5-Aminolevulinic acid (BioDeep_00000001259)

 

Secondary id: BioDeep_00000400275

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Bertek brand OF aminolevulinic acid hydrochloride

化学式: C5H9NO3 (131.0582404)
中文名称: 5-氨基乙酰丙酸, 5-氨基乙酰丙酸, 5-氨基酮戊酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.93%

分子结构信息

SMILES: C(CC(=O)O)C(=O)CN
InChI: InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)

描述信息

5-Aminolevulinic acid, also known as 5-aminolevulinate or 5-amino-4-oxopentanoate, belongs to the class of organic compounds known as delta amino acids and derivatives. Delta amino acids and derivatives are compounds containing a carboxylic acid group and an amino group at the C5 carbon atom. 5-Aminolevulinic acid is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. 5-Aminolevulinic acid exists in all living species, ranging from bacteria to humans. 5-aminolevulinic acid can be biosynthesized from glycine and succinyl-CoA by the enzyme 5-aminolevulinate synthase. The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. In humans, 5-aminolevulinic acid is involved in the metabolic disorder called the dimethylglycine dehydrogenase deficiency pathway. Outside of the human body, 5-Aminolevulinic acid has been detected, but not quantified in several different foods, such as american butterfish, vaccinium (blueberry, cranberry, huckleberry), amaranths, purple mangosteens, and garden cress. Used (in the form of the hydrochloride salt) in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin.
An intermediate in heme synthesis. This is the first compound in the porphyrin synthesis pathway. It is produced by the enzyme ALA synthase, from glycine and succinyl CoA. This reaction is known as the Shemin pathway. Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp. [HMDB]. 5-Aminolevulinic acid is found in many foods, some of which are fireweed, chia, sesbania flower, and taro.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XD - Sensitizers used in photodynamic/radiation therapy
Acquisition and generation of the data is financially supported in part by CREST/JST.
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
C1420 - Photosensitizing Agent
D003879 - Dermatologic Agents
KEIO_ID A052

同义名列表

38 个代谢物同义名

Bertek brand OF aminolevulinic acid hydrochloride; delta-Aminolevulinic acid hydrochloride; Hydrochloride, aminolevulinic acid; Acid hydrochloride, aminolevulinic; Aminolevulinic acid hydrochloride; 5-Amino-4-oxo-pentanoic acid; 5-Amino-4-oxopentanoic acid; Acid, Delta-aminolevulinic; Delta Aminolevulinic acid; 5-Amino-4-oxovaleric acid; delta-Aminolevulinic acid; 5(d)-Aminolevulinic Acid; 5-Amino-4-oxo-pentanoate; 5-Amino-4-oxopentanoate; 5-amino-levulinic acid; 5-Aminolaevulinic acid; 5-Aminolevulinic acid; Δ-aminolevulinic acid; 5-Amino-4-oxovalerate; delta-Aminolevulinate; Amino-levulinic acid; Acid, aminolevulinic; Aminolevulinic Acid; 5-Aminolaevulinate; 5 Aminolaevulinate; 5-Amino-levulinate; 5 Aminolevulinate; Δ-aminolevulinate; 5-Aminolevulinate; Aminolevulinate; delta-ALA; Kerastick; Aladerm; Levulan; 5-ALA; Δ-ala; DALA; 5-Aminolevulinic acid



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

62 个相关的代谢反应过程信息。

Reactome(10)

BioCyc(3)

WikiPathways(2)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(45)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Peiyu Xu, Jing Liu, Ying Yi, Zhi Cai, Yihua Yin, Weiquan Cai, Jingli Zhang, Zhixia Gong, Yaqi Xiao. A dew-responsive pectin-based herbicide for enhanced photodynamic inactivation. Carbohydrate polymers. 2024 Jul; 336(?):122114. doi: 10.1016/j.carbpol.2024.122114. [PMID: 38670775]
  • Lu Chen, Yong Zhao, Qiandai Shi, Yu Du, Qiaohui Zeng, Haiquan Liu, Zhaohuan Zhang, Huaming Zheng, Jing Jing Wang. Preservation effects of photodynamic inactivation-mediated antibacterial film on storage quality of salmon fillets: Insights into protein quality. Food chemistry. 2024 Jun; 444(?):138685. doi: 10.1016/j.foodchem.2024.138685. [PMID: 38341917]
  • Qianyun Guo, Xiaoli Ji, Lei Zhang, Xingyun Liu, Yutian Wang, Zijian Liu, Jianqiu Jin, Ying Han, Hongwei Liu. Differences in the response of normal oral mucosa, oral leukoplakia, oral squamous cell carcinoma-derived mesenchymal stem cells, and epithelial cells to photodynamic therapy. Journal of photochemistry and photobiology. B, Biology. 2024 Jun; 255(?):112907. doi: 10.1016/j.jphotobiol.2024.112907. [PMID: 38677259]
  • Kai Chen, Yan-Yan Hu, Shan-Shan Qian, Jin-Zhao Wu, Li-Juan Cao, Lin-Lin Wang, Meng Li, Yu-Xin Xia, Qian Jiang, Hong-Ying Chen, Liu-Qing Chen, Dong-Sheng Li. A novel glycyrrhizic acid-based dressing effectively improved photodynamic therapy-caused skin barrier damage in port-wine stains. Journal of cosmetic dermatology. 2024 Jun; 23(6):2301-2303. doi: 10.1111/jocd.16250. [PMID: 38410871]
  • Isabela Santos Lopes, Jullio Kennedy Castro Soares, Lívia Soman de Medeiros, Lilia Coronato Courrol. Evaluation of ALA-capped silver, copper, and silver-copper nanoparticles for controlling fungal plant pathogens. Microbial pathogenesis. 2024 Jun; 191(?):106672. doi: 10.1016/j.micpath.2024.106672. [PMID: 38705219]
  • Zhengda Zhang, Jiao Dang, Luqiao Yuan, Yuhui Zhang, Fan Zhou, Tianlai Li, Xiaohui Hu. Exogenous 5-Aminolevulinic acid improved low-temperature tolerance tomato seedling by regulating starch content and phenylalanine metabolism. Plant physiology and biochemistry : PPB. 2024 May; 210(?):108083. doi: 10.1016/j.plaphy.2023.108083. [PMID: 38615441]
  • Xiaoli Chen, Min Li, Wen Li, Wenai Zheng, Weiwei Wu. Photodynamic therapy successfully treats refractory onychomycosis caused by Trichosporon asahii: a case report. Photodiagnosis and photodynamic therapy. 2024 Apr; 46(?):104045. doi: 10.1016/j.pdpdt.2024.104045. [PMID: 38479606]
  • Paulina Szczepanik-Kułak, Joanna Bartosińska, Dorota Kowalczuk, Agnieszka Gerkowicz, Iwona Bojar, Mirosław Kwaśny, Dorota Krasowska. Efficacy of photodynamic therapy using ALAHCl in gel with a lipid nanoemulsion and MALHCl in cream in superficial basal cell carcinoma. Annals of agricultural and environmental medicine : AAEM. 2024 Mar; 31(1):94-99. doi: 10.26444/aaem/183059. [PMID: 38549482]
  • Beata Čunderlíková, Kristína Klučková, Pavel Babál, Peter Mlkvý, Tibor Teplický. Modifications of DAMPs levels in extracellular environment induced by aminolevulinic acid-based photodynamic therapy of esophageal cancer cells. International journal of radiation biology. 2024 Feb; ?(?):1-15. doi: 10.1080/09553002.2024.2310002. [PMID: 38319688]
  • Fujun Huang, Qiang Fu, Lei Tang, Mingdan Zhao, Mengya Huang, Xun Zhou. Trends in photodynamic therapy for dermatology in recent 20 years: A scientometric review based on CiteSpace. Journal of cosmetic dermatology. 2024 Feb; 23(2):391-402. doi: 10.1111/jocd.16033. [PMID: 37815144]
  • Liuzi Zhang, Jiangting Zhang, Bo Wei, Yage Li, Xiang Fang, Yan Zhong, Liangju Wang. Transcription factor MdNAC33 is involved in ALA-induced anthocyanin accumulation in apples. Plant science : an international journal of experimental plant biology. 2024 Feb; 339(?):111949. doi: 10.1016/j.plantsci.2023.111949. [PMID: 38065304]
  • Juan Ji, Chu-Ting Liang, Jiao-Jiao Zhong, Xue Kong, Hao-Xiang Xu, Chang-Chun Xu, Mei-Hua Fu. 5-aminolevulinic acid-based photodynamic therapy in combination with antifungal agents for adult kerion and facial ulcer caused by Trichophyton rubrum. Photodiagnosis and photodynamic therapy. 2024 Feb; 45(?):103954. doi: 10.1016/j.pdpdt.2023.103954. [PMID: 38145772]
  • Weiming Zhang, Zhao Jin, Tingting Gao, Li Fan, Weizhen Wang, Xianyu Zeng, Li Qin. Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat warts. Photodiagnosis and photodynamic therapy. 2024 Feb; 45(?):103934. doi: 10.1016/j.pdpdt.2023.103934. [PMID: 38097120]
  • Josephine Herbst, Xiaoqing Pang, Lena Roling, Bernhard Grimm. The novel tetratricopeptide-repeat protein TTP1 forms complexes with GluTR and POR during tetrapyrrole biosynthesis. Journal of experimental botany. 2023 Dec; ?(?):. doi: 10.1093/jxb/erad491. [PMID: 38070484]
  • Hamid Mohammadi, Parviz Ezati, Saeid Hazrati, Mansour Ghorbanpour. Exogenously applied 5-aminolevulinic acid modulates growth, yield, and physiological parameters in lentil (Lens culinaris Medik.) under rain-fed and supplemental irrigation conditions. Scientific reports. 2023 12; 13(1):21312. doi: 10.1038/s41598-023-48732-y. [PMID: 38042953]
  • Huihui Liu, Qing Wang, Jingru Guo, Kai Feng, Yiling Ruan, Zhihao Zhang, Xin Ji, Jigang Wang, Tao Zhang, Xiaolian Sun. Prodrug-based strategy with a two-in-one liposome for Cerenkov-induced photodynamic therapy and chemotherapy. Journal of controlled release : official journal of the Controlled Release Society. 2023 12; 364(?):206-215. doi: 10.1016/j.jconrel.2023.10.036. [PMID: 37884209]
  • Weinan Zhang, Zhiqiang He, Yingyue Qin, Jie Gong, Wenjun Xie, Li Tong, Shulei Liu, Luoyingzi Xie. 5-aminolevulinic acid photodynamic therapy using 560-1200 nm followed by 420-1200 nm broadband light in the treatment of moderate-to-severe acne. Photodiagnosis and photodynamic therapy. 2023 Dec; 44(?):103902. doi: 10.1016/j.pdpdt.2023.103902. [PMID: 37984524]
  • Zhimin Duan, Jianbo Tong, Nana Zheng, Rong Zeng, Yuzhen Liu, Min Li. Effect of 5-Aminolevulinic Acid Photodynamic Therapy on Aspergillus fumigatus Biofilms in Vitro. Current microbiology. 2023 Sep; 80(10):334. doi: 10.1007/s00284-023-03351-8. [PMID: 37659001]
  • Xiaojie Liu, Jin Wang, Jipeng Yu, Weibin Xing, Junling Zhang. Experience analysis of a combined photodynamic/electrodesiccation therapy in the treatment of 11 cases of large patches of Bowen's disease. Photodiagnosis and photodynamic therapy. 2023 Sep; 43(?):103710. doi: 10.1016/j.pdpdt.2023.103710. [PMID: 37527695]
  • Xinru Xue, Minghui Xie, Li Zhu, Dong Wang, Zeping Xu, Le Liang, Jianwei Zhang, Linyu Xu, Peihan Zhou, Jianzhao Ran, Guofeng Yu, Yunsong Lai, Bo Sun, Yi Tang, Huanxiu Li. 5-ALA Improves the Low Temperature Tolerance of Common Bean Seedlings through a Combination of Hormone Transduction Pathways and Chlorophyll Metabolism. International journal of molecular sciences. 2023 Aug; 24(17):. doi: 10.3390/ijms241713189. [PMID: 37685996]
  • Oladayo A Oyebanji, Chad Brewer, Sharlo Bayless, Benjamin Schmeusser, Danielle A Corbin, Courtney E W Sulentic, Catherine M T Sherwin, Yanfang Chen, Christine M Rapp, Elizabeth E Cates, Yuhan Long, Jeffrey B Travers, Craig A Rohan. Topical Photodynamic Therapy Generates Bioactive Microvesicle Particles: Evidence for a Pathway Involved in Immunosuppressive Effects. The Journal of investigative dermatology. 2023 07; 143(7):1279-1288.e9. doi: 10.1016/j.jid.2022.12.018. [PMID: 36708950]
  • Zhen Kang, Yong Zhang, Xiongchun Cai, Zhengda Zhang, Zijian Xu, Xiangguang Meng, Xiaojing Li, Xiaohui Hu. Crosstalk between 5-Aminolevulinic Acid and Abscisic Acid Adjusted Leaf Iron Accumulation and Chlorophyll Synthesis to Enhance the Cold Tolerance in Solanum lycopersicum Seedlings. International journal of molecular sciences. 2023 Jun; 24(13):. doi: 10.3390/ijms241310781. [PMID: 37445959]
  • Daniel Wittmann, Peter Geigenberger, Bernhard Grimm. NTRC and TRX-f Coordinately Affect the Levels of Enzymes of Chlorophyll Biosynthesis in a Light-Dependent Manner. Cells. 2023 06; 12(12):. doi: 10.3390/cells12121670. [PMID: 37371140]
  • Shintaro Hamada, Yukari Mae, Tomoaki Takata, Hinako Hanada, Misaki Kubo, Sosuke Taniguchi, Takuji Iyama, Takaaki Sugihara, Hajime Isomoto. Five-Aminolevulinic Acid (5-ALA) Induces Heme Oxygenase-1 and Ameliorates Palmitic Acid-Induced Endoplasmic Reticulum Stress in Renal Tubules. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210151. [PMID: 37373300]
  • Jiheng Zhang, Lulu Liu, Xinying Li, Xiaoxiao Shen, Guihong Yang, Yumeng Deng, Zhengwei Hu, Junbo Zhang, Yuangang Lu. 5-ALA-PDT induced ferroptosis in keloid fibroblasts via ROS, accompanied by downregulation of xCT, GPX4. Photodiagnosis and photodynamic therapy. 2023 Jun; 42(?):103612. doi: 10.1016/j.pdpdt.2023.103612. [PMID: 37220842]
  • Peiru Wang, Fang Xie, Linglin Zhang, Shuang Zhao, Lude Zhu, Shuzhan Shen, Dongsheng Li, Zhou Chen, Rong Xiao, Yan Lu, Xia Lei, Yan Li, Guolong Zhang, Weihui Zeng, Xiuli Wang. Plum-blossom needle tapping enhances the efficacy of ALA photodynamic therapy for facial actinic keratosis in Chinese population: a randomized, multicenter, prospective, and observer-blind study. Photodiagnosis and photodynamic therapy. 2023 Jun; 42(?):103611. doi: 10.1016/j.pdpdt.2023.103611. [PMID: 37211296]
  • Xiaoqing Xiang, Yanliang Li, Yibo Tang, Runqun Liu, Tianming Ma, Xiguang Liu, Guozhang Ma. Efficacy of hematoporphyrin injection (HpD) photodynamic therapy in the treatment of widespread extramammary Paget's disease. Photodiagnosis and photodynamic therapy. 2023 Jun; 42(?):103649. doi: 10.1016/j.pdpdt.2023.103649. [PMID: 37302640]
  • Tingting Fan, Lena Roling, Boris Hedtke, Bernhard Grimm. FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway. The New phytologist. 2023 May; ?(?):. doi: 10.1111/nph.18952. [PMID: 37161708]
  • Cengiz Kaya, Muhammed Ashraf, Mohammed Nasser Alyemeni, Jörg Rinklebe, Parvaiz Ahmad. Alleviation of arsenic toxicity in pepper plants by aminolevulinic acid and heme through modulating its sequestration and distribution within cell organelles. Environmental pollution (Barking, Essex : 1987). 2023 May; ?(?):121747. doi: 10.1016/j.envpol.2023.121747. [PMID: 37146870]
  • Zishu Xu, Jianmin Pan, Najeeb Ullah, Yi Duan, Ruiyong Hao, Juanjuan Li, Qian Huang, Ling Xu. 5-Aminolevulinic acid mitigates the chromium-induced changes in Helianthus annuus L. as revealed by plant defense system enhancement. Plant physiology and biochemistry : PPB. 2023 May; 198(?):107701. doi: 10.1016/j.plaphy.2023.107701. [PMID: 37105019]
  • Huan Liu, Jingliang Sun, Jixiang Zou, Baisheng Li, Hua Jin. MeJA-mediated enhancement of salt-tolerance of Populus wutunensis by 5-aminolevulinic acid. BMC plant biology. 2023 Apr; 23(1):185. doi: 10.1186/s12870-023-04161-7. [PMID: 37024791]
  • Hang Zhao, Panxin Peng, Zhenkai Luo, Hailong Liu, Junwei Sun, Xuming Wang, Qiang Jia, Zhihao Yang. Comparison of hexaminolevulinate (HAL) -guided versus white light transurethral resection for NMIBC: A systematic review and meta-analysis of randomized controlled trials. Photodiagnosis and photodynamic therapy. 2023 Mar; 41(?):103220. doi: 10.1016/j.pdpdt.2022.103220. [PMID: 36462704]
  • Lu Chen, Qiandai Shi, Qingfeng Dong, Yu Du, Zhiyun Peng, Qiaohui Zeng, Zihao Lin, Jieer Qiu, Yong Zhao, Jing Jing Wang. Covalent Grafting of 5-Aminolevulinic Acid onto Polylactic Acid Films and Their Photodynamic Potency in Preserving Salmon. Journal of agricultural and food chemistry. 2023 Jan; 71(1):905-919. doi: 10.1021/acs.jafc.2c08340. [PMID: 36548110]
  • Guanghui Jin, Na Guo, Yasong Liu, Lele Zhang, Liang Chen, Tao Dong, Wei Liu, Xiaomei Zhang, Yong Jiang, Guo Lv, Fei Zhao, Wei Liu, Ziqing Hei, Yang Yang, Jingxing Ou. 5-aminolevulinate and CHIL3/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury. Theranostics. 2023; 13(14):4802-4820. doi: 10.7150/thno.83163. [PMID: 37771779]
  • Qianqian Li, Fei Zhang, Litao Zhang. Development of a 5-aminolevulinic acid feeding strategy capable of enhancing Haematococcus pluvialis biomass, astaxanthin, and fatty acid yields. Bioresource technology. 2023 Jan; 368(?):128319. doi: 10.1016/j.biortech.2022.128319. [PMID: 36375699]
  • Xiang Fang, Liuzi Zhang, Lingfei Shangguan, Liangju Wang. MdMYB110a, directly and indirectly, activates the structural genes for the ALA-induced accumulation of anthocyanin in apple. Plant science : an international journal of experimental plant biology. 2023 Jan; 326(?):111511. doi: 10.1016/j.plantsci.2022.111511. [PMID: 36377142]
  • NaiJia Bao, TianShu Gu, Jing Zeng, Yan Wu, Yan Sun, XingHua Gao, HongDuo Chen. Combined therapy of 5-aminolevulinic acid photodynamic therapy and intense pulsed light for rosacea. Lasers in medical science. 2022 Dec; 38(1):17. doi: 10.1007/s10103-022-03685-y. [PMID: 36562857]
  • Zheng Chen, Liangju Wang. ALA Upregulates MdPTPA Expression to Increase the PP2A Activity and Promote Stomatal Opening in Apple Leaves. Plant science : an international journal of experimental plant biology. 2022 Dec; 325(?):111490. doi: 10.1016/j.plantsci.2022.111490. [PMID: 36216297]
  • Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, Shouji Matsushima, Tomoko Koumura, Ken-Ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui. Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis. Science signaling. 2022 11; 15(758):eabn8017. doi: 10.1126/scisignal.abn8017. [PMID: 36318618]
  • Si Long, Bowen Liu, Jiongjiong Gong, Ruijia Wang, Shuanghong Gao, Tianqi Zhu, Huan Guo, Tieyuan Liu, Yuefei Xu. 5-Aminolevulinic acid promotes low-light tolerance by regulating chloroplast ultrastructure, photosynthesis, and antioxidant capacity in tall fescue. Plant physiology and biochemistry : PPB. 2022 Nov; 190(?):248-261. doi: 10.1016/j.plaphy.2022.09.010. [PMID: 36152510]
  • Neha Sinha, Jürgen Eirich, Iris Finkemeier, Bernhard Grimm. Glutamate 1-semialdehyde aminotransferase is connected to GluTR by GluTR-binding protein and contributes to the rate-limiting step of 5-aminolevulinic acid synthesis. The Plant cell. 2022 10; 34(11):4623-4640. doi: 10.1093/plcell/koac237. [PMID: 35972388]
  • Zhengda Zhang, Luqiao Yuan, Yongbo Ma, Zhen Kang, Fan Zhou, Yi Gao, Shichun Yang, Tianlai Li, Xiaohui Hu. Exogenous 5-aminolevulinic acid alleviates low-temperature damage by modulating the xanthophyll cycle and nutrient uptake in tomato seedlings. Plant physiology and biochemistry : PPB. 2022 Oct; 189(?):83-93. doi: 10.1016/j.plaphy.2022.08.013. [PMID: 36058015]
  • Lihua Qiu, Jingran Li, Fei Chen, Yifeng Wang, Yue Wang, Xinyu Wang, Qiubo Lv, Changzhong Li, Mingzhu Li, Qiuyun Yang, Dan Wu, Youzhong Zhang, Yuquan Zhang, Mengzhen Zhang, Yu Zhang, Mingrong Qie, Huaijun Zhou, Jiade Zhou, Weidong Zhao, Bairong Xia, Xuefang Liang, Yunlang Cai, Yincheng Teng, Zheng Huang, Long Sui, Lihui Wei, Wen Di. Chinese expert consensus on the clinical applications of aminolevulinic acid-based photodynamic therapy in female lower genital tract diseases (2022). Photodiagnosis and photodynamic therapy. 2022 Sep; 39(?):102993. doi: 10.1016/j.pdpdt.2022.102993. [PMID: 35781093]
  • Enyi Ye, Wei Wang, Yangfan Wu, Qingyun Yang, Tingkai Xiang, Beilei He, Zhangyu Bu. Cryotherapy combined with photodynamic therapy for successful treatment of condyloma acuminatum in special sites such as the nipple and the nasal vestibule: A series of two case reports. Photodiagnosis and photodynamic therapy. 2022 Sep; 39(?):102930. doi: 10.1016/j.pdpdt.2022.102930. [PMID: 35644347]
  • Shaila Mudambi, Megan Fitzgerald, Paula Pera, Deschana Washington, Sarah Chamberlain, Eszter Fidrus, Csaba Hegedűs, Eva Remenyik, Gal Shafirstein, David Bellnier, Gyorgy Paragh. KDM1A inhibition increases UVA toxicity and enhances photodynamic therapy efficacy. Photodermatology, photoimmunology & photomedicine. 2022 Aug; ?(?):. doi: 10.1111/phpp.12826. [PMID: 35968606]
  • Yuxian Yang, Xiang Fang, Mengxia Chen, Lingyu Wang, Jiaxin Xia, Zicheng Wang, Jinggui Fang, Lam-Son Phan Tran, Lingfei Shangguan. Copper stress in grapevine: Consequences, responses, and a novel mitigation strategy using 5-aminolevulinic acid. Environmental pollution (Barking, Essex : 1987). 2022 Aug; 307(?):119561. doi: 10.1016/j.envpol.2022.119561. [PMID: 35659552]
  • Meng Jiang, Shang Dai, Yun-Chao Zheng, Rui-Qing Li, Yuan-Yuan Tan, Gang Pan, Ian Max Møller, Shi-Yong Song, Jian-Zhong Huang, Qing-Yao Shu. An alanine to valine mutation of glutamyl-tRNA reductase enhances 5-aminolevulinic acid synthesis in rice. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2022 Aug; 135(8):2817-2831. doi: 10.1007/s00122-022-04151-7. [PMID: 35779128]
  • Yue Wu, Jing Li, Junwen Wang, Mohammed Mujitaba Dawuda, Weibiao Liao, Xin Meng, Hong Yuan, Jianming Xie, Zhongqi Tang, Jian Lyu, Jihua Yu. Heme is involved in the exogenous ALA-promoted growth and antioxidant defense system of cucumber seedlings under salt stress. BMC plant biology. 2022 Jul; 22(1):329. doi: 10.1186/s12870-022-03717-3. [PMID: 35804328]
  • Diego Vera-Yunca, Karol M Córdoba, Zinnia P Parra-Guillen, Daniel Jericó, Antonio Fontanellas, Iñaki F Trocóniz. Mechanistic modelling of enzyme-restoration effects of new recombinant liver-targeted proteins in acute intermittent porphyria. British journal of pharmacology. 2022 07; 179(14):3815-3830. doi: 10.1111/bph.15821. [PMID: 35170015]
  • Taylor A Bullock, Jeffrey Negrey, Bo Hu, Christine B Warren, Tayyaba Hasan, Edward V Maytin. Significant improvement of facial actinic keratoses after blue light photodynamic therapy with oral vitamin D pretreatment: An interventional cohort-controlled trial. Journal of the American Academy of Dermatology. 2022 07; 87(1):80-86. doi: 10.1016/j.jaad.2022.02.067. [PMID: 35314199]
  • Hideyuki Negoro, Christos Chatziantonio, Mohammed S Razzaque. Therapeutic potential of 5-aminolevulinic acid and sodium-ferrous citrate for viral insults: relevance to the COVID-19 crisis. Expert review of anti-infective therapy. 2022 05; 20(5):657-661. doi: 10.1080/14787210.2022.2020097. [PMID: 34927515]
  • Federico Brilli, Sara Pignattelli, Rita Baraldi, Luisa Neri, Susanna Pollastri, Cristina Gonnelli, Alessio Giovannelli, Francesco Loreto, Claudia Cocozza. Root Exposure to 5-Aminolevulinic Acid (ALA) Affects Leaf Element Accumulation, Isoprene Emission, Phytohormonal Balance, and Photosynthesis of Salt-Stressed Arundo donax. International journal of molecular sciences. 2022 Apr; 23(8):. doi: 10.3390/ijms23084311. [PMID: 35457125]
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