(+)-Himbacine (BioDeep_00001028453)

   


代谢物信息卡片


(+)-Himbacine

化学式: C22H35NO2 (345.2668)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C
InChI: InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1

描述信息

D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics

同义名列表

2 个代谢物同义名

(+)-Himbacine; Himbacine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ADRA2A, CHAT, MT3, PIK3C3, PTGS1, TRIM32
Peripheral membrane protein 1 PTGS1
Endoplasmic reticulum membrane 1 PTGS1
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 4 CHAT, MT3, PLCZ1, TRIM32
autophagosome 2 PIK3C3, TRIM32
cytosol 8 CHAT, LIPA, LIPE, MT3, PIK3C3, PLCZ1, PRKCQ, TRIM32
dendrite 2 CHRM2, HTR2C
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 TRIM32
nucleoplasm 2 LIPA, PLCZ1
Cell membrane 8 ADRA2A, CHRM2, F2R, GRID1, HTR2C, KCNK10, LIPE, P2RY12
Multi-pass membrane protein 8 ADRA2A, CHRM2, F2R, GRID1, HTR2C, KCNA3, KCNK10, P2RY12
Synapse 3 CHAT, CHRM2, HTR2C
cell surface 2 F2R, P2RY12
glutamatergic synapse 5 ADRA2A, CHRM2, GRID1, KCNA3, PIK3C3
Golgi apparatus 3 F2R, NPY, PTGS1
neuromuscular junction 1 F2R
neuronal cell body 2 ADRA2A, CHRM2
presynaptic membrane 2 CHRM2, KCNA3
synaptic vesicle 1 MT3
Cytoplasm, cytosol 1 LIPE
Lysosome 1 LIPA
endosome 1 PIK3C3
plasma membrane 10 ADRA2A, CHRM2, F2R, GCG, GRID1, HTR2C, KCNA3, KCNK10, P2RY12, PRKCQ
Membrane 6 CHRM2, KCNA3, KCNK10, LIPE, P2RY12, PIK3C3
axon 2 KCNA3, MT3
basolateral plasma membrane 1 ADRA2A
caveola 2 F2R, LIPE
extracellular exosome 2 GRID1, PTGS1
endoplasmic reticulum 1 TRIM32
extracellular space 3 GCG, MT3, NPY
lysosomal lumen 1 LIPA
perinuclear region of cytoplasm 3 KCNA3, MT3, PLCZ1
mitochondrion 1 TRIM32
intracellular membrane-bounded organelle 2 LIPA, PTGS1
Microsome membrane 1 PTGS1
pronucleus 1 PLCZ1
Secreted 2 GCG, NPY
extracellular region 3 F2R, GCG, NPY
mitochondrial outer membrane 1 MT3
astrocyte end-foot 1 MT3
centriolar satellite 1 PRKCQ
photoreceptor outer segment 1 PTGS1
dendritic spine 1 MT3
nucleolus 1 PLCZ1
midbody 1 PIK3C3
Early endosome 1 F2R
postsynaptic membrane 4 CHRM2, F2R, GRID1, KCNA3
presynaptic active zone membrane 1 ADRA2A
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 KCNA3
microtubule 1 MT3
GABA-ergic synapse 4 ADRA2A, GRID1, NPY, PIK3C3
Peroxisome 1 PIK3C3
axoneme 1 PIK3C3
Postsynaptic cell membrane 2 CHRM2, GRID1
Late endosome 2 F2R, PIK3C3
receptor complex 1 ADRA2A
neuron projection 2 CHAT, PTGS1
phagocytic vesicle membrane 1 PIK3C3
[Isoform 2]: Cell membrane 1 KCNA3
fibrillar center 1 LIPA
Endomembrane system 1 PTGS1
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
monoatomic ion channel complex 1 KCNK10
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 1 GCG
endoplasmic reticulum lumen 1 GCG
axon terminus 2 ADRA2A, CHRM2
postsynaptic density membrane 2 ADRA2A, GRID1
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
neuronal dense core vesicle 1 NPY
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 CHRM2
[Isoform 1]: Cell membrane 1 KCNA3
dopaminergic synapse 1 ADRA2A
postsynaptic endosome 1 PIK3C3
cholinergic synapse 1 CHRM2
ribosome 1 MT3
symmetric synapse 1 CHRM2
[Glucagon-like peptide 1]: Secreted 1 GCG
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
Autolysosome 1 PIK3C3
sperm head 1 PLCZ1
inclusion body 1 MT3
platelet dense tubular network 1 F2R
asymmetric synapse 1 CHRM2
cell body membrane 1 P2RY12
cell projection membrane 1 P2RY12
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
G protein-coupled serotonin receptor complex 1 HTR2C
striated muscle myosin thick filament 1 TRIM32


文献列表

  • Mariappan V Chelliah, Samuel Chackalamannil, Yan Xia, Keith Eagen, William J Greenlee, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Yunsheng Hsieh, Matthew Bryant, Tze-Ming Chan, Madhu Chintala. Discovery of nor-seco himbacine analogs as thrombin receptor antagonists. Bioorganic & medicinal chemistry letters. 2012 Apr; 22(7):2544-9. doi: 10.1016/j.bmcl.2012.01.138. [PMID: 22405832]
  • Satin Salehi, Shannon R Long, Philip J Proteau, Theresa M Filtz. Hawthorn (Crataegus monogyna Jacq.) extract exhibits atropine-sensitive activity in a cultured cardiomyocyte assay. Journal of natural medicines. 2009 Jan; 63(1):1-8. doi: 10.1007/s11418-008-0278-4. [PMID: 18696181]