Diethyl phthalic acid (BioDeep_00000001132)

 

Secondary id: BioDeep_00000402551

human metabolite Industrial Pollutants


代谢物信息卡片


1,2-Benzenedicarboxylic acid diethyl ester

化学式: C12H14O4 (222.0892)
中文名称: 邻苯二甲酸二乙酯
谱图信息: 最多检出来源 Homo sapiens(plant) 10.6%

分子结构信息

SMILES: c1ccc(c(c1)C(=O)OCC)C(=O)OCC
InChI: InChI=1S/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3

描述信息

Diethyl phthalic acid, also known as diethyl phthalate, 1,2-diethyl phthalic acid or 1,2-benzenedicarboxylic acid diethyl ester, is classified as a member of the benzoic acid esters. Benzoic acid esters are ester derivatives of benzoic acid. Diethyl phthalic acid is considered to be practically insoluble (in water) and basic. This substance is commonly used to make plastics more flexible. Products in which it is found include toothbrushes, automobile parts, tools, toys, and food packaging. Diethyl phthalic acid can be released fairly easily from these products, as it is not part of the chain of chemicals (polymers) that makes up the plastic. Diethyl phthalic acid is also used in cosmetics, insecticides, and aspirin. Phthalate esters can cause reproductive and developmental toxicity. (L1900, A2883) It is a non-carcinogenic (not listed by IARC) potentially toxic compound. (ChemoSummarizer)
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3672
Same as: D03804

同义名列表

26 个代谢物同义名

1,2-Benzenedicarboxylic acid diethyl ester; O-Benzenedicarboxylic acid diethyl ester; 1,2-Benzenedicarboxylate diethyl ester; 1,2-diethyl benzene-1,2-dicarboxylate; Diethyl benzene-1,2-dicarboxylic acid; Diethyl 1,2-benzenedicarboxylic acid; O-Benzenedicarboxylate diethyl ester; Diethyl benzene-1,2-dicarboxylate; Diethyl 1,2-benzenedicarboxylate; O-Bis(ethoxycarbonyl)benzene; Phthalic acid diethyl ester; Phthalsaeurediaethylester; 1,2-Diethyl phthalic acid; Phthalate diethyl ester; Diethyl O-phthalic acid; Diethyl phthalic acid; 1,2-Diethyl phthalate; Diethyl O-phthalate; Ethyl phthalic acid; DIETHYL PHTHALATE; Diethyl-phthalate; Ethyl phthalate; DEP; DEPA; Diethyl phthalate; Diethyl phthalate



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 APAF1, AR, CASP3, CAT, ESR1, HPGDS
Peripheral membrane protein 3 ACHE, CYP1B1, ESR1
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 5 ACHE, APAF1, AR, CASP3, ESR1
cytosol 7 APAF1, AR, CASP3, CAT, ESR1, GSR, HPGDS
nucleoplasm 5 AR, CASP3, CD2, ESR1, HPGDS
Cell membrane 5 ACHE, CD2, CD86, ESR1, TNF
Cytoplasmic side 1 ESR1
Multi-pass membrane protein 2 TM2D1, TMC4
Synapse 1 ACHE
cell surface 4 ACHE, CD2, CD86, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 3 ACHE, CD2, ESR1
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
plasma membrane 9 ACHE, AR, CD2, CD86, ESR1, IGHE, TM2D1, TMC4, TNF
Membrane 9 ACHE, APAF1, AR, CAT, CD86, CYP1B1, ESR1, TM2D1, TMC4
extracellular exosome 5 APAF1, CAT, CD86, GSR, TMC4
extracellular space 6 ACHE, IGHE, IL10, IL4, INS, TNF
perinuclear region of cytoplasm 1 ACHE
mitochondrion 3 CAT, CYP1B1, GSR
protein-containing complex 5 APAF1, AR, CAT, CD2, ESR1
intracellular membrane-bounded organelle 3 CAT, CYP1B1, HPGDS
Microsome membrane 1 CYP1B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD2, CD86, IGHE
Secreted 4 ACHE, IL10, IL4, INS
extracellular region 9 ACHE, APAF1, CAT, CD2, IGHE, IL10, IL4, INS, TNF
cytoplasmic side of plasma membrane 1 CD2
mitochondrial matrix 2 CAT, GSR
Extracellular side 1 ACHE
transcription regulator complex 1 ESR1
centriolar satellite 1 CD86
external side of plasma membrane 4 CD2, CD86, GSR, TNF
cell-cell junction 1 CD2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
nuclear speck 1 AR
chromatin 2 AR, ESR1
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
euchromatin 1 ESR1
side of membrane 1 ACHE
ficolin-1-rich granule lumen 2 APAF1, CAT
secretory granule lumen 3 APAF1, CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 APAF1
ribonucleoprotein complex 1 ELAVL3
[Isoform 1]: Nucleus 1 ESR1
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jones B Graceli, Charles S da Costa, Mary J Laws, Ashley R K Deviney, Daryl Meling, Jodi A Flaws. Chronic exposure to a mixture of phthalates shifts the white and brown adipose tissue phenotype in female mice. Toxicological sciences : an official journal of the Society of Toxicology. 2023 Apr; ?(?):. doi: 10.1093/toxsci/kfad032. [PMID: 37021957]
  • Pradeep Kumkar, Manoj Pise, Chandani R Verma, Tushar Khare, Miloslav Petrtýl, Lukáš Kalous. Micro-contaminant, but immense impact: Source and influence of diethyl phthalate plasticizer on bottom-dwelling fishes. Chemosphere. 2022 Nov; 306(?):135563. doi: 10.1016/j.chemosphere.2022.135563. [PMID: 35787876]
  • Md Saidur Rahman, Won-Ki Pang, Shehreen Amjad, Do-Yeal Ryu, Elikanah Olusayo Adegoke, Yoo-Jin Park, Myung-Geol Pang. Hepatic consequences of a mixture of endocrine-disrupting chemicals in male mice. Journal of hazardous materials. 2022 08; 436(?):129236. doi: 10.1016/j.jhazmat.2022.129236. [PMID: 35739755]
  • Daniel Wolecki, Barbara Trella, Fei Qi, Piotr Stepnowski, Jolanta Kumirska. Evaluation of the Removal of Selected Phthalic Acid Esters (PAEs) in Municipal Wastewater Treatment Plants Supported by Constructed Wetlands. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226966. [PMID: 34834057]
  • Thiago de Freitas, Joyce R Zapaterini, Cristiane M Moreira, Ariana M de Aquino, Luiz G Alonso-Costa, Lucas T Bidinotto, Laura Kass, Jodi A Flaws, Wellerson R Scarano, Luis F Barbisan. Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Oct; 156(?):112519. doi: 10.1016/j.fct.2021.112519. [PMID: 34428494]
  • Ling Huang, Xunzhi Zhu, Shixing Zhou, Zhenrui Cheng, Kai Shi, Chi Zhang, Hua Shao. Phthalic Acid Esters: Natural Sources and Biological Activities. Toxins. 2021 07; 13(7):. doi: 10.3390/toxins13070495. [PMID: 34357967]
  • Tianhong Nie, Xing Yang, Hanbo Chen, Karin Müller, Sabry M Shaheen, Jörg Rinklebe, Hocheol Song, Song Xu, Fengchang Wu, Hailong Wang. Effect of biochar aging and co-existence of diethyl phthalate on the mono-sorption of cadmium and zinc to biochar-treated soils. Journal of hazardous materials. 2021 04; 408(?):124850. doi: 10.1016/j.jhazmat.2020.124850. [PMID: 33385726]
  • Hanbo Chen, Peng Qin, Xing Yang, Amit Bhatnagar, Sabry M Shaheen, Jörg Rinklebe, Fengchang Wu, Song Xu, Lei Che, Hailong Wang. Sorption of diethyl phthalate and cadmium by pig carcass and green waste-derived biochars under single and binary systems. Environmental research. 2021 02; 193(?):110594. doi: 10.1016/j.envres.2020.110594. [PMID: 33307079]
  • Huan-Yu Tao, Jiawei Zhang, Jianghong Shi, Wei Guo, Xiaowei Liu, Mengtao Zhang, Hui Ge, Xiao-Yan Li. Occurrence and emission of phthalates, bisphenol A, and oestrogenic compounds in concentrated animal feeding operations in Southern China. Ecotoxicology and environmental safety. 2021 Jan; 207(?):111521. doi: 10.1016/j.ecoenv.2020.111521. [PMID: 33254396]
  • James A Weaver, Brandiese E J Beverly, Nagalakshmi Keshava, Anuradha Mudipalli, Xabier Arzuaga, Christine Cai, Andrew K Hotchkiss, Susan L Makris, Erin E Yost. Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies. Environment international. 2020 12; 145(?):105848. doi: 10.1016/j.envint.2020.105848. [PMID: 32958228]
  • Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee. Risk assessment for humans using physiologically based pharmacokinetic model of diethyl phthalate and its major metabolite, monoethyl phthalate. Archives of toxicology. 2020 07; 94(7):2377-2400. doi: 10.1007/s00204-020-02748-9. [PMID: 32303804]
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  • Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee. Simultaneous determination of diethyl phthalate and its major metabolite, monoethyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study by ultrahigh performance liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 173(?):108-119. doi: 10.1016/j.jpba.2019.05.027. [PMID: 31125947]
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