022 10; 34(11):4623-4640. doi: 10.1093/plcell/koac237. [PMID: 35972388]
  • Zhengda Zhang, Luqiao Yuan, Yongbo Ma, Zhen Kang, Fan Zhou, Yi Gao, Shichun Yang, Tianlai Li, Xiaohui Hu. Exogenous 5-aminolevulinic acid alleviates low-temperature damage by modulating the xanthophyll cycle and nutrient uptake in tomato seedlings. Plant physiology and biochemistry : PPB. 2022 Oct; 189(?):83-93. doi: 10.1016/j.plaphy.2022.08.013. [PMID: 36058015]
  • Lihua Qiu, Jingran Li, Fei Chen, Yifeng Wang, Yue Wang, Xinyu Wang, Qiubo Lv, Changzhong Li, Mingzhu Li, Qiuyun Yang, Dan Wu, Youzhong Zhang, Yuquan Zhang, Mengzhen Zhang, Yu Zhang, Mingrong Qie, Huaijun Zhou, Jiade Zhou, Weidong Zhao, Bairong Xia, Xuefang Liang, Yunlang Cai, Yincheng Teng, Zheng Huang, Long Sui, Lihui Wei, Wen Di. Chinese expert consensus on the clinical applications of aminolevulinic acid-based photodynamic therapy in female lower genital tract diseases (2022). Photodiagnosis and photodynamic therapy. 2022 Sep; 39(?):102993. doi: 10.1016/j.pdpdt.2022.102993. [PMID: 35781093]
  • Enyi Ye, Wei Wang, Yangfan Wu, Qingyun Yang, Tingkai Xiang, Beilei He, Zhangyu Bu. Cryotherapy combined with photodynamic therapy for successful treatment of condyloma acuminatum in special sites such as the nipple and the nasal vestibule: A series of two case reports. Photodiagnosis and photodynamic therapy. 2022 Sep; 39(?):102930. doi: 10.1016/j.pdpdt.2022.102930. [PMID: 35644347]
  • Shaila Mudambi, Megan Fitzgerald, Paula Pera, Deschana Washington, Sarah Chamberlain, Eszter Fidrus, Csaba Hegedűs, Eva Remenyik, Gal Shafirstein, David Bellnier, Gyorgy Paragh. KDM1A inhibition increases UVA toxicity and enhances photodynamic therapy efficacy. Photodermatology, photoimmunology & photomedicine. 2022 Aug; ?(?):. doi: 10.1111/phpp.12826. [PMID: 35968606]
  • Yuxian Yang, Xiang Fang, Mengxia Chen, Lingyu Wang, Jiaxin Xia, Zicheng Wang, Jinggui Fang, Lam-Son Phan Tran, Lingfei Shangguan. Copper stress in grapevine: Consequences, responses, and a novel mitigation strategy using 5-aminolevulinic acid. Environmental pollution (Barking, Essex : 1987). 2022 Aug; 307(?):119561. doi: 10.1016/j.envpol.2022.119561. [PMID: 35659552]
  • Meng Jiang, Shang Dai, Yun-Chao Zheng, Rui-Qing Li, Yuan-Yuan Tan, Gang Pan, Ian Max Møller, Shi-Yong Song, Jian-Zhong Huang, Qing-Yao Shu. An alanine to valine mutation of glutamyl-tRNA reductase enhances 5-aminolevulinic acid synthesis in rice. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2022 Aug; 135(8):2817-2831. doi: 10.1007/s00122-022-04151-7. [PMID: 35779128]
  • Yue Wu, Jing Li, Junwen Wang, Mohammed Mujitaba Dawuda, Weibiao Liao, Xin Meng, Hong Yuan, Jianming Xie, Zhongqi Tang, Jian Lyu, Jihua Yu. Heme is involved in the exogenous ALA-promoted growth and antioxidant defense system of cucumber seedlings under salt stress. BMC plant biology. 2022 Jul; 22(1):329. doi: 10.1186/s12870-022-03717-3. [PMID: 35804328]
  • Diego Vera-Yunca, Karol M Córdoba, Zinnia P Parra-Guillen, Daniel Jericó, Antonio Fontanellas, Iñaki F Trocóniz. Mechanistic modelling of enzyme-restoration effects of new recombinant liver-targeted proteins in acute intermittent porphyria. British journal of pharmacology. 2022 07; 179(14):3815-3830. doi: 10.1111/bph.15821. [PMID: 35170015]
  • Taylor A Bullock, Jeffrey Negrey, Bo Hu, Christine B Warren, Tayyaba Hasan, Edward V Maytin. Significant improvement of facial actinic keratoses after blue light photodynamic therapy with oral vitamin D pretreatment: An interventional cohort-controlled trial. Journal of the American Academy of Dermatology. 2022 07; 87(1):80-86. doi: 10.1016/j.jaad.2022.02.067. [PMID: 35314199]
  • Hideyuki Negoro, Christos Chatziantonio, Mohammed S Razzaque. Therapeutic potential of 5-aminolevulinic acid and sodium-ferrous citrate for viral insults: relevance to the COVID-19 crisis. Expert review of anti-infective therapy. 2022 05; 20(5):657-661. doi: 10.1080/14787210.2022.2020097. [PMID: 34927515]
  • Federico Brilli, Sara Pignattelli, Rita Baraldi, Luisa Neri, Susanna Pollastri, Cristina Gonnelli, Alessio Giovannelli, Francesco Loreto, Claudia Cocozza. Root Exposure to 5-Aminolevulinic Acid (ALA) Affects Leaf Element Accumulation, Isoprene Emission, Phytohormonal Balance, and Photosynthesis of Salt-Stressed Arundo donax. International journal of molecular sciences. 2022 Apr; 23(8):. doi: 10.3390/ijms23084311. [PMID: 35457125]
  • Ben Novak, Janet DuBois, Osama Chahrour, Tamara Papusha, Stefan Hirt, Thomas Philippi, Corinna Zogel, Katharina Osenberg, Beate Schmitz, Hermann Lübbert. Clinical Pharmacokinetics and Safety of a 10\% Aminolevulinic Acid Hydrochloride Nanoemulsion Gel (BF-200 ALA) in Photodynamic Therapy of Patients Extensively Affected With Actinic Keratosis: Results of 2 Maximal Usage Pharmacokinetic Trials. Clinical pharmacology in drug development. 2022 04; 11(4):535-550. doi: 10.1002/cpdd.1023. [PMID: 34633154]
  • Alex Gomez-Gomez, Paula Aguilera, Klaus Langohr, Gregori Casals, Cristina Pavon, Josep Marcos, Jordi To-Figueras, Oscar J Pozo. Evaluation of Metabolic Changes in Acute Intermittent Porphyria Patients by Targeted Metabolomics. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23063219. [PMID: 35328641]
  • Haiwen Zhang, Huihui Tao, Hao Yang, Liuzi Zhang, Guizhi Feng, Yuyan An, Liangju Wang. MdSCL8 as a Negative Regulator Participates in ALA-Induced FLS1 to Promote Flavonol Accumulation in Apples. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042033. [PMID: 35216148]
  • Parwiz Abrahimi, Timothy McClure. Emerging Intraoperative Imaging Technologies in Urologic Oncology. The Urologic clinics of North America. 2022 Feb; 49(1):57-63. doi: 10.1016/j.ucl.2021.08.002. [PMID: 34776054]
  • Keiji Inoue, Hideo Fukuhara, Shinkuro Yamamoto, Takashi Karashima, Atsushi Kurabayashi, Mutsuo Furihata, Kazuhiro Hanazaki, Hung Wei Lai, Shun-Ichiro Ogura. Current status of photodynamic technology for urothelial cancer. Cancer science. 2022 Feb; 113(2):392-398. doi: 10.1111/cas.15193. [PMID: 34750935]
  • Shuya Tan, Jie Cao, Xinli Xia, Zhonghai Li. Advances in 5-Aminolevulinic Acid Priming to Enhance Plant Tolerance to Abiotic Stress. International journal of molecular sciences. 2022 Jan; 23(2):. doi: 10.3390/ijms23020702. [PMID: 35054887]
  • Ruixue Chang, Congyun Xu, Yixun Liu, Jinli Liu, Wei Liu, Faxing Jiang, Siping Zhang. 5-aminolevulinic acid photodynamic therapy and holmium laser treatment for intraurethral condylomata acuminata in a renal transplant patient. Photodiagnosis and photodynamic therapy. 2021 Dec; 36(?):102496. doi: 10.1016/j.pdpdt.2021.102496. [PMID: 34428575]
  • Jiayi Yang, Lei Shi, Detian Xu, Jia Liu, Linglin Zhang, Xiaojing Liu, Qingyu Zeng, Xiuli Wang. 5-Aminolaevulinic acid photodynamic therapy suppresses lipid secretion of primary sebocytes through AMPK/SREBP-1 pathway. Photodiagnosis and photodynamic therapy. 2021 Dec; 36(?):102537. doi: 10.1016/j.pdpdt.2021.102537. [PMID: 34536608]
  • Takaaki Hashimoto, Takaaki Sugihara, Tsutomu Kanda, Tomoaki Takata, Hajime Isomoto. 5-Aminolevulinic Acid Attenuates Glucose-Regulated Protein 78 Expression and Hepatocyte Lipoapoptosis via Heme Oxygenase-1 Induction. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111405. [PMID: 34768836]
  • V Lopes de Andrade, D Serrazina, M L Mateus, C Batoréu, M Aschner, A P Marreilha Dos Santos. Multibiomarker approach to assess the magnitude of occupational exposure and effects induced by a mixture of metals. Toxicology and applied pharmacology. 2021 10; 429(?):115684. doi: 10.1016/j.taap.2021.115684. [PMID: 34437931]
  • Liyun Zeng, Qiongyan Zou, Peng Huang, Li Xiong, Yan Cheng, Qitong Chen, Yitong Li, Hongye He, Wenjun Yi, Wu Wei. Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):111994. doi: 10.1016/j.biopha.2021.111994. [PMID: 34411921]
  • Huiping Wang, Zeci Liu, Shilei Luo, Jing Li, Jing Zhang, Lushan Li, Jianming Xie. 5-Aminolevulinic acid and hydrogen sulphide alleviate chilling stress in pepper (Capsicum annuum L.) seedlings by enhancing chlorophyll synthesis pathway. Plant physiology and biochemistry : PPB. 2021 Oct; 167(?):567-576. doi: 10.1016/j.plaphy.2021.08.031. [PMID: 34455225]
  • Junhao Chen, Xiaohong Li, Yumei Liu, Tianyuan Su, Changsen Lin, Lijun Shao, Lanhua Li, Wanwei Li, Guoyu Niu, Jing Yu, Ling Liu, Miaomiao Li, Xiaoli Yu, Qian Wang. Engineering a probiotic strain of Escherichia coli to induce the regression of colorectal cancer through production of 5-aminolevulinic acid. Microbial biotechnology. 2021 09; 14(5):2130-2139. doi: 10.1111/1751-7915.13894. [PMID: 34272828]
  • Dihui Liu, Shuang Zhao, Jinmao Li, Mingliang Chen, Lisha Wu. The application of physical pretreatment in photodynamic therapy for skin diseases. Lasers in medical science. 2021 Sep; 36(7):1369-1377. doi: 10.1007/s10103-020-03233-6. [PMID: 33404884]
  • Mohammad Saidur Rhaman, Shahin Imran, Md Masudul Karim, Jotirmoy Chakrobortty, Md Asif Mahamud, Prosenjit Sarker, Md Tahjib-Ul-Arif, Arif Hasan Khan Robin, Wenxiu Ye, Yoshiyuki Murata, Mirza Hasanuzzaman. 5-aminolevulinic acid-mediated plant adaptive responses to abiotic stress. Plant cell reports. 2021 Aug; 40(8):1451-1469. doi: 10.1007/s00299-021-02690-9. [PMID: 33839877]
  • Makito Miyake, Yasushi Nakai, Nobutaka Nishimura, Sayuri Ohnishi, Yuki Oda, Tomomi Fujii, Takuya Owari, Shunta Hori, Yosuke Morizawa, Daisuke Gotoh, Satoshi Anai, Kazumasa Torimoto, Nobumichi Tanaka, Yoshihiko Hirao, Kiyohide Fujimoto. Hexylaminolevulinate-mediated fluorescent urine cytology with a novel automated detection technology for screening and surveillance of bladder cancer. BJU international. 2021 08; 128(2):244-253. doi: 10.1111/bju.15368. [PMID: 33580627]
  • Siqi Dai, Sijin He, Xiaowen Huang, Pingjiao Chen, Qian Li, Jia Guo, Menghua Zhu, Jing Shen, Kang Zeng. Safety and effectiveness of 5-aminolevulinic acid photodynamic therapy combined with fractional micro-plasma radio-frequency treatment for verrucous epidermal nevus: A retrospective study with long-term follow-up. The Journal of dermatology. 2021 Aug; 48(8):1229-1235. doi: 10.1111/1346-8138.15923. [PMID: 33896053]
  • Jing Han, Caiyu Li, Zhi Dai, Juanhui Duan, Wen Cai, Yong Wang, Youcai Zhang. Yinzhihuang Oral Liquid Ameliorates Hyperbilirubinemia Induced by δ-Aminolevulinic Acid and Novobiocin in Neonatal Rats. Chemistry & biodiversity. 2021 Aug; 18(8):e2100222. doi: 10.1002/cbdv.202100222. [PMID: 34085382]
  • Marie Andersson, Marthe Berger, Karsten Zieger, Per-Uno Malmström, Mats Bläckberg. The diagnostic challenge of suspicious or positive malignant urine cytology findings when cystoscopy findings are normal: an outpatient blue-light flexible cystoscopy may solve the problem. Scandinavian journal of urology. 2021 Aug; 55(4):263-267. doi: 10.1080/21681805.2021.1928746. [PMID: 34037496]
  • Rachana K Gandhi Mehta, James B Caress, Sean R Rudnick, Herbert L Bonkovsky. Porphyric neuropathy. Muscle & nerve. 2021 08; 64(2):140-152. doi: 10.1002/mus.27232. [PMID: 33786855]
  • Yasuko Ichihara, Shizue Masuki, Koji Uchida, Kiwamu Takahashi, Motowo Nakajima, Hiroshi Nose. Effects of 5-aminolevulinic acid with iron supplementation on respiratory responses to graded cycling and interval walking training achievement in older women over 75 yrs. Experimental gerontology. 2021 07; 150(?):111356. doi: 10.1016/j.exger.2021.111356. [PMID: 33864830]
  • Eiji Kobayashi. Testing of human equivalent dose of health food 5-aminolevulinic acid using the experimental pig. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 07; 139(?):111629. doi: 10.1016/j.biopha.2021.111629. [PMID: 33906080]
  • Zhiwei Hou, Xiaoqing Pang, Boris Hedtke, Bernhard Grimm. In vivo functional analysis of the structural domains of FLUORESCENT (FLU). The Plant journal : for cell and molecular biology. 2021 07; 107(2):360-376. doi: 10.1111/tpj.15293. [PMID: 33901334]
  • Dhiman Maitra, Benjamin M Pinsky, Amenah Soherawardy, Haiyan Zheng, Ruma Banerjee, M Bishr Omary. Protein-aggregating ability of different protoporphyrin-IX nanostructures is dependent on their oxidation and protein-binding capacity. The Journal of biological chemistry. 2021 07; 297(1):100778. doi: 10.1016/j.jbc.2021.100778. [PMID: 34023387]
  • Linglin Zhang, Jiayi Yang, Xiaojing Liu, Detian Xu, Lei Shi, Jia Liu, Qingyu Zeng, Xiuli Wang. 5-Aminolaevulinic acid photodynamic therapy amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8. Experimental dermatology. 2021 07; 30(7):923-931. doi: 10.1111/exd.14357. [PMID: 33860562]
  • Yuji Shishido, Masataka Amisaki, Yoshiaki Matsumi, Haruna Yakura, Yuji Nakayama, Wataru Miyauchi, Kozo Miyatani, Tomoyuki Matsunaga, Takehiko Hanaki, Kyoichi Kihara, Manabu Yamamoto, Naruo Tokuyasu, Shuichi Takano, Teruhisa Sakamoto, Soichiro Honjo, Toshimichi Hasegawa, Yoshiyuki Fujiwara. Antitumor Effect of 5-Aminolevulinic Acid Through Ferroptosis in Esophageal Squamous Cell Carcinoma. Annals of surgical oncology. 2021 Jul; 28(7):3996-4006. doi: 10.1245/s10434-020-09334-4. [PMID: 33210267]
  • Lilia Coronato Courrol, Flávia Rodrigues de Oliveira Silva, Valdivel Masilamani. SARS-CoV-2, hemoglobin and protoporphyrin IX: Interactions and perspectives. Photodiagnosis and photodynamic therapy. 2021 Jun; 34(?):102324. doi: 10.1016/j.pdpdt.2021.102324. [PMID: 33965601]
  • Takuya Owari, Takashi Iwamoto, Satoshi Anai, Makito Miyake, Yasushi Nakai, Shunta Hori, Takeshi Hara, Takuya Ishii, Urara Ota, Kazumasa Torimoto, Hiroki Kuniyasu, Tomomi Fujii, Nobumichi Tanaka, Kiyohide Fujimoto. The sustaining of fluorescence in photodynamic diagnosis after the administration of 5-aminolevulinic acid in carcinogen-induced bladder cancer orthotopic rat model and urothelial cancer cell lines. Photodiagnosis and photodynamic therapy. 2021 Jun; 34(?):102309. doi: 10.1016/j.pdpdt.2021.102309. [PMID: 33901687]
  • Zhimei Xiao, Bo Zhuang, Guoli Zhang, Miao Li, Yiguang Jin. Pulmonary delivery of cationic liposomal hydroxycamptothecin and 5-aminolevulinic acid for chemo-sonodynamic therapy of metastatic lung cancer. International journal of pharmaceutics. 2021 May; 601(?):120572. doi: 10.1016/j.ijpharm.2021.120572. [PMID: 33831485]
  • Mengru Chang, Mingcong Li, Min Li, Yuhuai Xie, Yan Li, Weiren Yang, Zheng Gao. Changes of gut microbiota in pregnant sows induced by 5-Aminolevulinic acid. Research in veterinary science. 2021 May; 136(?):57-65. doi: 10.1016/j.rvsc.2021.01.021. [PMID: 33588095]
  • Kit Man Chan, Jonathan Gleadle, Jordan Li, Thomas Danny Michl, Krasimir Vasilev, Melanie MacGregor. Improving hexaminolevulinate enabled cancer cell detection in liquid biopsy immunosensors. Scientific reports. 2021 03; 11(1):7283. doi: 10.1038/s41598-021-86649-6. [PMID: 33790357]
  • Taku Nakayama, Tomonori Sano, Yoshiki Oshimo, Chiaki Kawada, Moe Kasai, Shinkuro Yamamoto, Hideo Fukuhara, Keiji Inoue, Shun-Ichiro Ogura. Enhanced lipid metabolism induces the sensitivity of dormant cancer cells to 5-aminolevulinic acid-based photodynamic therapy. Scientific reports. 2021 03; 11(1):7290. doi: 10.1038/s41598-021-86886-9. [PMID: 33790399]
  • Alexandra N Gewirtz, Virginia Gao, Sarah C Parauda, Matthew S Robbins. Posterior Reversible Encephalopathy Syndrome. Current pain and headache reports. 2021 Feb; 25(3):19. doi: 10.1007/s11916-020-00932-1. [PMID: 33630183]
  • Kulwinder Sagoo, Nathan Cumberbatch, Adam Holland, Graham Hungerford. Rapid (FLASH-FLIM) imaging of protoporphyrin IX in a lipid mixture using a CMOS based widefield fluorescence lifetime imaging camera in real time for margin demarcation applications. Methods and applications in fluorescence. 2021 Jan; 9(1):. doi: 10.1088/2050-6120/abbcc6. [PMID: 32992309]
  • Fenghua Zhang, Daoyun Li, Lijuan Shi, Yijia Gu, Yun Xu, Changping Wu. Efficacy of 5-Aminolevulinic Acid (ALA)-Photodynamic Therapy (PDT) in Refractory Vulvar Lichen Sclerosus: Preliminary Results. Medical science monitor : international medical journal of experimental and clinical research. 2021 Jan; 27(?):e927406. doi: 10.12659/msm.927406. [PMID: 33411697]
  • Melanie MacGregor, Hanieh Safizadeh Shirazi, Kit Man Chan, Kola Ostrikov, Kym McNicholas, Alex Jay, Michael Chong, Alexander H Staudacher, Thomas D Michl, Aigerim Zhalgasbaikyzy, Michael P Brown, Moein Navvab Kashani, Adam Di Fiore, Alex Grochowski, Stephen Robb, Simon Belcher, Jordan Li, Jonathan M Gleadle, Krasimir Vasilev. Cancer cell detection device for the diagnosis of bladder cancer from urine. Biosensors & bioelectronics. 2021 Jan; 171(?):112699. doi: 10.1016/j.bios.2020.112699. [PMID: 33068879]
  • Xiao Sheng, Xinhua Ye, Xiaoqi Shi, Lin Lu, Aijiao Lu, Yun Xue, Yunfeng Du, Jinluo Cheng. A combination of plasma exchange and steroids in the treatment of a-lipoic acid-induced insulin autoimmune syndrome. Endokrynologia Polska. 2021; 72(1):81-82. doi: 10.5603/ep.a2020.0085. [PMID: 33295634]
  • Akira Ono, Hyogo Horiguchi. Reassessment of the threshold of the blood lead level to increase urinary δ-aminolevulinic acid based on their relationship in recent lead workers in Japan. Journal of occupational health. 2021 Jan; 63(1):e12202. doi: 10.1002/1348-9585.12202. [PMID: 33543569]
  • Yukiko Imi, Katsumi Shibata. Nutritional Factors That Affect the Formation of 5-Aminolevulinic Acid, a Key Intermediate of Heme Biosynthesis. Journal of nutritional science and vitaminology. 2021; 67(5):339-350. doi: 10.3177/jnsv.67.339. [PMID: 34719620]
  • Wei Yang, Haitao Xu, Qinghao Liu, Chunxun Liu, Jiahe Hu, Ping Liu, Tianyi Fang, Yuxian Bai, Jiuxin Zhu, Rui Xie. 5-Aminolevulinic acid hydrochloride loaded microbubbles-mediated sonodynamic therapy in pancreatic cancer cells. Artificial cells, nanomedicine, and biotechnology. 2020 Dec; 48(1):1178-1188. doi: 10.1080/21691401.2020.1813743. [PMID: 32924612]
  • Peipei Ma, Lin Zhu, Siqing Zhu, Ruiteng Li, Yijing Liu, Lulu Pang, Jinqiu Ma, Yu Li, Lina Du. Topical photodynamic therapy combined with ablative 'light needles' against basal cell carcinoma. International journal of pharmaceutics. 2020 Nov; 590(?):119898. doi: 10.1016/j.ijpharm.2020.119898. [PMID: 32971175]
  • Ravinder Singh, Anup Kumar Kesavan, Marco Landi, Satwinderjeet Kaur, Sharad Thakur, Bingsong Zheng, Renu Bhardwaj, Anket Sharma. 5-aminolevulinic acid regulates Krebs cycle, antioxidative system and gene expression in Brassica juncea L. to confer tolerance against lead toxicity. Journal of biotechnology. 2020 Nov; 323(?):283-292. doi: 10.1016/j.jbiotec.2020.09.004. [PMID: 32976866]
  • Krzysztof Zduniak, Katarzyna Gdesz-Birula, Marta Woźniak, Kamila Duś-Szachniewicz, Piotr Ziółkowski. The Assessment of the Combined Treatment of 5-ALA Mediated Photodynamic Therapy and Thalidomide on 4T1 Breast Carcinoma and 2H11 Endothelial Cell Line. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215184. [PMID: 33171718]
  • Richard Howley, Matthew Mansi, Janhavi Shinde, Juliana Restrepo, Bin Chen. Evaluation of aminolevulinic acid-mediated protoporphyrin IX fluorescence and enhancement by ABCG2 inhibitors in renal cell carcinoma cells. Journal of photochemistry and photobiology. B, Biology. 2020 Oct; 211(?):112017. doi: 10.1016/j.jphotobiol.2020.112017. [PMID: 32919173]
  • Lirong Ma, Xuanlin Yang, Xiuzhong Yao, Weiyu Weng. Solubilization of Hexyl Aminolevulinate by Surfactants for Tumor Fluorescence Detection. Photochemistry and photobiology. 2020 09; 96(5):1088-1095. doi: 10.1111/php.13252. [PMID: 32125708]
  • Atefeh Vejdani Noghreiyan, Armin Imanparast, Elham Shayesteh Ara, Samaneh Soudmand, Vajiheh Vejdani Noghreiyan, Ameneh Sazgarnia. In-vitro investigation of cold atmospheric plasma induced photodynamic effect by Indocyanine green and Protoporphyrin IX. Photodiagnosis and photodynamic therapy. 2020 Sep; 31(?):101822. doi: 10.1016/j.pdpdt.2020.101822. [PMID: 32428573]
  • Julia J Shen, Gregor B E Jemec, Maiken C Arendrup, Ditte Marie L Saunte. Photodynamic therapy treatment of superficial fungal infections: A systematic review. Photodiagnosis and photodynamic therapy. 2020 Sep; 31(?):101774. doi: 10.1016/j.pdpdt.2020.101774. [PMID: 32339671]