acyclovir (BioDeep_00000408846)
Main id: BioDeep_00000001849
Chemicals and Drugs Antibiotics
代谢物信息卡片
acyclovir
化学式: C8H11N5O3 (225.0862)
中文名称: 阿昔洛韦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC2=C(N1COCCO)N=C(NC2=O)N
InChI: InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
描述信息
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AD - Antivirals
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
CONFIDENCE standard compound; INTERNAL_ID 2780
Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].
同义名列表
4 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:2453
- KEGG: C06810
- KEGGdrug: D00222
- PubChem: 135398513
- DrugBank: DB00787
- ChEMBL: CHEMBL184
- MeSH: Acyclovir
- CAS: 141294-79-3
- CAS: 88713-38-6
- CAS: 59277-89-3
- MoNA: AU278006
- MoNA: AU278005
- MoNA: AU278002
- MoNA: AU278001
- MoNA: WA001206
- MoNA: WA001205
- MoNA: WA001204
- MoNA: WA001203
- MoNA: WA001202
- PubChem: 9029
- PDB-CCD: AC2
- NIKKAJI: J11.247J
- medchemexpress: HY-17422
- KNApSAcK: 2453
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qi Yang, Lili Fan, Erwei Hao, Xiaotao Hou, Jiagang Deng, Zhongshang Xia, Zhengcai Du. Machine Learning Exploration of the Relationship Between Drugs and the Blood-Brain Barrier: Guiding Molecular Modification.
Pharmaceutical research.
2024 May; 41(5):863-875. doi:
10.1007/s11095-024-03686-2. [PMID: 38605261] - Elisa Vicente Ribelato, Jéssica Wouk, Gabriela Gomes Celestino, Bianca Cerqueira Dias Rodrigues, Maria Laura Goussain Darido, Mario Gabriel Lopes Barboza, Tatiana Jabor Botura, Maylla Cardoso de Oliveira, Fábio Goulart de Andrade, Audrey A S G Lonni, João Carlos Palazzo de Mello, Sérgio Paulo Dejato da Rocha, Lígia C Faccin-Galhardi. Topical formulations containing Trichilia catigua extract as therapeutic options for a genital and an acyclovir-resistant strain of herpes recurrent infection.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].
2023 Jun; ?(?):. doi:
10.1007/s42770-023-01027-w. [PMID: 37338788] - Hongji Lu, Yingdi Liao, Changlin Zhang, Wanxin Wen, Yaming Du, Min Zhao, Lixin Wang. A case of herpes simplex virus induced peripheral neuropathy and encephalitis with positive GM3 and CASPR2 antibody.
BMC neurology.
2023 May; 23(1):199. doi:
10.1186/s12883-023-03238-y. [PMID: 37210504] - Jing-Yu Weng, Xin-Xing Chen, Xiao-Hua Wang, Hui-Er Ye, Yan-Ping Wu, Wan-Yang Sun, Lei Liang, Wen-Jun Duan, Hiroshi Kurihara, Feng Huang, Xin-Xin Sun, Shu-Hua Ou-Yang, Rong-Rong He, Yi-Fang Li. Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1.
Acta pharmacologica Sinica.
2023 May; ?(?):. doi:
10.1038/s41401-023-01095-6. [PMID: 37193755] - Yi Zhang, Lei Fang, Yi Zhou, Yongqing Zhang, Bing Liang, Chuanzhu Yan, Ling Li. A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing.
BMC neurology.
2023 May; 23(1):192. doi:
10.1186/s12883-023-03227-1. [PMID: 37194001] - Tian Tao, Jun Chen, Kunlan Long, Lijia Zhi, Song Zhang, Shuqin Liu, Yuexian Ma, Hong Yan, Lizeyu Lv, Yue Xu, Ling Wu, Liangbin Zhao, Peiyang Gao. Severe varicella-zoster virus meningoencephalomyelitis coexisting with visceral disseminated varicella-zoster virus infection in a patient with lupus nephritis: A case report.
Medicine.
2023 Apr; 102(14):e33459. doi:
10.1097/md.0000000000033459. [PMID: 37026945] - Dalia M Soleman, Omayma A Eldahshan, Mona H Ibrahim, Hanan A Ogaly, Heba M Galal, Gaber El-Saber Batiha, Rawah H Elkousy. GC/MS Analysis, Cytotoxicity, and Antiviral Activities of Annona glabra Hexane Extract Supported by In Silico Study.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041628. [PMID: 36838616] - Ping Liu, Lishan Zhong, Ji Xiao, Yuze Hu, Tao Liu, Zhe Ren, Yifei Wang, Kai Zheng. Ethanol extract from Artemisia argyi leaves inhibits HSV-1 infection by destroying the viral envelope.
Virology journal.
2023 01; 20(1):8. doi:
10.1186/s12985-023-01969-5. [PMID: 36647143] - Tong Liu, Qingqing Shao, Wenjia Wang, Yonggui Ma, Tianli Liu, Ximing Jin, Jianguo Fang, Guangying Huang, Zhuo Chen. Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription JieZe-1 in protecting against HSV-2 infection.
Pharmaceutical biology.
2022 Dec; 60(1):451-466. doi:
10.1080/13880209.2022.2038209. [PMID: 35180012] - Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice.
Life sciences.
2022 Sep; 304(?):120725. doi:
10.1016/j.lfs.2022.120725. [PMID: 35751919] - Kousalya Selvaraj, Gowthamarajan Kuppusamy, Vyshnavi Tallapaneni, Veera Venkata Satyanarayana Reddy Karri. Brain targeted intra nasal acyclovir lipid nanoparticles; in-vitro characterization and in-vivo biodistribution studies.
Pakistan journal of pharmaceutical sciences.
2022 Sep; 35(5):1363-1369. doi:
. [PMID: 36451565] - Xuewei Ding, Lina Liu, Guang Yang, Hui Liu. Establishment and clinical application of an assay for the activity of circulating immune complexes using human O-erythrocytes as an indicator system.
Clinica chimica acta; international journal of clinical chemistry.
2022 Aug; 533(?):156-167. doi:
10.1016/j.cca.2022.06.023. [PMID: 35787990] - Kensuke Shoji, Jumpei Saito, Yusa Nagai, Itaru Hayakawa, Yusuke Oho, Hiroki Kato, Chiaki Tao, Takanori Funaki, Masaki Yamada, Chikara Ogimi. Serum and cerebrospinal fluid acyclovir pharmacokinetics in a neonate with HSV-2 meningoencephalitis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Aug; 28(8):1168-1171. doi:
10.1016/j.jiac.2022.03.022. [PMID: 35370079] - Ranmini Kularatne, Johanna M E Venter, Venessa Maseko, Etienne Muller, Tendesayi Kufa. Etiological Surveillance of Genital Ulcer Syndrome in South Africa: 2019 to 2020.
Sexually transmitted diseases.
2022 08; 49(8):571-575. doi:
10.1097/olq.0000000000001645. [PMID: 35551170] - Rinu Sivarajan, Heike Oberwinkler, Valeria Roll, Eva-Maria König, Maria Steinke, Jochen Bodem. A defined anthocyanin mixture sourced from bilberry and black currant inhibits Measles virus and various herpesviruses.
BMC complementary medicine and therapies.
2022 Jul; 22(1):181. doi:
10.1186/s12906-022-03661-7. [PMID: 35804339] - Suhad Sami Humadi, Samir Mohamed Awad, Ahmed Abd Elkader El-Rashedy, Mohamed Fathy El-Shehry. Design, synthesis, ADME, biological evaluation and molecular dynamic studies of natural and synthetic remedy of Herpes simplex virus type-1.
Pakistan journal of pharmaceutical sciences.
2022 Jul; 35(4(Special)):1181-1190. doi:
. [PMID: 36218096] - Lindsay A Petty, Preeti N Malani. Oral Antiviral Medications for COVID-19.
JAMA.
2022 06; 327(24):2464. doi:
10.1001/jama.2022.6876. [PMID: 35467696] - María Del Carmen Vázquez Friol, Hortensia Álvarez, Cintia Tuñas Gesto. Intracerebral Varicella Zoster Virus Vasculopathy in a Patient with Systemic Lupus Erythematosus and Imaging-Clinical Discordance.
The American journal of case reports.
2022 Jun; 23(?):e936707. doi:
10.12659/ajcr.936707. [PMID: 35666704] - Yuan Wang, Jing Zhou, Ming-Ming Yuan, Xiao-Han Zheng, Lei Zhang. [Protective effect of Forsythiae Fructus extract on mice with herpes simplex encephalitis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jun; 47(11):3023-3028. doi:
10.19540/j.cnki.cjcmm.20220124.401. [PMID: 35718526] - In-Cheon You, Min Ahn, Nam-Chun Cho. A Case Report of Herpes Zoster Ophthalmicus and Meningitis After COVID-19 Vaccination.
Journal of Korean medical science.
2022 May; 37(20):e165. doi:
10.3346/jkms.2022.37.e165. [PMID: 35607743] - Stephan Spahn, Reimer Riessen, Christoph P Berg, Nisar P Malek, Marzena H Emrich, Kristina Lohrengel, Tina Ganzenmueller, Thomas Iftner, Gerald Kleymann, Klaus Hamprecht. Comprehensive clinical and virological characterization of three cases of fulminant liver failure owing to HSV1 primary infection.
Liver international : official journal of the International Association for the Study of the Liver.
2022 05; 42(5):1005-1011. doi:
10.1111/liv.15215. [PMID: 35230726] - Tahereh Toulabi, Bahram Delfan, Marzieh Rashidipour, Sajad Yarahmadi, Farzaneh Ravanshad, Amir Javanbakht, Mohammad Almasian. The efficacy of olive leaf extract on healing herpes simplex virus labialis: A randomized double-blind study.
Explore (New York, N.Y.).
2022 May; 18(3):287-292. doi:
10.1016/j.explore.2021.01.003. [PMID: 33541815] - S Gupta, A Dutta, U Chakraborty, R Kumar, D Das, B K Ray. Post-COVID-19 HSV encephalitis: a review.
QJM : monthly journal of the Association of Physicians.
2022 Apr; 115(4):222-227. doi:
10.1093/qjmed/hcac060. [PMID: 35199176] - M Ramírez-Colombres, C E Maenza, N S Rocchetti, S P Gattino, S Diodati, C A Luchitta, M D Ré, C J Settecase, D H Bagilet. [COVID-19 and herpesvirus encephalitis].
Revista de neurologia.
2022 04; 74(8):280-283. doi:
10.33588/rn.7408.2021121. [PMID: 35383876] - Rami A Al-Dwairi, Abdelwahab Aleshawi, Sharaf Adi, Laith Abu-Zreig. Reactivation of Herpes Simplex Keratitis on a Corneal Graft Following SARS-CoV-2 mRNA Vaccination.
Medical archives (Sarajevo, Bosnia and Herzegovina).
2022 Apr; 76(2):146-148. doi:
10.5455/medarh.2022.76.146-148. [PMID: 35774041] - Andreas Ärlemalm, Anders Helldén, Louise Karlsson, Björn Carlsson. Rapid determination of acyclovir, its main metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum using LC-MS/MS.
Biomedical chromatography : BMC.
2022 Apr; 36(4):e5315. doi:
10.1002/bmc.5315. [PMID: 34981553] - SeungHoon Yun, Jinyong Kim, Hye-Rim Shin. A Case Report of Varicella Zoster Meningitis as Co-Infection With Breakthrough COVID-19 in an Immunocompetent Patient.
Journal of Korean medical science.
2022 Feb; 37(8):e61. doi:
10.3346/jkms.2022.37.e61. [PMID: 35226419] - Obaidur Rehman, Sudesh Kumar Arya, Ujjwal Prakash Jha, Shifali Nayyar, Itisha Goel. Herpes Zoster Ophthalmicus After COVID-19 Vaccination: Chance Occurrence or More?.
Cornea.
2022 Feb; 41(2):254-256. doi:
10.1097/ico.0000000000002881. [PMID: 34690265] - Luca Roncati, Antonio Manenti, Luca Fabbiani, Claudia Malagoli, Vincenzo Nasillo, Beatrice Lusenti, Massimo Lupi, Giuliana Zanelli, Tiziana Salviato, Matteo Costantini, Tommaso Trenti, Antonio Maiorana. HSV1 viremia with fulminant hepatitis as opportunistic sequela in severe COVID-19.
Annals of hematology.
2022 01; 101(1):229-231. doi:
10.1007/s00277-021-04417-y. [PMID: 33458783] - Nadia Shamshad Malik, Mahmood Ahmad, Mohammed S Alqahtani, Arshad Mahmood, Kashif Barkat, Muhammad Tariq Khan, Ume Ruqia Tulain, Ayesha Rashid. β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation.
Drug delivery.
2021 Dec; 28(1):1093-1108. doi:
10.1080/10717544.2021.1921074. [PMID: 34114907] - Wessam H Abd-Elsalam, Reem R Ibrahim. Span 80/TPGS modified lipid-coated chitosan nanocomplexes of acyclovir as a topical delivery system for viral skin infections.
International journal of pharmaceutics.
2021 Nov; 609(?):121214. doi:
10.1016/j.ijpharm.2021.121214. [PMID: 34678396] - Zoltan Paluch, Milan Trojánek, Zuzana Velíšková, Jana Mlíchová, Pavel Chrbolka, Jana Gregorová, Emanuel Marques, Dagmar Kalatova, Dušan Pícha. Neurotoxic side effects of acyclovir: two case reports.
Neuro endocrinology letters.
2021 Oct; 42(6):375-382. doi:
NULL. [PMID: 34713692] - Sung Min Han, Hyun Su Lee, Hee Sung Chae, Young-Joon Seo. Usefulness of vertebrobasilar artery radiological finding as a predictive and prognostic factor for sudden sensorineural hearing loss.
Auris, nasus, larynx.
2021 Oct; 48(5):823-829. doi:
10.1016/j.anl.2021.01.002. [PMID: 33451886] - Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir. Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir.
Molecules (Basel, Switzerland).
2021 Sep; 26(18):. doi:
10.3390/molecules26185432. [PMID: 34576904] - James Richardson-May, Alice Rothwell, Mohammed Rashid. Reactivation of herpes simplex keratitis following vaccination for COVID-19.
BMJ case reports.
2021 Sep; 14(9):. doi:
10.1136/bcr-2021-245792. [PMID: 34493563] - Andrea C Brum, M Patricia Glasman, M Cristina De Luca, Carlos A Rugilo, M Inés Urquizu Handal, Armando O Picon, Cristina Cook, Nestor E Vain. Ischemic Lesions in the Brain of a Neonate With SARS-CoV-2 Infection.
The Pediatric infectious disease journal.
2021 09; 40(9):e340-e343. doi:
10.1097/inf.0000000000003244. [PMID: 34288632] - Elise Yvin, François Beloncle, Sylvain Thépot, Laurence Lagarce, Jean-François Augusto, Anne-Sophie Garnier. Severe polyuria secondary to acyclovir induced-proximal tubulopathy.
Therapie.
2021 Sep; 76(5):498-499. doi:
10.1016/j.therap.2020.08.001. [PMID: 32919761] - Al Ozonoff, Etsuro Nanishi, Ofer Levy. Bell's palsy and SARS-CoV-2 vaccines-an unfolding story - Authors' reply.
The Lancet. Infectious diseases.
2021 09; 21(9):1211-1212. doi:
10.1016/s1473-3099(21)00323-6. [PMID: 34111410] - Muhannad I Alkhalifah, Haneen E Alsobki, Haifa M Alwael, Abdullah M Al Fawaz, Hani S Al-Mezaine. Herpes Simplex Virus Keratitis Reactivation after SARS-CoV-2 BNT162b2 mRNA Vaccination: A Report of Two Cases.
Ocular immunology and inflammation.
2021 Aug; 29(6):1238-1240. doi:
10.1080/09273948.2021.1986548. [PMID: 34637667] - Rumeysa Yalçınkaya, Fatma Nur Öz, Ayşe Kaman, Türkan Aydın Teke, Sevgi Yaşar Durmuş, Evra Çelikkaya, Gönül Tanır. Factors associated with acyclovir nephrotoxicity in children: data from 472 pediatric patients from the last 10 years.
European journal of pediatrics.
2021 Aug; 180(8):2521-2527. doi:
10.1007/s00431-021-04093-0. [PMID: 33956193] - Romana Urinovska, Ivana Kacirova, Jiri Sagan. Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanide in human serum by ultra-high-performance liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2021 Aug; 44(16):3080-3088. doi:
10.1002/jssc.202100241. [PMID: 34165890] - David Brandariz-Nuñez, Marcelo Correas-Sanahuja, Sara Maya-Gallego, Isabel Martín Herranz. Neurotoxicity associated with acyclovir and valacyclovir: A systematic review of cases.
Journal of clinical pharmacy and therapeutics.
2021 Aug; 46(4):918-926. doi:
10.1111/jcpt.13464. [PMID: 34146428] - Yuichi Hayashi, Natsuko Ueda, Hideaki Shibata, Tomonori Yaguchi, Nobuaki Yoshikura, Megumi Yamada, Akio Kimura, Takashi Inuzuka, Takayoshi Shimohata. Clinical characteristics of intractable or persistent hiccups and nausea associated with herpes zoster.
Clinical neurology and neurosurgery.
2021 08; 207(?):106751. doi:
10.1016/j.clineuro.2021.106751. [PMID: 34119896] - Renato Meneghetti Peres, Jéssica Maiara Leme Sousa, Mariana Oliva de Oliveira, Maura Vincenza Rossi, Rene Ramos de Oliveira, Nelson Batista de Lima, Ayrton Bernussi, Juliusz Warzywoda, Bruno Sarmento, Antonio Hortencio Munhoz. Pseudoboehmite as a drug delivery system for acyclovir.
Scientific reports.
2021 07; 11(1):15448. doi:
10.1038/s41598-021-94325-y. [PMID: 34326377] - Lixia Li, Rui Wang, Huaiyue Hu, Xu Chen, Zhongqiong Yin, Xiaoxia Liang, Changliang He, Lizi Yin, Gang Ye, Yuanfeng Zou, Guizhou Yue, Huaqiao Tang, Renyong Jia, Xu Song. The antiviral activity of kaempferol against pseudorabies virus in mice.
BMC veterinary research.
2021 Jul; 17(1):247. doi:
10.1186/s12917-021-02953-3. [PMID: 34275451] - Mohammad Hailat, Israa Al-Ani, Mohammed Hamad, Zainab Zakareia, Wael Abu Dayyih. Development and Validation of a Method for Quantification of Favipiravir as COVID-19 Management in Spiked Human Plasma.
Molecules (Basel, Switzerland).
2021 Jun; 26(13):. doi:
10.3390/molecules26133789. [PMID: 34206357] - Punyanuch Pisitpayat, Passara Jongkhajornpong, Kaevalin Lekhanont, Manachai Nonpassopon. Role of Intravenous Acyclovir in Treatment of Herpes Simplex Virus Stromal Keratitis with Ulceration: A Review of 2 Cases.
The American journal of case reports.
2021 Jun; 22(?):e930467. doi:
10.12659/ajcr.930467. [PMID: 34133412] - Sanjiv Sharma, Jigish Ruparelia, Suryanarayanan Bhaskar, Sarbesh Tiwari, Vijaya Lakshmi Nag, Samhita Panda. Acute Fulminant Cerebellitis in Children with COVID-19 Infection: A Rare But Treatable Complication.
Pediatric neurology.
2021 06; 119(?):45-47. doi:
10.1016/j.pediatrneurol.2021.03.004. [PMID: 33894640] - Rawah H Elkousy, Zeinab N A Said, Mohamed A Abd El-Baseer, Salwa A Abu El Wafa. Antiviral activity of castor oil plant (Ricinus communis) leaf extracts.
Journal of ethnopharmacology.
2021 May; 271(?):113878. doi:
10.1016/j.jep.2021.113878. [PMID: 33515683] - Gergely Losonczy, Marlies Gijs, Rudy M M A Nuijts. Nivolumab-Induced Ulcerative Keratitis-A Case Report.
Cornea.
2021 May; 40(5):656-658. doi:
10.1097/ico.0000000000002460. [PMID: 32826643] - Mohammed Kamal Badawy, Sophie Hurrell, Catherine Baldwin, Heba Hassan. Prolonged fever and hyperferritinaemia: a puzzling diagnosis of neonatal herpes simplex virus infection during COVID-19 pandemic.
BMJ case reports.
2021 Mar; 14(3):. doi:
10.1136/bcr-2020-241405. [PMID: 33692072] - Ze'ev Itsekson Hayosh, Yvonne Schwammenthal, David Orion. Can other coronavirus infections cause a cryptogenic stroke in a young patient?.
BMJ case reports.
2021 Mar; 14(3):. doi:
10.1136/bcr-2020-239113. [PMID: 33658214] - Christos Theophanous, Jonathan D Santoro, Reem Itani. Bell's palsy in a pediatric patient with hyper IgM syndrome and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Brain & development.
2021 Feb; 43(2):357-359. doi:
10.1016/j.braindev.2020.08.017. [PMID: 32950319] - Charalampia Papadopoulou, Muthana Al Obaidi, Elena Moraitis, Sandrine Compeyrot-Lacassagne, Despina Eleftheriou, Paul Brogan. Management of severe hyperinflammation in the COVID-19 era: the role of the rheumatologist.
Rheumatology (Oxford, England).
2021 02; 60(2):911-917. doi:
10.1093/rheumatology/keaa652. [PMID: 33197261] - Tania Sarsam, Stephen J McWilliam. Aciclovir and acute kidney injury: putting the research in context.
Archives of disease in childhood.
2020 12; 105(12):1206-1207. doi:
10.1136/archdischild-2019-318764. [PMID: 33032994] - Santosh K Maurya, Akhilesh Kumar Maurya, Nidhi Mishra, Hifzur R Siddique. Virtual screening, ADME/T, and binding free energy analysis of anti-viral, anti-protease, and anti-infectious compounds against NSP10/NSP16 methyltransferase and main protease of SARS CoV-2.
Journal of receptor and signal transduction research.
2020 Dec; 40(6):605-612. doi:
10.1080/10799893.2020.1772298. [PMID: 32476594] - Blake J Sandery, Jonathan H Erlich, Sean E Kennedy. Acute kidney injury following intravenous acyclovir in children.
Archives of disease in childhood.
2020 12; 105(12):1215-1219. doi:
10.1136/archdischild-2019-317990. [PMID: 32404442] - Ahmad Nofal, Mohamed M Fawzy, Sherif M Sharaf El Deen, Esraa E El-Hawary. Herpes zoster ophthalmicus in COVID-19 patients.
International journal of dermatology.
2020 Dec; 59(12):1545-1546. doi:
10.1111/ijd.15240. [PMID: 33040343] - ZheLun Shen, QingQing Yu, YangLei Li, YiQi Bao, Hong Lu. Determination of acyclovir in renal microdialysis fluid and confirmation of renal function index.
Drug and chemical toxicology.
2020 Nov; 43(6):574-580. doi:
10.1080/01480545.2018.1524474. [PMID: 30486699] - Syed Mahmood, Kong Chak Kiong, Chun Shern Tham, Tan Choo Chien, Ayah Rebhi Hilles, Jayarama Reddy Venugopal. PEGylated Lipid Polymeric Nanoparticle-Encapsulated Acyclovir for In Vitro Controlled Release and Ex Vivo Gut Sac Permeation.
AAPS PharmSciTech.
2020 Oct; 21(7):285. doi:
10.1208/s12249-020-01810-0. [PMID: 33057878] - L Niu, G Yang, C-X Liu, X-Z Zhao, X-Y Li, M Yu. Observation of the efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and its impacts on IL-1 and IL-6.
European review for medical and pharmacological sciences.
2020 10; 24(20):10736-10744. doi:
10.26355/eurrev_202010_23434. [PMID: 33155234] - Johan Virhammar, Eva Kumlien, David Fällmar, Robert Frithiof, Sven Jackmann, Mattias K Sköld, Mohamed Kadir, Jens Frick, Jonas Lindeberg, Henrik Olivero-Reinius, Mats Ryttlefors, Janet L Cunningham, Johan Wikström, Anna Grabowska, Kåre Bondeson, Jonas Bergquist, Henrik Zetterberg, Elham Rostami. Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid.
Neurology.
2020 09; 95(10):445-449. doi:
10.1212/wnl.0000000000010250. [PMID: 32586897] - Aleksandra Bełz, Paulina Dębowska, Joanna Głogowska-Szeląg. Acyclovir Neurotoxicity in an Elderly Patient With End-Stage Renal Failure.
American journal of therapeutics.
2020 Sep; 27(5):e525-e527. doi:
10.1097/mjt.0000000000001012. [PMID: 31794437] - Takuya Inagaki, Souichi Yamada, Hikaru Fujii, Tomoki Yoshikawa, Miho Shibamura, Shizuko Harada, Shuetsu Fukushi, Mai Quynh Le, Co Thach Nguyen, Thi Thu Thuy Nguyen, Thanh Thuy Nguyen, Thanh Thuy Nguyen, Van Tay Quach, Vu Dinh Thong, Kazuki Mori, Michihito Sasaki, Agus Setiyono, Ekowati Handharyani, Haruko Takeyama, Futoshi Hasebe, Masayuki Saijo. Characterization of a Novel Alphaherpesvirus Isolated from the Fruit Bat Pteropus lylei in Vietnam.
Journal of virology.
2020 08; 94(18):. doi:
10.1128/jvi.00673-20. [PMID: 32669329] - Julia L Shamshina, Robin D Rogers. Are Myths and Preconceptions Preventing us from Applying Ionic Liquid Forms of Antiviral Medicines to the Current Health Crisis?.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21176002. [PMID: 32825444] - Federico Tartari, Alberto Spadotto, Corrado Zengarini, Rossana Zanoni, Alba Guglielmo, Alexander Adorno, Cinzia Valzania, Alessandro Pileri. Herpes zoster in COVID-19-positive patients.
International journal of dermatology.
2020 Aug; 59(8):1028-1029. doi:
10.1111/ijd.15001. [PMID: 32530063] - A Collet, D Baes, A Mambie, K Hembert, C Boulle, I Gana, X Lemaire. VZV meningoencephalitis treated with ganciclovir.
Medecine et maladies infectieuses.
2020 Aug; 50(5):444-445. doi:
10.1016/j.medmal.2020.03.001. [PMID: 32204960] - Yoshiki Kondo, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Atsushi Sugiyama. Electropharmacological Characterization of Aciclovir in the Halothane-Anesthetized Dogs: A Proposal of Evaluation Method for Cardiovascular Safety Pharmacology of Anti-virus Drugs.
Cardiovascular toxicology.
2020 08; 20(4):419-426. doi:
10.1007/s12012-020-09568-4. [PMID: 32193875] - Jonathan Wickel, Ha-Yeun Chung, Stephanie Platzer, Thomas Lehmann, Harald Prüss, Frank Leypoldt, Albrecht Günther, André Scherag, Christian Geis. Generate-Boost: study protocol for a prospective, multicenter, randomized controlled, double-blinded phase II trial to evaluate efficacy and safety of bortezomib in patients with severe autoimmune encephalitis.
Trials.
2020 Jul; 21(1):625. doi:
10.1186/s13063-020-04516-7. [PMID: 32641101] - Duygu D Corum, Orhan Corum, Orkun Atik, Hatice E Faki, Feray Altan, Kamil Uney. Effect of benzylpenicillin on intravenous pharmacokinetics of acyclovir in red-eared slider turtles (Trachemys scripta elegans).
Journal of veterinary pharmacology and therapeutics.
2020 Jul; 43(4):319-324. doi:
10.1111/jvp.12860. [PMID: 32212341] - Izabela Muszalska-Kolos, Monika A Lesniewska-Kowiel, Szymon Plewa, Agnieszka Klupczyńska. Tricyclic Derivative of Acyclovir and Its Esters in Relation to the Esters of Acyclovir Enzymatic Stability: Enzymatic Stability Study.
Molecules (Basel, Switzerland).
2020 May; 25(9):. doi:
10.3390/molecules25092156. [PMID: 32380673] - Xing-Hua Zhang, Yan Lu, Li-Li Sun, Zi-Xue Sun. [Psychological nursing for genital herpes patients receiving acyclovir plus thymosin and its effect on the incidence of adverse reactions].
Zhonghua nan ke xue = National journal of andrology.
2020 May; 26(5):436-440. doi:
". [PMID: 33354953] - H Tabaja, S L Sharara, Y Abi Aad, N Beydoun, S Tabbal, A Makki, R Mahfouz, S S Kanj. Varicella zoster virus infection of the central nervous system in a tertiary care center in Lebanon.
Medecine et maladies infectieuses.
2020 May; 50(3):280-287. doi:
10.1016/j.medmal.2019.08.005. [PMID: 31526545] - Kevin J Downes, Craig L K Boge, Elande Baro, Gerold T Wharton, Kellie M Liston, Brittany L Haltzman, Hannah M Emerson, Edwin Doe, Rosanna Fulchiero, Van Tran, Lilly Yen, Phuong Lieu, Sara L Van Driest, Alison G Grisso, Ida T Aka, Jennifer Hale, Jessica Gillon, Julie S Pingel, Susan E Coffin, Ann W McMahon. Acute Kidney Injury During Treatment with Intravenous Acyclovir for Suspected or Confirmed Neonatal Herpes Simplex Virus Infection.
The Journal of pediatrics.
2020 04; 219(?):126-132.e2. doi:
10.1016/j.jpeds.2019.12.056. [PMID: 32037154] - Godsfavour O Umoru, Punit J Shah, Farheen Tariq. A Case Report of Neurotoxicity After Prolonged Doses of Acyclovir in a Patient With Renal Dysfunction.
Journal of pharmacy practice.
2020 Apr; 33(2):217-221. doi:
10.1177/0897190018825033. [PMID: 30669921] - Pongprueth Rujirachun, Jirath Sangwongwanich, Methee Chayakulkeeree. Triple infection with Cryptococcus, varicella-zoster virus, and Mycobacterium abscessus in a patient with anti-interferon-gamma autoantibodies: a case report.
BMC infectious diseases.
2020 Mar; 20(1):232. doi:
10.1186/s12879-020-4949-4. [PMID: 32188404] - Qianni Duan, Tong Liu, Ping Yuan, Cong Huang, Qingqing Shao, Lijun Xu, Jun Sun, Guangyin Huang, Zhuo Chen. Antiviral effect of Chinese herbal prescription JieZe-1 on adhesion and penetration of VK2/E6E7 with herpes simplex viruses type 2.
Journal of ethnopharmacology.
2020 Mar; 249(?):112405. doi:
10.1016/j.jep.2019.112405. [PMID: 31743766] - Daniele Zendrini Rechenchoski, Karoline Fontana Agostinho, Ligia Carla Faccin-Galhardi, Audrey Alesandra Stinghen Garcia Lonni, João Vinícius Honório da Silva, Fábio Goulart de Andrade, Arcelina Pacheco Cunha, Nágila Maria Pontes Silva Ricardo, Carlos Nozawa, Rosa Elisa Carvalho Linhares. Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir - resistant herpes simplex virus 1 infection.
Bioorganic & medicinal chemistry.
2020 02; 28(4):115304. doi:
10.1016/j.bmc.2020.115304. [PMID: 31956052] - Jun Aoyagi, Takahiro Kanai, Tomomi Maru, Jun Odaka, Takashi Saito, Hiroyuki Betsui, Takanori Yamagata. Efficacy of plasma exchange with a high dose of acyclovir for disseminated varicella infection.
CEN case reports.
2020 02; 9(1):15-18. doi:
10.1007/s13730-019-00415-2. [PMID: 31520251] - Oskar Bunz, Kemal Mese, Christina Funk, Maximilan Wulf, Susanne M Bailer, Andree Piwowarczyk, Anja Ehrhardt. Cold atmospheric plasma as antiviral therapy - effect on human herpes simplex virus type 1.
The Journal of general virology.
2020 02; 101(2):208-215. doi:
10.1099/jgv.0.001382. [PMID: 31961788] - F Reizine, C Pronier, C Lepart, C Grolhier, M Revest, V Thibault, P Tattevin. Biphasic evolution of varicella-zoster virus meningoencephalitis : Diagnostic challenges.
Medecine et maladies infectieuses.
2020 02; 50(1):87-89. doi:
10.1016/j.medmal.2019.10.016. [PMID: 31767157] - Roberto X Calix, Kelsey B Loeliger, Martina S Burn, Katherine H Campbell. Acute Herpes Simplex Virus Hepatitis in Pregnancy.
Obstetrics and gynecology.
2020 Feb; 135(2):396-400. doi:
10.1097/aog.0000000000003613. [PMID: 31923059] - Wen'ge Huang, Yingzhuo Yang, Wen Wen, Yu Luo, Jiasi Wu, Li Xiang, Yinfan Hu, Shijun Xu, Simin Chen, Ping Wang. Vanillin enhances the passive transport rate and absorption of drugs with moderate oral bioavailability in vitro and in vivo by affecting the membrane structure.
Food & function.
2020 Jan; 11(1):700-710. doi:
10.1039/c9fo02846c. [PMID: 31909774] - Soyoung Shin, Tae Hwan Kim, Da Young Lee, Seung Eun Chung, Jong Bong Lee, Do-Hyung Kim, Beom Soo Shin. Development of a Population Pharmacokinetics-Based in vitro-in vivo Correlation Model for Drugs with Site-Dependent Absorption: the Acyclovir Case Study.
The AAPS journal.
2020 01; 22(2):27. doi:
10.1208/s12248-019-0382-2. [PMID: 31938935] - Ana Coscojuela Otto, Jose María Peña Porta, Rafael Álvarez Lipe. Aciclovir-induced acute kidney injury.
Medicina clinica.
2020 01; 154(1):36. doi:
10.1016/j.medcli.2019.03.031. [PMID: 31160042] - Khaoula El Montacer, Wafaa Hliwa, Fz El Rhaoussi, Mohammed Tahiri, Fouad Haddad, Ahmed Bellabah, Wafaa Badre. [Autoimmune hepatitis following acute severe Epstein-Barr virus hepatitis].
The Pan African medical journal.
2020; 37(?):77. doi:
10.11604/pamj.2020.37.77.20817. [PMID: 33244340] - Mustafa Altındiş, Ferhat Gürkan Aslan, Hüseyin Uzuner, Havva Ünal, Mehmet Köroğlu, Sedat Kulaç, Aynur Karadenizli. [Comparison of Antiviral Effect of Olive Leaf Extract and Propolis with Acyclovir on Herpes Simplex Virus Type 1].
Mikrobiyoloji bulteni.
2020 Jan; 54(1):79-94. doi:
10.5578/mb.69019. [PMID: 32050880] - Sevda Demir, Ali Timucin Atayoglu, Fabio Galeotti, Emanuele U Garzarella, Vincenzo Zaccaria, Nicola Volpi, Ali Karagoz, Fikrettin Sahin. Antiviral activity of different extracts of standardized propolis preparations against HSV.
Antiviral therapy.
2020; 25(7):353-363. doi:
10.3851/imp3383. [PMID: 33620334] - Chandran Ramakrishna, Stacee Mendonca, Paul M Ruegger, Jane Hannah Kim, James Borneman, Edouard M Cantin. Herpes simplex virus infection, Acyclovir and IVIG treatment all independently cause gut dysbiosis.
PloS one.
2020; 15(8):e0237189. doi:
10.1371/journal.pone.0237189. [PMID: 32760124] - Xiao-Ying Liao, Qiang-Qiang Deng, Li Han, Zhi-Tao Wu, Zhao-Liang Peng, Yuan Xie, Guang-Ji Wang, Ji-Ye Aa, Guo-Yu Pan. Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2.
Acta pharmacologica Sinica.
2020 Jan; 41(1):129-137. doi:
10.1038/s41401-019-0283-z. [PMID: 31341258] - Sanaa A El-Gizawy, Gamal M El-Maghraby, Asmaa A Hedaya. Formulation of acyclovir-loaded solid lipid nanoparticles: 2. Brain targeting and pharmacokinetic study.
Pharmaceutical development and technology.
2019 Dec; 24(10):1299-1307. doi:
10.1080/10837450.2019.1667386. [PMID: 31507245] - Johan Lindström, Anders Helldén, Jan Lycke, Anna Grahn, Marie Studahl. An unexpectedly high occurrence of aciclovir-induced neuropsychiatric symptoms in patients treated for herpesvirus CNS infection: a prospective observational study.
The Journal of antimicrobial chemotherapy.
2019 12; 74(12):3565-3572. doi:
10.1093/jac/dkz357. [PMID: 31504577] - Sanaa A El-Gizawy, Gamal M El-Maghraby, Asmaa A Hedaya. Formulation of acyclovir-loaded solid lipid nanoparticles: design, optimization, and in-vitro characterization.
Pharmaceutical development and technology.
2019 Dec; 24(10):1287-1298. doi:
10.1080/10837450.2019.1667385. [PMID: 31507232] - João Paulo Bizarro Lopes, Luana Silva, Marco Antonio Ceschi, Diogo Seibert Lüdtke, Aline Rigon Zimmer, Thais Carine Ruaro, Rafael Ferreira Dantas, Cristiane Martins Cardoso de Salles, Floriano Paes Silva-Jr, Mario Roberto Senger, Gisele Barbosa, Lídia Moreira Lima, Isabella Alvim Guedes, Laurent Emmanuel Dardenne. Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling.
MedChemComm.
2019 Dec; 10(12):2089-2101. doi:
10.1039/c9md00358d. [PMID: 32904099] - Yuwei Wang, Hong Nian, Ziwei Li, Wenjuan Wang, Xin Wang, Yan Cui. Human encephalitis complicated with bilateral acute retinal necrosis associated with pseudorabies virus infection: A case report.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2019 Dec; 89(?):51-54. doi:
10.1016/j.ijid.2019.09.019. [PMID: 31562933] - Hyun Mi Kang, Jung Hwa Lim, Kyung Hee Noh, Dongmin Park, Hyun-Soo Cho, Katalin Susztak, Cho-Rok Jung. Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.
Scientific reports.
2019 11; 9(1):17610. doi:
10.1038/s41598-019-53855-2. [PMID: 31772214] - Jocelyne Piret, Manuel Schibler, Van Dung Pham, Sébastien Hantz, Federica Giannotti, Stavroula Masouridi-Levrat, Laurent Kaiser, Nathalie Goyette, Sophie Alain, Rong Shi, Guy Boivin. Compartmentalization of a Multidrug-Resistant Cytomegalovirus UL54 Mutant in a Stem Cell Transplant Recipient with Encephalitis.
The Journal of infectious diseases.
2019 09; 220(8):1302-1306. doi:
10.1093/infdis/jiz298. [PMID: 31199457] - Adam Uslu, Alpay Ari, Cenk Simsek, Ali Ilgin Olgut, Murat Karatas, Ahmet Aykas, Ismail Can Tercan, Erhan Tatar. Evaluation of a Cytomegalovirus Prophylaxis Protocol in Cytomegalovirus-IgG Positive Renal Transplant Recipients (R+).
Transplantation proceedings.
2019 Sep; 51(7):2350-2354. doi:
10.1016/j.transproceed.2019.01.196. [PMID: 31358453] - Jay Patel, Brendan Hayes, Laura Bauler, Joshua Mastenbrook. Neurologic Acyclovir Toxicity in the Absence of Kidney Injury.
The Journal of emergency medicine.
2019 Aug; 57(2):e35-e39. doi:
10.1016/j.jemermed.2019.03.050. [PMID: 31171414]
