Imetit (BioDeep_00000011970)

 

Secondary id: BioDeep_00001869147

human metabolite blood metabolite


代谢物信息卡片


{[2-(1H-imidazol-5-yl)ethyl]sulfanyl}methanimidamide

化学式: C6H10N4S (170.062614)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 83.33%

分子结构信息

SMILES: C(CSC(=N)N)c1c[nH]cn1
InChI: InChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10)

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D017442 - Histamine Agonists

同义名列表

4 个代谢物同义名

{[2-(1H-imidazol-5-yl)ethyl]sulfanyl}methanimidamide; 2-(1H-Imidazol-5-yl)ethyl imidothiocarbamate; S-(2-(4-Imidazolyl)ethyl)isothiourea; imetit



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • C Hass, B P Panda, R Khanam, A K Najmi, M Akhtar. Histamine H3 Receptor Agonist Imetit Attenuated Isoproterenol Induced Renin Angiotensin System and Sympathetic Nervous System Overactivity in Myocardial Infarction of Rats. Drug research. 2016 Jun; 66(6):324-9. doi: 10.1055/s-0035-1569448. [PMID: 27011384]
  • Chander Hass Yadav, Abul Kalam Najmi, Mohd Akhtar, Razia Khanam. Cardioprotective role of H₃R agonist imetit on isoproterenol-induced hemodynamic changes and oxidative stress in rats. Toxicology mechanisms and methods. 2015; 25(4):235-40. doi: 10.3109/15376516.2014.997946. [PMID: 25496245]
  • Melanie B Henry, Shuqin Zheng, Chenxia Duan, Bhuneshwari Patel, Galya Vassileva, Christopher Sondey, Jean Lachowicz, Joyce J Hwa. Antidiabetic properties of the histamine H3 receptor protean agonist proxyfan. Endocrinology. 2011 Mar; 152(3):828-35. doi: 10.1210/en.2010-0757. [PMID: 21239440]
  • Cm Kurz, U Baranowska, S Lupiński, M Göthert, B Malinowska, E Schlicker. Urethane, but not pentobarbitone, attenuates presynaptic receptor function in rats: a contribution to the choice of anaesthetic. British journal of pharmacology. 2009 Aug; 157(8):1474-82. doi: 10.1111/j.1476-5381.2009.00315.x. [PMID: 19681871]
  • Ruggero Galici, Jamin D Boggs, Leah Aluisio, Ian C Fraser, Pascal Bonaventure, Brian Lord, Timothy W Lovenberg. JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. Neuropharmacology. 2009 Jun; 56(8):1131-7. doi: 10.1016/j.neuropharm.2009.03.011. [PMID: 19345233]
  • Ryo Yoshimoto, Yasuhisa Miyamoto, Ken Shimamura, Akane Ishihara, Kazuhiko Takahashi, Hidehito Kotani, Airu S Chen, Howard Y Chen, Douglas J Macneil, Akio Kanatani, Shigeru Tokita. Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. 2006 Sep; 103(37):13866-71. doi: 10.1073/pnas.0506104103. [PMID: 16954192]
  • Kathleen M Krueger, David G Witte, Lynne Ireland-Denny, Thomas R Miller, John L Baranowski, Steve Buckner, Ivan Milicic, Timothy A Esbenshade, Arthur A Hancock. G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. The Journal of pharmacology and experimental therapeutics. 2005 Jul; 314(1):271-81. doi: 10.1124/jpet.104.078865. [PMID: 15821027]
  • Hanneke Pm van der Kleij, John Bienenstock. Significance of Conversation between Mast Cells and Nerves. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 2005 Jun; 1(2):65-80. doi: 10.1186/1710-1492-1-2-65. [PMID: 20529227]
  • Kazuhiko Takahashi, Shigeru Tokita, Hidehito Kotani. Generation and characterization of highly constitutive active histamine H3 receptors. The Journal of pharmacology and experimental therapeutics. 2003 Oct; 307(1):213-8. doi: 10.1124/jpet.103.053249. [PMID: 12954820]
  • Jingcai Chen, Changlu Liu, Timothy W Lovenberg. Molecular and pharmacological characterization of the mouse histamine H3 receptor. European journal of pharmacology. 2003 Apr; 467(1-3):57-65. doi: 10.1016/s0014-2999(03)01635-2. [PMID: 12706455]
  • Astrid Sasse, Xavier Ligneau, Agnès Rouleau, Sigurd Elz, C Robin Ganellin, Jean-Michel Arrang, Jean-Charles Schwartz, Walter Schunack, Holger Stark. Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. Journal of medicinal chemistry. 2002 Aug; 45(18):4000-10. doi: 10.1021/jm020910m. [PMID: 12190321]
  • Y Zhu, D Michalovich, H Wu, K B Tan, G M Dytko, I J Mannan, R Boyce, J Alston, L A Tierney, X Li, N C Herrity, L Vawter, H M Sarau, R S Ames, C M Davenport, J P Hieble, S Wilson, D J Bergsma, L R Fitzgerald. Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Molecular pharmacology. 2001 Mar; 59(3):434-41. doi: 10.1124/mol.59.3.434. [PMID: 11179436]