Deoxycytidine (BioDeep_00000001206)

 

Secondary id: BioDeep_00000398681, BioDeep_00000399893

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


4-Amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one

化学式: C9H13N3O4 (227.0906)
中文名称: 2'-脱氧胞苷
谱图信息: 最多检出来源 Homo sapiens(blood) 20.08%

Reviewed

Last reviewed on 2024-08-21.

Cite this Page

Deoxycytidine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/deoxycytidine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001206). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C(C(OC1N2C=CC(=NC2=O)N)CO)O
InChI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)

描述信息

Deoxycytidine, also known as dC, belongs to the class of organic compounds known as pyrimidine 2-deoxyribonucleosides. Pyrimidine 2-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2. Deoxycytidine is also classified as a deoxyribonucleoside, a component of deoxyribonucleic acid (DNA). Deoxycytidine is similar to the ribonucleoside cytidine, but with one hydroxyl group removed from the 2 position. Deoxycytidine exists in all living species, ranging from bacteria to plants to humans. Degradation of DNA through apoptosis or cell death produces deoxycytidine. Within humans, deoxycytidine participates in a number of enzymatic reactions. In particular, deoxycytidine can be biosynthesized from dCMP through the action of the enzyme cytosolic purine 5-nucleotidase. In addition, deoxycytidine can be converted into dCMP; which is mediated by the enzyme uridine-cytidine kinase-like 1. Deoxycytidine can be phosphorylated at the C-5 position by the enzyme deoxycytidine kinase to produce deoxycytidine monophosphate (dCMP), and to a lesser extent, deoxycytidine diphosphate (dCDP), and deoxycytidine triphosphate (dCTP). Deoxycytidine can also be phosphorylated by thymidine kinase 2 (TK2). Deoxycytidine can potentially be used for the treatment of the metabolic disorder known as thymidine kinase 2 deficiency (TK2 deficiency). TK2 deficiency has three disease subtypes: i) infantile-onset myopathy with rapid progression to early death ii) childhood-onset myopathy, which resembles spinal muscular atrophy (SMA) type III, begins between ages 1 and 12 years with progression to loss of ambulation within few years and iii) late-onset myopathy starting at age 12 year or later with moderate to severe myopathy manifesting as either isolated chronic progressive external ophthalmoplegia (CPEO) or a generalized myopathy with CPEO plus facial and limb weakness, gradual progression, and, in some cases, respiratory failure and loss of ability to walk in adulthood (PMID: 28318037). In mouse models of TK2, dC was shown to delay disease onset, prolong life span and restore mtDNA copy number as well as respiratory chain enzyme activities (PMID: 28318037).
One of the principal nucleosides of DNA composed of cytosine and deoxyribose. A nucleoside consists of only a pentose sugar linked to a purine or pyrimidine base, without a phosphate group. When N1 is linked to the C1 of deoxyribose, deoxynucleosides and nucleotides are formed from cytosine and deoxyribose; deoxycytidine monophosphate (dCMP), deoxycytidine diphosphate (dCDP), deoxycytidine triphosphate (dCTP). CTP is the source of the cytidine in RNA (ribonucleic acid) and deoxycytidine triphosphate (dCTP) is the source of the deoxycytidine in DNA (deoxyribonucleic acid). [HMDB]. Deoxycytidine is found in many foods, some of which are japanese pumpkin, turmeric, prairie turnip, and kai-lan.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
Acquisition and generation of the data is financially supported in part by CREST/JST.
C26170 - Protective Agent > C2459 - Chemoprotective Agent
COVID info from COVID-19 Disease Map
KEIO_ID D055; [MS2] KO008940
Corona-virus
KEIO_ID D055
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer[1][2].
2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).

同义名列表

26 个代谢物同义名

4-Amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one; 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one; 4-Amino-1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-2(1H)-pyrimidinone; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone; 4-Amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone; 1-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-cytosine; 1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-cytosine; 1-(2-Deoxy-beta-delta-ribofuranosyl)cytosine; 1-(2-Deoxy-beta-D-ribofuranosyl)cytosine; 1-(2-Deoxy-b-D-ribofuranosyl)cytosine; Deoxyribonucleoside, cytosine; Cytosine deoxyribonucleoside; 2-Deoxycytidine monohydrate; Deoxyriboside, cytosine; Cytosine deoxyriboside; Deoxyribose cytidine; 2-Deoxy-cytidine; 2-Deoxycytidine; Desoxycytidine; Deoxy-cytidine; Deoxycytidine; DCYD; dC; Deoxycytidine; 2'-Deoxycytidine; Deoxycytidine



数据库引用编号

44 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(0)

代谢反应

371 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(95)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(253)

COVID-19 Disease Map(1)

PathBank(21)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ADA, APOB, APOBEC3G, BCL2, CASP3, CMPK1, DCK, DCTD, DGUOK, HPRT1, NT5C2, PNP, TK2, TYMS
Peripheral membrane protein 1 ADA
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 2 APOB, BCL2
Nucleus 11 ADK, APOBEC3G, BCL2, CASP3, CMPK1, DCK, DGUOK, DNMT1, TK1, TYMS, UNG
cytosol 17 ADA, ADK, APOB, APOBEC3G, BCL2, CASP3, CDA, CMPK1, DCK, DCTD, DGUOK, HPRT1, NGF, NT5C2, PNP, TK1, TYMS
dendrite 1 NGF
nucleoplasm 6 ADK, CASP3, CMPK1, DCK, DNMT1, UNG
Cell membrane 1 ADA
cell junction 1 ADA
cell surface 1 ADA
glutamatergic synapse 1 CASP3
mitochondrial inner membrane 1 TYMS
neuronal cell body 2 APOB, CASP3
smooth endoplasmic reticulum 1 APOB
synaptic vesicle 1 NGF
Cytoplasm, cytosol 1 NT5C2
Lysosome 1 ADA
plasma membrane 3 ADA, ADK, APOB
Membrane 2 ADA, BCL2
axon 1 NGF
extracellular exosome 4 APOB, CMPK1, HPRT1, PNP
endoplasmic reticulum 1 BCL2
extracellular space 3 APOB, NGF, PNP
lysosomal lumen 1 APOB
mitochondrion 7 BCL2, DCK, DGUOK, DNMT1, TK2, TYMS, UNG
protein-containing complex 1 BCL2
intracellular membrane-bounded organelle 1 APOB
postsynaptic density 1 CASP3
pericentric heterochromatin 1 DNMT1
Secreted 3 APOB, NGF, PNP
extracellular region 4 APOB, CDA, NGF, PNP
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TYMS
mitochondrial matrix 3 DGUOK, TK2, TYMS
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ADA
chylomicron 1 APOB
low-density lipoprotein particle 1 APOB
very-low-density lipoprotein particle 1 APOB
nucleolus 1 CMPK1
Cytoplasm, P-body 1 APOBEC3G
P-body 1 APOBEC3G
Early endosome 1 APOB
Mitochondrion inner membrane 1 TYMS
pore complex 1 BCL2
apolipoprotein B mRNA editing enzyme complex 1 APOBEC3G
endosome lumen 2 APOB, NGF
Lipid droplet 1 APOB
female germ cell nucleus 1 DNMT1
replication fork 1 DNMT1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CDA, PNP
secretory granule lumen 2 CDA, PNP
Golgi lumen 1 NGF
endoplasmic reticulum lumen 1 APOB
tertiary granule lumen 1 CDA
endoplasmic reticulum exit site 1 APOB
[Isoform 2]: Cytoplasm 1 ADK
clathrin-coated endocytic vesicle membrane 1 APOB
ribonucleoprotein complex 1 APOBEC3G
[Isoform 1]: Nucleus 1 ADK
death-inducing signaling complex 1 CASP3
endocytic vesicle lumen 1 APOB
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
mature chylomicron 1 APOB
BAD-BCL-2 complex 1 BCL2


文献列表

  • Binbin Luo, Linyi Song, Limiao Chen, Yue Cai, Mingwei Zhang, Shenyi Wang. Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155675. doi: 10.1016/j.phymed.2024.155675. [PMID: 38678954]
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  • Su-Li Zhu, Ming Qi, Mei-Ting Chen, Jia-Peng Lin, Hai-Fu Huang, Li-Juan Deng, Xing-Wang Zhou. A novel DDIT3 activator dehydroevodiamine effectively inhibits tumor growth and tumor cell stemness in pancreatic cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155377. doi: 10.1016/j.phymed.2024.155377. [PMID: 38503154]
  • Sofia Sturm, Günter Niegisch, Joachim Windolf, Christoph V Suschek. Exposure of Bladder Cancer Cells to Blue Light (λ = 453 nm) in the Presence of Riboflavin Synergistically Enhances the Cytotoxic Efficiency of Gemcitabine. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094868. [PMID: 38732087]
  • Jingcheng Zhang, Yutong Wang, Lejunzi Wang, Lei You, Taiping Zhang. Pancreatic ductal adenocarcinoma chemoresistance: From metabolism reprogramming to novel treatment. Chinese medical journal. 2024 Feb; 137(4):408-420. doi: 10.1097/cm9.0000000000002758. [PMID: 37545027]
  • Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia. Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer. Journal of controlled release : official journal of the Controlled Release Society. 2024 Jan; 365(?):112-131. doi: 10.1016/j.jconrel.2023.11.028. [PMID: 37981050]
  • Ji He, Piyush Bugde, Jiawei Li, Riya Biswas, Siting Li, Xuewei Yang, Fang Tian, Zimei Wu, Yan Li. Multidrug resistance protein 5 affects cell proliferation, migration and gemcitabine sensitivity in pancreatic cancer MIA Paca‑2 and PANC‑1 cells. Oncology reports. 2024 Jan; 51(1):. doi: 10.3892/or.2023.8666. [PMID: 37975256]
  • Shukui Qin, Jin Li, Yuxian Bai, Zishu Wang, Zhendong Chen, Ruihua Xu, Jianming Xu, Hongmei Zhang, Jia Chen, Ying Yuan, Tianshu Liu, Lin Yang, Haijun Zhong, Donghui Chen, Lin Shen, Chunyi Hao, Deliang Fu, Ying Cheng, Jianwei Yang, Qiong Wang, Baoli Qin, Hongming Pan, Jun Zhang, Xianhong Bai, Qingshan Zheng. Nimotuzumab Plus Gemcitabine for K-Ras Wild-Type Locally Advanced or Metastatic Pancreatic Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Nov; 41(33):5163-5173. doi: 10.1200/jco.22.02630. [PMID: 37647576]
  • Xuena Dong, Yuhan Wang, Shuhui Wang, Cong Li, Min Zhang, Fanglin Hou. Clinical Effect of the Combination of Compound Kushen Injection and Gemcitabine on Postoperative Patients with Non-Muscle Invasive Bladder Cancer and Its Influence on Serum-Related Factors. Archivos espanoles de urologia. 2023 Nov; 76(9):657-665. doi: 10.56434/j.arch.esp.urol.20237609.80. [PMID: 38053420]
  • Myeong Jin Kim, Hyung Sun Kim, Hyeon Woong Kang, Da Eun Lee, Woosol Chris Hong, Ju Hyun Kim, Minsoo Kim, Jae-Ho Cheong, Hyo Jung Kim, Joon Seong Park. SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine Resistance in Pancreatic Cancer. Cells. 2023 10; 12(20):. doi: 10.3390/cells12202509. [PMID: 37887353]
  • Epiphane K Silli, Mengfei Li, Yuting Shao, Yiran Zhang, Guilin Hou, Jiaqian Du, Jingdan Liang, Ying Wang. Liposomal Nanostructures for Gemcitabine and Paclitaxel Delivery in Pancreatic Cancer. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023 Sep; ?(?):. doi: 10.1016/j.ejpb.2023.09.014. [PMID: 37758121]
  • Wanhui Wei, Yuanyuan Lu, Qian Hu, Jinwen Yin, Youwei Wang, Heng Zhang, Qiu Zhao, Lan Liu. Synergistic antitumor efficacy of gemcitabine and cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via Sp1-SAT1-polyamine metabolism pathway. Cellular oncology (Dordrecht). 2023 Sep; ?(?):. doi: 10.1007/s13402-023-00870-1. [PMID: 37684512]
  • Andriana Inkoom, Nkafu Bechem Ndemazie, Taylor Smith, Esther Frimpong, Raviteja Bulusu, Rosemary Poku, Xue Zhu, Bo Han, Jose Trevino, Edward Agyare. Biological evaluation of novel gemcitabine analog in patient-derived xenograft models of pancreatic cancer. BMC cancer. 2023 May; 23(1):435. doi: 10.1186/s12885-023-10928-w. [PMID: 37179357]
  • Ran Qi, Yixuan Bai, Kun Li, Nanbin Liu, Yan Xu, Emre Dal, Yufeng Wang, Rui Lin, Hui Wang, Zhongyan Liu, Xinbo Li, Xiuyan Wang, Baomin Shi. Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2023 Mar; 68(?):100960. doi: 10.1016/j.drup.2023.100960. [PMID: 37003125]
  • Shruti Gupta, Hemanth Naick Banavath, Kiran Kumar Tejavath. Pharmacoinformatic screening of phytoconstituent and evaluation of its anti-PDAC effect using in vitro studies. Journal of biomolecular structure & dynamics. 2022 Dec; ?(?):1-15. doi: 10.1080/07391102.2022.2155701. [PMID: 36510680]
  • San-Hua Su, Navaneethan Sundhar, Wei-Wen Kuo, Shang-Chih Lai, Chia-Hua Kuo, Tsung-Jung Ho, Pi-Yu Lin, Shinn-Zong Lin, Cheng Yen Shih, Yu-Jung Lin, Chih-Yang Huang. Artemisia argyi extract induces apoptosis in human gemcitabine-resistant lung cancer cells via the PI3K/MAPK signaling pathway. Journal of ethnopharmacology. 2022 Dec; 299(?):115658. doi: 10.1016/j.jep.2022.115658. [PMID: 36075273]
  • Tingting Luo, Luhua Bai, Yi Zhang, Leidan Huang, Hui Li, Shunji Gao, Xiaoxiao Dong, Ningshan Li, Zheng Liu. Optimal treatment occasion for ultrasound stimulated microbubbles in promoting gemcitabine delivery to VX2 tumors. Drug delivery. 2022 Dec; 29(1):2796-2804. doi: 10.1080/10717544.2022.2115163. [PMID: 36047064]
  • Ashwaq A Al-Mutairi, Mayson H Alkhatib. Antitumour effects of a solid lipid nanoparticle loaded with gemcitabine and oxaliplatin on the viability, apoptosis, autophagy, and Hsp90 of ovarian cancer cells. Journal of microencapsulation. 2022 Aug; 39(5):467-480. doi: 10.1080/02652048.2022.2109218. [PMID: 35916335]
  • Taro Horino, Satoshi Inotani, Masayuki Ishihara, Yoshio Terada. Gemcitabine-induced renal thrombotic microangiopathy. Nephrology (Carlton, Vic.). 2022 08; 27(8):724-725. doi: 10.1111/nep.14043. [PMID: 35429056]
  • Xiang Dong, Zewu Zhang, Qin Zhang, Lu Chen, Guangtai Cao, Chen Liu, Tianqiang Song, Wei Lu, Wei Zhang. Triple therapy in biliary tract cancers: GemOX plus immune checkpoint inhibitor in combination with lenvatinib or NGS-guided targeted therapy. Journal of cancer research and clinical oncology. 2022 Jul; ?(?):. doi: 10.1007/s00432-022-04166-z. [PMID: 35802197]
  • Lin Zhu, Rui Chen, Qianyu Yang, Hongxia Liu, Qingshan Zheng, Lujin Li. Modelling an evaluation of the efficacy and safety of gemcitabine combined with platinum in the treatment of non-small cell lung cancer. Journal of clinical pharmacy and therapeutics. 2022 Jul; 47(7):986-994. doi: 10.1111/jcpt.13632. [PMID: 35246996]
  • Concetta Panebianco, Annacandida Villani, Federica Pisati, Fabrizio Orsenigo, Marynka Ulaszewska, Tiziana Pia Latiano, Adele Potenza, Annapaola Andolfo, Fulvia Terracciano, Claudio Tripodo, Francesco Perri, Valerio Pazienza. Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113163. doi: 10.1016/j.biopha.2022.113163. [PMID: 35617803]
  • Siamak Daneshmand, Iris S G Brummelhuis, Kamal S Pohar, Gary D Steinberg, Manju Aron, Christopher J Cutie, Kirk A Keegan, John C Maffeo, Donald L Reynolds, Bradley Raybold, Albert Chau, J Alfred Witjes. The safety, tolerability, and efficacy of a neoadjuvant gemcitabine intravesical drug delivery system (TAR-200) in muscle-invasive bladder cancer patients: a phase I trial. Urologic oncology. 2022 07; 40(7):344.e1-344.e9. doi: 10.1016/j.urolonc.2022.02.009. [PMID: 35431132]
  • Wenyue Zhou, Lu Ni, Manxi Luo, Xinyao Shu, Peng Cao, Meng Qiu. Rare capecitabine-induced acute hypertriglyceridemia with angina: a case report and review of the literature. Annals of palliative medicine. 2022 Jun; 11(6):2152-2156. doi: 10.21037/apm-21-1109. [PMID: 34498471]
  • Jia Huo, Lijun Fu, Mengyuan Jin, Zhaoming Li, Mingzhi Zhang. IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4. Investigational new drugs. 2022 06; 40(3):537-545. doi: 10.1007/s10637-022-01224-8. [PMID: 35226228]
  • Seung Soo Hong, Sena Lee, Sung Hwan Lee, Seonhowa Kim, Doyoung Kim, Hanseul Park, Jongook Lee, Jung Hwan Lee, Chang Moo Kang. Anticancer effect of locally applicable aptamer-conjugated gemcitabine-loaded atelocollagen patch in pancreatic cancer patient-derived xenograft models. Cancer science. 2022 May; 113(5):1752-1762. doi: 10.1111/cas.15318. [PMID: 35243724]
  • Goro Ueno, Yoshifumi Iwagami, Shogo Kobayashi, Suguru Mitsufuji, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi. ACAT-1-Regulated Cholesteryl Ester Accumulation Modulates Gemcitabine Resistance in Biliary Tract Cancer. Annals of surgical oncology. 2022 May; 29(5):2899-2909. doi: 10.1245/s10434-021-11152-1. [PMID: 34994902]
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  • Juan Zhang, Hong-Xi Xu, William Chi Shing Cho, Wah Cheuk, Yang Li, Qiong-Hui Huang, Wen Yang, Yan-Fang Xian, Zhi-Xiu Lin. Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway. Journal of experimental & clinical cancer research : CR. 2022 Mar; 41(1):90. doi: 10.1186/s13046-022-02270-z. [PMID: 35272669]
  • Aleksandra Skalska-Bugala, Marta Starczak, Łukasz Szukalski, Maciej Gawronski, Agnieszka Siomek-Gorecka, Justyna Szpotan, Anna Labejszo, Ewelina Zarakowska, Anna Szpila, Anna Jachalska, Adriana Szukalska, Marcin Kruszewski, Anna Sadowska, Aleksandra Wasilow, Patrycja Baginska, Jaroslaw Czyz, Ryszard Olinski, Rafal Rozalski, Daniel Gackowski. Diagnostic and Prognostic Power of Active DNA Demethylation Pathway Intermediates in Acute Myelogenous Leukemia and Myelodysplastic Syndromes. Cells. 2022 03; 11(5):. doi: 10.3390/cells11050888. [PMID: 35269510]
  • Rocio Garcia-Carbonero, Miriam Bazan-Peregrino, Marta Gil-Martín, Rafael Álvarez, Teresa Macarulla, Maria C Riesco-Martinez, Helena Verdaguer, Carmen Guillén-Ponce, Martí Farrera-Sal, Rafael Moreno, Ana Mato-Berciano, Maria Victoria Maliandi, Silvia Torres-Manjon, Marcel Costa, Natalia Del Pozo, Jaime Martínez de Villarreal, Francisco X Real, Noemí Vidal, Gabriel Capella, Ramon Alemany, Emma Blasi, Carmen Blasco, Manel Cascalló, Ramon Salazar. Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors. Journal for immunotherapy of cancer. 2022 03; 10(3):. doi: 10.1136/jitc-2021-003255. [PMID: 35338084]
  • Yangyang Guo, Hengyue Zhu, Yanyi Xiao, Hangcheng Guo, Miaomiao Lin, Ziwei Yuan, Xuejia Yang, Youze Huang, Qiyu Zhang, Yongheng Bai. The anthelmintic drug niclosamide induces GSK-β-mediated β-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression. Cell death & disease. 2022 02; 13(2):112. doi: 10.1038/s41419-022-04573-7. [PMID: 35115509]
  • Jochen Rutz, Sebastian Maxeiner, Eva Juengel, Felix K-H Chun, Igor Tsaur, Roman A Blaheta. Olive Mill Wastewater Inhibits Growth and Proliferation of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro by Down-Regulating the Akt/mTOR-Signaling Pathway. Nutrients. 2022 Jan; 14(2):. doi: 10.3390/nu14020369. [PMID: 35057550]
  • Theodora Chatzisideri, George Leonidis, Theodoros Karampelas, Eleni Skavatsou, Angeliki Velentza-Almpani, Francesca Bianchini, Constantin Tamvakopoulos, Vasiliki Sarli. Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine. Journal of medicinal chemistry. 2022 01; 65(1):271-284. doi: 10.1021/acs.jmedchem.1c01468. [PMID: 34967607]
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