Isoglutamine (BioDeep_00000011343)

   


代谢物信息卡片


4,5-Diamino-5-oxopentanoic acid

化学式: C5H10N2O3 (146.0691)
中文名称: 4,5-二氨基-5-氧代戊酸
谱图信息: 最多检出来源 Homo sapiens(plant) 3.93%

分子结构信息

SMILES: C(CC(=O)O)C(C(=O)N)N
InChI: InChI=1S/C5H10N2O3/c6-3(5(7)10)1-2-4(8)9/h3H,1-2,6H2,(H2,7,10)(H,8,9)



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 GFAP, GLUL, LGALS1, MVD, NOD1, NOD2, NT5C2, TLR2, VIM
Nucleus 1 GLUL
cytosol 10 CD44, GFAP, GLS, GLUL, LGALS1, MVD, NOD1, NOD2, NT5C2, VIM
phagocytic vesicle 3 NOD1, NOD2, VIM
Cell membrane 6 CD44, GLUL, NOD1, NOD2, TNF, VIM
Lipid-anchor 3 GLUL, NOD1, NOD2
Synapse 1 GLS
cell surface 4 CD44, NOD2, TLR2, TNF
Golgi apparatus 3 CD44, NOD2, TLR2
neuronal cell body 1 TNF
Cytoplasm, cytosol 3 GLS, GLUL, NT5C2
Lysosome 1 CTSA
plasma membrane 8 CD44, GLUL, LGALS1, NOD1, NOD2, TLR2, TNF, VIM
Membrane 3 CD44, CTSA, TLR2
apical plasma membrane 2 CD44, NOD1
axon 1 VIM
basolateral plasma membrane 3 CD44, NOD1, NOD2
extracellular exosome 6 CD44, CTSA, GLUL, LGALS1, LYZ, VIM
endoplasmic reticulum 2 CTSA, GLUL
extracellular space 6 CPB1, IFNG, IL6, LGALS1, LYZ, TNF
lysosomal lumen 1 CTSA
mitochondrion 3 GLS, GLUL, NOD2
protein-containing complex 1 NOD2
intracellular membrane-bounded organelle 1 CTSA
Single-pass type I membrane protein 2 CD44, TLR2
Secreted 5 CD44, CPB1, IFNG, IL6, LGALS1
extracellular region 7 CD44, CTSA, IFNG, IL6, LGALS1, LYZ, TNF
Single-pass membrane protein 1 CD44
astrocyte end-foot 1 GFAP
mitochondrial matrix 1 GLS
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 LGALS1
cytoplasmic vesicle 1 CPB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 NOD2
Apical cell membrane 1 NOD1
Membrane raft 2 TLR2, TNF
Cytoplasm, cytoskeleton 2 NOD2, VIM
focal adhesion 2 CD44, VIM
Peroxisome 1 VIM
collagen-containing extracellular matrix 1 LGALS1
intermediate filament 2 GFAP, VIM
lateral plasma membrane 1 NOD1
receptor complex 1 TLR2
neuron projection 1 VIM
cell leading edge 1 VIM
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 3 CD44, GFAP, TLR2
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 TLR2
cytoskeleton 2 NOD2, VIM
[Isoform 1]: Mitochondrion 1 GLS
Basolateral cell membrane 2 NOD1, NOD2
microvillus 1 CD44
microtubule organizing center 1 VIM
Cell projection, microvillus 1 CD44
cell body 3 GFAP, GLUL, TLR2
intermediate filament cytoskeleton 2 GFAP, VIM
[Isoform 3]: Cytoplasm 1 NOD2
Microsome 1 GLUL
secretory granule membrane 2 CD44, TLR2
endoplasmic reticulum lumen 2 IL6, LGALS1
nuclear matrix 1 VIM
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
azurophil granule lumen 2 CTSA, LYZ
Nucleus matrix 1 VIM
[Isoform 3]: Mitochondrion 1 GLS
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
extrinsic component of plasma membrane 1 NOD2
Zymogen granule lumen 1 CPB1
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
cytoplasmic side of lysosomal membrane 1 GFAP
glial cell projection 1 GLUL
lamellipodium membrane 1 CD44
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
macrophage migration inhibitory factor receptor complex 1 CD44
galectin complex 1 LGALS1
interleukin-6 receptor complex 1 IL6
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Erik R Nöldeke, Lena M Muckenfuss, Volker Niemann, Anna Müller, Elena Störk, Georg Zocher, Tanja Schneider, Thilo Stehle. Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus. Scientific reports. 2018 08; 8(1):12953. doi: 10.1038/s41598-018-31098-x. [PMID: 30154570]
  • Ingmar J J Claes, Geert Schoofs, Krzysztof Regulski, Pascal Courtin, Marie-Pierre Chapot-Chartier, Thomas Rolain, Pascal Hols, Ingemar von Ossowski, Justus Reunanen, Willem M de Vos, Airi Palva, Jos Vanderleyden, Sigrid C J De Keersmaecker, Sarah Lebeer. Genetic and biochemical characterization of the cell wall hydrolase activity of the major secreted protein of Lactobacillus rhamnosus GG. PloS one. 2012; 7(2):e31588. doi: 10.1371/journal.pone.0031588. [PMID: 22359601]
  • Frederick A Luzzio, Damien Y Duveau, Erin R Lepper, William D Figg. Synthesis of racemic cis-5-hydroxy-3-phthalimidoglutarimide. A metabolite of thalidomide isolated from human plasma. The Journal of organic chemistry. 2005 Nov; 70(24):10117-20. doi: 10.1021/jo0514772. [PMID: 16292851]
  • Z Zídek, K Masek, D Franková, M Flegel. T-cell-dependent immunobiological activity of a desmuramyl analog of muramyl dipeptide, adamantylamide dipeptide (AdDP), and D-isoglutamine. International journal of immunopharmacology. 1993 Jul; 15(5):631-7. doi: 10.1016/0192-0561(93)90081-9. [PMID: 8375945]
  • M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]