CITCO (BioDeep_00000010808)

   


代谢物信息卡片


6-(4-Chlorophenyl)imidazo[2,1-B][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime

化学式: C19H12Cl3N3OS (434.9766632000001)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C2=C(N3C=CSC3=N2)C=NOCC4=CC(=C(C=C4)Cl)Cl)Cl
InChI: InChI=1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+

描述信息

同义名列表

3 个代谢物同义名

CITCO; 6-(4-Chlorophenyl)imidazo[2,1-B][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; CITCO



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wenwei Lin, Monicah Bwayi, Jing Wu, Yongtao Li, Sergio C Chai, Andrew D Huber, Taosheng Chen. CITCO Directly Binds to and Activates Human Pregnane X Receptor. Molecular pharmacology. 2020 03; 97(3):180-190. doi: 10.1124/mol.119.118513. [PMID: 31882411]
  • Asmita Pant, Elizabeth A Rondini, Thomas A Kocarek. Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells. Toxicology and applied pharmacology. 2019 02; 365(?):61-70. doi: 10.1016/j.taap.2019.01.003. [PMID: 30611723]
  • Jan Dusek, Alejandro Carazo, Frantisek Trejtnar, Lucie Hyrsova, Ondřej Holas, Tomas Smutny, Stanislav Micuda, Petr Pavek. Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Nov; 109(Pt 1):130-142. doi: 10.1016/j.fct.2017.09.007. [PMID: 28887089]
  • Benjamin A Kandel, Maria Thomas, Stefan Winter, Georg Damm, Daniel Seehofer, Oliver Burk, Matthias Schwab, Ulrich M Zanger. Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes. Biochimica et biophysica acta. 2016 09; 1859(9):1218-1227. doi: 10.1016/j.bbagrm.2016.03.007. [PMID: 26994748]
  • Ruixin Hao, Shengzhong Su, Yinan Wan, Frank Shen, Ben Niu, Denise M Coslo, Istvan Albert, Xing Han, Curtis J Omiecinski. Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver. Biochimica et biophysica acta. 2016 09; 1859(9):1228-1237. doi: 10.1016/j.bbagrm.2016.04.002. [PMID: 27080131]
  • Alice Marmugi, Céline Lukowicz, Frederic Lasserre, Alexandra Montagner, Arnaud Polizzi, Simon Ducheix, Adeline Goron, Laurence Gamet-Payrastre, Sabine Gerbal-Chaloin, Jean Marc Pascussi, Marthe Moldes, Thierry Pineau, Hervé Guillou, Laila Mselli-Lakhal. Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way. Toxicology and applied pharmacology. 2016 07; 303(?):90-100. doi: 10.1016/j.taap.2016.05.006. [PMID: 27180240]
  • Xiao-Jie Zhang, Zhe Shi, Jing-Xi Lyv, Xuyan He, Neal A Englert, Shu-Yun Zhang. Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Oct; 147(2):436-45. doi: 10.1093/toxsci/kfv142. [PMID: 26160115]
  • Tao Chen, Elizabeth M Laurenzana, Denise M Coslo, Fengming Chen, Curtis J Omiecinski. Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. The Biochemical journal. 2014 Feb; 458(1):95-107. doi: 10.1042/bj20130685. [PMID: 24224465]
  • Hui Yang, Brandy Garzel, Scott Heyward, Timothy Moeller, Paul Shapiro, Hongbing Wang. Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling. Molecular pharmacology. 2014 Feb; 85(2):249-60. doi: 10.1124/mol.113.089763. [PMID: 24252946]
  • Fengming Chen, Stephanie M Zamule, Denise M Coslo, Tao Chen, Curtis J Omiecinski. The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. Developmental biology. 2013 Dec; 384(2):155-65. doi: 10.1016/j.ydbio.2013.10.012. [PMID: 24144921]
  • Katie B Paul, Jerry T Thompson, Steven O Simmons, John P Vanden Heuvel, Kevin M Crofton. Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors. Toxicology in vitro : an international journal published in association with BIBRA. 2013 Oct; 27(7):2049-60. doi: 10.1016/j.tiv.2013.07.008. [PMID: 23899473]
  • Cong Xu, Si-Yun Xu, Hai-Hong Hu, Lu-Shan Yu, Su Zeng. [Establishment of in vitro evaluation model for CYP2B6 induction and its application to screen inducers among TCMs]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Jan; 48(1):119-24. doi: . [PMID: 23600152]
  • Elizabeth M Laurenzana, Tao Chen, Malavika Kannuswamy, Brian E Sell, Stephen C Strom, Yong Li, Curtis J Omiecinski. The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3). Molecular pharmacology. 2012 Nov; 82(5):918-28. doi: 10.1124/mol.112.080721. [PMID: 22896671]
  • Fadheela Al-Salman, Nick Plant. Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner. Toxicology and applied pharmacology. 2012 Aug; 263(1):7-13. doi: 10.1016/j.taap.2012.05.016. [PMID: 22664347]
  • Aik Jiang Lau, Guixiang Yang, Thomas K H Chang. Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants. The Journal of pharmacology and experimental therapeutics. 2011 Nov; 339(2):704-15. doi: 10.1124/jpet.111.186130. [PMID: 21862659]
  • Cyril Breuker, Amélie Moreau, Laila Lakhal, Viola Tamasi, Yannick Parmentier, Urs Meyer, Patrick Maurel, Serge Lumbroso, Marie-José Vilarem, Jean-Marc Pascussi. Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). Endocrinology. 2010 Apr; 151(4):1653-61. doi: 10.1210/en.2009-1435. [PMID: 20185760]
  • Hisashi Masuyama, Hideki Nakatsukasa, Yuji Hiramatsu. Effect of oncostatin M on uridine diphosphate-5'-glucuronosyltransferase 1A1 through cross talk with constitutive androstane receptor. Molecular endocrinology (Baltimore, Md.). 2010 Apr; 24(4):745-53. doi: 10.1210/me.2009-0478. [PMID: 20197307]
  • Stephanie M Zamule, Stephen C Strom, Curtis J Omiecinski. Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. Chemico-biological interactions. 2008 Jun; 173(3):179-86. doi: 10.1016/j.cbi.2008.03.015. [PMID: 18468591]