Angiotensin III (BioDeep_00000010941)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(2S)-2-({[(2S)-1-[(2S)-2-{[(2S,3S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-amino-5-carbamimidamido-1-hydroxypentylidene]amino}-1-hydroxy-3-methylbutylidene]amino}-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxy-3-methylpentylidene]amino}-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-3-phenylpropanoate

化学式: C46H66N12O9 (930.5075466000001)
中文名称: 人血管紧缩素II醋酸盐水合物, 血管紧张素III
谱图信息: 最多检出来源 Homo sapiens(blood) 99.16%

分子结构信息

SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N
InChI: InChI=1S/C46H66N12O9/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51)

描述信息

Angiotensin III (AngIII) is one of the N-terminal angiotensin degradation products of angiotensin II. AngIII shares some of its properties with Ang II, including chemotaxis and production of growth factors and chemokines. AngIII generated within the brain acts within neural circuits of the central nervous system to regulate body fluid balance. The stimulation of vasopressin release by AngIII is thought to be one of the mechanisms by which AngIII controls volume homeostasis under conditions of hypovolemia, by reducing renal water loss and increasing blood pressure. Brain aminopeptidase A, the enzyme forming central AngIII, could constitute a putative central therapeutic target for the treatment of hypertension. (PMID: 17210474, 11751722, 11295571) [HMDB]
Angiotensin III (AngIII) is one of the N-terminal angiotensin degradation products of angiotensin II. AngIII shares some of its properties with Ang II, including chemotaxis and production of growth factors and chemokines. AngIII generated within the brain acts within neural circuits of the central nervous system to regulate body fluid balance. The stimulation of vasopressin release by AngIII is thought to be one of the mechanisms by which AngIII controls volume homeostasis under conditions of hypovolemia, by reducing renal water loss and increasing blood pressure. Brain aminopeptidase A, the enzyme forming central AngIII, could constitute a putative central therapeutic target for the treatment of hypertension. (PMID: 17210474, 11751722, 11295571).
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Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.

同义名列表

15 个代谢物同义名

(2S)-2-({[(2S)-1-[(2S)-2-{[(2S,3S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-amino-5-carbamimidamido-1-hydroxypentylidene]amino}-1-hydroxy-3-methylbutylidene]amino}-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxy-3-methylpentylidene]amino}-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-3-phenylpropanoate; (2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid; (2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid; Angiotensin III, human, mouse(Acetate); Angiotensin III, 4-L-isoleucine-; Des-aspartyl-angiotensin II; Des aspartyl angiotensin II; Des-asp-1-angiotensin II; Angiotensin II, des-asp; Des-asp angiotensin II; Des asp angiotensin II; Angiotensin III,human; Angiotensin III TFA; Angiotensin III; Angiotensin III, human, mouse



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ann Tenneil O'Connor, Dhanush Haspula, Ahmed Z Alanazi, Michelle A Clark. Roles of Angiotensin III in the brain and periphery. Peptides. 2022 07; 153(?):170802. doi: 10.1016/j.peptides.2022.170802. [PMID: 35489649]
  • Ana Belén Segarra, Germán Domínguez-Vías, José Redondo, Magdalena Martínez-Cañamero, Manuel Ramírez-Sánchez, Isabel Prieto. Hypothalamic Renin-Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet. Nutrients. 2021 Jan; 13(2):. doi: 10.3390/nu13020480. [PMID: 33572630]
  • Guoqing Yao, Wenjing Li, Wenzhao Liu, Jingbo Xing, Cheng Zhang. The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2021; 2021(?):1704762. doi: 10.1155/2021/1704762. [PMID: 34603502]
  • Erkan Cure, Tevfik Bulent Ilcol, Medine Cumhur Cure. Angiotensin II, III, and IV may be important in the progression of COVID-19. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2020 Oct; 21(4):1470320320972019. doi: 10.1177/1470320320972019. [PMID: 33169633]
  • Lucinda M Hilliard Krause, Brandon A Kemp, Amanda Suan Jui Tan, Emma S Jones, Mark P Del Borgo, Marie-Isabel Aguilar, Kate M Denton, Robert M Carey, Robert E Widdop. Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats. Clinical science (London, England : 1979). 2020 04; 134(7):871-884. doi: 10.1042/cs20200153. [PMID: 32202299]
  • F K Suessenbach, B B Burckhardt. Levels of angiotensin peptides in healthy and cardiovascular/renal-diseased paediatric population-an investigative review. Heart failure reviews. 2019 09; 24(5):709-723. doi: 10.1007/s10741-019-09797-y. [PMID: 31104255]
  • Jia L Zhuo, Xiao C Li. Angiotensin III/AT2 Receptor/NHE3 Signaling Pathway in the Proximal Tubules of the Kidney: A Novel Natriuretic and Antihypertensive Mechanism in Hypertension. Journal of the American Heart Association. 2019 05; 8(9):e012644. doi: 10.1161/jaha.119.012644. [PMID: 31039655]
  • Brandon A Kemp, Nancy L Howell, Susanna R Keller, John J Gildea, Weijian Shao, Luis Gabriel Navar, Robert M Carey. Defective Renal Angiotensin III and AT2 Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats. Journal of the American Heart Association. 2019 05; 8(9):e012016. doi: 10.1161/jaha.119.012016. [PMID: 31039659]
  • Frans H H Leenen, Monir Ahmad, Yannick Marc, Catherine Llorens-Cortes. Specific Inhibition of Brain Angiotensin III Formation as a New Strategy for Prevention of Heart Failure After Myocardial Infarction. Journal of cardiovascular pharmacology. 2019 02; 73(2):82-91. doi: 10.1097/fjc.0000000000000638. [PMID: 30531435]
  • Jürgen M Bohlender, Jürg Nussberger, Hendrik Tevaearai, Hans Imboden. Angiotensinergic Innervation of the Human Right Atrium: Implications for Cardiac Reflexes. American journal of hypertension. 2018 01; 31(2):188-196. doi: 10.1093/ajh/hpx163. [PMID: 28985343]
  • Robert M Carey. Update on angiotensin AT2 receptors. Current opinion in nephrology and hypertension. 2017 03; 26(2):91-96. doi: 10.1097/mnh.0000000000000304. [PMID: 27906747]
  • Hyung Wook Kim, Young Ok Kim, Sun Ae Yoon, Jeong-Sun Han, Hyun-Bae Chun, Young Soo Kim. Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells. The Korean journal of internal medicine. 2016 Jan; 31(1):116-24. doi: 10.3904/kjim.2016.31.1.116. [PMID: 26767865]
  • Mark Del Borgo, Yan Wang, Sanja Bosnyak, Morimer Khan, Pia Walters, Iresha Spizzo, Patrick Perlmutter, Lucinda Hilliard, Kate Denton, Marie-Isabel Aguilar, Robert E Widdop, Emma S Jones. β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats. Clinical science (London, England : 1979). 2015 Sep; 129(6):505-13. doi: 10.1042/cs20150077. [PMID: 26186568]
  • Mariola Olkowicz, Adrianna Radulska, Joanna Suraj, Agnieszka Kij, Maria Walczak, Stefan Chlopicki, Ryszard T Smolenski. Development of a sensitive, accurate and robust liquid chromatography/mass spectrometric method for profiling of angiotensin peptides in plasma and its application for atherosclerotic mice. Journal of chromatography. A. 2015 May; 1393(?):37-46. doi: 10.1016/j.chroma.2015.03.012. [PMID: 25817477]
  • Zhoufang Zeng, Yandong Wang, Xinhua Guo, Ling Wang, Nan Lu. On-plate self-desalting and matrix-free LDI MS analysis of peptides with a surface patterned sample support. Journal of the American Society for Mass Spectrometry. 2014 May; 25(5):895-8. doi: 10.1007/s13361-014-0845-8. [PMID: 24658805]
  • Alijana Trošt Rupnik, Jernej Pajek, Andrej Guček, Joško Osredkar, Damjan Kovač, Andrej Bren, Dimitrij Klančič, Silvan Saksida, Igor Rus, Mateja Globokar, Andrej Drozg, Marjeta Lešnik, Zala Plešivčnik, Robert Ekart, Simona Lopert, Jelka Lindič. Influence of renin-angiotensin-aldosterone system-blocking drugs on peritoneal membrane in peritoneal dialysis patients. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2013 Aug; 17(4):425-30. doi: 10.1111/1744-9987.12091. [PMID: 23931884]
  • Byung Mun Park, Young-Bin Oh, Shan Gao, Seung Ah Cha, Kyung Pyo Kang, Suhn Hee Kim. Angiotensin III stimulates high stretch-induced ANP secretion via angiotensin type 2 receptor. Peptides. 2013 Apr; 42(?):131-7. doi: 10.1016/j.peptides.2013.01.018. [PMID: 23419986]
  • Claudia A McCarthy, Robert E Widdop, Kate M Denton, Emma S Jones. Update on the angiotensin AT(2) receptor. Current hypertension reports. 2013 Feb; 15(1):25-30. doi: 10.1007/s11906-012-0321-4. [PMID: 23224511]
  • Michael Bader. ACE2, angiotensin-(1–7), and Mas: the other side of the coin. Pflugers Archiv : European journal of physiology. 2013 Jan; 465(1):79-85. doi: 10.1007/s00424-012-1120-0. [PMID: 23463883]
  • Brandon A Kemp, John F Bell, Daniele M Rottkamp, Nancy L Howell, Weijian Shao, L Gabriel Navar, Shetal H Padia, Robert M Carey. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension (Dallas, Tex. : 1979). 2012 Aug; 60(2):387-95. doi: 10.1161/hypertensionaha.112.191403. [PMID: 22689743]
  • Frédéric Lancien, Marty Wong, Ali Al Arab, Nagi Mimassi, Yoshio Takei, Jean-Claude Le Mével. Central ventilatory and cardiovascular actions of angiotensin peptides in trout. American journal of physiology. Regulatory, integrative and comparative physiology. 2012 Aug; 303(3):R311-20. doi: 10.1152/ajpregu.00145.2012. [PMID: 22696574]
  • Nadja Grobe, Khalid M Elased, David R Cool, Mariana Morris. Mass spectrometry for the molecular imaging of angiotensin metabolism in kidney. American journal of physiology. Endocrinology and metabolism. 2012 Apr; 302(8):E1016-24. doi: 10.1152/ajpendo.00515.2011. [PMID: 22318946]
  • Rui Yang, Ilse Smolders, Alain G Dupont. Blood pressure and renal hemodynamic effects of angiotensin fragments. Hypertension research : official journal of the Japanese Society of Hypertension. 2011 Jun; 34(6):674-83. doi: 10.1038/hr.2011.24. [PMID: 21412242]
  • Junichi Yatabe, Minoru Yoneda, Midori S Yatabe, Tsuyoshi Watanabe, Robin A Felder, Pedro A Jose, Hironobu Sanada. Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology. 2011 Apr; 152(4):1582-8. doi: 10.1210/en.2010-1070. [PMID: 21303953]
  • Felicia M Rabey, Vardan T Karamyan, Robert C Speth. Distribution of a novel binding site for angiotensins II and III in mouse tissues. Regulatory peptides. 2010 Jun; 162(1-3):5-11. doi: 10.1016/j.regpep.2010.02.007. [PMID: 20171994]
  • Belinda L Houghton, Chunlong Huang, Edward J Johns. Influence of dietary sodium on the blood pressure and renal sympathetic nerve activity responses to intracerebroventricular angiotensin II and angiotensin III in anaesthetized rats. Experimental physiology. 2010 Feb; 95(2):282-95. doi: 10.1113/expphysiol.2009.049833. [PMID: 19880539]
  • Changping Hu, Bum-Yong Kang, Judit Megyesi, Gur P Kaushal, Robert L Safirstein, Jawahar L Mehta. Deletion of LOX-1 attenuates renal injury following angiotensin II infusion. Kidney international. 2009 Sep; 76(5):521-7. doi: 10.1038/ki.2009.234. [PMID: 19553911]
  • Shetal H Padia, Brandon A Kemp, Nancy L Howell, John J Gildea, Susanna R Keller, Robert M Carey. Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 2009 Feb; 53(2):338-43. doi: 10.1161/hypertensionaha.108.124198. [PMID: 19075092]
  • Manuel A Méndez, Michel Prudent, Bin Su, Hubert H Girault. Peptide-phospholipid complex formation at liquid-liquid interfaces. Analytical chemistry. 2008 Dec; 80(24):9499-507. doi: 10.1021/ac801651f. [PMID: 19072264]
  • Peter Rossing. Is renal Na+,K+-ATPase a new target for renin-angiotensin blocking agents in diabetic nephropathy?. The Journal of physiology. 2008 Nov; 586(22):5283. doi: 10.1113/jphysiol.2008.164723. [PMID: 19011129]
  • Shetal H Padia, Brandon A Kemp, Nancy L Howell, Marie-Claude Fournie-Zaluski, Bernard P Roques, Robert M Carey. Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats. Hypertension (Dallas, Tex. : 1979). 2008 Feb; 51(2):460-5. doi: 10.1161/hypertensionaha.107.103242. [PMID: 18158338]
  • Susana de la Chica-Rodríguez, Pedro Cortés-Denia, María Jesús Ramírez-Expósito, José Manuel Arias de Saavedra, Rafael Sánchez-Agesta, María del Cármen Pérez, José Manuel Martínez-Martos. Doxazosin blockade of alpha 1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis. Fertility and sterility. 2007 Oct; 88(4 Suppl):1071-5. doi: 10.1016/j.fertnstert.2006.12.021. [PMID: 17445810]
  • Shetal H Padia, Brandon A Kemp, Nancy L Howell, Helmy M Siragy, Marie-Claude Fournie-Zaluski, Bernard P Roques, Robert M Carey. Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats. Hypertension (Dallas, Tex. : 1979). 2007 Mar; 49(3):625-30. doi: 10.1161/01.hyp.0000254833.85106.4d. [PMID: 17190872]
  • I Gammelgaard, S Wamberg, P Bie. Systemic effects of angiotensin III in conscious dogs during acute double blockade of the renin-angiotensin-aldosterone-system. Acta physiologica (Oxford, England). 2006 Oct; 188(2):129-38. doi: 10.1111/j.1748-1716.2006.01595.x. [PMID: 16948800]
  • Franziska Faber, Florian Gembardt, Xiaoou Sun, Shigehiko Mizutani, Wolf-Eberhard Siems, Thomas Walther. Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice. Regulatory peptides. 2006 Sep; 136(1-3):130-7. doi: 10.1016/j.regpep.2006.06.001. [PMID: 16889841]
  • Shetal H Padia, Nancy L Howell, Helmy M Siragy, Robert M Carey. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Hypertension (Dallas, Tex. : 1979). 2006 Mar; 47(3):537-44. doi: 10.1161/01.hyp.0000196950.48596.21. [PMID: 16380540]
  • A B Segarra, M Ramírez, I Banegas, F Hermoso, F Vargas, F Vives, F Alba, M de Gasparo, I Prieto. Influence of thyroid disorders on kidney angiotensinase activity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2006 Jan; 38(1):48-52. doi: 10.1055/s-2006-924978. [PMID: 16477541]
  • Andrzej Mogielnicki, Ewa Chabielska, Robert Pawlak, Janusz Szemraj, Wlodzimierz Buczko. Angiotensin II enhances thrombosis development in renovascular hypertensive rats. Thrombosis and haemostasis. 2005 Jun; 93(6):1069-76. doi: 10.1160/th04-10-0701. [PMID: 15968390]
  • Bernard R Chaitman, Alla Y Ivleva, Marek Ujda, Jacque H F Lenis, Csaba Toth, David M Stieber, Leonardo H Reisin, Andreas M Pangerl, Julie B Friedman, John H Lawrence. Antianginal efficacy of omapatrilat in patients with chronic angina pectoris. The American journal of cardiology. 2005 Jun; 95(11):1283-9. doi: 10.1016/j.amjcard.2005.01.069. [PMID: 15904630]
  • Jean-Philippe Godin, Jörg Hau, Laurent-Bernard Fay, Gérard Hopfgartner. Isotope ratio monitoring of small molecules and macromolecules by liquid chromatography coupled to isotope ratio mass spectrometry. Rapid communications in mass spectrometry : RCM. 2005; 19(18):2689-98. doi: 10.1002/rcm.2117. [PMID: 16124031]
  • Alan Daugherty, Debra L Rateri, Hong Lu, Tadashi Inagami, Lisa A Cassis. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation. 2004 Dec; 110(25):3849-57. doi: 10.1161/01.cir.0000150540.54220.c4. [PMID: 15596561]
  • Paul Lijnen, Victor Petrov, Guillermo Diaz-Araya, Robert Fagard. Effect of bestatin on angiotensin I-, II- and III-induced collagen gel contraction in cardiac fibroblasts. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2004 Dec; 5(4):183-8. doi: 10.3317/jraas.2004.038. [PMID: 15803436]
  • M R Mustafa, M Dharmani, N K Kunheen, M K Sim. Effects of des-aspartate-angiotensin I on the actions of angiotensin III in the renal and mesenteric vasculature of normo- and hypertensive rats. Regulatory peptides. 2004 Aug; 120(1-3):15-22. doi: 10.1016/j.regpep.2003.12.010. [PMID: 15177916]
  • Christian Wamberg, Ronni R Plovsing, Niels C F Sandgaard, Peter Bie. Effects of different angiotensins during acute, double blockade of the renin system in conscious dogs. American journal of physiology. Regulatory, integrative and comparative physiology. 2003 Nov; 285(5):R971-80. doi: 10.1152/ajpregu.00262.2003. [PMID: 12869367]
  • Ronni R Plovsing, Christian Wamberg, Niels C F Sandgaard, Jane A Simonsen, Niels-Henrik Holstein-Rathlou, Poul Flemming Hoilund-Carlsen, Peter Bie. Effects of truncated angiotensins in humans after double blockade of the renin system. American journal of physiology. Regulatory, integrative and comparative physiology. 2003 Nov; 285(5):R981-91. doi: 10.1152/ajpregu.00263.2003. [PMID: 12869368]
  • Johannes Stegbauer, Oliver Vonend, Vitus Oberhauser, Lars Christian Rump. Effects of angiotensin-(1-7) and other bioactive components of the renin-angiotensin system on vascular resistance and noradrenaline release in rat kidney. Journal of hypertension. 2003 Jul; 21(7):1391-9. doi: 10.1097/00004872-200307000-00030. [PMID: 12817189]
  • Paul Lijnen, Victor Petrov, Kandelaria Rumilla, Robert Fagard. Stimulation of collagen gel contraction by angiotensin II and III in cardiac fibroblasts. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2002 Sep; 3(3):160-6. doi: 10.3317/jraas.2002.036. [PMID: 12563566]
  • Annette Hus-Citharel, Jeannine Marchetti, Pierre Corvol, Catherine Llorens-Cortes. Potentiation of [Ca2+]i response to angiotensin III by cAMP in cortical thick ascending limb. Kidney international. 2002 Jun; 61(6):1996-2005. doi: 10.1046/j.1523-1755.2002.00366.x. [PMID: 12028440]
  • Óscar Lorenzo, Marta Ruiz-Ortega, Yusuke Suzuki, Mónica Rupérez, Vanesa Esteban, Takeshi Sugaya, Jesús Egido. Angiotensin III activates nuclear transcription factor-kappaB in cultured mesangial cells mainly via AT(2) receptors: studies with AT(1) receptor-knockout mice. Journal of the American Society of Nephrology : JASN. 2002 May; 13(5):1162-1171. doi: 10.1681/asn.v1351162. [PMID: 11961003]
  • Lucienne S Lara, Rafael B S Bica, Sílvia L F Sena, Juliana S Correa, Maria F Marques-Fernandes, Aníbal G Lopes, Celso Caruso-Neves. Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor. Regulatory peptides. 2002 Jan; 103(1):17-22. doi: 10.1016/s0167-0115(01)00322-6. [PMID: 11738244]
  • P G Du, S Kato, Y H Li, T Maeda, T Yamane, S Yamamoto, M Fujiwara, Y Yamamoto, K Nishi, I Ohkubo. Rat tripeptidyl peptidase I: molecular cloning, functional expression, tissue localization and enzymatic characterization. Biological chemistry. 2001 Dec; 382(12):1715-25. doi: 10.1515/bc.2001.207. [PMID: 11843185]
  • M Ruiz-Ortega, O Lorenzo, M Rupérez, V Esteban, Y Suzuki, S Mezzano, J J Plaza, J Egido. Role of the renin-angiotensin system in vascular diseases: expanding the field. Hypertension (Dallas, Tex. : 1979). 2001 Dec; 38(6):1382-7. doi: 10.1161/hy1201.100589. [PMID: 11751722]
  • M J McKinley, A M Allen, M L Mathai, C May, R M McAllen, B J Oldfield, R S Weisinger. Brain angiotensin and body fluid homeostasis. The Japanese journal of physiology. 2001 Jun; 51(3):281-9. doi: 10.2170/jjphysiol.51.281. [PMID: 11492952]
  • M Ruiz-Ortega, O Lorenzo, J Egido. Angiotensin III increases MCP-1 and activates NF-kappaB and AP-1 in cultured mesangial and mononuclear cells. Kidney international. 2000 Jun; 57(6):2285-98. doi: 10.1046/j.1523-1755.2000.00089.x. [PMID: 10844599]
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