Moxestrol (BioDeep_00000010131)
代谢物信息卡片
化学式: C21H26O3 (326.1881846)
中文名称: 甲氧炔雌醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#CC1(O)CCC2C3CCc4cc(O)ccc4C3C(OC)CC21C
InChI: InChI=1S/C21H26O3/c1-4-21(23)10-9-17-16-7-5-13-11-14(22)6-8-15(13)19(16)18(24-3)12-20(17,21)2/h1,6,8,11,16-19,22-23H,5,7,9-10,12H2,2-3H3/t16-,17-,18-,19+,20-,21-/m0/s1
描述信息
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens > G03CB - Synthetic estrogens, plain
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
ATC code: G03CB04
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:34857
- KEGG: C14757
- PubChem: 11954041
- Metlin: METLIN70311
- DrugBank: DB13418
- ChEMBL: CHEMBL1628161
- CAS: 34816-55-2
- PMhub: MS000023967
- PubChem: 17395755
- NIKKAJI: J17.707E
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.
Toxicological sciences : an official journal of the Society of Toxicology.
2015 Feb; 143(2):333-48. doi:
10.1093/toxsci/kfu231. [PMID: 25349334] - N Erwin Ivessa, Edward Rehberg, Bernadette Kienzle, Fridolin Seif, Robert Hermann, Marcela Hermann, Wolfgang J Schneider, David A Gordon. Molecular cloning, expression, and hormonal regulation of the chicken microsomal triglyceride transfer protein.
Gene.
2013 Jul; 523(1):1-9. doi:
10.1016/j.gene.2013.03.102. [PMID: 23542778] - Gyesik Min. Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells.
Experimental & molecular medicine.
2010 Nov; 42(11):731-8. doi:
10.3858/emm.2010.42.11.074. [PMID: 20871212] - D Marilley, D Robyr, C Schild-Poulter, W Wahli. Regulation of the vitellogenin gene B1 promoter after transfer into hepatocytes in primary cultures.
Molecular and cellular endocrinology.
1998 Jun; 141(1-2):79-93. doi:
10.1016/s0303-7207(98)00090-2. [PMID: 9723889] - M Hermann, F Seif, W J Schneider, N E Ivessa. Estrogen dependence of synthesis and secretion of apolipoprotein B-containing lipoproteins in the chicken hepatoma cell line, LMH-2A.
Journal of lipid research.
1997 Jul; 38(7):1308-17. doi:
. [PMID: 9254058] - G G Kuiper, B Carlsson, K Grandien, E Enmark, J Häggblad, S Nilsson, J A Gustafsson. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.
Endocrinology.
1997 Mar; 138(3):863-70. doi:
10.1210/endo.138.3.4979. [PMID: 9048584] - S K Banerjee, S Banerjee, S A Li, J J Li. Induction of chromosome aberrations in Syrian hamster renal cortical cells by various estrogens.
Mutation research.
1994 Dec; 311(2):191-7. doi:
10.1016/0027-5107(94)90176-7. [PMID: 7526183] - H F VanBrocklin, K E Carlson, J A Katzenellenbogen, M J Welch. 16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors.
Journal of medicinal chemistry.
1993 May; 36(11):1619-29. doi:
10.1021/jm00063a012. [PMID: 7684451] - B T Zhu, D Roy, J G Liehr. The carcinogenic activity of ethinyl estrogens is determined by both their hormonal characteristics and their conversion to catechol metabolites.
Endocrinology.
1993 Feb; 132(2):577-83. doi:
10.1210/endo.132.2.8381068. [PMID: 8381068] - P Lointier, D M Wildrick, B M Boman. The effects of steroid hormones on a human colon cancer cell line in vitro.
Anticancer research.
1992 Jul; 12(4):1327-30. doi:
. [PMID: 1503430] - P Lointier, M J Wargovich, S Saez, B Levin, D M Wildrick, B M Boman. The role of vitamin D3 in the proliferation of a human colon cancer cell line in vitro.
Anticancer research.
1987 Jul; 7(4B):817-21. doi:
. [PMID: 2823686] - D Hochner-Celnikier, A Marandici, F Iohan, C Monder. Estrogen and progesterone receptors in the organs of prenatal cynomolgus monkey and laboratory mouse.
Biology of reproduction.
1986 Oct; 35(3):633-40. doi:
10.1095/biolreprod35.3.633. [PMID: 3790664] - M Edery, W Imagawa, L Larson, S Nandi. Regulation of estrogen and progesterone receptor levels in mouse mammary epithelial cells grown in serum-free collagen gel cultures.
Endocrinology.
1985 Jan; 116(1):105-12. doi:
10.1210/endo-116-1-105. [PMID: 2981060] - G A Robinson, A M Gibbins. Induction of vitellogenesis in Japanese quail as a sensitive indicator of the estrogen-mimetic effect of a variety of environmental contaminants.
Poultry science.
1984 Aug; 63(8):1529-36. doi:
10.3382/ps.0631529. [PMID: 6237320] - A M Soto, H Lee, P K Siiteri, J T Murai, C Sonnenschein. Estrogen induction of progestophilins in rat estrogen-sensitive cells grown in media supplemented with sera from castrated rats and from rats bearing an alpha-fetoprotein-secreting hepatoma.
Experimental cell research.
1984 Feb; 150(2):390-9. doi:
10.1016/0014-4827(84)90582-2. [PMID: 6198194] - J Salmon, D Coussediere, C Cousty, J P Raynaud. Pharmacokinetics and metabolism of moxestrol in animals--rat, dog and monkey.
Journal of steroid biochemistry.
1983 Aug; 19(2):1223-34. doi:
10.1016/0022-4731(83)90421-1. [PMID: 6887930] - J Salmon, D Coussediere, C Cousty, J P Raynaud. Pharmacokinetics and metabolism of moxestrol in humans.
Journal of steroid biochemistry.
1983 May; 18(5):565-73. doi:
10.1016/0022-4731(83)90132-2. [PMID: 6855232] - B Vannier, J P Raynaud. Long-term effects of prenatal oestrogen treatment on genital morphology and reproductive function in the rat.
Journal of reproduction and fertility.
1980 May; 59(1):43-9. doi:
10.1530/jrf.0.0590043. [PMID: 7401044] - C Robyn, M Vekemans, M Rozencweig, D Chigot, J P Raynaud. Double-blind crossover clinical pharmacology study comparing moxestrol (R 2858) and ethinyl estradiol in postmenopausal women.
Journal of clinical pharmacology.
1978 Jan; 18(1):29-34. doi:
10.1002/j.1552-4604.1978.tb01557.x. [PMID: 338643] - P A Kelly, J Asselin, M G Caron, J P Raynaud, F Labrie. High inhibitory activity of a new antiestrogen, RU 16117 (11alpha-methoxy ethinyl estradiol), on the development of dimethylbenz(a)anthracene-induced mammary tumors.
Cancer research.
1977 Jan; 37(1):76-81. doi:
NULL. [PMID: 187338] - B Vannier, J P Raynaud. Effect of estrogen plasma binding on sexual differentiation of the rat fetus.
Molecular and cellular endocrinology.
1975 Nov; 3(5):323-37. doi:
10.1016/0303-7207(75)90034-9. [PMID: 53165]