2-Deoxyguanosine-5-triphosphate (BioDeep_00001868446)

Main id: BioDeep_00000004407

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


2-Deoxyguanosine-5-triphosphate

化学式: C10H16N5O13P3 (506.9957476)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(OC1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
InChI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1

描述信息

COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

1 个代谢物同义名

2-Deoxyguanosine-5-triphosphate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(2)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Peng Peng, Yanjuan Xu, Adrian M Di Bisceglie, Xiaofeng Fan. A novel target enrichment strategy in next-generation sequencing through 7-deaza-dGTP-resistant enzymatic digestion. BMC research notes. 2020 Sep; 13(1):445. doi: 10.1186/s13104-020-05292-y. [PMID: 32948245]
  • A Ditta, H Nawaz, T Mahmood, M I Majeed, M Tahir, N Rashid, M Muddassar, A A Al-Saadi, H J Byrne. Principal components analysis of Raman spectral data for screening of Hepatitis C infection. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Oct; 221(?):117173. doi: 10.1016/j.saa.2019.117173. [PMID: 31158766]
  • Yiqing Chen, Jing Zhang, Hehua Liu, Yanqing Gao, Xuhang Li, Lina Zheng, Ruixue Cui, Qingqing Yao, Liang Rong, Jixi Li, Zhen Huang, Jinbiao Ma, Jianhua Gan. Unique 5'-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X. PLoS biology. 2017 02; 15(2):e1002599. doi: 10.1371/journal.pbio.1002599. [PMID: 28245220]
  • Vi N Nguyen, Annsea Park, Anting Xu, John R Srouji, Steven E Brenner, Jack F Kirsch. Substrate specificity characterization for eight putative nudix hydrolases. Evaluation of criteria for substrate identification within the Nudix family. Proteins. 2016 12; 84(12):1810-1822. doi: 10.1002/prot.25163. [PMID: 27618147]
  • Mark D Evans, Vilas Mistry, Rajinder Singh, Daniel Gackowski, Rafał Różalski, Agnieszka Siomek-Gorecka, David H Phillips, Jie Zuo, Leon Mullenders, Alex Pines, Yusaku Nakabeppu, Kunihiko Sakumi, Mutsuo Sekiguchi, Teruhisa Tsuzuki, Margherita Bignami, Ryszard Oliński, Marcus S Cooke. Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. Free radical biology & medicine. 2016 10; 99(?):385-391. doi: 10.1016/j.freeradbiomed.2016.08.018. [PMID: 27585947]
  • Ilaria Dalla Rosa, Yolanda Cámara, Romina Durigon, Chloe F Moss, Sara Vidoni, Gokhan Akman, Lilian Hunt, Mark A Johnson, Sarah Grocott, Liya Wang, David R Thorburn, Michio Hirano, Joanna Poulton, Robert W Taylor, Greg Elgar, Ramon Martí, Peter Voshol, Ian J Holt, Antonella Spinazzola. MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria. PLoS genetics. 2016 Jan; 12(1):e1005779. doi: 10.1371/journal.pgen.1005779. [PMID: 26760297]
  • Kumudha Balakrishnan, Farhad Ravandi, Shanta Bantia, Anna Franklin, Varsha Gandhi. Preclinical and clinical evaluation of forodesine in pediatric and adult B-cell acute lymphoblastic leukemia. Clinical lymphoma, myeloma & leukemia. 2013 Aug; 13(4):458-66. doi: 10.1016/j.clml.2013.04.009. [PMID: 23773454]
  • Stephan Bender, Thomas Rellum, Christine Freitag, Franz Resch, Marcella Rietschel, Jens Treutlein, Christine Jennen-Steinmetz, Daniel Brandeis, Tobias Banaschewski, Manfred Laucht. Dopamine inactivation efficacy related to functional DAT1 and COMT variants influences motor response evaluation. PloS one. 2012; 7(5):e37814. doi: 10.1371/journal.pone.0037814. [PMID: 22649558]
  • Martin Pabst, Josephine Grass, Richard Fischl, Renaud Léonard, Chunsheng Jin, Georg Hinterkörner, Nicole Borth, Friedrich Altmann. Nucleotide and nucleotide sugar analysis by liquid chromatography-electrospray ionization-mass spectrometry on surface-conditioned porous graphitic carbon. Analytical chemistry. 2010 Dec; 82(23):9782-8. doi: 10.1021/ac101975k. [PMID: 21043458]
  • Kumudha Balakrishnan, Dushyant Verma, Susan O'Brien, John Michael Kilpatrick, Yuling Chen, Brenita F Tyler, Susan Bickel, Shanta Bantia, Michael J Keating, Hagop Kantarjian, Varsha Gandhi, Farhad Ravandi. Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia. Blood. 2010 Aug; 116(6):886-92. doi: 10.1182/blood-2010-02-272039. [PMID: 20427701]
  • Peter Møller, Steffen Loft. Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution. Environmental health perspectives. 2010 Aug; 118(8):1126-36. doi: 10.1289/ehp.0901725. [PMID: 20423813]
  • Sanjay U C Sankatsing, Jan M Prins, Si-La L Yong, Jeroen Roelofsen, André B P van Kuilenburg, Steve Kewn, David J Back, Frederike J Bemelman, Ineke J M ten Berge. Mycophenolate mofetil inhibits T-cell proliferation in kidney transplant recipients without lowering intracellular dGTP and GTP. Transplant international : official journal of the European Society for Organ Transplantation. 2008 Nov; 21(11):1066-71. doi: 10.1111/j.1432-2277.2008.00739.x. [PMID: 18699845]
  • Varsha Gandhi, Kumudha Balakrishnan. Pharmacology and mechanism of action of forodesine, a T-cell targeted agent. Seminars in oncology. 2007 Dec; 34(6 Suppl 5):S8-12. doi: 10.1053/j.seminoncol.2007.11.003. [PMID: 18086347]
  • Farhad Ravandi, Varsha Gandhi. Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma. Expert opinion on investigational drugs. 2006 Dec; 15(12):1601-13. doi: 10.1517/13543784.15.12.1601. [PMID: 17107284]
  • Carlos M Galmarini. Drug evaluation: forodesine - PNP inhibitor for the treatment of leukemia, lymphoma and solid tumor. IDrugs : the investigational drugs journal. 2006 Oct; 9(10):712-22. doi: . [PMID: 17016779]
  • Rupinderjeet Kaur, Roger Bedimo, Mary Beth Kvanli, Diana Turner, Leslie Shaw, David Margolis. A placebo-controlled pilot study of intensification of antiretroviral therapy with mycophenolate mofetil. AIDS research and therapy. 2006 May; 3(?):16. doi: 10.1186/1742-6405-3-16. [PMID: 16729890]
  • Tadeusz Robak, Ewa Lech-Maranda, Anna Korycka, Ewa Robak. Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. Current medicinal chemistry. 2006; 13(26):3165-89. doi: 10.2174/092986706778742918. [PMID: 17168705]
  • Varsha Gandhi, John M Kilpatrick, William Plunkett, Mary Ayres, Leigh Harman, Min Du, Shanta Bantia, Jan Davisson, William G Wierda, Stefan Faderl, Hagop Kantarjian, Deborah Thomas. A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine). Blood. 2005 Dec; 106(13):4253-60. doi: 10.1182/blood-2005-03-1309. [PMID: 16131572]
  • Kent Persson, Keith Hamby, Luis A Ugozzoli. Four-color multiplex reverse transcription polymerase chain reaction--overcoming its limitations. Analytical biochemistry. 2005 Sep; 344(1):33-42. doi: 10.1016/j.ab.2005.06.026. [PMID: 16039598]
  • Chun Hung Ma, Joannie Hui, Janet Tsui Ying Tang, Danny Tze Ming Leung, Yiu Loon Chui, Tai Fai Fok, Pak-Leong Lim. Antibodies to guanosine triphosphate misidentified as anti-double-stranded DNA antibodies in a patient with antinuclear antibody-negative lupus, due to buckling of insolubilized assay DNA. Arthritis and rheumatism. 2004 May; 50(5):1533-8. doi: 10.1002/art.20188. [PMID: 15146423]
  • Shanta Bantia, John Michael Kilpatrick. Purine nucleoside phosphorylase inhibitors in T-cell malignancies. Current opinion in drug discovery & development. 2004 Mar; 7(2):243-7. doi: . [PMID: 15603259]
  • Sanjay U C Sankatsing, Patrick G Hoggard, Alwin D R Huitema, Rolf W Sparidans, Stephen Kewn, Kristel M L Crommentuyn, Joep M A Lange, Jos H Beijnen, David J Back, Jan M Prins. Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools. Clinical pharmacokinetics. 2004; 43(12):823-32. doi: 10.2165/00003088-200443120-00004. [PMID: 15355127]
  • Francis J Giles, Paula M Fracasso, Hagop M Kantarjian, Jorge E Cortes, Randy A Brown, Srdan Verstovsek, Yesid Alvarado, Deborah A Thomas, Stefan Faderl, Guillermo Garcia-Manero, Lisa P Wright, Tom Samson, Ann Cahill, Paula Lambert, William Plunkett, Mario Sznol, John F DiPersio, Varsha Gandhi. Phase I and pharmacodynamic study of Triapine, a novel ribonucleotide reductase inhibitor, in patients with advanced leukemia. Leukemia research. 2003 Dec; 27(12):1077-83. doi: 10.1016/s0145-2126(03)00118-8. [PMID: 12921943]
  • David M Margolis, Stephen Kewn, Jason J Coull, Loyda Ylisastigui, Diana Turner, Holly Wise, Mohammed M Hossain, E Randall Lanier, Leslie M Shaw, David Back. The addition of mycophenolate mofetil to antiretroviral therapy including abacavir is associated with depletion of intracellular deoxyguanosine triphosphate and a decrease in plasma HIV-1 RNA. Journal of acquired immune deficiency syndromes (1999). 2002 Sep; 31(1):45-9. doi: 10.1097/00126334-200209010-00006. [PMID: 12352149]
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  • V Gandhi, W Plunkett, S Weller, M Du, M Ayres, C O Rodriguez, P Ramakrishna, G L Rosner, J P Hodge, S O'Brien, M J Keating. Evaluation of the combination of nelarabine and fludarabine in leukemias: clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2001 Apr; 19(8):2142-52. doi: 10.1200/jco.2001.19.8.2142. [PMID: 11304766]
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