FA 6:3;O2 (BioDeep_00000628923)
Secondary id: BioDeep_00000001306, BioDeep_00000004464, BioDeep_00000017800, BioDeep_00000405605
PANOMIX_OTCML-2023
代谢物信息卡片
(2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoic acid
化学式: C6H6O4 (142.0266076)
中文名称: 顺,顺-粘康酸, 2-羟基木聚糖半醛
谱图信息:
最多检出来源 Macaca mulatta(otcml) 2.41%
分子结构信息
SMILES: C(=CC(=O)C(=O)O)C=CO
InChI: InChI=1S/C6H6O4/c7-4-2-1-3-5(8)6(9)10/h1-4,8H,(H,9,10)
描述信息
cis,cis-Muconic acid, a metabolic intermediate of Klebsiella pneumonia, can be converted to adipic acid and terephthalic acid, which are important monomers of synthetic polymers. cis,cis-Muconic acid is also a biochemical material that can be used for the production of various plastics and polymers and is particularly gaining attention as an adipic acid precursor for the synthesis of nylon-6,6[1][2].
同义名列表
11 个代谢物同义名
2E,4E-hexadienedioic acid; trans-trans-muconic acid; FA 6:3;O2; 2Z,4Z-hexadienedioic acid; cis,cis-Muconic acid; 2-hydroxy-6-oxohexa-2,4-dienoic acid; hydroxymuconic semialdehyde; (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoic acid; (2E,4Z)-4-hydroxymuconic semialdehyde; (2E,4Z)-2-hydroxy-6-oxohexa-2,4-dienoic acid; 2-hydroxymuconic semialdehyde
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:16508
- ChEBI: CHEBI:17236
- ChEBI: CHEBI:71207
- ChEBI: CHEBI:67103
- ChEBI: CHEBI:67110
- KEGG: C02480
- KEGG: C00682
- PubChem: 5280518
- PubChem: 70678534
- PubChem: 6276412
- PubChem: 5280366
- LipidMAPS: LMFA01170124
- LipidMAPS: LMFA01170077
- LipidMAPS: LMFA01030970
- LipidMAPS: LMFA01030927
- LipidMAPS: LMFA01030926
- CAS: 1119-72-8
- CAS: 3270-98-2
- CAS: 77934-57-7
- PubChem: 3951
- 3DMET: B00155
- PubChem: 5495
- KNApSAcK: C00007490
- CAS: 505-70-4
- PDB-CCD: CCU
- 3DMET: B00448
- NIKKAJI: J73.682A
- medchemexpress: HY-W000800
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 252963 - Plakortis simplex: 10.1021/NP000413D
- 303 - Pseudomonas putida: 10.1021/BI036205C
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sepideh Abbaszadeh, Saeed Yousefinejad, Saeed Jafari, Esmaeel Soleimani. In-syringe ionic liquid-dispersive liquid-liquid microextraction coupled with HPLC for the determination of trans,trans-muconic acid in human urine sample.
Journal of separation science.
2021 Aug; 44(16):3126-3136. doi:
10.1002/jssc.202100044. [PMID: 34114310] - Marcia Domínguez, Juan F Blandez, Beatriz Lozano-Torres, Cristina de la Torre, Maurizio Licchelli, Carlo Mangano, Valeria Amendola, Félix Sancenón, Ramón Martínez-Máñez. A Nanoprobe Based on Gated Mesoporous Silica Nanoparticles for The Selective and Sensitive Detection of Benzene Metabolite t,t-Muconic Acid in Urine.
Chemistry (Weinheim an der Bergstrasse, Germany).
2021 Jan; 27(4):1306-1310. doi:
10.1002/chem.202004272. [PMID: 33064343] - Sunisa Chaiklieng, Pornnapa Suggaravetsiri, Herman Autrup. Biomatrix of health risk assessment of benzene-exposed workers at Thai gasoline stations.
Journal of occupational health.
2021 Jan; 63(1):e12307. doi:
10.1002/1348-9585.12307. [PMID: 34957641] - Barbara Rodrigues Geraldino, Rafaella Ferreira Nascimento Nunes, Juliana Barroso Gomes, Isabela Giardini, Paula Vieira Baptista da Silva, Élida Campos, Katia Soares da Poça, Rocio Hassan, Ubirani Barros Otero, Marcia Sarpa. Analysis of Benzene Exposure in Gas Station Workers Using Trans,Trans-Muconic Acid.
International journal of environmental research and public health.
2020 07; 17(15):. doi:
10.3390/ijerph17155295. [PMID: 32717818] - Luigi De Maria, Caterina Ledda, Antonio Caputi, Francesca Mansi, Enza Sabrina Silvana Cannone, Stefania Sponselli, Domenica Cavone, Francesco Birtolo, Emanuele Cannizzaro, Giovanni Maria Ferri, Venerando Rapisarda, Luigi Vimercati. Biological Monitoring of Exposure to Benzene in Port Workers.
Frontiers in public health.
2020; 8(?):271. doi:
10.3389/fpubh.2020.00271. [PMID: 32766192] - Sunisa Chaiklieng, Pornnapa Suggaravetsiri, Norbert Kaminski, Herman Autrup. Factors Affecting Urinary tt-Muconic Acid Detection among Benzene Exposed Workers at Gasoline Stations.
International journal of environmental research and public health.
2019 10; 16(21):. doi:
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Annals of work exposures and health.
2019 10; 63(8):890-897. doi:
10.1093/annweh/wxz055. [PMID: 31382272] - Norma Pérez-Herrera, Lorena Díaz de León-Martínez, Rogelio Flores-Ramírez, Olivier Barbier, Manolo Ortega-Romero, Fernando May-Euán, Kelvin Saldaña-Villanueva, Javier Perera-Rios, Francisco Javier Pérez-Vázquez. Evaluation of Benzene Exposure and Early Biomarkers of Kidney Damage in Children Exposed to Solvents Due to Precarious Work in Ticul, Yucatán, México.
Annals of global health.
2019 07; 85(1):. doi:
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Environmental science and pollution research international.
2018 Dec; 25(34):34046-34052. doi:
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Toxicology letters.
2018 Dec; 298(?):70-75. doi:
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Industrial health.
2018 Jul; 56(4):346-355. doi:
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International journal of environmental research and public health.
2018 04; 15(4):. doi:
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2018 Jan; 41(2):501-508. doi:
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2017 Dec; 278(?):256-268. doi:
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La Clinica terapeutica.
2017 Nov; 168(6):e380-e387. doi:
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Bulletin of environmental contamination and toxicology.
2017 Aug; 99(2):258-263. doi:
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2017 Feb; 93(?):157-162. doi:
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PloS one.
2017; 12(9):e0183602. doi:
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Environmental and molecular mutagenesis.
2016 Mar; 57(2):151-8. doi:
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Environmental toxicology and pharmacology.
2016 Jan; 41(?):54-61. doi:
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Environment international.
2015 Feb; 75(?):136-43. doi:
10.1016/j.envint.2014.10.028. [PMID: 25461422] - Elisabetta Chellini, Maria Cristina Fondelli, Maria Teresa Maurello, Gianfranco Sciarra, Maria Cristina Aprea, Giulia Carreras. [Pollutants from a plant which burns toxic waste in the Province of Arezzo (Tuscany Region, Central Italy): human biomonitoring pilot study to evaluate the possible type of environmental exposure].
Epidemiologia e prevenzione.
2015 Jan; 39(1):28-35. doi:
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Mutation research. Genetic toxicology and environmental mutagenesis.
2014 Aug; 770(?):61-5. doi:
10.1016/j.mrgentox.2014.05.008. [PMID: 25344165] - Piero Lovreglio, Francesca Maffei, Mariella Carrieri, Maria N D'Errico, Ignazio Drago, Patrizia Hrelia, Giovanni B Bartolucci, Leonardo Soleo. Evaluation of chromosome aberration and micronucleus frequencies in blood lymphocytes of workers exposed to low concentrations of benzene.
Mutation research. Genetic toxicology and environmental mutagenesis.
2014 Aug; 770(?):55-60. doi:
10.1016/j.mrgentox.2014.04.022. [PMID: 25344164] - Yoon-Hyeong Choi, Jin Hee Kim, Bo-Eun Lee, Yun-Chul Hong. Urinary benzene metabolite and insulin resistance in elderly adults.
The Science of the total environment.
2014 Jun; 482-483(?):260-8. doi:
10.1016/j.scitotenv.2014.02.121. [PMID: 24657371] - Khadiga S Ibrahim, Nagat M Amer, Elsaid A El-dossuky, Ahmed M Emara, Abd El-Samei M Abd El-Fattah, Eman Mohamed Shahy. Hematological effect of benzene exposure with emphasis of muconic acid as a biomarker.
Toxicology and industrial health.
2014 Jun; 30(5):467-74. doi:
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2014 Feb; 32(2):142-4. doi:
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Environmental science and pollution research international.
2014 Feb; 21(4):2826-36. doi:
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Biomedical chromatography : BMC.
2013 May; 27(5):664-8. doi:
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Analytical and bioanalytical chemistry.
2013 Jan; 405(1):341-9. doi:
10.1007/s00216-012-6474-9. [PMID: 23079953] - T Tunsaringkarn, S Soogarun, A Palasuwan. Occupational exposure to benzene and changes in hematological parameters and urinary trans, trans-muconic acid.
The international journal of occupational and environmental medicine.
2013 Jan; 4(1):45-9. doi:
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The Science of the total environment.
2012 Oct; 435-436(?):115-23. doi:
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La Medicina del lavoro.
2012 Sep; 103(5):338-46. doi:
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La Medicina del lavoro.
2012 Sep; 103(5):324-37. doi:
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Toxicology letters.
2012 Aug; 213(1):57-62. doi:
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Toxicology letters.
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The Analyst.
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2012 May; 14(6):1542-50. doi:
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Chemosphere.
2012 May; 87(7):813-9. doi:
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Indoor air.
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2012 Apr; 85(3):261-71. doi:
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2012 Feb; 120(2):229-34. doi:
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Journal of environmental monitoring : JEM.
2011 Oct; 13(10):2921-8. doi:
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Journal of occupational and environmental medicine.
2011 Oct; 53(10):1194-8. doi:
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Environmental and molecular mutagenesis.
2011 May; 52(4):310-8. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2011 Apr; 33(2):117-24. doi:
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Asian Pacific journal of cancer prevention : APJCP.
2011; 12(1):223-7. doi:
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Industrial health.
2011; 49(1):8-14. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2011 Jan; 33(1):41-6. doi:
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Environment international.
2010 Oct; 36(7):779-87. doi:
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Environmental health perspectives.
2010 Jun; 118(6):833-9. doi:
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Toxicology letters.
2010 Apr; 193(3):229-35. doi:
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Chemico-biological interactions.
2010 Mar; 184(1-2):299-301. doi:
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Toxicology letters.
2010 Jan; 192(1):61-5. doi:
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Toxicology letters.
2010 Jan; 192(1):22-8. doi:
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Toxicology letters.
2010 Jan; 192(1):29-33. doi:
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Toxicology letters.
2010 Jan; 192(1):17-21. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2010 Jan; 32(1):49-58. doi:
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International archives of occupational and environmental health.
2009 Aug; 82(8):985-95. doi:
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Annales de biologie clinique.
2009 Mar; 67(2):163-9. doi:
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Wei sheng yan jiu = Journal of hygiene research.
2008 Nov; 37(6):757-9. doi:
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Toxicology letters.
2008 Sep; 181(1):25-30. doi:
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Archives of environmental contamination and toxicology.
2008 Aug; 55(2):329-40. doi:
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Environmental health : a global access science source.
2008 Jun; 7(?):26. doi:
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2008 Jun; 17(6):1460-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 May; 867(1):26-31. doi:
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Chemico-biological interactions.
2008 Apr; 172(3):185-94. doi:
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Journal of forensic sciences.
2008 Jan; 53(1):232-7. doi:
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Journal of immunotoxicology.
2008 Jan; 5(1):69-80. doi:
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Journal of occupational and environmental hygiene.
2007 Aug; 4(8):71-7. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2007 Jul; 29(3 Suppl):528-9. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2007 Jul; 29(3 Suppl):555-6. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2007 Jul; 29(3 Suppl):541-2. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2007 Jul; 29(3 Suppl):538-9. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2007 Jul; 29(3 Suppl):522-3. doi:
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Industrial health.
2007 Jun; 45(3):396-401. doi:
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Journal of applied toxicology : JAT.
2007 May; 27(3):238-46. doi:
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Toxicology and industrial health.
2007 Apr; 23(3):167-75. doi:
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Toxicology letters.
2007 Feb; 168(3):200-9. doi:
10.1016/j.toxlet.2006.09.013. [PMID: 17157453] - Zhongqi He, Rebecca E Parales, Jim C Spain, Glenn R Johnson. Novel organization of catechol meta pathway genes in the nitrobenzene degrader Comamonas sp. JS765 and its evolutionary implication.
Journal of industrial microbiology & biotechnology.
2007 Feb; 34(2):99-104. doi:
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Toxicologic pathology.
2007 Feb; 35(2):268-9. doi:
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Toxicology letters.
2006 Dec; 167(2):142-51. doi:
10.1016/j.toxlet.2006.08.016. [PMID: 17056211] - Sungkyoon Kim, Roel Vermeulen, Suramya Waidyanatha, Brent A Johnson, Qing Lan, Martyn T Smith, Luoping Zhang, Guilan Li, Min Shen, Songnian Yin, Nathaniel Rothman, Stephen M Rappaport. Modeling human metabolism of benzene following occupational and environmental exposures.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2006 Nov; 15(11):2246-52. doi:
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Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2006 Nov; 24(11):676-9. doi:
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Biomedical and environmental sciences : BES.
2006 Aug; 19(4):292-6. doi:
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Se pu = Chinese journal of chromatography.
2006 May; 24(3):260-2. doi:
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Journal of analytical toxicology.
2006 May; 30(4):258-61. doi:
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Toxicology letters.
2006 Apr; 162(2-3):146-52. doi:
10.1016/j.toxlet.2005.09.036. [PMID: 16289653] - Sungkyoon Kim, Roel Vermeulen, Suramya Waidyanatha, Brent A Johnson, Qing Lan, Nathaniel Rothman, Martyn T Smith, Luoping Zhang, Guilan Li, Min Shen, Songnian Yin, Stephen M Rappaport. Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism.
Carcinogenesis.
2006 Apr; 27(4):772-81. doi:
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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2006 Jan; 11(1):28-52. doi:
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Asian Pacific journal of cancer prevention : APJCP.
2006 Jan; 7(1):149-50. doi:
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International immunopharmacology.
2005 Sep; 5(10):1554-9. doi:
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2005 Sep; 14(9):2237-44. doi:
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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2005 Sep; 10(5):336-41. doi:
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Giornale italiano di medicina del lavoro ed ergonomia.
2005 Jul; 27(3):329-31. doi:
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Respiratory medicine.
2005 Jun; 99(6):788-91. doi:
10.1016/j.rmed.2004.10.017. [PMID: 15878497] - Sara Negri, Roberto Bono, Luciano Maestri, Sergio Ghittori, Marcello Imbriani. High-pressure liquid chromatographic-mass spectrometric determination of sorbic acid in urine: verification of formation of trans,trans-muconic acid.
Chemico-biological interactions.
2005 May; 153-154(?):243-6. doi:
10.1016/j.cbi.2005.03.029. [PMID: 15935821]