ADEFOVIR (BioDeep_00000001199)
代谢物信息卡片
9-(2-Phosphonylmethoxyethyl)adenine
化学式: C8H12N5O4P (273.06268819999997)
中文名称: 阿德福韦
谱图信息:
最多检出来源 Mentha canadensis(plant) 87.5%
分子结构信息
SMILES: C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)N
InChI: InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
描述信息
A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Same as: D02768
同义名列表
3 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:134512
- ChEBI: CHEBI:2469
- KEGG: C11277
- KEGGdrug: D02768
- PubChem: 60172
- Metlin: METLIN68958
- DrugBank: DB13868
- ChEMBL: CHEMBL484
- CAS: 106941-25-7
- PMhub: MS000000110
- MetaboLights: MTBLC2469
- PubChem: 13454
- PDB-CCD: 5HG
- NIKKAJI: J291.907I
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Adefovir Dipivoxil Metabolism Pathway:
Adefovir + Adenosine triphosphate ⟶ Adefovir Monophosphate + Adenosine diphosphate
PharmGKB(0)
1 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ju Zhang, Xiaojun Shi, Jing Wang, Jiaping Qi, Yixuan Li, Huan Jiang, Qiong Sun, Qinchen Gu, Chen Li, Zhenhua Ying. Adefovir-induced hypophosphatemic osteochondrosis mimicks ankylosing spondylitis.
International journal of rheumatic diseases.
2024 Jan; 27(1):e15040. doi:
10.1111/1756-185x.15040. [PMID: 38287538] - Yan Zhou, Mengmeng Wei, Mingkang Zhang, Jianping Zhang, Fabing Tang, Xin'an Wu. Adefovir accumulation in the renal interstitium triggers mast cell degranulation and promotes renal interstitial fibrosis.
Toxicology letters.
2022 Apr; 359(?):10-21. doi:
10.1016/j.toxlet.2022.01.018. [PMID: 35114312] - Ting Wang, Yanli Qin, Jing Zhang, Xinyan Li, Shuping Tong, Weifeng Zhao, Jiming Zhang. An antiviral drug-resistant mutant of hepatitis B virus with high replication capacity in association with a large in-frame deletion in the preS1 region of viral surface gene.
Virus genes.
2020 Dec; 56(6):677-686. doi:
10.1007/s11262-020-01787-9. [PMID: 32840739] - Rongjuan Chen, Yan Liu, Dan Luo, Lanlan Si, Bixia Huang, Jun Wang, Xiaodong Li, Fengjuan Cheng, Dongping Xu, Changzhu Duan. Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients.
Antiviral research.
2020 08; 180(?):104852. doi:
10.1016/j.antiviral.2020.104852. [PMID: 32569703] - Hyun Young Woo, Jun Yong Park, Si Hyun Bae, Chang Wook Kim, Jae Young Jang, Won Young Tak, Dong Joon Kim, In Hee Kim, Jeong Heo, Sang Hoon Ahn. Entecavir+tenofovir vs. lamivudine/telbivudine+adefovir in chronic hepatitis B patients with prior suboptimal response.
Clinical and molecular hepatology.
2020 07; 26(3):352-363. doi:
10.3350/cmh.2019.0044n. [PMID: 32460460] - Julian Hercun, Christopher Koh, Theo Heller. Hepatitis Delta: Prevalence, Natural History, and Treatment Options.
Gastroenterology clinics of North America.
2020 06; 49(2):239-252. doi:
10.1016/j.gtc.2020.01.004. [PMID: 32389361] - Zhidan Zheng, Wei Liao, Lili Liu, Shaohang Cai, Haipeng Zhu, Sichun Yin. Effect of nucleos(t)ide analogue on serum HBsAg level in chronic hepatitis B patients: A 3-years study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Feb; 122(?):109698. doi:
10.1016/j.biopha.2019.109698. [PMID: 31918272] - Oliver Scherf-Clavel, Martina Kinzig, Marc S Stoffel, Uwe Fuhr, Fritz Sörgel. Quantification of adefovir and pitavastatin in human plasma and urine by LC-MS/MS: A useful tool for drug-drug interaction studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Sep; 1125(?):121718. doi:
10.1016/j.jchromb.2019.121718. [PMID: 31330406] - Wen Jia, Men Qi Zhu, Xun Qi, Ting Wang, Xiao Wen, Pei Dong Chen, Qing Qi Fan, Wen-Hong Zhang, Ji Ming Zhang. Serum hepatitis B virus RNA levels as a predictor of HBeAg seroconversion during treatment with peginterferon alfa-2a.
Virology journal.
2019 05; 16(1):61. doi:
10.1186/s12985-019-1152-6. [PMID: 31064399] - Yan Zhou, Yuquan Yang, Pei Wang, Mengmeng Wei, Yanrong Ma, Xin'an Wu. Adefovir accumulation and nephrotoxicity in renal interstitium: Role of organic anion transporters of kidney.
Life sciences.
2019 May; 224(?):41-50. doi:
10.1016/j.lfs.2019.03.042. [PMID: 30902543] - Q Zhang, L Zhang, Y Xing, Y Qin, G Liu. Comparison of the 48-week efficacy of Lamivudine plus Adefovir or Entecavir monotherapy in patients with HBeAg negative hepatitis following Lamivudine treatment failure.
Acta gastro-enterologica Belgica.
2019 Jan; 82(1):31-34. doi:
. [PMID: 30888751] - Prowpanga Udompap, Donghee Kim, Aijaz Ahmed, W Ray Kim. Longitudinal trends in renal function in chronic hepatitis B patients receiving oral antiviral treatment.
Alimentary pharmacology & therapeutics.
2018 12; 48(11-12):1282-1289. doi:
10.1111/apt.15020. [PMID: 30370967] - Qian Su, Yanyan Liu, Jiabin Li. Combined effect of pegylated interferon α with adefovir on renal function in Chinese patients with chronic hepatitis B.
Medicine.
2018 Aug; 97(34):e12089. doi:
10.1097/md.0000000000012089. [PMID: 30142868] - Ling Zou, Adrian Stecula, Anshul Gupta, Bhagwat Prasad, Huan-Chieh Chien, Sook Wah Yee, Li Wang, Jashvant D Unadkat, Simone H Stahl, Katherine S Fenner, Kathleen M Giacomini. Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
Molecular pharmacology.
2018 07; 94(1):689-699. doi:
10.1124/mol.117.111153. [PMID: 29720497] - Doo Hyun Kim, Hong Seok Kang, Seong-Suk Hur, Seobo Sim, Sung Hyun Ahn, Yong Kwang Park, Eun-Sook Park, Ah Ram Lee, Soree Park, So Young Kwon, Jeong-Hoon Lee, Kyun-Hwan Kim. Direct Detection of Drug-Resistant Hepatitis B Virus in Serum Using a Dendron-Modified Microarray.
Gut and liver.
2018 May; 12(3):331-341. doi:
10.5009/gnl17336. [PMID: 29271185] - Chau-Ting Yeh, Christopher Sung-Huan Yeh, Yu-De Chu, Yang-Jen Chiang. Seroclearance of hepatitis B surface antigen following hepatitis E exacerbation on chronic hepatitis E and B dual infection in a renal transplant recipient: a case report.
Journal of medical case reports.
2018 Feb; 12(1):50. doi:
10.1186/s13256-018-1586-2. [PMID: 29486803] - Kazumoto Murata, Mai Asano, Akihiro Matsumoto, Masaya Sugiyama, Nao Nishida, Eiji Tanaka, Taisuke Inoue, Minoru Sakamoto, Nobuyuki Enomoto, Takayoshi Shirasaki, Masao Honda, Shuichi Kaneko, Hiroyuki Gatanaga, Shinichi Oka, Yuki I Kawamura, Taeko Dohi, Yasutaka Shuno, Hideaki Yano, Masashi Mizokami. Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection.
Gut.
2018 02; 67(2):362-371. doi:
10.1136/gutjnl-2016-312653. [PMID: 27789659] - Heon Ju Lee, Sang Jin Kim, Young Oh Kweon, Soo Young Park, Jeong Heo, Hyun Young Woo, Jae Seok Hwang, Woo Jin Chung, Chang Hyeong Lee, Byung Seok Kim, Jeong Ill Suh, Won Young Tak, Byoung Kuk Jang. Evaluating the efficacy of switching from lamivudine plus adefovir to tenofovir disoproxil fumarate monotherapy in lamivudine-resistant stable hepatitis B patients.
PloS one.
2018; 13(1):e0190581. doi:
10.1371/journal.pone.0190581. [PMID: 29329305] - Ting Wu, Haixin Li, Jiasheng Chen, Ying Cao, Weimin Fu, Pingzheng Zhou, Jianxin Pang. Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1).
Pharmacological reports : PR.
2017 Dec; 69(6):1254-1262. doi:
10.1016/j.pharep.2017.06.012. [PMID: 29128807] - Dante A Suffredini, Yan Li, Wanying Xu, Mahtab Moayeri, Stephen Leppla, Yvonne Fitz, Xizhong Cui, Peter Q Eichacker. Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.
American journal of physiology. Heart and circulatory physiology.
2017 Nov; 313(5):H946-H958. doi:
10.1152/ajpheart.00285.2017. [PMID: 28887331] - M-L Wang, E-Q Chen, D-M Zhang, L-Y Du, L-B Yan, T-Y Zhou, X-Z Lei, B-J Lei, J-J Lu, J Liao, H Tang. Efficacy and safety of three adefovir-based combination therapies in HBeAg-positive chronic hepatitis B patients with suboptimal response to adefovir monotherapy.
Journal of viral hepatitis.
2017 11; 24 Suppl 1(?):21-28. doi:
10.1111/jvh.12792. [PMID: 29082645] - Guosheng Yuan, Chengguang Hu, Yuchen Zhou, Junwei Liu, Huaping Huang, Yuan Li, Dinghua Yang, Fuyuan Zhou, Yong-Yuan Zhang, Yuanping Zhou. A different inhibitor is required for overcoming entecavir resistance: a comparison of four rescue therapies in a retrospective study.
British journal of clinical pharmacology.
2017 Oct; 83(10):2259-2265. doi:
10.1111/bcp.13330. [PMID: 28511283] - Samel Park, Woo-Il Kim, Dai-Hyun Cho, Yeo-Joo Kim, Hong-Soo Kim, Ji-Hee Kim, Seung-Kuy Cha, Kyu-Sang Park, Ji-Hye Lee, Sang Mi Lee, Eun Young Lee. Adefovir-induced Fanconi syndrome associated with osteomalacia.
Clinical and molecular hepatology.
2017 09; 24(3):339-344. doi:
10.3350/cmh.2017.0009. [PMID: 28859264] - Jueying Lin, Yufeng Zhuo, Dongdong Zhang. Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B.
BMC nephrology.
2017 Aug; 18(1):275. doi:
10.1186/s12882-017-0693-4. [PMID: 28851305] - Annikki de Niet, Louis Jansen, Femke Stelma, Sophie B Willemse, Sjoerd D Kuiken, Sebastiaan Weijer, Carin M J van Nieuwkerk, Hans L Zaaijer, Richard Molenkamp, R Bart Takkenberg, Maarten Koot, Joanne Verheij, Ulrich Beuers, Hendrik W Reesink. Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial.
The lancet. Gastroenterology & hepatology.
2017 08; 2(8):576-584. doi:
10.1016/s2468-1253(17)30083-3. [PMID: 28522204] - Massimo Fasano, Paolo Maggi, Armando Leone, Anna Volpe, Jose Ramon Fiore, Gioacchino Angarano, Teresa Antonia Santantonio. Long-term efficacy and safety of switching from lamivudine+adefovir to tenofovir disoproxil fumarate in virologically suppressed patients.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2017 May; 49(5):530-534. doi:
10.1016/j.dld.2017.01.140. [PMID: 28179096] - Xinbin Zhao, Kun Sun, Zhou Lan, Wenxin Song, Lili Cheng, Wenna Chi, Jing Chen, Yi Huo, Lina Xu, Xiaohui Liu, Haiteng Deng, Julie A Siegenthaler, Ligong Chen. Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Scientific reports.
2017 04; 7(?):46344. doi:
10.1038/srep46344. [PMID: 28397817] - Goh Eun Chung, Eun Ju Cho, Jeong-Hoon Lee, Jeong-Ju Yoo, Minjong Lee, Yuri Cho, Dong Hyeon Lee, Hwi Young Kim, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Fabien Zoulim. Tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis B patients compared to nucleos(t)ide-naïve patients.
Clinical and molecular hepatology.
2017 Mar; 23(1):66-73. doi:
10.3350/cmh.2016.0060. [PMID: 28190329] - Ching-Lung Lai, Danny Wong, Philip Ip, Malgorzata Kopaniszen, Wai-Kay Seto, James Fung, Fung-Yu Huang, Brian Lee, Giuseppe Cullaro, Chun Kong Chong, Ringo Wu, Charles Cheng, John Yuen, Vincent Ngai, Man-Fung Yuen. Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B.
Journal of hepatology.
2017 02; 66(2):275-281. doi:
10.1016/j.jhep.2016.08.022. [PMID: 27639844] - Xinyu Wang, Jing-Lin Gao, Chaohui Du, Jing An, MengJiao Li, Haiyan Ma, Lina Zhang, Ye Jiang. A novel pretreatment method combining sealing technique with direct injection technique applied for improving biosafety.
Bioanalysis.
2017 Jan; 9(2):173-182. doi:
10.4155/bio-2016-0154. [PMID: 27960549] - Marianne Uteng, Andreas Mahl, Nicolau Beckmann, Alessandro Piaia, David Ledieu, Valerie Dubost, Elaine Tritto, Armin Wolf, Pierre Moulin, Li Li, Salah-Dine Chibout, Francois Pognan. Editor's Highlight: Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 01; 155(1):283-297. doi:
10.1093/toxsci/kfw208. [PMID: 27742868] - Hye Won Lee, Jun Yong Park, Beom Kyung Kim, Moon Young Kim, Jung Il Lee, Young Suk Kim, Ki Tae Yoon, Kwang-Hyub Han, Sang Hoon Ahn. Efficacy of switching from adefovir to tenofovir in chronic hepatitis B patients who exhibit suboptimal responses to adefovir-based combination rescue therapy due to resistance to nucleoside analogues (SATIS study).
Clinical and molecular hepatology.
2016 Dec; 22(4):443-449. doi:
10.3350/cmh.2016.0037. [PMID: 27880997] - Ziyue Li, Chuan Shen, Yadong Wang, Wei Wang, Qian Zhao, Zhenzhong Liu, Yang Wang, Caiyan Zhao. Circulating kidney injury molecule-1 is a novel diagnostic biomarker for renal dysfunction during long-term adefovir therapy in chronic hepatitis B.
Medicine.
2016 Nov; 95(44):e5264. doi:
10.1097/md.0000000000005264. [PMID: 27858892] - Tomas Laho, John D Clarke, Anika L Dzierlenga, Hui Li, David M Klein, Michael Goedken, Stanislav Micuda, Nathan J Cherrington. Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.
Biochemical pharmacology.
2016 09; 115(?):144-51. doi:
10.1016/j.bcp.2016.07.001. [PMID: 27381944] - Kyle E Giesler, Jose Marengo, Dennis C Liotta. Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity.
Journal of medicinal chemistry.
2016 08; 59(15):7097-110. doi:
10.1021/acs.jmedchem.6b00428. [PMID: 27405794] - Shaohang Cai, Tao Yu, Yegui Jiang, Yonghong Zhang, Fangfang Lv, Jie Peng. Comparison of entecavir monotherapy and de novo lamivudine and adefovir combination therapy in HBeAg-positive chronic hepatitis B with high viral load: 48-week result.
Clinical and experimental medicine.
2016 Aug; 16(3):429-36. doi:
10.1007/s10238-015-0373-2. [PMID: 26164128] - Cesare Mazzaro, Luigino Dal Maso, Teresa Urraro, Endri Mauro, Laura Castelnovo, Pietro Casarin, Giuseppe Monti, Valter Gattei, Anna Linda Zignego, Gabriele Pozzato. Hepatitis B virus related cryoglobulinemic vasculitis: A multicentre open label study from the Gruppo Italiano di Studio delle Crioglobulinemie - GISC.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2016 Jul; 48(7):780-4. doi:
10.1016/j.dld.2016.03.018. [PMID: 27106525] - S B Willemse, L Jansen, A de Niet, M J Sinnige, R B Takkenberg, J Verheij, N A Kootstra, H W Reesink. Intrahepatic IP-10 mRNA and plasma IP-10 levels as response marker for HBeAg-positive chronic hepatitis B patients treated with peginterferon and adefovir.
Antiviral research.
2016 07; 131(?):148-55. doi:
10.1016/j.antiviral.2016.05.002. [PMID: 27155352] - Qingqing Xiao, Dan Wang, Wanqiu Yang, Lin Chen, Yitao Ding, Jin Yang. Simultaneous determination of pradefovir, PMEA and tenofovir in HBV patient serum using liquid chromatography-tandem mass spectrometry and application to phase 2 clinical trial.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jun; 1022(?):133-140. doi:
10.1016/j.jchromb.2016.04.019. [PMID: 27089519] - Hung-Wen Tsai, Yih-Jyh Lin, Han-Chieh Wu, Ting-Tsung Chang, I-Chin Wu, Pin-Nan Cheng, Chia-Jui Yen, Shih-Huang Chan, Wenya Huang, Ih-Jen Su. Resistance of ground glass hepatocytes to oral antivirals in chronic hepatitis B patients and implication for the development of hepatocellular carcinoma.
Oncotarget.
2016 May; 7(19):27724-34. doi:
10.18632/oncotarget.8388. [PMID: 27027237] - Ye Zhang, Lu Shen, Ying Zhan, Qing-Qing Xiao, Jin Yang. Development and Validation of a Sensitive LC-MS-MS Method for the Determination of Adefovir in Human Serum and Urine: Application to a Clinical Pharmacokinetic Study.
Journal of chromatographic science.
2016 Apr; 54(4):507-15. doi:
10.1093/chromsci/bmv172. [PMID: 26657410] - Tom T G Nieskens, Janny G P Peters, Marieke J Schreurs, Niels Smits, Rob Woestenenk, Katja Jansen, Thom K van der Made, Melanie Röring, Constanze Hilgendorf, Martijn J Wilmer, Rosalinde Masereeuw. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.
The AAPS journal.
2016 Mar; 18(2):465-75. doi:
10.1208/s12248-016-9871-8. [PMID: 26821801] - L Jansen, Neeltje A Kootstra, Karel A van Dort, R Bart Takkenberg, Hendrik W Reesink, Hans L Zaaijer. Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues.
The Journal of infectious diseases.
2016 Jan; 213(2):224-32. doi:
10.1093/infdis/jiv397. [PMID: 26216905] - Ching-Chung Lin, Ming-Jong Bair, Chih-Jen Chen, Keng-Han Lee, Ming-Jen Chen, Chia-Yuan Liu, Chen-Wang Chang, Kuang-Chun Hu, Tai-Cherng Liou, Shee-Chan Lin, Horng-Yuan Wang, Cheng-Hsin Chu, Shou-Chuan Shih, Tsang-En Wang. Off-treatment efficacy of 3-year nucleos(t)ide analogues in chronic hepatitis B patients.
The Kaohsiung journal of medical sciences.
2016 Jan; 32(1):10-5. doi:
10.1016/j.kjms.2015.11.005. [PMID: 26853169] - Myung Jin Oh, Heon Ju Lee. Antiviral efficacy of entecavir versus entecavir plus adefovir for hepatitis B virus rtA181V/T mutants alone.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.
2016 Jan; 22(1):37-42. doi:
10.4103/1319-3767.173757. [PMID: 26831605] - Ming-Tsung Lin, Yi-Hao Yen, Ming-Chao Tsai, Po-Lin Tseng, Kuo-Chin Chang, Cheng-Kun Wu, Tsung-Hui Hu. Comparison of the Efficacies and Safety of Combined Therapy between Telbivudine Plus Adefovir and Lamivudine Plus Adefovir in Patients with Hepatitis B Virus Infection in Real-World Practice.
PloS one.
2016; 11(11):e0165416. doi:
10.1371/journal.pone.0165416. [PMID: 27806120] - Aung Myint Thu, Kittiyod Poovorawan, Chatporn Kittitrakul, Apichart Nontprasert, Natthida Sriboonvorakul, Weerapong Phumratanaprapin, Pisit Tangkijvanich, Wattana Leowattana, Polrat Wilairatana. Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand.
BMC pharmacology & toxicology.
2015 Dec; 16(?):38. doi:
10.1186/s40360-015-0037-6. [PMID: 26651337] - Pietro Lampertico, Federica Invernizzi, Mauro Viganò, Alessandro Loglio, Giampaolo Mangia, Floriana Facchetti, Massimo Primignani, Manol Jovani, Massimo Iavarone, Mirella Fraquelli, Giovanni Casazza, Roberto de Franchis, Massimo Colombo. The long-term benefits of nucleos(t)ide analogs in compensated HBV cirrhotic patients with no or small esophageal varices: A 12-year prospective cohort study.
Journal of hepatology.
2015 Nov; 63(5):1118-25. doi:
10.1016/j.jhep.2015.06.006. [PMID: 26100495] - Jia Lian, Tao Han, Huiling Xiang, Fang Liu, Hongmin Lyu, Yanying Gao, Fengmei Wang. [A randomized controlled trial on 240-week monotherapy with entecavir or adefovir in patients with chronic hepatitis B and cirrhosis].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2015 Oct; 23(10):733-7. doi:
10.3760/cma.j.issn.1007-3418.2015.10.005. [PMID: 26573188] - Jae Geun Lee, Juhan Lee, Jung Jun Lee, Seung Hwan Song, Man Ki Ju, Gi Hong Choi, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim, Dong Jin Joo. Adefovir- or Lamivudine-Induced Renal Tubular Dysfunction after Liver Transplantation.
Medicine.
2015 Sep; 94(38):e1569. doi:
10.1097/md.0000000000001569. [PMID: 26402818] - Jung Gil Park, Soo Young Park. Entecavir plus tenofovir versus entecavir plus adefovir in chronic hepatitis B patients with a suboptimal response to lamivudine and adefovir combination therapy.
Clinical and molecular hepatology.
2015 Sep; 21(3):242-8. doi:
10.3350/cmh.2015.21.3.242. [PMID: 26523269] - Yuri Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Hyo-Suk Lee, Yoon Jun Kim. Comparison of the efficacies of entecavir 0.5 and 1.0 mg combined with adefovir in patients with chronic hepatitis B who had failed on prior nucleos(t)ide analogue treatments.
Journal of medical virology.
2015 Jun; 87(6):999-1007. doi:
10.1002/jmv.24150. [PMID: 25711201] - Wenhao Hua, Guanbin Zhang, Shujun Guo, Weijie Li, Lanhua Sun, Guangxin Xiang. Microarray-based genotyping and detection of drug-resistant HBV mutations from 620 Chinese patients with chronic HBV infection.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.
2015 May; 19(3):291-5. doi:
10.1016/j.bjid.2015.03.012. [PMID: 25982306] - Mojgan Pourfarzib, Rasoul Dinarvand, Behrouz Akbari-Adergani, Ali Mehramizi, Hossein Rastegar, Maryam Shekarchi. Water-compatible molecularly imprinted polymer as a sorbent for the selective extraction and purification of adefovir from human serum and urine.
Journal of separation science.
2015 May; 38(10):1755-62. doi:
10.1002/jssc.201401492. [PMID: 25763883] - Paolo Maggi, Vincenzo Montinaro, Armando Leone, Massimo Fasano, Anna Volpe, Chiara Bellacosa, Vito Grattagliano, Laura Coladonato, Giovanni Lapadula, Teresa Santantonio, Gioacchino Angarano. Bone and kidney toxicity induced by nucleotide analogues in patients affected by HBV-related chronic hepatitis: a longitudinal study.
The Journal of antimicrobial chemotherapy.
2015 Apr; 70(4):1150-4. doi:
10.1093/jac/dku502. [PMID: 25525197] - Xun Qi, Jinyu Wang, Liang Chen, Yuxian Huang, Yanli Qin, Richeng Mao, Jiming Zhang. Impact of nucleos(t)ide analogue combination therapy on the estimated glomerular filtration rate in patients with chronic hepatitis B.
Medicine.
2015 Apr; 94(15):e646. doi:
10.1097/md.0000000000000646. [PMID: 25881837] - Dan-Hong Yang, Yuan-Jun Xie, Nian-Feng Zhao, Hong-Ying Pan, Ming-Wei Li, Hai-Jun Huang. Tenofovir disoproxil fumarate is superior to lamivudine plus adefovir in lamivudine-resistant chronic hepatitis B patients.
World journal of gastroenterology.
2015 Mar; 21(9):2746-53. doi:
10.3748/wjg.v21.i9.2746. [PMID: 25759545] - Xiaodong Li, Lihong Jiang, Fan Li, Yan Liu, Jiuzeng Dai, Pan Zhao, Yaqun Qin, Jin Li, Dongping Xu. [Clinical emergence features and implications of hepatitis B virus rtA181T mutation].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2015 Jan; 23(1):23-7. doi:
10.3760/cma.j.issn.1007-3418.2015.01.007. [PMID: 25751382] - In-Soo Yoon, Jun-Hyeng Son, Sang-Bum Kim, Min-Koo Choi, Han-Joo Maeng. Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats.
Biological & pharmaceutical bulletin.
2015; 38(11):1732-7. doi:
10.1248/bpb.b15-00356. [PMID: 26521823] - Maria Antonia De Francesco, Franco Gargiulo, Angiola Spinetti, Serena Zaltron, Cinzia Giagulli, Francesca Caccuri, Francesco Castelli, Arnaldo Caruso. Clinical course of chronic hepatitis B patients receiving nucleos(t)ide analogues after virological breakthrough during monotherapy with lamivudine.
The new microbiologica.
2015 Jan; 38(1):29-37. doi:
NULL. [PMID: 25742145] - M Lee, S Oh, H J Lee, T-S Yeum, J-H Lee, S J Yu, H Y Kim, J-H Yoon, H-S Lee, Y J Kim. Telbivudine protects renal function in patients with chronic hepatitis B infection in conjunction with adefovir-based combination therapy.
Journal of viral hepatitis.
2014 Dec; 21(12):873-81. doi:
10.1111/jvh.12217. [PMID: 24351112] - Louis Jansen, Annikki de Niet, Femke Stelma, Erik P A van Iperen, Karel A van Dort, Marjan J Tempelmans Plat-Sinnige, R Bart Takkenberg, Daniel J Chin, A H Koos Zwinderman, Uri Lopatin, Neeltje A Kootstra, Hendrik W Reesink. HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels.
Journal of hepatology.
2014 Oct; 61(4):730-7. doi:
10.1016/j.jhep.2014.05.004. [PMID: 24824278] - Teng Zeng, Hua Xu, Jun-Ying Liu, Yu Lei, Shan Zhong, Zhi Zhou. Entecavir plus adefovir combination therapy versus lamivudine add-on adefovir for lamivudine-resistant chronic hepatitis B: A meta-analysis.
Journal of clinical pharmacology.
2014 Sep; 54(9):959-67. doi:
10.1002/jcph.351. [PMID: 24964070] - Ying Ge, Deming Li, Yunming Fan, Haihong Yang, Wei Lyu, Hongwei Fan, Baotong Zhou, Xiaoqing Liu, Zhengyin Liu. [Tenofovir rescue therapy for chronic hepatitis B patients after suboptimal response to treatment with lamivudine plus adefovir dipivoxil].
Zhonghua nei ke za zhi.
2014 Sep; 53(9):697-700. doi:
. [PMID: 25511401] - Kazuya Maeda, Ying Tian, Tomoe Fujita, Yasuhiko Ikeda, Yuji Kumagai, Tsunenori Kondo, Kazunari Tanabe, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara, Yuichi Sugiyama. Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Aug; 59(?):94-103. doi:
10.1016/j.ejps.2014.04.004. [PMID: 24747579] - Yu-Hua Liu, Tao Wu, Ning Sun, Guang-Li Wang, Jian-Zhi Yuan, Yu-Rong Dai, Xiao-Hui Zhou. Combination therapy with pegylated interferon alpha-2b and adefovir dipivoxil in HBeAg-positive chronic hepatitis B versus interferon alone: a prospective, randomized study.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2014 Aug; 34(4):542-547. doi:
10.1007/s11596-014-1312-2. [PMID: 25135724] - Michele Barone, Andrea Iannone, Alfredo Di Leo. HBsAg clearance by Peg-interferon addition to a long-term nucleos(t)ide analogue therapy.
World journal of gastroenterology.
2014 Jul; 20(26):8722-5. doi:
10.3748/wjg.v20.i26.8722. [PMID: 25024631] - Hyun Young Woo, Jong Young Choi, Seung Kew Yoon, Dong Jin Suh, Seung Woon Paik, Kwang Hyub Han, Soon Ho Um, Byung Ik Kim, Heon Ju Lee, Mong Cho, Chun Kyon Lee, Dong Joon Kim, Jae Seok Hwang. Rescue therapy with adefovir in decompensated liver cirrhosis patients with lamivudine-resistant hepatitis B virus.
Clinical and molecular hepatology.
2014 Jun; 20(2):168-76. doi:
10.3350/cmh.2014.20.2.168. [PMID: 25032183] - Joonhee Park, Jin-Oh Kwak, Brigitte Riederer, Ursula Seidler, Susan P C Cole, Hwa Jeong Lee, Min Goo Lee. Na⁺/H⁺ exchanger regulatory factor 3 is critical for multidrug resistance protein 4-mediated drug efflux in the kidney.
Journal of the American Society of Nephrology : JASN.
2014 Apr; 25(4):726-36. doi:
10.1681/asn.2013040438. [PMID: 24436471] - J-H Cho, J-H Lim, G-Y Park, J-S Kim, Y-J Kang, O Kwon, J-Y Choi, S-H Park, Y-L Kim, H-K Kim, S Huh, C-D Kim. Successful withdrawal of antiviral treatment in kidney transplant recipients with chronic hepatitis B viral infection.
Transplant infectious disease : an official journal of the Transplantation Society.
2014 Apr; 16(2):295-303. doi:
10.1111/tid.12202. [PMID: 24628837] - James Fung, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen. Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
Journal of gastroenterology and hepatology.
2014 Mar; 29(3):428-34. doi:
10.1111/jgh.12499. [PMID: 24372662] - Cristina Pérez-Cameo, Mònica Pons, Rafael Esteban. New therapeutic perspectives in HBV: when to stop NAs.
Liver international : official journal of the International Association for the Study of the Liver.
2014 Feb; 34 Suppl 1(?):146-53. doi:
10.1111/liv.12398. [PMID: 24373092] - Michela Triolo, Cristina Della Corte, Massimo Colombo. Impact of HBV therapy on the incidence of hepatocellular carcinoma.
Liver international : official journal of the International Association for the Study of the Liver.
2014 Feb; 34 Suppl 1(?):139-45. doi:
10.1111/liv.12394. [PMID: 24373091] - Hyung Joon Yim, Hyun Jung Lee, Sang Jun Suh, Yeon Seok Seo, Chang Wook Kim, Chang Don Lee, Sang Hoon Park, Myung Seok Lee, Choong Kee Park, Hee Bok Chae, Moon Young Kim, Soon Koo Baik, Yun Soo Kim, Ju Hyun Kim, Jung Il Lee, Jin Woo Lee, Sun Pyo Hong, Soon Ho Um. Adefovir and lamivudine combination therapy in patients with entecavir-resistant chronic hepatitis B: antiviral responses and evolution of mutations.
Intervirology.
2014; 57(5):239-47. doi:
10.1159/000360399. [PMID: 24993731] - Tomohiro Terasaka, Eijiro Ueta, Hirotaka Ebara, Koichi Waseda, Yoshihisa Hanayama, Akinobu Takaki, Tomoko Kawabata, Hitoshi Sugiyama, Ko Hidani, Fumio Otsuka. Long-term observation of osteomalacia caused by adefovir-induced Fanconi's syndrome.
Acta medica Okayama.
2014; 68(1):53-6. doi:
10.18926/amo/52145. [PMID: 24553490] - C Pipili, E Cholongitas, G Papatheodoridis. Review article: nucleos(t)ide analogues in patients with chronic hepatitis B virus infection and chronic kidney disease.
Alimentary pharmacology & therapeutics.
2014 Jan; 39(1):35-46. doi:
10.1111/apt.12538. [PMID: 24299322] - Linda Ichchou, Stéphanie Rist, Eric Lespessailles, Dominique Prié, Claude-Laurent Benhamou. Reversible increase in FGF23 in a hypophosphatemic renal and bone disease linked to antiviral therapy by adefovir.
Joint bone spine.
2013 Dec; 80(6):668-9. doi:
10.1016/j.jbspin.2013.02.014. [PMID: 23583281] - Faye Wang, Oliver P Flint. BMS-986001, an HIV nucleoside reverse transcriptase inhibitor, does not degrade mitochondrial DNA in long-term primary cultures of cells isolated from human kidney, muscle, and adipose tissue.
Antimicrobial agents and chemotherapy.
2013 Dec; 57(12):6205-12. doi:
10.1128/aac.01206-13. [PMID: 24080659] - Wai-Kay Seto, Kevin Liu, Danny Ka-Ho Wong, James Fung, Fung-Yu Huang, Ivan Fan-Ngai Hung, Ching-Lung Lai, Man-Fung Yuen. Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment.
Journal of hepatology.
2013 Oct; 59(4):709-16. doi:
10.1016/j.jhep.2013.06.007. [PMID: 23792029] - Jana Mandíková, Marie Volková, Petr Pávek, Michal Česnek, Zlatko Janeba, Vladimír Kubíček, František Trejtnar. Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates.
Toxicology.
2013 Sep; 311(3):135-46. doi:
10.1016/j.tox.2013.07.004. [PMID: 23856525] - Qing-Wei Du, Ji-Guang Ding, Qing-Feng Sun, Liang Hong, Fu-Jing Cai, Qing-Qing Zhou, Yang-He Wu, Rong-Quan Fu. Combination lamivudine and adefovir versus entecavir for the treatment of naïve chronic hepatitis B patients: a pilot study.
Medical science monitor : international medical journal of experimental and clinical research.
2013 Sep; 19(?):751-6. doi:
10.12659/msm.889443. [PMID: 24019010] - Yu Fukuda, Kazumasa Takenaka, Alex Sparreboom, Satish B Cheepala, Chung-Pu Wu, Sean Ekins, Suresh V Ambudkar, John D Schuetz. Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.
Molecular pharmacology.
2013 Sep; 84(3):361-71. doi:
10.1124/mol.113.086967. [PMID: 23775562] - Sibel Aydoğan, Koray Ergünay, Yasemin Balaban, Alpaslan Alp, Halis Simşek, Gonca Tatar, Gülşen Hasçelik, Dürdal Us. [Detection of resistance mutations in chronic hepatitis B patients receiving antiviral therapy for over one year].
Mikrobiyoloji bulteni.
2013 Jul; 47(3):472-81. doi:
10.5578/mb.5625. [PMID: 23971924] - Zhen-huan Cao, Li-na Ma, Ya-li Liu, Yi Jin, Zhi-min He, Jun-feng Lu, Yong-hong Zhang, Xin-yue Chen. [Efficacy and safety of peginterferon alfa-2a (40 kd) plus adefovir for 96 weeks in HBeAg-negative chronic hepatitis B patients].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2013 Jul; 21(7):498-501. doi:
10.3760/cma.j.issn.1007-3418.2013.07.006. [PMID: 24074706] - Young-Suk Lim, Ji-Young Lee, Danbi Lee, Ju Hyun Shim, Han Chu Lee, Yung Sang Lee, Dong Jin Suh. Randomized trial of the virologic response during up to two years of entecavir-adefovir combination therapy in multiple-drug-refractory chronic hepatitis B virus patients.
Antimicrobial agents and chemotherapy.
2013 Jul; 57(7):3369-74. doi:
10.1128/aac.00587-13. [PMID: 23650172] - Norah Terrault. Prophylaxis in HBV-infected liver transplant patients: end of the HBIG era?.
The American journal of gastroenterology.
2013 Jun; 108(6):949-51. doi:
10.1038/ajg.2013.122. [PMID: 23735916] - R Salpini, C Alteri, V Cento, M Pollicita, V Micheli, G Gubertini, G M De Sanctis, M Visca, S Romano, C Sarrecchia, M Andreoni, M Angelico, G Parruti, V Svicher, C F Perno. Snapshot on drug-resistance rate and profiles in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice.
Journal of medical virology.
2013 Jun; 85(6):996-1004. doi:
10.1002/jmv.23567. [PMID: 23588725] - Xian-Hua Xu, Gai-Li Li, Yang Qin, Qiang Li, Fa-Qun He, Jin-Ye Li, Quan-Rong Pan, Jie-Yin Deng. Entecavir plus adefovir rescue therapy for chronic hepatitis B patients after multiple treatment failures in real-life practice.
Virology journal.
2013 May; 10(?):162. doi:
10.1186/1743-422x-10-162. [PMID: 23706010] - Emanuele Durante-Mangoni, Domenico Iossa, Daniela Pinto, Rosa Molaro, Federica Agrusta, Cristiano Amarelli, Enrico Ragone, Maria Grimaldi, Ciro Maiello, Riccardo Utili. Adefovir treatment for chronic hepatitis B in heart transplant recipients.
Clinical transplantation.
2013 May; 27(3):E282-8. doi:
10.1111/ctr.12109. [PMID: 23517019] - J L Hartono, M O Aung, Y Y Dan, M Gowans, K Lim, Y M Lee, G H Lee, H C Low, P S Tan, M A Thwin, C Soon, L-L Chiu, M J Khoo, E Koay, S G Lim. Resolution of adefovir-related nephrotoxicity by adefovir dose-reduction in patients with chronic hepatitis B.
Alimentary pharmacology & therapeutics.
2013 Apr; 37(7):710-9. doi:
10.1111/apt.12251. [PMID: 23432107] - Edward J Gane, Scott Patterson, Simone I Strasser, Geoffrey W McCaughan, Peter W Angus. Combination of lamivudine and adefovir without hepatitis B immune globulin is safe and effective prophylaxis against hepatitis B virus recurrence in hepatitis B surface antigen-positive liver transplant candidates.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2013 Mar; 19(3):268-74. doi:
10.1002/lt.23600. [PMID: 23447403] - Fenglei Li, Hairong Wei, Haiming Wei, Yufeng Gao, Long Xu, Wenwei Yin, Rui Sun, Zhigang Tian. Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice.
Gastroenterology.
2013 Feb; 144(2):392-401. doi:
10.1053/j.gastro.2012.10.039. [PMID: 23103614] - Dwayne M Baxa, Ashish D Thekdi, Alicia Golembieski, Prashant V Krishnan, Omar Sharif, Anne Kizy, Lynne Shetron-Rama, John Jovanovich, Brandi J Chappell, Andrea Snow-Lampart, Katyna Borroto-Esoda, Stuart C Gordon. Evaluation of anti-HBV drug resistant mutations among patients with acute symptomatic hepatitis B in the United States.
Journal of hepatology.
2013 Feb; 58(2):212-6. doi:
10.1016/j.jhep.2012.09.014. [PMID: 23022497] - Ersin Karatayli, Ramazan Idilman, Senem C Karatayli, Emrah Cevik, Mustafa Yakut, Gülseren Seven, Gökhan Kabaçam, A Mithat Bozdayi, Cihan Yurdaydin. Clonal analysis of the quasispecies of antiviral-resistant HBV genomes in patients with entecavir resistance during rescue treatment and successful treatment of entecavir resistance with tenofovir.
Antiviral therapy.
2013; 18(1):77-85. doi:
10.3851/imp2294. [PMID: 22878399] - Hakan Alagozlu, Oztürk Ozdemir, Binnur Koksal, Abdulkerim Yilmaz, Mahmut Coskun. Prevelance of common YMDD motif mutations in long term treated chronic HBV infections in a Turkish population.
Asian Pacific journal of cancer prevention : APJCP.
2013; 14(9):5489-94. doi:
10.7314/apjcp.2013.14.9.5489. [PMID: 24175847] - Young Eun Chon, Jun Yong Park, Sang Hoon Ahn, Do Young Kim, Kwang-Hyub Han, Chae Yoon Chon, Ara Choi, Seung Up Kim. Partial virological response to adefovir add-on lamivudine rescue therapy in patients with lamivudine-resistant chronic hepatitis B.
Digestion.
2013; 87(3):196-203. doi:
10.1159/000348853. [PMID: 23689059] - Hana Park, Jun Yong Park, Seung Up Kim, Do Young Kim, Kwang-Hyub Han, Chae Yoon Chon, Sang Hoon Ahn. Efficacy of switching to telbivudine plus adefovir in suboptimal responders to lamivudine plus adefovir.
World journal of gastroenterology.
2013; 19(43):7671-9. doi:
10.3748/wjg.v19.i43.7671. [PMID: 24431895] - Alessandra Maciel Almeida, Anderson Lourenço da Silva, Cristina Mariano Ruas Brandão, Mariângela Leal Cherchiglia, Eli Iola Gurgel Andrade, Gustavo Laine Araújo de Oliveira, Ricardo Andrade Carmo, Francisco de Assis Acurcio. [Cost-effectiveness of nucleoside/nucleotide analogues in chronic hepatitis B].
Revista de saude publica.
2012 Dec; 46(6):942-9. doi:
NULL. [PMID: 23503535] - Soon Young Ko, Byung Kook Kim, So Young Kwon, Kyun-Hwan Kim, Jeong Han Kim, Won Hyeok Choe, Chang Hong Lee. Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment.
World journal of gastroenterology.
2012 Nov; 18(44):6437-46; discussion p.6445. doi:
10.3748/wjg.v18.i44.6437. [PMID: 23197889]