Fustin (BioDeep_00000001043)
Secondary id: BioDeep_00001045414
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C15H12O6 (288.06338519999997)
中文名称: 黄颜木素, 黄颜木素
谱图信息:
最多检出来源 Viridiplantae(plant) 0.7%
分子结构信息
SMILES: C1=CC(=C(C=C1C2C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O
InChI: InChI=1S/C15H12O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,14-18,20H
描述信息
Fustin is a natural product found in Acacia vestita, Acacia carneorum, and other organisms with data available.
See also: Cotinus coggygria whole (part of); Toxicodendron succedaneum whole (part of).
A dihydroflavonol that is the 2,3-dihydro derivative of fisetin.
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1].
同义名列表
35 个代谢物同义名
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, (2R,3R)-rel-; 4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIHYDROXYPHENYL)-2,3-DIHYDRO-3,7-DIHYDROXY-, (2R-TRANS)-; 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-,(2R,3R)-rel-; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, (2R,3R)-; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, trans-; (2R,3R)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-4H-1-benzopyran-4-one; (2R,3S)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-2,3-dihydro-4H-chromen-4-one; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-2,3-dihydrochromen-4-one; trans-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-4-benzopyrone; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chroman-4-one; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxychroman-4-one; TRANS-(+/-)-3,3,4,7-TETRAHYDROXYFLAVANONE; Flavanone, 3,3,4,7-tetrahydroxy- (VAN); Flavanone, 3,3,4,7-tetrahydroxy-, (+)-; Flavanone, 3,3,4,7-tetrahydroxy-(VAN); 3,7,3,4-Tetrahydroxyflavanone; 3,7,3,4-Tetrahydroxy-flavanon; 3,3,4,7-tetrahydroxyflavanone; Fustin (2R,3R)-form [MI]; Tetrahydroxyflavanone; 2,3-Dihydrofisetin; 2,3-TRANS-FUSTIN; FUSTIN, (+/-)-; Dihydrofisetin; Fustin, (+)-; (+/-)-Fustin; FUSTIN [MI]; (+)-Fustin; AC1NSVLG; Fustin; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-chromanone; 20725-03-5; C01378; (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:5202
- KEGG: C01378
- PubChem: 5317435
- PubChem: 246330
- Metlin: METLIN64207
- ChEMBL: CHEMBL470267
- Wikipedia: Fustin
- MeSH: fustin
- ChemIDplus: 0004382369
- KNApSAcK: C00008561
- CAS: 20725-03-5
- CAS: 4382-36-9
- MoNA: TY000232
- medchemexpress: HY-N8376
- PMhub: MS000010495
- MetaboLights: MTBLC5202
- ChEBI: CHEBI:228234
- PubChem: 4573
- KNApSAcK: C00000963
- 3DMET: B01445
- NIKKAJI: J231.369C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PharmGKB(0)
169 个相关的物种来源信息
- 33090 皂角刺: -
- 33090 荠菜: -
- 138515 Acacia cultriformis: 10.1016/S0031-9422(00)85959-2
- 1378370 Acacia kettlewelliae: 10.1016/S0031-9422(00)85959-2
- 138518 Acacia leucoclada: 10.1016/S0031-9422(00)85959-2
- 383647 Acacia mabellae: 10.1016/S0031-9422(00)85959-2
- 139006 Acacia calamifolia: 10.1016/S0031-9422(00)85959-2
- 383640 Acacia constablei: 10.1016/S0031-9422(00)85959-2
- 1174753 Acacia chrysotricha: 10.1016/S0031-9422(00)85959-2
- 383648 Acacia mollifolia:
- 204988 Acacia adunca: 10.1016/S0031-9422(00)85959-2
- 139012 Acacia mearnsii: 10.1016/S0031-9422(00)85959-2
- 205042 Acacia dealbata: 10.1016/S0031-9422(00)85959-2
- 383632 Acacia baileyana:
- 1174755 Acacia clunies-rossiae: 10.1016/S0031-9422(00)85959-2
- 139008 Acacia falciformis: 10.1016/S0031-9422(00)85959-2
- 383645 Acacia irrorata: 10.1016/S0031-9422(00)85959-2
- 1280824 Acacia rubida: 10.1016/S0031-9422(00)85959-2
- 205063 Acacia silvestris: 10.1016/S0031-9422(00)85959-2
- 383638 Acacia cardiophylla: 10.1016/S0031-9422(00)85959-2
- 1174771 Acacia decora: 10.1016/S0031-9422(00)85959-2
- 205356 Acacia deanei: 10.1016/S0031-9422(00)85959-2
- 383643 Acacia filicifolia: 10.1016/S0031-9422(00)85959-2
- 138037 Acacia parramattensis: 10.1016/S0031-9422(00)85959-2
- 383658 Acacia trachyphloia: 10.1016/S0031-9422(00)85959-2
- 1120476 Acacia vestita: 10.1016/S0031-9422(00)85959-2
- 138021 Acacia elata: 10.1016/S0031-9422(00)85959-2
- 21010 Acacia fimbriata: 10.1016/S0031-9422(00)85959-2
- 138512 Acacia binervata: 10.1016/S0031-9422(00)85959-2
- 1174746 Acacia buxifolia: 10.1016/S0031-9422(00)85959-2
- 383657 Acacia terminalis: 10.1016/S0031-9422(00)85959-2
- 383653 Acacia oshanesii: 10.1016/S0031-9422(00)85959-2
- 205053 Acacia neriifolia: 10.1016/S0031-9422(00)85959-2
- 880440 Acacia pycnantha: 10.1016/S0031-9422(00)85959-2
- 1969222 Baptisia lecontei: 10.1016/S0031-9422(00)84834-7
- 138022 Acacia fasciculifera: 10.1039/P19810002483
- 1173639 Acacia carneorum: 10.1039/P19810000514
- 58847 Virgilia oroboides: 10.1016/0031-9422(90)80205-U
- 4013 Toxicodendron vernicifluum:
- 35938 Robinia pseudoacacia: 10.1042/BJ0820324
- 1174866 Acacia peuce: 10.1039/P19790000777
- 1300370 Acacia saxatilis: 10.1016/S0031-9422(00)86939-3
- 255348 Rhus typhina:
- 269719 Cotinus coggygria:
- 141191 Lawsonia inermis: 10.1016/J.PHYTOL.2011.05.007
- 66093 Gleditsia japonica: 10.1248/YAKUSHI1947.77.11_1208
- 210348 Brucea javanica: 10.1016/J.FITOTE.2007.07.008
- 1940515 Prosopidastrum globosum: 10.1021/NP50045A029
- 1173639 Acacia carneorum:
- 138022 Acacia fasciculifera:
- 1300370 Acacia saxatilis:
- 1174866 Acacia peuce:
- 1378370 Acacia kettlewelliae:
- 383640 Acacia constablei:
- 383645 Acacia irrorata:
- 138515 Acacia cultriformis:
- 880440 Acacia pycnantha:
- 383638 Acacia cardiophylla:
- 383643 Acacia filicifolia:
- 205053 Acacia neriifolia:
- 383658 Acacia trachyphloia:
- 205042 Acacia dealbata:
- 138037 Acacia parramattensis:
- 1174755 Acacia clunies-rossiae:
- 1174746 Acacia buxifolia:
- 383657 Acacia terminalis:
- 1120476 Acacia vestita:
- 383653 Acacia oshanesii:
- 1280824 Acacia rubida:
- 205063 Acacia silvestris:
- 205356 Acacia deanei:
- 383648 Acacia mollifolia:
- 21010 Acacia fimbriata:
- 138518 Acacia leucoclada:
- 383632 Acacia baileyana:
- 139008 Acacia falciformis:
- 139006 Acacia calamifolia:
- 1174753 Acacia chrysotricha:
- 204988 Acacia adunca:
- 383647 Acacia mabellae:
- 1174771 Acacia decora:
- 138021 Acacia elata:
- 2839963 Zanthoxylum asiaticum: 10.1016/S0031-9422(00)97163-2
- 45837 Solanum pseudocapsicum: 10.1016/0031-9422(71)85124-5
- 139012 Acacia mearnsii: 10.1042/BJ0820320
- 138515 Acacia cultriformis: 10.1016/S0031-9422(00)85959-2
- 1378370 Acacia kettlewelliae: 10.1016/S0031-9422(00)85959-2
- 138518 Acacia leucoclada: 10.1016/S0031-9422(00)85959-2
- 383647 Acacia mabellae: 10.1016/S0031-9422(00)85959-2
- 139006 Acacia calamifolia: 10.1016/S0031-9422(00)85959-2
- 383640 Acacia constablei: 10.1016/S0031-9422(00)85959-2
- 1174753 Acacia chrysotricha: 10.1016/S0031-9422(00)85959-2
- 383648 Acacia mollifolia:
- 204988 Acacia adunca: 10.1016/S0031-9422(00)85959-2
- 139012 Acacia mearnsii: 10.1016/S0031-9422(00)85959-2
- 205042 Acacia dealbata: 10.1016/S0031-9422(00)85959-2
- 383632 Acacia baileyana:
- 1174755 Acacia clunies-rossiae: 10.1016/S0031-9422(00)85959-2
- 139008 Acacia falciformis: 10.1016/S0031-9422(00)85959-2
- 383645 Acacia irrorata: 10.1016/S0031-9422(00)85959-2
- 1280824 Acacia rubida: 10.1016/S0031-9422(00)85959-2
- 205063 Acacia silvestris: 10.1016/S0031-9422(00)85959-2
- 383638 Acacia cardiophylla: 10.1016/S0031-9422(00)85959-2
- 1174771 Acacia decora: 10.1016/S0031-9422(00)85959-2
- 205356 Acacia deanei: 10.1016/S0031-9422(00)85959-2
- 383643 Acacia filicifolia: 10.1016/S0031-9422(00)85959-2
- 138037 Acacia parramattensis: 10.1016/S0031-9422(00)85959-2
- 383658 Acacia trachyphloia: 10.1016/S0031-9422(00)85959-2
- 1120476 Acacia vestita: 10.1016/S0031-9422(00)85959-2
- 138021 Acacia elata: 10.1016/S0031-9422(00)85959-2
- 21010 Acacia fimbriata: 10.1016/S0031-9422(00)85959-2
- 138512 Acacia binervata: 10.1016/S0031-9422(00)85959-2
- 1174746 Acacia buxifolia: 10.1016/S0031-9422(00)85959-2
- 383657 Acacia terminalis: 10.1016/S0031-9422(00)85959-2
- 383653 Acacia oshanesii: 10.1016/S0031-9422(00)85959-2
- 205053 Acacia neriifolia: 10.1016/S0031-9422(00)85959-2
- 880440 Acacia pycnantha: 10.1016/S0031-9422(00)85959-2
- 1969222 Baptisia lecontei: 10.1016/S0031-9422(00)84834-7
- 138022 Acacia fasciculifera: 10.1039/P19810002483
- 1173639 Acacia carneorum: 10.1039/P19810000514
- 58847 Virgilia oroboides: 10.1016/0031-9422(90)80205-U
- 4013 Toxicodendron vernicifluum:
- 35938 Robinia pseudoacacia: 10.1042/BJ0820324
- 1174866 Acacia peuce: 10.1039/P19790000777
- 1300370 Acacia saxatilis: 10.1016/S0031-9422(00)86939-3
- 255348 Rhus typhina:
- 269719 Cotinus coggygria:
- 141191 Lawsonia inermis: 10.1016/J.PHYTOL.2011.05.007
- 66093 Gleditsia japonica: 10.1248/YAKUSHI1947.77.11_1208
- 210348 Brucea javanica: 10.1016/J.FITOTE.2007.07.008
- 1940515 Prosopidastrum globosum: 10.1021/NP50045A029
- 1173639 Acacia carneorum:
- 138022 Acacia fasciculifera:
- 1300370 Acacia saxatilis:
- 1174866 Acacia peuce:
- 1378370 Acacia kettlewelliae:
- 383640 Acacia constablei:
- 383645 Acacia irrorata:
- 138515 Acacia cultriformis:
- 880440 Acacia pycnantha:
- 383638 Acacia cardiophylla:
- 383643 Acacia filicifolia:
- 205053 Acacia neriifolia:
- 383658 Acacia trachyphloia:
- 205042 Acacia dealbata:
- 138037 Acacia parramattensis:
- 1174755 Acacia clunies-rossiae:
- 1174746 Acacia buxifolia:
- 383657 Acacia terminalis:
- 1120476 Acacia vestita:
- 383653 Acacia oshanesii:
- 1280824 Acacia rubida:
- 205063 Acacia silvestris:
- 205356 Acacia deanei:
- 383648 Acacia mollifolia:
- 21010 Acacia fimbriata:
- 138518 Acacia leucoclada:
- 383632 Acacia baileyana:
- 139008 Acacia falciformis:
- 139006 Acacia calamifolia:
- 1174753 Acacia chrysotricha:
- 204988 Acacia adunca:
- 383647 Acacia mabellae:
- 1174771 Acacia decora:
- 138021 Acacia elata:
- 2839963 Zanthoxylum asiaticum: 10.1016/S0031-9422(00)97163-2
- 45837 Solanum pseudocapsicum: 10.1016/0031-9422(71)85124-5
- 139012 Acacia mearnsii: 10.1042/BJ0820320
- 569774 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- A S Bawadood, F A Al-Abbasi, A M Alghamdi, M M Alqurashi, R A Sheikh, S I Alzarea, N Sayyed, I Kazmi. Fustin alleviates lipopolysaccharide-induced anxiety-depression-like performances by modulation of oxidative stress/neuroinflammatory markers/ NF-κB/caspase-3/BDNF expression in rodents.
European review for medical and pharmacological sciences.
2024 Jan; 28(1):419-432. doi:
10.26355/eurrev_202401_34931
. [PMID: 38235894] - Muhammad Afzal, Fahad A Al-Abbasi, Imran Kazmi, Syed Sarim Imam, Sultan Alshehri, Mohammed M Ghoneim, Waleed Hassan Almalki, Muhammad Shahid Nadeem, Nadeem Sayyed. Fustin Inhibits Oxidative Free Radicals and Inflammatory Cytokines in Cerebral Cortex and Hippocampus and Protects Cognitive Impairment in Streptozotocin-Induced Diabetic Rats.
ACS chemical neuroscience.
2021 12; 12(24):4587-4597. doi:
10.1021/acschemneuro.1c00712
. [PMID: 34860003] - Laura Marín, Ignacio Gutiérrez-Del-Río, Claudio Jesús Villar, Felipe Lombó. De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activity.
Microbial biotechnology.
2021 09; 14(5):2009-2024. doi:
10.1111/1751-7915.13874
. [PMID: 34216097] - Miroslav Novakovic, Iris Djordjevic, Nina Todorovic, Snezana Trifunovic, Boban Andjelkovic, Boris Mandic, Milka Jadranin, Ivan Vuckovic, Vlatka Vajs, Slobodan Milosavljevic, Vele Tesevic. New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop.
Natural product research.
2019 Oct; 33(19):2837-2844. doi:
10.1080/14786419.2018.1508141
. [PMID: 30513208] - Seon-Ok Lee, Sung-Ji Kim, Ju-Sung Kim, Hyuk Ji, Eun-Ok Lee, Hyo-Jeong Lee. Comparison of the main components and bioactivity of Rhus verniciflua Stokes extracts by different detoxification processing methods.
BMC complementary and alternative medicine.
2018 Aug; 18(1):242. doi:
10.1186/s12906-018-2310-x
. [PMID: 30165848] - Hongxia Chen, Chengzhang Wang, Hao Zhou, Ran Tao, Jianzhong Ye, Wenjun Li. Antioxidant capacity and identification of the constituents of ethyl acetate fraction from Rhus verniciflua Stokes by HPLC-MS.
Natural product research.
2017 Jul; 31(13):1573-1577. doi:
10.1080/14786419.2016.1277353
. [PMID: 28100074] - Tae Gyu Nam, Bong Han Lee, Hyo-Kyoung Choi, Ahmad Rois Mansur, Sang Gil Lee, Dae-Ok Kim. Rhus verniciflua Stokes Extract and Its Flavonoids Protect PC-12 Cells against H2O2-Induced Cytotoxicity.
Journal of microbiology and biotechnology.
2017 Jun; 27(6):1090-1097. doi:
10.4014/jmb.1612.12018
. [PMID: 28376611] - Won Kyun Im, Hyun Jung Park, Kwang Soo Lee, Jung Hoon Lee, Young Dong Kim, Kyeong-Hee Kim, Sang-Jae Park, Seokmann Hong, Sung Ho Jeon. Fisetin-Rich Extracts of Rhus verniciflua Stokes Improve Blood Flow Rates in Mice Fed Both Normal and High-Fat Diets.
Journal of medicinal food.
2016 Feb; 19(2):120-6. doi:
10.1089/jmf.2015.3515
. [PMID: 26741654] - Ji Eun Moon, Jae-Ho Shin, Oran Kwon, Ji Yeon Kim. A Standardized Extract of Rhus verniciflua Stokes Protects Wistar Rats Against Lipopolysaccharide-Induced Acute Inflammation.
Journal of medicinal food.
2015 Nov; 18(11):1223-30. doi:
10.1089/jmf.2014.3411
. [PMID: 26501382] - Guan Chen, Cheng-Bin Cui, Ai-Di Qi, Chang-Wei Li, Zun-Wei Tao, Rong Ren. Polyanthumin, a novel cyclobutane chalcone trimmer from Memecylon polyanthum.
Journal of Asian natural products research.
2015; 17(2):170-7. doi:
10.1080/10286020.2014.945439
. [PMID: 25434469] - Myeong Hyeon Park, In Sook Kim, Sun-A Kim, Chun-Soo Na, Cheol Yi Hong, Mi-Sook Dong, Hye Hyun Yoo. Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component.
Bioorganic & medicinal chemistry letters.
2014 Apr; 24(7):1730-3. doi:
10.1016/j.bmcl.2014.02.039
. [PMID: 24630560] - Nattapong Chaipukdee, Somdej Kanokmedhakul, Ratsami Lekphrom, Kwanjai Kanokmedhakul. Two new flavanonols from the bark of Akschindlium godefroyanum.
Natural product research.
2014; 28(3):191-5. doi:
10.1080/14786419.2013.866113
. [PMID: 24354343] - U R Kuppusamy, N P Das. Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes.
Biochemical pharmacology.
1992 Oct; 44(7):1307-15. doi:
10.1016/0006-2952(92)90531-m
. [PMID: 1384499]