Methylthioadenosine (BioDeep_00000399874)

Main id: BioDeep_00000001262

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


(2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol

化学式: C11H15N5O3S (297.0896)
中文名称: 5'-脱氧-5'-(甲硫基)腺苷
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-11-05.

Cite this Page

Methylthioadenosine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/methylthioadenosine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000399874). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CSCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
InChI: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
Adenosine with the hydroxy group at C-5 substituted with a methylthio (methylsulfanyl) group.
COVID info from COVID-19 Disease Map
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

5'-(Methylthio)adenosine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=2457-80-9 (retrieved 2024-11-05) (CAS RN: 2457-80-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

10 个代谢物同义名

5-Deoxy-5-Methylthioadenosine; 5-S-Methyl-5-thioadenosine; Adenylthiomethylpentose; 5-Methylthioadenosine; NCGC00263645-02_C11H15N5O3S_5-Methylthioadenosine; 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine; 5'-Methylthioadenosine; 5'-Methylthioadenosine



数据库引用编号

23 个数据库交叉引用编号

分类词条

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ADA, AHCY, AKT1, APRT, CDKN2A, MAPK14, ODC1, PNP, PRMT5
Peripheral membrane protein 1 ADA
Nucleus 6 AHCY, AKT1, CDKN2A, JUND, MAPK14, PRMT5
cytosol 15 ADA, AHCY, AKT1, AMD1, APRT, CDKN2A, MAPK14, MAT1A, MAT2A, NGF, ODC1, PNP, PRMT5, SMS, SRM
dendrite 1 NGF
nucleoplasm 6 AKT1, APRT, CDKN2A, JUND, MAPK14, PRMT5
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 3 ADA, AKT1, TNF
lamellipodium 1 AKT1
cell cortex 1 AKT1
cell junction 1 ADA
cell surface 2 ADA, TNF
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 1 PRMT5
lysosomal membrane 1 EGF
neuronal cell body 1 TNF
postsynapse 1 AKT1
synaptic vesicle 1 NGF
Lysosome 1 ADA
plasma membrane 5 ADA, AKT1, EGF, IFNLR1, TNF
Membrane 4 ADA, AKT1, EGF, IFNLR1
axon 1 NGF
extracellular exosome 5 AHCY, APRT, EGF, PNP, SMS
endoplasmic reticulum 1 AHCY
extracellular space 5 EGF, IL6, NGF, PNP, TNF
mitochondrion 2 CDKN2A, MAPK14
protein-containing complex 2 AKT1, CDKN2A
Single-pass type I membrane protein 1 IFNLR1
Secreted 3 IL6, NGF, PNP
extracellular region 7 APRT, EGF, IL6, MAPK14, NGF, PNP, TNF
mitochondrial matrix 1 CDKN2A
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
transcription regulator complex 1 JUND
external side of plasma membrane 2 ADA, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 CDKN2A
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
spindle 1 AKT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
ciliary basal body 1 AKT1
chromatin 2 JUND, PRMT5
phagocytic cup 1 TNF
Chromosome 1 PRMT5
Nucleus, nucleolus 1 CDKN2A
spindle pole 1 MAPK14
endosome lumen 1 NGF
Nucleus, nucleoplasm 1 CDKN2A
Melanosome 1 AHCY
ficolin-1-rich granule lumen 2 MAPK14, PNP
secretory granule lumen 3 APRT, MAPK14, PNP
Golgi lumen 1 NGF
endoplasmic reticulum lumen 1 IL6
histone methyltransferase complex 1 PRMT5
transcription repressor complex 1 JUND
platelet alpha granule lumen 1 EGF
methylosome 1 PRMT5
clathrin-coated endocytic vesicle membrane 1 EGF
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
senescence-associated heterochromatin focus 1 CDKN2A
methionine adenosyltransferase complex 2 MAT1A, MAT2A
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform smARF]: Mitochondrion 1 CDKN2A


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