Polidocanol (BioDeep_00001871405)

Main id: BioDeep_00000009466

 


代谢物信息卡片


Nonaethylene glycol monododecyl ether

化学式: C30H62O10 (582.4343)
中文名称: α-异十三烷基-ω-羟基-聚(氧-1,2-亚乙基), 聚醚醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI: InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3

描述信息

C - Cardiovascular system > C05 - Vasoprotectives > C05B - Antivaricose therapy > C05BB - Sclerosing agents for local injection
C274 - Antineoplastic Agent > C2196 - Antimetastatic Agent
C78274 - Agent Affecting Cardiovascular System

同义名列表

3 个代谢物同义名

Nonaethylene glycol monododecyl ether; Polidocanol; Polidocanol



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, ANG, AXIN2, CALCA, CASP3, EDN1, PDGFB, PQBP1, VEGFA
Peripheral membrane protein 1 MFGE8
Nucleus 6 ALB, ANG, AXIN2, CASP3, PQBP1, VEGFA
cytosol 4 ALB, ANG, AXIN2, CASP3
nuclear body 1 PQBP1
centrosome 2 ALB, AXIN2
nucleoplasm 3 ATP2B1, CASP3, PQBP1
Cell membrane 1 ATP2B1
Cytoplasmic granule 1 PQBP1
Multi-pass membrane protein 2 ATP2B1, ATP4A
Synapse 2 ATP2B1, TAC1
cell surface 4 ICAM1, PDGFB, SERPINF2, VEGFA
glutamatergic synapse 2 ATP2B1, CASP3
Golgi apparatus 2 ALB, VEGFA
Golgi membrane 2 INS, PDGFB
growth cone 1 ANG
neuronal cell body 4 ANG, CALCA, CASP3, TAC1
presynaptic membrane 1 ATP2B1
plasma membrane 5 ATP2B1, ATP4A, AXIN2, F2, ICAM1
synaptic vesicle membrane 1 ATP2B1
terminal bouton 1 CALCA
Membrane 7 ATP2B1, ATP4A, ICAM1, MFGE8, PDGFB, TMEM123, VEGFA
apical plasma membrane 1 ATP4A
axon 1 TAC1
basolateral plasma membrane 2 ATP2B1, PDGFB
extracellular exosome 6 ALB, ATP2B1, F2, ICAM1, MFGE8, SERPINF2
endoplasmic reticulum 2 ALB, VEGFA
extracellular space 15 ALB, ANG, ATP4A, CALCA, CSF3, EDN1, F2, ICAM1, IL6, INS, MFGE8, PDGFB, SERPINF2, TAC1, VEGFA
lysosomal lumen 1 CSF3
adherens junction 1 VEGFA
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 ICAM1, TMEM123
Secreted 11 ALB, ANG, CALCA, CSF3, EDN1, F2, IL6, INS, MFGE8, PDGFB, VEGFA
extracellular region 13 ALB, ANG, CALCA, CSF3, EDN1, F2, IL6, INS, MFGE8, PDGFB, SERPINF2, TAC1, VEGFA
basal part of cell 1 EDN1
hippocampal mossy fiber to CA3 synapse 1 CALCA
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 3 ICAM1, MFGE8, TMEM123
Extracellular vesicle 1 MFGE8
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 TMEM123
nucleolus 1 ANG
Apical cell membrane 1 ATP4A
Membrane raft 1 ICAM1
focal adhesion 1 ICAM1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
collagen-containing extracellular matrix 5 F2, ICAM1, MFGE8, PDGFB, SERPINF2
secretory granule 1 VEGFA
lateral plasma membrane 1 ATP2B1
nuclear speck 1 PQBP1
ciliary basal body 1 ALB
cell projection 1 ATP2B1
Chromosome 1 ANG
centriole 1 ALB
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 3 ALB, F2, SERPINF2
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PQBP1
Nucleus speckle 1 PQBP1
Presynaptic cell membrane 1 ATP2B1
secretory granule lumen 1 INS
Golgi lumen 3 F2, INS, PDGFB
endoplasmic reticulum lumen 6 ALB, F2, IL6, INS, MFGE8, PDGFB
platelet alpha granule lumen 4 ALB, PDGFB, SERPINF2, VEGFA
endocytic vesicle 1 ANG
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 2 ATP2B1, ICAM1
neuronal dense core vesicle 1 CALCA
death-inducing signaling complex 1 CASP3
acrosomal membrane 1 MFGE8
Cytoplasmic vesicle, secretory vesicle, acrosome membrane 1 MFGE8
neuronal ribonucleoprotein granule 1 PQBP1
endocytic vesicle lumen 1 CSF3
platelet-derived growth factor complex 1 PDGFB
fibrinogen complex 1 SERPINF2
angiogenin-PRI complex 1 ANG
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
interleukin-6 receptor complex 1 IL6
photoreceptor ribbon synapse 1 ATP2B1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
potassium:proton exchanging ATPase complex 1 ATP4A
ciliary transition fiber 1 ALB


文献列表

  • Kurosh Parsi, David E Connor, Anne Pilotelle, Joyce Low, David D F Ma, Joanne E Joseph. Low concentration detergent sclerosants induce platelet activation but inhibit aggregation due to suppression of GPIIb/IIIa activation in vitro. Thrombosis research. 2012 Sep; 130(3):472-8. doi: 10.1016/j.thromres.2012.03.023. [PMID: 22531012]
  • NULL. Management of chronic Achilles tendinopathy. Drug and therapeutics bulletin. 2012 Aug; 50(8):93-6. doi: 10.1136/dtb.2012.08.0124. [PMID: 22875366]
  • Adriana Smarandache. Laser beams interaction with polidocanol foam: molecular background. Photomedicine and laser surgery. 2012 May; 30(5):262-7. doi: 10.1089/pho.2011.3187. [PMID: 22417110]
  • Mayank Agarwal, Madhu S Agrawal, Ruchi Mittal, Vivek Sachan. A randomized study of aspiration and sclerotherapy versus laparoscopic deroofing in management of symptomatic simple renal cysts. Journal of endourology. 2012 May; 26(5):561-5. doi: 10.1089/end.2011.0559. [PMID: 22091534]
  • Jeong Ho Kim, Min-Ok Kim, Young Jin Choi, Hyun Young Han, Kang Seo Park, Byung Sun Cho, Dong Wook Kang. A giant retroperitoneal lymphangioma in a patient with neurofibromatosis type 1. Journal of the Korean Surgical Society. 2011 Jun; 80 Suppl 1(?):S43-6. doi: 10.4174/jkss.2011.80.suppl1.s43. [PMID: 22066082]
  • M N van Sterkenburg, C N van Dijk. Injection treatment for chronic midportion Achilles tendinopathy: do we need that many alternatives?. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2011 Apr; 19(4):513-5. doi: 10.1007/s00167-011-1415-2. [PMID: 21290104]
  • K Parsi, T Exner, J Low, D D Fung Ma, J E Joseph. In vitro effects of detergent sclerosants on clot formation and fibrinolysis. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2011 Feb; 41(2):267-77. doi: 10.1016/j.ejvs.2010.10.004. [PMID: 21183368]
  • Karolina M Stepien, Peter Prinsloo, Tony Hitch, Thomas A McCulloch, Rebecca Sims. Acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient. International journal of nephrology. 2011; 2011(?):679160. doi: 10.4061/2011/679160. [PMID: 21785726]
  • Javier Molina-Infante, Gema Vinagre-Rodríguez, Elisa Martín-Noguerol, Jesús M González Santiago, Carmen Martínez-Alcalá. [Dieulafoy's lesion on the pectineal line]. Gastroenterologia y hepatologia. 2010 Dec; 33(10):756-7. doi: 10.1016/j.gastrohep.2010.08.006. [PMID: 21051111]
  • Nicola Maffulli, Umile Giuseppe Longo, Vincenzo Denaro. Novel approaches for the management of tendinopathy. The Journal of bone and joint surgery. American volume. 2010 Nov; 92(15):2604-13. doi: 10.2106/jbjs.i.01744. [PMID: 21048180]
  • Kurosh Parsi, Thomas Exner, David Dang Fung Ma, Joanne Emily Joseph. In vitro effects of detergent sclerosants on fibrinolytic enzymes and inhibitors. Thrombosis research. 2010 Oct; 126(4):328-36. doi: 10.1016/j.thromres.2010.06.028. [PMID: 20682454]
  • Ana Maria S Simão, Manisha C Yadav, Sonoko Narisawa, Mayte Bolean, Joao Martins Pizauro, Marc F Hoylaerts, Pietro Ciancaglini, José Luis Millán. Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics. The Journal of biological chemistry. 2010 Mar; 285(10):7598-609. doi: 10.1074/jbc.m109.079830. [PMID: 20048161]
  • K Parsi, T Exner, J Low, D Dang Fung Ma, J E Joseph. In vitro effects of detergent sclerosants on antithrombotic mechanisms. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2009 Aug; 38(2):220-8. doi: 10.1016/j.ejvs.2009.03.026. [PMID: 19442540]
  • D Rabago, T M Best, A E Zgierska, E Zeisig, M Ryan, D Crane. A systematic review of four injection therapies for lateral epicondylosis: prolotherapy, polidocanol, whole blood and platelet-rich plasma. British journal of sports medicine. 2009 Jul; 43(7):471-81. doi: 10.1136/bjsm.2008.052761. [PMID: 19028733]
  • K Parsi, T Exner, D E Connor, A Herbert, D D F Ma, J E Joseph. The lytic effects of detergent sclerosants on erythrocytes, platelets, endothelial cells and microparticles are attenuated by albumin and other plasma components in vitro. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2008 Aug; 36(2):216-223. doi: 10.1016/j.ejvs.2008.03.001. [PMID: 18396426]
  • N Scutt, C G Rolf, A Scutt. Tissue specific characteristics of cells isolated from human and rat tendons and ligaments. Journal of orthopaedic surgery and research. 2008 Jul; 3(?):32. doi: 10.1186/1749-799x-3-32. [PMID: 18652675]
  • Mehmet Kilinc, Osman Tufan, Selcuk Guven, Kemal Odev, Recai Gurbuz. Percutaneous injection sclerotherapy with tetracycline hydrochloride in simple renal cysts. International urology and nephrology. 2008; 40(3):609-13. doi: 10.1007/s11255-007-9316-5. [PMID: 18085424]
  • K Parsi, T Exner, D E Connor, D D F Ma, J E Joseph. In vitro effects of detergent sclerosants on coagulation, platelets and microparticles. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2007 Dec; 34(6):731-40. doi: 10.1016/j.ejvs.2007.07.011. [PMID: 17919946]
  • Cataldo Di Bisceglie, Angela Bertagna, Matteo Baldi, Fabio Lanfranco, Milena Tagliabue, Carlo Gazzera, Giovanni Gandini, Chiara Manieri. Varicocele sclerotherapy improves serum inhibin B levels and seminal parameters. International journal of andrology. 2007 Dec; 30(6):531-6. doi: 10.1111/j.1365-2605.2007.00747.x. [PMID: 17376219]
  • Ana Maria S Simão, Márcio M Beloti, Rodrigo M Cezarino, Adalberto Luiz Rosa, João M Pizauro, Pietro Ciancaglini. Membrane-bound alkaline phosphatase from ectopic mineralization and rat bone marrow cell culture. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2007 Apr; 146(4):679-87. doi: 10.1016/j.cbpa.2006.05.008. [PMID: 16798036]
  • Volker Unger, Christian Grosse-Siestrup, Claudia Fehrenberg, Axel Fischer, Michael Meissler, David A Groneberg. Reference values and physiological characterization of a specific isolated pig kidney perfusion model. Journal of occupational medicine and toxicology (London, England). 2007 Jan; 2(?):1. doi: 10.1186/1745-6673-2-1. [PMID: 17261183]
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  • F Paysant, A Baert, I Morel, F Le Gall, M Le Gueut. [Case of death occurred after an injection of aetoxisclerol. The responsibility of the product should be discussed]. Acta clinica Belgica. 2006; 61 Suppl 1(?):51-3. doi: ". [PMID: 16700152]
  • Amritlal Mandal, Sudip Das, Tapati Chakraborti, Pulak Kar, Biswarup Ghosh, Sajal Chakraborti. Solubilization, purification and reconstitution of Ca(2+)-ATPase from bovine pulmonary artery smooth muscle microsomes by different detergents: preservation of native structure and function of the enzyme by DHPC. Biochimica et biophysica acta. 2006 Jan; 1760(1):20-31. doi: 10.1016/j.bbagen.2005.09.013. [PMID: 16278046]
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  • Necati Ormeci, Ramazan Idilman, Ali Tüzün, Hakan Erdem, Murat Palabiyikoğlu. A new percutaneous approach for the treatment of hydatid cyst of the kidney: long-term follow-up. International urology and nephrology. 2005; 37(3):461-4. doi: 10.1007/s11255-004-0022-2. [PMID: 16307318]
  • Simone Agostini, Giovanni Luca Dedola, Silvia Gabbrielli, Sabino Scelzi, Eugenio Dattolo, Francesco Muzzillo, Andrea Masi. Percutaneous treatment of simple renal cysts with sclerotherapy and extended drainage. La Radiologia medica. 2004 Nov; 108(5-6):522-9. doi: NULL. [PMID: 15722998]
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  • Pavel Skok, Igor Krizman, Marija Skok. Argon plasma coagulation versus injection sclerotherapy in peptic ulcer hemorrhage--a prospective, controlled study. Hepato-gastroenterology. 2004 Jan; 51(55):165-70. doi: . [PMID: 15011856]
  • Shigenaga Matsui, Masatoshi Kudo, Ryousuke Nakaoka, Mikio Shiomi, Toshihiko Kawasaki. Comparison of argon plasma coagulation and paravariceal injection sclerotherapy with 1\% polidocanol in mucosa-fibrosing therapy for esophageal varices. Journal of gastroenterology. 2004; 39(4):397-9. doi: 10.1007/s00535-003-1309-2. [PMID: 15168254]
  • Abeer Al-Bawab. Investigation of the phase behavior and an evaporation study of systems of lavender oil, water, Laureth 4, and Tween 80. Journal of cosmetic science. 2003 Sep; 54(5):429-41. doi: ". [PMID: 14605685]
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  • Omar Alqawi, Elias Georges. The multidrug resistance protein ABCC1 drug-binding domains show selective sensitivity to mild detergents. Biochemical and biophysical research communications. 2003 Apr; 303(4):1135-41. doi: 10.1016/s0006-291x(03)00492-3. [PMID: 12684054]
  • Young-Je Cho, D Julian McClements, Eric A Decker. Ability of surfactant micelles to alter the physical location and reactivity of iron in oil-in-water emulsion. Journal of agricultural and food chemistry. 2002 Sep; 50(20):5704-10. doi: 10.1021/jf020433g. [PMID: 12236702]
  • Fernando L Camolezi, Katia R P Daghastanli, Prislaine P Magalhães, João M Pizauro, Pietro Ciancaglini. Construction of an alkaline phosphatase-liposome system: a tool for biomineralization study. The international journal of biochemistry & cell biology. 2002 Sep; 34(9):1091-101. doi: 10.1016/s1357-2725(02)00029-8. [PMID: 12009304]
  • C Brunken, D Pfeiffer, R Tauber. [Long term outcome after percutaneous sclerotherapy of renal cysts with polidocanol]. Der Urologe. Ausg. A. 2002 May; 41(3):263-6. doi: 10.1007/s00120-001-0144-4. [PMID: 12132276]
  • E A Hosny, H I al-Shora, M M A Elmazar. Effect of bioadhesive polymers, sodium salicylate, polyoxyethylene-9-lauryl ether, and method of preparation on the relative hypoglycemia produced by insulin enteric-coated capsules in diabetic beagle dogs. Drug development and industrial pharmacy. 2002 May; 28(5):563-70. doi: 10.1081/ddc-120003452. [PMID: 12098845]
  • E A Hosny, H I al-Shora, M M A el-mazar. Effect of bio-adhesive polymers, sodium salicylate, polyoxyethylene-9-lauryl ether and method of preparation on the relative hypoglycemia produced by insulin enteric coated capsules in diabetic beagle dogs. Bollettino chimico farmaceutico. 2002 Jan; 141(1):67-74. doi: NULL. [PMID: 12064061]
  • E A Hosny, H I Al-Shora, M M Elmazar. Relative hypoglycemic effect of insulin suppositories in diabetic beagle dogs: optimization of various concentrations of sodium salicylate and polyoxyethylene-9-lauryl ether. Biological & pharmaceutical bulletin. 2001 Nov; 24(11):1294-7. doi: 10.1248/bpb.24.1294. [PMID: 11725967]