Bombykol (BioDeep_00000011455)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


hexadeca-10E,12Z-dien-1-ol

化学式: C16H30O (238.2297)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 3.53%

分子结构信息

SMILES: C(=C/C=C\CCC)\CCCCCCCCCO
InChI: InChI=1S/C16H30O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h4-7,17H,2-3,8-16H2,1H3/b5-4-,7-6+

描述信息

Bombykol, the first insect sex pheromone, is identified as the female-produced sex attractant of the silkworm moth Bombyx mori[1][2][3].

同义名列表

7 个代谢物同义名

Bombykol; hexadeca-10E,12Z-dien-1-ol; 10E,12Z-hexadecadien-1-ol; FOH 16:2; 10,12-Hexadecadien-1-ol; Isobombycol; Bombykol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ALDOB, CD36, DST
Endoplasmic reticulum membrane 2 DST, HMGCR
Nucleus 2 DST, PLCZ1
cytosol 6 AKR1A1, ALDOB, DST, LIPE, PLCZ1, PPAT
phagocytic vesicle 1 CD36
nucleoplasm 2 DST, PLCZ1
Cell membrane 4 CD36, DST, GPRC5A, LIPE
Lipid-anchor 1 DST
Cell projection, axon 1 DST
Multi-pass membrane protein 4 CATSPER3, CD36, GPRC5A, HMGCR
Synapse 1 AKR1A1
cell cortex 1 DST
cell junction 1 DST
cell surface 1 CD36
Golgi apparatus 2 ATRN, CD36
Cytoplasm, cytosol 3 AKR1A1, ALDOB, LIPE
acrosomal vesicle 1 CATSPER3
plasma membrane 5 ATRN, CATSPER3, CD36, DST, GPRC5A
Membrane 4 CD36, DST, HMGCR, LIPE
apical plasma membrane 2 AKR1A1, CD36
axon 1 DST
caveola 2 CD36, LIPE
extracellular exosome 4 AKR1A1, ALDOB, ATRN, GPRC5A
endoplasmic reticulum 2 CATSPER3, HMGCR
extracellular space 3 AKR1A1, ATRN, CD36
perinuclear region of cytoplasm 1 PLCZ1
intracellular membrane-bounded organelle 1 GPRC5A
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 ATRN
Single-pass membrane protein 1 DST
[Isoform 2]: Secreted 1 ATRN
centriolar satellite 1 ALDOB
motile cilium 1 CATSPER3
external side of plasma membrane 1 CD36
actin cytoskeleton 1 DST
Z disc 1 DST
cytoplasmic vesicle 1 DST
microtubule cytoskeleton 1 DST
nucleolus 2 GPRC5A, PLCZ1
axon cytoplasm 1 DST
vesicle 1 GPRC5A
Apical cell membrane 2 AKR1A1, CD36
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 CD36
Cytoplasm, cytoskeleton 1 DST
focal adhesion 1 DST
microtubule 1 DST
basement membrane 1 DST
collagen trimer 1 CD36
peroxisomal membrane 1 HMGCR
intermediate filament 1 DST
receptor complex 2 CD36, GPRC5A
cell leading edge 1 DST
cell projection 1 DST
cell periphery 1 CD36
cytoskeleton 1 DST
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite 1 ALDOB
brush border membrane 1 CD36
Cytoplasm, cell cortex 1 DST
[Isoform 3]: Secreted 1 ATRN
nuclear envelope 1 DST
Nucleus envelope 1 DST
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
microtubule organizing center 1 ALDOB
Cell projection, cilium, flagellum membrane 1 CATSPER3
Cytoplasmic vesicle membrane 1 GPRC5A
specific granule membrane 1 CD36
intermediate filament cytoskeleton 1 DST
Peroxisome membrane 1 HMGCR
stress fiber 1 DST
basal plasma membrane 1 DST
endocytic vesicle membrane 1 CD36
microtubule plus-end 1 DST
Cytoplasm, cytoskeleton, stress fiber 1 DST
H zone 1 DST
[Isoform 1]: Cytoplasm, cytoskeleton 1 DST
[Isoform 1]: Cell membrane 1 ATRN
platelet alpha granule membrane 1 CD36
sperm head 1 PLCZ1
hemidesmosome 1 DST
CatSper complex 1 CATSPER3
Cytoplasm, myofibril, sarcomere, H zone 1 DST
[Isoform 2]: Cytoplasm, cytoskeleton 1 DST
[Isoform 6]: Nucleus 1 DST
[Isoform 7]: Cytoplasm, cytoskeleton 1 DST
[Isoform 8]: Cytoplasm, cytoskeleton 1 DST
organelle 1 DST


文献列表

  • Mengfang Du, Xiaoguang Liu, Xiaoming Liu, Xinming Yin, Shuangyin Han, Qisheng Song, Shiheng An. Glycerol-3-phosphate O-acyltransferase is required for PBAN-induced sex pheromone biosynthesis in Bombyx mori. Scientific reports. 2015 Jan; 5(?):8110. doi: 10.1038/srep08110. [PMID: 25630665]
  • Song-Dou Zhang, Xun Li, Zhu Bin, Meng-Fang Du, Xin-Ming Yin, Shi-Heng An. Molecular identification of a pancreatic lipase-like gene involved in sex pheromone biosynthesis of Bombyx mori. Insect science. 2014 Aug; 21(4):459-68. doi: 10.1111/1744-7917.12053. [PMID: 23955937]
  • Mengfang Du, Songdou Zhang, Bin Zhu, Xinming Yin, Shiheng An. Identification of a diacylglycerol acyltransferase 2 gene involved in pheromone biosynthesis activating neuropeptide stimulated pheromone production in Bombyx mori. Journal of insect physiology. 2012 May; 58(5):699-703. doi: 10.1016/j.jinsphys.2012.02.002. [PMID: 22387497]
  • Eriko Harada, Jun Nakagawa, Tsunaki Asano, Masato Taoka, Hiroyuki Sorimachi, Yoshihiro Ito, Toshiro Aigaki, Takashi Matsuo. Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila. PloS one. 2012; 7(1):e29710. doi: 10.1371/journal.pone.0029710. [PMID: 22238638]
  • Mengfang Du, Xinming Yin, Songdou Zhang, Bin Zhu, Qisheng Song, Shiheng An. Identification of lipases involved in PBAN stimulated pheromone production in Bombyx mori using the DGE and RNAi approaches. PloS one. 2012; 7(2):e31045. doi: 10.1371/journal.pone.0031045. [PMID: 22359564]
  • Ken-Ichi Moto, Shogo Matsumoto. Construction of an in vivo system for functional analysis of the genes involved in sex pheromone production in the silkmoth, Bombyx mori. Frontiers in endocrinology. 2012; 3(?):30. doi: 10.3389/fendo.2012.00030. [PMID: 22649415]
  • Nina Deisig, Jan Kropf, Simon Vitecek, Delphine Pevergne, Angela Rouyar, Jean-Christophe Sandoz, Philippe Lucas, Christophe Gadenne, Sylvia Anton, Romina Barrozo. Differential interactions of sex pheromone and plant odour in the olfactory pathway of a male moth. PloS one. 2012; 7(3):e33159. doi: 10.1371/journal.pone.0033159. [PMID: 22427979]
  • Jiao Yin, Honglin Feng, Hongyan Sun, Jinghui Xi, Yazhong Cao, Kebin Li. Functional analysis of general odorant binding protein 2 from the meadow moth, Loxostege sticticalis L. (Lepidoptera: Pyralidae). PloS one. 2012; 7(3):e33589. doi: 10.1371/journal.pone.0033589. [PMID: 22479417]
  • Atsushi Ohnishi, J Joe Hull, Misato Kaji, Kana Hashimoto, Jae Min Lee, Kazuhide Tsuneizumi, Takehiro Suzuki, Naoshi Dohmae, Shogo Matsumoto. Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca2+/calmodulin-dependent protein kinase II-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage droplet protein-1 (BmLsd1). The Journal of biological chemistry. 2011 Jul; 286(27):24101-12. doi: 10.1074/jbc.m111.250555. [PMID: 21572162]
  • Atsushi Ohnishi, Misato Kaji, Kana Hashimoto, Shogo Matsumoto. Screening for the Genes Involved in Bombykol Biosynthesis: Identification and Functional Characterization of Bombyx mori Acyl Carrier Protein. Frontiers in endocrinology. 2011; 2(?):92. doi: 10.3389/fendo.2011.00092. [PMID: 22649392]
  • Angela Rouyar, Virginie Party, Janez Prešern, Andrej Blejec, Michel Renou. A general odorant background affects the coding of pheromone stimulus intermittency in specialist olfactory receptor neurones. PloS one. 2011; 6(10):e26443. doi: 10.1371/journal.pone.0026443. [PMID: 22028879]
  • Kevin W Wanner, Andrew S Nichols, Jean E Allen, Peggy L Bunger, Stephen F Garczynski, Charles E Linn, Hugh M Robertson, Charles W Luetje. Sex pheromone receptor specificity in the European corn borer moth, Ostrinia nubilalis. PloS one. 2010 Jan; 5(1):e8685. doi: 10.1371/journal.pone.0008685. [PMID: 20084285]
  • Ewald Große-Wilde, Regina Stieber, Maike Forstner, Jürgen Krieger, Dieter Wicher, Bill S Hansson. Sex-specific odorant receptors of the tobacco hornworm manduca sexta. Frontiers in cellular neuroscience. 2010; 4(?):. doi: 10.3389/fncel.2010.00022. [PMID: 20725598]
  • Ya-Long Xu, Peng He, Lan Zhang, Shao-Qing Fang, Shuang-Lin Dong, Yong-Jun Zhang, Fei Li. Large-scale identification of odorant-binding proteins and chemosensory proteins from expressed sequence tags in insects. BMC genomics. 2009 Dec; 10(?):632. doi: 10.1186/1471-2164-10-632. [PMID: 20034407]
  • Quan-You Yu, Cheng Lu, Wen-Le Li, Zhong-Huai Xiang, Ze Zhang. Annotation and expression of carboxylesterases in the silkworm, Bombyx mori. BMC genomics. 2009 Nov; 10(?):553. doi: 10.1186/1471-2164-10-553. [PMID: 19930670]
  • Karl-Ernst Kaissling. Olfactory perireceptor and receptor events in moths: a kinetic model revised. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 2009 Oct; 195(10):895-922. doi: 10.1007/s00359-009-0461-4. [PMID: 19697043]
  • Jonathan D Bohbot, Joseph C Dickens. Characterization of an enantioselective odorant receptor in the yellow fever mosquito Aedes aegypti. PloS one. 2009 Sep; 4(9):e7032. doi: 10.1371/journal.pone.0007032. [PMID: 19753115]
  • Atsushi Ohnishi, Kana Hashimoto, Kiyohiro Imai, Shogo Matsumoto. Functional characterization of the Bombyx mori fatty acid transport protein (BmFATP) within the silkmoth pheromone gland. The Journal of biological chemistry. 2009 Feb; 284(8):5128-36. doi: 10.1074/jbc.m806072200. [PMID: 19112106]
  • Shigehiro Namiki, Satoshi Iwabuchi, Ryohei Kanzaki. Representation of a mixture of pheromone and host plant odor by antennal lobe projection neurons of the silkmoth Bombyx mori. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 2008 May; 194(5):501-15. doi: 10.1007/s00359-008-0325-3. [PMID: 18389256]
  • J Joe Hull, Ryosuke Kajigaya, Kiyohiro Imai, Shogo Matsumoto. Sex pheromone production in the silkworm, Bombyx mori, is mediated by store-operated Ca2+ channels. Bioscience, biotechnology, and biochemistry. 2007 Aug; 71(8):1993-2001. doi: 10.1271/bbb.70175. [PMID: 17690463]
  • Shogo Matsumoto, J Joe Hull, Atsushi Ohnishi, Ken'ichi Moto, Adrien Fónagy. Molecular mechanisms underlying sex pheromone production in the silkmoth, Bombyx mori: characterization of the molecular components involved in bombykol biosynthesis. Journal of insect physiology. 2007 Aug; 53(8):752-9. doi: 10.1016/j.jinsphys.2007.02.014. [PMID: 17448494]
  • María Gabriela de Brito Sanchez, Karl-Ernst Kaissling. Inhibitory and excitatory effects of iodobenzene on the antennal benzoic acid receptor cells of the female silk moth Bombyx mori L. Chemical senses. 2005 Jun; 30(5):435-42. doi: 10.1093/chemse/bji038. [PMID: 15901657]
  • Adrien Fónagy, Atsushi Ohnishi, Yasuaki Esumi, Yoshikatsu Suzuki, Shogo Matsumoto. Further studies of lipid droplets in the bombykol-producing pheromone gland of Bombyx mori. Annals of the New York Academy of Sciences. 2005 Apr; 1040(?):310-4. doi: 10.1196/annals.1327.049. [PMID: 15891049]
  • R Maida, M Mameli, B Müller, J Krieger, R A Steinbrecht. The expression pattern of four odorant-binding proteins in male and female silk moths, Bombyx mori. Journal of neurocytology. 2005 Mar; 34(1-2):149-63. doi: 10.1007/s11068-005-5054-8. [PMID: 16374716]
  • N Yokoyama, Adrien Fónagy, S Tatsuki, T Arie, S Yamashita, S Matsumoto. Ultrastructural studies on the pheromone-producing cells in the silkmoth, Bombyx mori: formation of cytoplasmic lipid droplets before adult eclosion. Acta biologica Hungarica. 2003; 54(3-4):299-311. doi: 10.1556/abiol.54.2003.3-4.8. [PMID: 14711034]
  • A Fónagy, N Yokoyama, S Matsumoto. Physiological status and change of cytoplasmic lipid droplets in the pheromone-producing cells of the silkmoth, Bombyx mori (Lepidoptera, Bombycidae). Arthropod structure & development. 2001 Nov; 30(2):113-23. doi: 10.1016/s1467-8039(01)00027-5. [PMID: 18088949]
  • A Fónagy, N Yokoyama, R Ozawa, K Okano, S Tatsuki, S Maeda, S Matsumoto. Involvement of calcineurin in the signal transduction of PBAN in the silkworm, Bombyx mori (Lepidoptera). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 1999 Sep; 124(1):51-60. doi: 10.1016/s0305-0491(99)00096-6. [PMID: 10582320]