acutumine (BioDeep_00000001075)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(1S,4S,6S,10R,11S)-11-chloro-4-hydroxy-3,4,5-trimethoxy-7-methylspiro[7-azatricyclo[4.3.3.01,6]dodec-4-ene-10,5-cyclopent-2-ene]-1,3-dione

化学式: C19H24ClNO6 (397.1292)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 96.92%

分子结构信息

SMILES: CN1CCC23C1(CC(C24C(C(=CC4=O)OC)O)Cl)C(=C(C(=O)C3)OC)OC
InChI: InChI=1S/C19H24ClNO6/c1-21-6-5-17-8-10(22)14(26-3)16(27-4)18(17,21)9-12(20)19(17)13(23)7-11(25-2)15(19)24/h7,12,15,24H,5-6,8-9H2,1-4H3/t12-,15+,17+,18+,19+/m0/s1

描述信息

Acutumine is an alkaloid.
Acutumine is a natural product found in Hypserpa nitida, Sinomenium acutum, and other organisms with data available.
Dauricumine is a natural product found in Hypserpa nitida, Sinomenium acutum, and Menispermum dauricum with data available.

同义名列表

7 个代谢物同义名

(1S,4S,6S,10R,11S)-11-chloro-4-hydroxy-3,4,5-trimethoxy-7-methylspiro[7-azatricyclo[4.3.3.01,6]dodec-4-ene-10,5-cyclopent-2-ene]-1,3-dione; (?)-Acutumine; ( )-Acutumine; Dauricumine; acutumine; (1S,4R,6S,10R,11S)-11-chloro-4-hydroxy-3,4,5-trimethoxy-7-methylspiro[7-azatricyclo[4.3.3.01,6]dodec-4-ene-10,5-cyclopent-2-ene]-1,3-dione; Acutumine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, BCL2, CASP3, CAT, EGFR, MAPK1, MAPK8, PIK3CA
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 BCL2, EGFR
Nucleus 5 BCL2, CASP3, EGFR, MAPK1, MAPK8
cytosol 7 BCL2, CASP3, CAT, MAPK1, MAPK8, PIK3CA, TNFRSF11A
centrosome 1 MAPK1
nucleoplasm 3 CASP3, MAPK1, MAPK8
Cell membrane 3 ABCB1, EGFR, OPRD1
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 ABCB1, OPRD1
Synapse 2 MAPK1, MAPK8
cell junction 1 EGFR
cell surface 3 ABCB1, EGFR, ITGA2
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 1 MAPK1
Golgi membrane 1 EGFR
neuronal cell body 1 CASP3
presynaptic membrane 1 OPRD1
endosome 1 EGFR
plasma membrane 7 ABCB1, EGFR, ITGA2, MAPK1, OPRD1, PIK3CA, TNFRSF11A
synaptic vesicle membrane 1 OPRD1
Membrane 6 ABCB1, BCL2, CAT, EGFR, ITGA2, OPRD1
apical plasma membrane 2 ABCB1, EGFR
axon 1 MAPK8
basolateral plasma membrane 1 EGFR
caveola 1 MAPK1
extracellular exosome 2 ABCB1, CAT
endoplasmic reticulum 1 BCL2
extracellular space 1 EGFR
perinuclear region of cytoplasm 3 EGFR, ITGA2, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CAT, MAPK1
protein-containing complex 3 BCL2, CAT, EGFR
intracellular membrane-bounded organelle 1 CAT
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 EGFR, ITGA2, TNFRSF11A
extracellular region 2 CAT, MAPK1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
basal part of cell 1 ITGA2
mitochondrial matrix 1 CAT
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 MAPK1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 2 ITGA2, TNFRSF11A
Early endosome 1 MAPK1
Apical cell membrane 1 ABCB1
Membrane raft 2 EGFR, TNFRSF11A
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 4 CAT, EGFR, ITGA2, MAPK1
spindle 1 MAPK1
Peroxisome 1 CAT
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Late endosome 1 MAPK1
receptor complex 1 EGFR
neuron projection 1 OPRD1
mitotic spindle 1 MAPK1
cytoskeleton 1 MAPK1
Membrane, caveola 1 MAPK1
myelin sheath 1 BCL2
pseudopodium 1 MAPK1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 CAT, MAPK1
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 MAPK1
axon terminus 2 ITGA2, OPRD1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 MAPK1
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
clathrin-coated endocytic vesicle membrane 1 EGFR
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 TNFRSF11A
dendrite membrane 1 OPRD1
integrin complex 1 ITGA2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
catalase complex 1 CAT
integrin alpha2-beta1 complex 1 ITGA2
BAD-BCL-2 complex 1 BCL2
spine apparatus 1 OPRD1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform RANK-e5a]: Cell membrane 1 TNFRSF11A


文献列表

  • Yu-Feng Huang, Fan He, Can-Jian Wang, Ying Xie, Yan-Yu Zhang, Zhen Sang, Ping Qiu, Pei Luo, Sheng-Yuan Xiao, Jing Li, Fei-Ci Wu, Liang Liu, Hua Zhou. Discovery of chemical markers for improving the quality and safety control of Sinomenium acutum stem by the simultaneous determination of multiple alkaloids using UHPLC-QQQ-MS/MS. Scientific reports. 2020 08; 10(1):14182. doi: 10.1038/s41598-020-71133-4. [PMID: 32843671]
  • Colin Y Kim, Andrew J Mitchell, Christopher M Glinkerman, Fu-Shuang Li, Tomáš Pluskal, Jing-Ke Weng. The chloroalkaloid (-)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants. Nature communications. 2020 04; 11(1):1867. doi: 10.1038/s41467-020-15777-w. [PMID: 32313070]
  • Sandra M King, Nicholas A Calandra, Seth B Herzon. Total syntheses of (-)-acutumine and (-)-dechloroacutumine. Angewandte Chemie (International ed. in English). 2013 Mar; 52(13):3642-5. doi: 10.1002/anie.201210076. [PMID: 23427090]
  • Li He, Yuan-Hu Zhang, Li-Jia Tang, Shao-Hui Song, Qian-Yun Sun. [Study on the alkaloids in the stems and leaves of Stephania cepharantha (II)]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Oct; 33(10):1568-70. doi: . [PMID: 21355192]
  • En-Jun Wang, Yun-Bao Ma, Xue-Mei Zhang, Zhi-Yong Jiang, Ji-Jun Chen. [Five alkaloids from vine stems of Diploclisia affinis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Nov; 33(21):2503-5. doi: . [PMID: 19149259]
  • Pi Cheng, Yun-bao Ma, Shu-ying Yao, Quan Zhang, En-jun Wang, Meng-hong Yan, Xue-mei Zhang, Feng-xue Zhang, Ji-jun Chen. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. Bioorganic & medicinal chemistry letters. 2007 Oct; 17(19):5316-20. doi: 10.1016/j.bmcl.2007.08.027. [PMID: 17723297]
  • Yukihiro Sugimoto, Miharu Matsui, Hirosato Takikawa, Mitsuru Sasaki, Masako Kato. Dechlorodauricumine from cultured roots of Menispermum dauricum. Phytochemistry. 2005 Nov; 66(22):2627-31. doi: 10.1016/j.phytochem.2005.09.023. [PMID: 16289151]
  • Y Sugimoto, H A Babiker, T Saisho, T Furumoto, S Inanaga, M Kato. Chlorinated alkaloids in Menispermum dauricum DC: root culture. The Journal of organic chemistry. 2001 May; 66(10):3299-302. doi: 10.1021/jo001494l. [PMID: 11348110]