7alpha-Hydroxypregnenolone (BioDeep_00001869987)

Main id: BioDeep_00000012040

 


代谢物信息卡片


7alpha-Hydroxypregnenolone

化学式: C21H32O3 (332.2351)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C
InChI: InChI=1S/C21H32O3/c1-12(22)15-4-5-16-19-17(7-9-21(15,16)3)20(2)8-6-14(23)10-13(20)11-18(19)24/h11,14-19,23-24H,4-10H2,1-3H3/t14-,15+,16-,17-,18+,19-,20-,21+/m0/s1

描述信息

A 20-oxo steroid that is pregnenolone carrying an additional hydroxy substituent at the 7alpha-position.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

1 个代谢物同义名

7alpha-Hydroxypregnenolone



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKR1D1, AR, CASP3, HSD3B2, HSF2, NR3C1, TTN, XBP1
Peripheral membrane protein 3 CYP11A1, CYP1B1, XBP1
Endoplasmic reticulum membrane 6 CYP1B1, CYP7B1, HSD3B2, SRD5A1, SRD5A3, XBP1
Mitochondrion membrane 1 CYP11A1
Nucleus 7 AR, CASP3, HSF2, NFIL3, NR3C1, TTN, XBP1
cytosol 6 AKR1D1, AR, CASP3, NR3C1, TTN, XBP1
mitochondrial membrane 1 HSD3B2
centrosome 1 NR3C1
nucleoplasm 5 AR, CASP3, HSF2, NR3C1, XBP1
RNA polymerase II transcription regulator complex 2 NFIL3, XBP1
Cell membrane 1 AVPR1A
Multi-pass membrane protein 5 AVPR1A, CYP7B1, SLC45A2, SRD5A1, SRD5A3
Synapse 1 NR3C1
glutamatergic synapse 1 CASP3
Golgi apparatus 1 NPY
mitochondrial inner membrane 2 CYP11A1, HSD3B2
neuronal cell body 2 CASP3, SRD5A1
endosome 1 AVPR1A
plasma membrane 2 AR, AVPR1A
Membrane 9 AR, CYP11A1, CYP1B1, CYP7B1, HSD3B2, NR3C1, SLC45A2, SRD5A1, XBP1
extracellular exosome 1 TTN
endoplasmic reticulum 3 HSD3B2, SRD5A3, XBP1
extracellular space 1 NPY
perinuclear region of cytoplasm 1 SRD5A1
mitochondrion 3 CYP11A1, CYP1B1, NR3C1
protein-containing complex 2 AR, NR3C1
intracellular membrane-bounded organelle 2 CYP1B1, HSD3B2
Microsome membrane 2 CYP1B1, CYP7B1
postsynaptic density 1 CASP3
Secreted 1 NPY
extracellular region 2 NPY, TTN
Single-pass membrane protein 1 HSD3B2
mitochondrial matrix 2 CYP11A1, NR3C1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
Z disc 1 TTN
nucleolus 1 HSD3B2
Melanosome membrane 1 SLC45A2
Single-pass type II membrane protein 1 XBP1
Mitochondrion inner membrane 1 CYP11A1
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 1 NR3C1
GABA-ergic synapse 1 NPY
mitochondrial intermembrane space 1 HSD3B2
nuclear speck 2 AR, NR3C1
chromatin 4 AR, HSF2, NFIL3, NR3C1
Chromosome 1 NR3C1
intercellular bridge 1 HSD3B2
Endomembrane system 1 SRD5A3
I band 1 TTN
M band 1 TTN
cell body fiber 1 SRD5A1
Nucleus, nucleoplasm 1 NR3C1
Smooth endoplasmic reticulum membrane 1 HSD3B2
endocytic vesicle 1 AVPR1A
neuronal dense core vesicle 1 NPY
condensed nuclear chromosome 1 TTN
[Isoform 2]: Nucleus 1 XBP1
[Isoform 1]: Nucleus 1 XBP1
death-inducing signaling complex 1 CASP3
[Isoform Alpha]: Cytoplasm 1 NR3C1
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
[X-box-binding protein 1, cytoplasmic form]: Cytoplasm 1 XBP1
striated muscle thin filament 1 TTN
organelle 1 TTN


文献列表

  • Shogo Haraguchi, Teppei Koyama, Itaru Hasunuma, Shin-ichiro Okuyama, Takayoshi Ubuka, Sakae Kikuyama, Jean-Luc Do Rego, Hubert Vaudry, Kazuyoshi Tsutsui. Acute stress increases the synthesis of 7α-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosterone action in newts. Endocrinology. 2012 Feb; 153(2):794-805. doi: 10.1210/en.2011-1422. [PMID: 22128027]
  • Ryuji Kouyama, Kiichiro Hiraishi, Toru Sugiyama, Hajime Izumiyama, Takanobu Yoshimoto, Takumi Akashi, Kazunori Kihara, Keiko Homma, Hirotaka Shibata, Yukio Hirata. Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical carcinoma. Endocrine journal. 2011; 58(7):527-34. doi: 10.1507/endocrj.k11e-026. [PMID: 21521927]