2,2-Dichlorethyl ether (BioDeep_00000010084)

   


代谢物信息卡片


1,5-Dichloro-3-oxapentane

化学式: C4H8Cl2O (141.9952)
中文名称: 二(2-氯乙基)醚, 双(2-氯乙基)醚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCl)OCCCl
InChI: InChI=1S/C4H8Cl2O/c5-1-3-7-4-2-6/h1-4H2



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 APOE, NOTCH2
Endoplasmic reticulum membrane 1 NOTCH2
Nucleus 4 APOE, JUN, JUND, NOTCH2
dendrite 1 APOE
nucleoplasm 4 ATP2B1, JUN, JUND, NOTCH2
RNA polymerase II transcription regulator complex 2 JUN, JUND
Cell membrane 4 ATP2B1, SLC38A3, SLC38A5, TNF
Multi-pass membrane protein 3 ATP2B1, SLC38A3, SLC38A5
Synapse 1 ATP2B1
cell surface 2 NOTCH2, TNF
glutamatergic synapse 2 APOE, ATP2B1
Golgi apparatus 2 APOE, ATRN
Golgi membrane 1 NOTCH2
neuronal cell body 2 APOE, TNF
presynaptic membrane 1 ATP2B1
plasma membrane 7 APOE, ATP2B1, ATRN, NOTCH2, SLC38A3, SLC38A5, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 5 APOE, ATP2B1, NOTCH2, SLC38A3, SLC38A5
apical plasma membrane 1 SLC38A3
basolateral plasma membrane 2 ATP2B1, SLC38A3
extracellular exosome 3 APOE, ATP2B1, ATRN
endoplasmic reticulum 1 APOE
extracellular space 3 APOE, ATRN, TNF
intracellular membrane-bounded organelle 1 ATP2B1
Single-pass type I membrane protein 2 ATRN, NOTCH2
Secreted 1 APOE
extracellular region 3 APOE, NOTCH2, TNF
[Isoform 2]: Secreted 1 ATRN
transcription regulator complex 2 JUN, JUND
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
Early endosome 1 APOE
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
extracellular matrix 1 APOE
collagen-containing extracellular matrix 1 APOE
lateral plasma membrane 1 ATP2B1
receptor complex 1 NOTCH2
cilium 1 NOTCH2
chromatin 2 JUN, JUND
cell projection 1 ATP2B1
phagocytic cup 1 TNF
Secreted, extracellular space 1 APOE
nuclear chromosome 1 JUN
blood microparticle 1 APOE
Basolateral cell membrane 2 ATP2B1, SLC38A3
[Isoform 3]: Secreted 1 ATRN
Melanosome 1 APOE
euchromatin 1 JUN
Presynaptic cell membrane 1 ATP2B1
endoplasmic reticulum lumen 1 APOE
transcription repressor complex 1 JUND
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 1 APOE
[Isoform 1]: Cell membrane 1 ATRN
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
transcription factor AP-1 complex 2 JUN, JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
photoreceptor ribbon synapse 1 ATP2B1
[Notch 2 extracellular truncation]: Cell membrane 1 NOTCH2
[Notch 2 intracellular domain]: Nucleus 1 NOTCH2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Maria D M Mutuc, Nancy G Love, Peter J Vikesland. Surface catalyzed Fenton treatment of bis(2-chloroethyl) ether and bis(2-chloroethoxy) methane. Chemosphere. 2008 Feb; 70(8):1390-8. doi: 10.1016/j.chemosphere.2007.09.061. [PMID: 18061235]
  • K Norpoth, M Heger, G Müller, E Mohtashamipur, A Kemena, C Witting. Investigations on metabolism, genotoxic effects and carcinogenicity of 2,2'-dichlorodiethylether. Journal of cancer research and clinical oncology. 1986; 112(2):125-30. doi: 10.1007/bf00404394. [PMID: 3771621]
  • R D Lingg, W H Kaylor, S M Pyle, M M Domino, C C Smith, G F Wolfe. Metabolism of bis(2-chloroethyl)ether and bis(2-chloroisopropyl)ether in the rat. Archives of environmental contamination and toxicology. 1982; 11(2):173-83. doi: 10.1007/bf01054894. [PMID: 6807217]
  • R D Lingg, W H Kaylor, S M Pyle, R G Tardiff. Thiodiglycolic acid: a major metabolite of bis(2-chloroethyl)ether. Toxicology and applied pharmacology. 1979 Jan; 47(1):23-34. doi: 10.1016/0041-008x(79)90067-x. [PMID: 425117]
  • H E Nielsen, M S Christensen, F Melsen. Hyperparathyroidism after renal transplantation. Lancet (London, England). 1977 May; 1(8020):1057. doi: 10.1016/s0140-6736(77)91293-4. [PMID: 67519]
  • G DEYSSON, R TRUHAUT. [Research on the anti-mitotic properties of compounds related to nitrogen mustards. I. Comparative activity, tested on plant cells, of "nitrogen mustard" HN 3 and its sulfur homologues (yperite) and oxygen homologues (chlorex)]. Bulletin de l'Association francaise pour l'etude du cancer. 1959 Nov; 46(?):762-9. doi: . [PMID: 13816347]