Dioctyl phthalate (BioDeep_00000001135)

Main id: BioDeep_00000001128

Secondary id: BioDeep_00000405806

human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019 Industrial Pollutants Volatile Flavor Compounds natural product


代谢物信息卡片


1,2-dioctyl benzene-1,2-dicarboxylate

化学式: C24H38O4 (390.2769948)
中文名称: 邻苯二甲酸二辛酯, 邻苯二甲酸双(2-乙基己基)酯, 邻苯二甲酸二(2-乙基己基)酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 16.67%

分子结构信息

SMILES: CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC
InChI: InChI=1S/C24H38O4/c1-3-5-7-9-11-15-19-27-23(25)21-17-13-14-18-22(21)24(26)28-20-16-12-10-8-6-4-2/h13-14,17-18H,3-12,15-16,19-20H2,1-2H3

描述信息

Di(n-octyl) phthalate, also known as dioctyl 1,2-benzenedicarboxylate or dehp, is a member of the class of compounds known as benzoic acid esters. Benzoic acid esters are ester derivatives of benzoic acid. Di(n-octyl) phthalate is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Di(n-octyl) phthalate can be found in kohlrabi, which makes di(n-octyl) phthalate a potential biomarker for the consumption of this food product. Di(n-octyl) phthalate is a non-carcinogenic (not listed by IARC) potentially toxic compound. Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called phthalate syndrome’ (A2883) (T3DB).
CONFIDENCE standard compound; INTERNAL_ID 198
D010968 - Plasticizers
DEHP (Bis(2-ethylhexyl) phthalate) is an endogenous metabolite.
DEHP (Bis(2-ethylhexyl) phthalate) is an endogenous metabolite.

同义名列表

24 个代谢物同义名

1,2-dioctyl benzene-1,2-dicarboxylate; Dioctyl 1,2-benzenedicarboxylic acid; Dioctyl 1,2-benzenedicarboxylate; Bis(2-ethylhexyl) phthalate; Bis(N-octyl) phthalic acid; Bis(2-ethylhexyl)phthalate; Di(2-ethylhexyl)phthalate; Di(N-octyl) phthalic acid; Di-2-ethylhexylphthalate; Di 2 ethylhexylphthalate; Phthalate, diethylhexyl; Bis(N-octyl) phthalate; Diethylhexyl phthalate; Dioctyl phthalic acid; Di-n-octyl phthalate; Phthalate, dioctyl; Dioctyl phthalate; Dioctylphthalate; DEHP; Ergoplast FDO; ESBO-D 82; DEHPA; Di-n-octyl phthalate; Bis(2-ethylhexyl)phthalate



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jing Zhang, Lei Wang, Mengbo Liu, Zhenyang Yu. Multi- and trans-generational effects of di-n-octyl phthalate on behavior, lifespan and reproduction of Caenorhabditis elegans through neural regulation and lipid metabolism. The Science of the total environment. 2023 Jul; ?(?):165268. doi: 10.1016/j.scitotenv.2023.165268. [PMID: 37406686]
  • Senyuan Huang, Shengtao Ma, Dongwu Wang, Hongli Liu, Guiying Li, Yingxin Yu. National-scale urinary phthalate metabolites in the general urban residents involving 26 provincial capital cities in China and the influencing factors as well as non-carcinogenic risks. The Science of the total environment. 2022 Sep; 838(Pt 2):156062. doi: 10.1016/j.scitotenv.2022.156062. [PMID: 35597362]
  • Ruxianguli Aimuzi, Senyuan Huang, Kai Luo, Shengtao Ma, Xiaona Huo, Guiying Li, Ying Tian, Jun Zhang, Yingxin Yu. Levels and health risks of urinary phthalate metabolites and the association between phthalate exposure and unexplained recurrent spontaneous abortion: a large case-control study from China. Environmental research. 2022 09; 212(Pt C):113393. doi: 10.1016/j.envres.2022.113393. [PMID: 35504341]
  • Taylor M Etzel, Joseph M Braun, Jordan R Kuiper, Antonia M Calafat, Kim M Cecil, Aimin Chen, Bruce P Lanphear, Kimberly Yolton, Heidi J Kalkwarf, Jessie P Buckley. Gestational and childhood phthalate exposures and adolescent body composition: The HOME study. Environmental research. 2022 Sep; 212(Pt B):113320. doi: 10.1016/j.envres.2022.113320. [PMID: 35461845]
  • Jane S Burns, Oleg Sergeyev, Mary M Lee, Paige L Williams, Lidia Mínguez-Alarcón, Bora Plaku-Alakbarova, Sergey Sokolov, Sergey Kovalev, Holger M Koch, Albert T Lebedev, Russ Hauser, Susan A Korrick. Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys. Environmental research. 2022 09; 212(Pt A):113218. doi: 10.1016/j.envres.2022.113218. [PMID: 35390299]
  • Hongxiu Liu, Yuyan Wang, Kurunthachalam Kannan, Mengling Liu, Hongkai Zhu, Yu Chen, Linda G Kahn, Melanie H Jacobson, Bo Gu, Shilpi Mehta-Lee, Sara G Brubaker, Akhgar Ghassabian, Leonardo Trasande. Determinants of phthalate exposures in pregnant women in New York City. Environmental research. 2022 09; 212(Pt A):113203. doi: 10.1016/j.envres.2022.113203. [PMID: 35358547]
  • Md Saidur Rahman, Won-Ki Pang, Shehreen Amjad, Do-Yeal Ryu, Elikanah Olusayo Adegoke, Yoo-Jin Park, Myung-Geol Pang. Hepatic consequences of a mixture of endocrine-disrupting chemicals in male mice. Journal of hazardous materials. 2022 08; 436(?):129236. doi: 10.1016/j.jhazmat.2022.129236. [PMID: 35739755]
  • Qian Chen, Qingmin Kong, Peijun Tian, Yufeng He, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen. Lactic acid bacteria alleviate di-(2-ethylhexyl) phthalate-induced liver and testis toxicity via their bio-binding capacity, antioxidant capacity and regulation of the gut microbiota. Environmental pollution (Barking, Essex : 1987). 2022 Jul; 305(?):119197. doi: 10.1016/j.envpol.2022.119197. [PMID: 35378196]
  • Zhaoqing Lyu, Kouji H Harada, Sungmin Kim, Tomoko Fujitani, Yang Cao, Toshiaki Hitomi, Yukiko Fujii, Younglim Kho, Kyungho Choi. Exposure to phthalate esters in Japanese females in Kyoto, Japan from 1993 to 2016: Temporal trends and associated health risks. Environment international. 2022 07; 165(?):107288. doi: 10.1016/j.envint.2022.107288. [PMID: 35588674]
  • Hongping Liao, Shulin Liu, Muhammad Junaid, Dandan Gao, Wenjie Ai, Guanglong Chen, Jun Wang. Di-(2-ethylhexyl) phthalate exacerbated the toxicity of polystyrene nanoplastics through histological damage and intestinal microbiota dysbiosis in freshwater Micropterus salmoides. Water research. 2022 Jul; 219(?):118608. doi: 10.1016/j.watres.2022.118608. [PMID: 35605397]
  • Tsu-I Hsia, Po-Chin Huang, Hsin-Chang Chen, Yuan-Ting C Lo, Wan-Ting Chang, Yann-Yuh Jou, Han-Bin Huang. Relationships among phthalate exposure, oxidative stress, and insulin resistance in young military soldiers: A cumulative risk assessment and mediation approach. Environment international. 2022 07; 165(?):107316. doi: 10.1016/j.envint.2022.107316. [PMID: 35635958]
  • Jordan R Kuiper, Katie M O'Brien, Barrett M Welch, Emily S Barrett, Ruby H N Nguyen, Sheela Sathyanarayana, Ginger L Milne, Shanna H Swan, Kelly K Ferguson, Jessie P Buckley. Combining Urinary Biomarker Data From Studies With Different Measures of Urinary Dilution. Epidemiology (Cambridge, Mass.). 2022 Jul; 33(4):533-540. doi: 10.1097/ede.0000000000001496. [PMID: 35473917]
  • Wei-Jie Wang, Chia-Sung Wang, Chi-Kang Wang, An-Ming Yang, Chien-Yu Lin. Urine Di-(2-ethylhexyl) Phthalate Metabolites Are Independently Related to Body Fluid Status in Adults: Results from a U.S. Nationally Representative Survey. International journal of environmental research and public health. 2022 Jun; 19(12):. doi: 10.3390/ijerph19126964. [PMID: 35742214]
  • Sori Mok, Jae-Eun Lim, Aram Lee, Sungmin Kim, Sunmi Kim, Inae Lee, Younglim Kho, Jeongim Park, Sungkyoon Kim, Kyungho Choi, Hyo-Bang Moon. Within- and between-person variability of urinary phthalate metabolites and bisphenol analogues over seven days: Considerations of biomonitoring study design. Environmental research. 2022 06; 209(?):112885. doi: 10.1016/j.envres.2022.112885. [PMID: 35131323]
  • Ao Li, Lingyi Kang, Runjie Li, Sijing Wu, Ke Liu, Xinke Wang. Modeling di (2-ethylhexyl) Phthalate (DEHP) and Its Metabolism in a Body's Organs and Tissues through Different Intake Pathways into Human Body. International journal of environmental research and public health. 2022 05; 19(9):. doi: 10.3390/ijerph19095742. [PMID: 35565138]
  • Chao Li, Yucheng Jin, Shen Xu, Huan He. A Pilot Study: Nails as a Non-invasive Biospecimen of Human Exposure to Phthalate Esters. Bulletin of environmental contamination and toxicology. 2022 May; 108(5):963-968. doi: 10.1007/s00128-021-03424-z. [PMID: 35039885]
  • Aurélie Thelliez, Bertrand Décaudin, Marie Lecoeur. Impact of the pathogen inactivation process on the migration of di(2-ethylhexyl) phthalate from plasma bags. Vox sanguinis. 2022 May; 117(5):724-728. doi: 10.1111/vox.13233. [PMID: 35023180]
  • Xianling Zhou, Zhigang Zhang, Heng Shi, Qiubo Liu, Yuling Chang, Weifeng Feng, Shiping Zhu, Shengyun Sun. Effects of Lycium barbarum glycopeptide on renal and testicular injury induced by di(2-ethylhexyl) phthalate. Cell stress & chaperones. 2022 05; 27(3):257-271. doi: 10.1007/s12192-022-01266-0. [PMID: 35362893]
  • Ana Socorro Rodríguez-Báez, Susanna Edith Medellín-Garibay, Maribel Rodríguez-Aguilar, Julia Sagahón-Azúa, Rosa Del Carmen Milán-Segoviaa, Rogelio Flores-Ramírez. Environmental endocrine disruptor concentrations in urine samples from Mexican Indigenous women. Environmental science and pollution research international. 2022 May; 29(25):38645-38656. doi: 10.1007/s11356-021-18197-5. [PMID: 35080728]
  • Yuhao Wu, Junke Wang, Tianxin Zhao, Jiadong Chen, Lian Kang, Yuexin Wei, Lindong Han, Lianju Shen, Chunlan Long, Shengde Wu, Guanghui Wei. Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1α/HO-1 signaling pathway in mouse testes. Journal of hazardous materials. 2022 03; 426(?):127807. doi: 10.1016/j.jhazmat.2021.127807. [PMID: 34863575]
  • Guowei Zeng, Qi Zhang, Xiaowei Wang, Kai-Hong Wu. Low-level plasticizer exposure and all-cause and cardiovascular disease mortality in the general population. Environmental health : a global access science source. 2022 03; 21(1):32. doi: 10.1186/s12940-022-00841-3. [PMID: 35264146]
  • Yaming Zhao, Xinyue Song, Shuang Ding, Wen Qi, Yuezhu Zhang, Qi Xu, Tianyang Zhao, Xueting Zhang, Xu Li, Fuju Wu, Lin Ye. The associations of urinary DEHP metabolite levels, serum thyroid hormones, and thyroid-related genes among the adolescent students from China: a cross-sectional study. Environmental science and pollution research international. 2022 Mar; 29(13):19081-19097. doi: 10.1007/s11356-021-16909-5. [PMID: 34708313]
  • Diana C Pacyga, Brad A Ryva, Romana A Nowak, Serdar E Bulun, Ping Yin, Zhong Li, Jodi A Flaws, Rita S Strakovsky. Midlife Urinary Phthalate Metabolite Concentrations and Prior Uterine Fibroid Diagnosis. International journal of environmental research and public health. 2022 02; 19(5):. doi: 10.3390/ijerph19052741. [PMID: 35270433]
  • Chien-Yu Lin, Ching-Way Chen, Hui-Ling Lee, Charlene Wu, Chikang Wang, Fung-Chang Sung, Ta-Chen Su. Global DNA methylation mediates the association between urine mono-2-ethylhexyl phthalate and serum apoptotic microparticles in a young Taiwanese population. The Science of the total environment. 2022 Feb; 808(?):152054. doi: 10.1016/j.scitotenv.2021.152054. [PMID: 34863772]
  • V Plichta, W Völkel, L Fembacher, M Wöckner, D Nowak, H Fromme. The oral bioavailability of di-2-ethylhexyl phthalate (DEHP), di-isononyl phthalate (DiNP) and di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH®) in house dust. Toxicology letters. 2022 Feb; 355(?):82-87. doi: 10.1016/j.toxlet.2021.11.010. [PMID: 34801639]
  • Anja Stajnko, Agneta Annika Runkel, Tina Kosjek, Janja Snoj Tratnik, Darja Mazej, Ingrid Falnoga, Milena Horvat. Assessment of susceptibility to phthalate and DINCH exposure through CYP and UGT single nucleotide polymorphisms. Environment international. 2022 01; 159(?):107046. doi: 10.1016/j.envint.2021.107046. [PMID: 34920277]
  • Shahzad Ahmad, Shikha Sharma, Mohd Amir Afjal, Haroon Habib, Juheb Akhter, Poonam Goswami, Suhel Parvez, Mohammad Akhtar, Sheikh Raisuddin. mRNA expression and protein-protein interaction (PPI) network analysis of adrenal steroidogenesis in response to exposure to phthalates in rats. Environmental toxicology and pharmacology. 2022 Jan; 89(?):103780. doi: 10.1016/j.etap.2021.103780. [PMID: 34864161]
  • Ilse Vanhorebeek, Govindan Malarvannan, Fabian Güiza, Giulia Poma, Inge Derese, Pieter J Wouters, Koen Joosten, Sascha Verbruggen, Philippe G Jorens, Adrian Covaci, Greet Van den Berghe. Phasing out DEHP from plastic indwelling medical devices used for intensive care: Does it reduce the long-term attention deficit of critically ill children?. Environment international. 2022 01; 158(?):106962. doi: 10.1016/j.envint.2021.106962. [PMID: 34739923]
  • Hui-Ju Tsai, Chia-Fang Wu, Chao A Hsiung, Chieng-Hung Lee, Shu-Li Wang, Mei-Lien Chen, Chu-Chih Chen, Po-Chin Huang, Yin-Han Wang, Yuh-An Chen, Bai-Hsiun Chen, Yun-Shiuan Chuang, Hui-Min Hsieh, Ming-Tsang Wu. Longitudinal changes in oxidative stress and early renal injury in children exposed to DEHP and melamine in the 2011 Taiwan food scandal. Environment international. 2022 01; 158(?):107018. doi: 10.1016/j.envint.2021.107018. [PMID: 34991270]
  • Tsung-Hua Hsieh, Chia-Yi Hsu, Pei-Jing Yang, Chien-Chih Chiu, Shih-Shin Liang, Fu Ou-Yang, Jung-Yu Kan, Ming-Feng Hou, Tsu-Nai Wang, Eing-Mei Tsai. DEHP mediates drug resistance by directly targeting AhR in human breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112400. doi: 10.1016/j.biopha.2021.112400. [PMID: 34801851]
  • Yi-Zhen Yuan, Chong Ye, Jia-Hui Sun, Meng-Yuan Hu, Shao-Jie Huo, Yu-Ting Zhu, Su-Yun Xiang, Shu-Qin Yu. Toxicokinetics of mono-(2-ethylhexyl) phthalate with low-dose exposure applying fluorescence tracing technique. Toxicology and applied pharmacology. 2022 01; 434(?):115814. doi: 10.1016/j.taap.2021.115814. [PMID: 34843800]
  • Ying-Jie Zhang, Jia-Liang Guo, Jing-Chuan Xue, Cui-Lan Bai, Ying Guo. Phthalate metabolites: Characterization, toxicities, global distribution, and exposure assessment. Environmental pollution (Barking, Essex : 1987). 2021 Dec; 291(?):118106. doi: 10.1016/j.envpol.2021.118106. [PMID: 34520948]
  • Fu-Wei Jiang, Zhou-Yi Yang, Yu-Feng Bian, Jia-Gen Cui, Hao Zhang, Yi Zhao, Jin-Long Li. The novel role of the aquaporin water channel in lycopene preventing DEHP-induced renal ionic homeostasis disturbance in mice. Ecotoxicology and environmental safety. 2021 Dec; 226(?):112836. doi: 10.1016/j.ecoenv.2021.112836. [PMID: 34601266]
  • Leny Mathew, Nathaniel W Snyder, Kristen Lyall, Brian K Lee, Leslie A McClure, Amy J Elliott, Craig J Newschaffer. Prenatal phthalate exposure measurement: A comparison of metabolites quantified in prenatal maternal urine and newborn's meconium. The Science of the total environment. 2021 Nov; 796(?):148898. doi: 10.1016/j.scitotenv.2021.148898. [PMID: 34280640]
  • Daniel Wolecki, Barbara Trella, Fei Qi, Piotr Stepnowski, Jolanta Kumirska. Evaluation of the Removal of Selected Phthalic Acid Esters (PAEs) in Municipal Wastewater Treatment Plants Supported by Constructed Wetlands. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226966. [PMID: 34834057]
  • Yanxia Zhang, Biao Huang, Huan He, Xinkai Wang, Clive E Sabel, Marianne Thomsen, Zhikun Chen, Weixi Wang. Urinary phthalate metabolites among workers in plastic greenhouses in western China. Environmental pollution (Barking, Essex : 1987). 2021 Nov; 289(?):117939. doi: 10.1016/j.envpol.2021.117939. [PMID: 34426182]
  • Mu-Zi Li, Yi Zhao, Hao-Ran Wang, Milton Talukder, Jin-Long Li. Lycopene Preventing DEHP-Induced Renal Cell Damage Is Targeted by Aryl Hydrocarbon Receptor. Journal of agricultural and food chemistry. 2021 Nov; 69(43):12853-12861. doi: 10.1021/acs.jafc.1c05250. [PMID: 34670089]
  • Yaoxing Wu, Zidong Song, John C Little, Min Zhong, Hongwan Li, Ying Xu. An integrated exposure and pharmacokinetic modeling framework for assessing population-scale risks of phthalates and their substitutes. Environment international. 2021 11; 156(?):106748. doi: 10.1016/j.envint.2021.106748. [PMID: 34256300]
  • Magdy M Awny, Asmaa K Al-Mokaddem, Bassam Mohamed Ali. Mangiferin mitigates di-(2-ethylhexyl) phthalate-induced testicular injury in rats by modulating oxidative stress-mediated signals, inflammatory cascades, apoptotic pathways, and steroidogenesis. Archives of biochemistry and biophysics. 2021 10; 711(?):108982. doi: 10.1016/j.abb.2021.108982. [PMID: 34400143]
  • Shuang Ding, Wen Qi, Qi Xu, Tianyang Zhao, Xu Li, Jianli Yin, Ruxuan Zhang, Chuanyi Huo, Liting Zhou, Lin Ye. Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses. Environmental pollution (Barking, Essex : 1987). 2021 Oct; 286(?):117570. doi: 10.1016/j.envpol.2021.117570. [PMID: 34438493]
  • Azam Hosseinzadeh, Saeed Mehrzadi, Amir Siahpoosh, Zahra Basir, Nosrat Bahrami, Mehdi Goudarzi. The ameliorative effect of ellagic acid on di-(2-ethylhexyl) phthalate-induced testicular structural alterations, oxidative stress, inflammation and sperm damages in adult mice. Reproductive biology and endocrinology : RB&E. 2021 Sep; 19(1):146. doi: 10.1186/s12958-021-00830-0. [PMID: 34537068]
  • Wei-Hsiang Chang, Samuel Herianto, Ching-Chang Lee, Hsin Hung, Hsiu-Ling Chen. The effects of phthalate ester exposure on human health: A review. The Science of the total environment. 2021 Sep; 786(?):147371. doi: 10.1016/j.scitotenv.2021.147371. [PMID: 33965815]
  • Lindong Han, Junke Wang, Tianxin Zhao, Yuhao Wu, Yuexin Wei, Jiadong Chen, Lian Kang, Lianju Shen, Chunlan Long, Zhengwei Yang, Shengde Wu, Guanghui Wei. Stereological analysis and transcriptome profiling of testicular injury induced by di-(2-ethylhexyl) phthalate in prepubertal rats. Ecotoxicology and environmental safety. 2021 Sep; 220(?):112326. doi: 10.1016/j.ecoenv.2021.112326. [PMID: 34015638]
  • Zhen Yu, Qiufeng Zhan, Ayun Chen, Junyong Han, Yuanyuan Zheng, Yuqing Gong, Rongmei Lu, Zeyu Zheng, Gang Chen. Intermittent fasting ameliorates di-(2-ethylhexyl) phthalate-induced precocious puberty in female rats: A study of the hypothalamic-pituitary-gonadal axis. Reproductive biology. 2021 Sep; 21(3):100513. doi: 10.1016/j.repbio.2021.100513. [PMID: 34049116]
  • Bukem Tanoren, Ugur Parlatan, Melita Parlak, Berzem Selcuk, Fatma Ates Alkan, Nural Pastaci Ozsobaci, Gurcan Albeniz, Leyla Turker Sener, Isil Albeniz, Mehmet Burcin Unlu. Determination of modifications in rat liver due to phthalate uptake by SAM, RS, and ICP-OES. Analytical methods : advancing methods and applications. 2021 07; 13(26):2926-2935. doi: 10.1039/d1ay00650a. [PMID: 34109334]
  • Ahmed Nadeem, Naif O Al-Harbi, Sheikh F Ahmad, Khalid Alhazzani, Sabry M Attia, Sary Alsanea, Ali Alhoshani, Hafiz M Mahmood, Ali S Alfardan, Saleh A Bakheet. Exposure to the plasticizer, Di-(2-ethylhexyl) phthalate during juvenile period exacerbates autism-like behavior in adult BTBR T + tf/J mice due to DNA hypomethylation and enhanced inflammation in brain and systemic immune cells. Progress in neuro-psychopharmacology & biological psychiatry. 2021 07; 109(?):110249. doi: 10.1016/j.pnpbp.2021.110249. [PMID: 33497755]
  • Jiufeng Li, Xi Qian, Yanqiu Zhou, Yuanyuan Li, Shunqing Xu, Wei Xia, Zongwei Cai. Trimester-specific and sex-specific effects of prenatal exposure to di(2-ethylhexyl) phthalate on fetal growth, birth size, and early-childhood growth: A longitudinal prospective cohort study. The Science of the total environment. 2021 Jul; 777(?):146146. doi: 10.1016/j.scitotenv.2021.146146. [PMID: 33684750]
  • Che-Yi Chou, Kuo-Hsiung Shu, Hung-Chun Chen, Ming-Cheng Wang, Chia-Chu Chang, Bang-Gee Hsu, Tzen-Wen Chen, Chien-Lung Chen, Chiu-Ching Huang. Urine phthalate metabolites are associated with urothelial cancer in chronic kidney disease patients. Chemosphere. 2021 Jun; 273(?):127834. doi: 10.1016/j.chemosphere.2020.127834. [PMID: 33077191]
  • Han-Bin Huang, Chi-Ying Siao, Yuan-Ting C Lo, Shu-Fang Shih, Chieh-Hua Lu, Po-Chin Huang. Mediation effects of thyroid function in the associations between phthalate exposure and glucose metabolism in adults. Environmental pollution (Barking, Essex : 1987). 2021 Jun; 278(?):116799. doi: 10.1016/j.envpol.2021.116799. [PMID: 33743268]
  • Hui-Ju Tsai, Fu-Chen Kuo, Chia-Fang Wu, Chien-Wen Sun, Chia-Jung Hsieh, Shu-Li Wang, Mei-Lien Chen, Hui-Min Hsieh, Yun-Shiuan Chuang, Ming-Tsang Wu. Association between two common environmental toxicants (phthalates and melamine) and urinary markers of renal injury in the third trimester of pregnant women: The Taiwan Maternal and Infant Cohort Study (TMICS). Chemosphere. 2021 Jun; 272(?):129925. doi: 10.1016/j.chemosphere.2021.129925. [PMID: 35534976]
  • Jiwon On, Shin-Hye Kim, Jeongae Lee, Mi Jung Park, Sang-Won Lee, Heesoo Pyo. Urinary di(2-ethylhexyl)phthalate metabolite ratios in obese children of South Korea. Environmental science and pollution research international. 2021 Jun; 28(23):29590-29600. doi: 10.1007/s11356-021-12823-y. [PMID: 33559826]
  • Xufeng Fu, Hang Han, Yuanyuan Li, Bo Xu, Wenjie Dai, Yaoxu Zhang, Feng Zhou, Huiming Ma, Xiuying Pei. Di-(2-ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice. Environmental toxicology. 2021 Jun; 36(6):1226-1242. doi: 10.1002/tox.23121. [PMID: 33665894]
  • Fateheya M Metwally, Asmaa M Elfiky, Neven E Sharaf, Hend Rashad. Evaluation of reproductive hormones in Egyptian workers occupationally exposed to di-2-ethylhexyl phthalate (DEHP): a cross-sectional study. Journal of complementary & integrative medicine. 2021 May; 18(4):851-857. doi: 10.1515/jcim-2020-0329. [PMID: 34008375]
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