Subcellular Location: Cytoplasmic vesicle, COPII-coated vesicle

Found 2 associated metabolites.

4 associated genes.

KLHL12, PDCD6, PDCD6-AHRR, YIPF5

TMPT

2-Ethyl-2(hydroxymethyl)-1,3-propanediol trimethacrylate

C18H26O6 (338.1729)

SR 12813

4-[2,2-Bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol

C24H42O7P2 (504.2406)

D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM[1][2]. SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR)[3].