SR 12813 (BioDeep_00000010798)
代谢物信息卡片
化学式: C24H42O7P2 (504.2406)
中文名称:
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: CCOP(=O)(C(=CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C)P(=O)(OCC)OCC)OCC
InChI: InChI=1S/C24H42O7P2/c1-11-28-32(26,29-12-2)21(33(27,30-13-3)31-14-4)17-18-15-19(23(5,6)7)22(25)20(16-18)24(8,9)10/h15-17,25H,11-14H2,1-10H3
描述信息
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM[1][2]. SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR)[3].
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:77317
- KEGG: C15628
- PubChem: 446313
- Metlin: METLIN70985
- DrugBank: DB04466
- ChEMBL: CHEMBL458767
- CAS: 126411-39-0
- PMhub: MS000024694
- PubChem: 17396618
- PDB-CCD: SRL
- NIKKAJI: J746.005H
- medchemexpress: HY-100793
- KNApSAcK: 77317
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yosuke Toyota, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto, Kenji Ohgane. Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation.
Bioorganic & medicinal chemistry.
2020 07; 28(14):115576. doi:
10.1016/j.bmc.2020.115576. [PMID: 32616181] - Jingjing Zhang, Lili Ding, Baocan Wang, Gaiyan Ren, Aning Sun, Chao Deng, Xiaohui Wei, Sridhar Mani, Zhengtao Wang, Wei Dou. Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation.
The Journal of pharmacology and experimental therapeutics.
2015 Feb; 352(2):315-24. doi:
10.1124/jpet.114.218750. [PMID: 25472953] - Navdar Sever, Peter C W Lee, Bao-Liang Song, Robert B Rawson, Russell A Debose-Boyd. Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
The Journal of biological chemistry.
2004 Oct; 279(41):43136-47. doi:
10.1074/jbc.m406406200. [PMID: 15247248] - T A Berkhout, H M Simon, B Jackson, J Yates, N Pearce, P H Groot, C Bentzen, E Niesor, W D Kerns, K E Suckling. SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis.
Atherosclerosis.
1997 Sep; 133(2):203-12. doi:
10.1016/s0021-9150(97)00131-7. [PMID: 9298680] - T A Berkhout, H M Simon, D D Patel, C Bentzen, E Niesor, B Jackson, K E Suckling. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
The Journal of biological chemistry.
1996 Jun; 271(24):14376-82. doi:
10.1074/jbc.271.24.14376. [PMID: 8662919]
