syringaresinol (BioDeep_00000406578)

 

Secondary id: BioDeep_00000017525, BioDeep_00000395621

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4-[4-(4-hydroxy-3,5-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan-1-yl]-2,6-dimethoxyphenol

化学式: C22H26O8 (418.1628)
中文名称: (+)-丁香树脂酚, DL-丁香树脂酚
谱图信息: 最多检出来源 Viridiplantae(plant) 87.2%

分子结构信息

SMILES: COC1=CC(=CC(=C1O)OC)C2C3COC(C3CO2)C4=CC(=C(C(=C4)OC)O)OC
InChI: InChI=1S/C22H26O8/c1-25-15-5-11(6-16(26-2)19(15)23)21-13-9-30-22(14(13)10-29-21)12-7-17(27-3)20(24)18(8-12)28-4/h5-8,13-14,21-24H,9-10H2,1-4H3

描述信息

同义名列表

6 个代谢物同义名

4-[4-(4-hydroxy-3,5-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan-1-yl]-2,6-dimethoxyphenol; (+)-Episyringaresinol; (+)-Syringaresinol; Symplicosigenol; syringaresinol; Lirioresinol A



相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

571 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Zak Towle, Faye Cruickshank, C Logan Mackay, David J Clarke, Louise E Horsfall. Utilising Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to track the oxidation of lignin by an alkaliphilic laccase. The Analyst. 2024 Apr; 149(8):2399-2411. doi: 10.1039/d4an00124a. [PMID: 38477231]
  • Yunhe Liu, Junzhe Wu, Luying Tan, Zhuoqiao Li, Peng Gao, Shanmei He, Qianyun Wang, Daohao Tang, Cuizhu Wang, Fang Wang, Pingya Li, Jinping Liu. (-)-Syringaresinol attenuates ulcerative colitis by improving intestinal epithelial barrier function and inhibiting inflammatory responses. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155292. doi: 10.1016/j.phymed.2023.155292. [PMID: 38190784]
  • Xian-Mei Piao, Ming-Feng Feng, Wei-Ping Zhao, Zhi-Hang Wu, Wen-Wen Zhang, Hui-Min Hou, Jin-Hui Wang, Li-Bo Wang, Jian Huang, Yan Zhang. Dendrocandin U from Dendrobium officinale Kimura et Migo Inhibits M1 Polarization in Alveolar Macrophage by Suppressing NF-κB Signaling Pathway. Chemistry & biodiversity. 2023 Nov; ?(?):e202300999. doi: 10.1002/cbdv.202300999. [PMID: 37933979]
  • Sijia Zhang, Lei Yang, Dongsheng Hu, Siqi He, Lingzhi Cui, Jiuling Zhao, Yuzhen Zhuo, Lanqiu Zhang, Ximo Wang. Syringaresinol alleviates IgG immune complex induced acute lung injury via activating PPARγ and suppressing pyroptosis. International immunopharmacology. 2023 Nov; 124(Pt B):111071. doi: 10.1016/j.intimp.2023.111071. [PMID: 37857123]
  • Lin Zhang, Jinyan Li, Li Hu, Yawen Wang, Zhanghua Wu, Yuanjun Meng, Zhiyun Liang, Li'e Yang, Gang Wei, Yuechun Huang. Identification of lignans and quality assessment in Dendrobium officinale under different cultivation modes. Rapid communications in mass spectrometry : RCM. 2023 Aug; 37(16):e9541. doi: 10.1002/rcm.9541. [PMID: 37190851]
  • Jianjie Wang, Jianqin Zou, Cheng Zhao, Han Yu, Jiajia Teng, Lei Dong. Syringaresinol inhibits cardiorenal fibrosis through HSP90 in a cardiorenal syndrome type 2. Human & experimental toxicology. 2023 Jan; 42(?):9603271231165678. doi: 10.1177/09603271231165678. [PMID: 36960691]
  • Yuzhen Zhuo, Lei Yang, Dihua Li, Lanqiu Zhang, Qi Zhang, Shukun Zhang, Caixia Li, Lihua Cui, Jian Hao, Jiarui Li, Ximo Wang. Syringaresinol Resisted Sepsis-Induced Acute Lung Injury by Suppressing Pyroptosis Via the Oestrogen Receptor-β Signalling Pathway. Inflammation. 2022 Apr; 45(2):824-837. doi: 10.1007/s10753-021-01587-9. [PMID: 34807349]
  • Lanqiu Zhang, Xiaolin Jiang, Jinlu Zhang, Hejun Gao, Lei Yang, Dihua Li, Qi Zhang, Botao Wang, Lihua Cui, Ximo Wang. (-)-Syringaresinol suppressed LPS-induced microglia activation via downregulation of NF-κB p65 signaling and interaction with ERβ. International immunopharmacology. 2021 Oct; 99(?):107986. doi: 10.1016/j.intimp.2021.107986. [PMID: 34303280]
  • Jin-Qiang Li, Chao-Jiang Xiao, Ye-Meng Li, Xin-Yan Tian, Xiang Dong, Bei Jiang. Astrernestin, a novel aurone-phenylpropanoid adduct from the roots of Astragalus ernestii. Natural product research. 2020 Oct; 34(20):2894-2899. doi: 10.1080/14786419.2019.1596101. [PMID: 30990071]
  • Guangru Li, Lei Yang, Lifeng Feng, Jiu Yang, Yafei Li, Jiale An, Dihua Li, Yang Xu, Yang Gao, Jing Li, Jie Liu, Liang Yang, Zhi Qi. Syringaresinol Protects against Type 1 Diabetic Cardiomyopathy by Alleviating Inflammation Responses, Cardiac Fibrosis, and Oxidative Stress. Molecular nutrition & food research. 2020 09; 64(18):e2000231. doi: 10.1002/mnfr.202000231. [PMID: 32729956]
  • Yifei Ma, Yongrui Bao, Wenjie Zhang, Xixiang Ying, Didier Stien. Four lignans from Portulaca oleracea L. and its antioxidant activities. Natural product research. 2020 Aug; 34(16):2276-2282. doi: 10.1080/14786419.2018.1534852. [PMID: 30580585]
  • Zsuzsanna Hajdú, Peter Forgo, Gergely Király, Gyula Pinke, István Zupkó, Judit Hohmann. Isolation of chemical constituents from Filago vulgaris and antiproliferative activity of the plant extract and its flavonoid against human tumor cell lines. Pakistan journal of pharmaceutical sciences. 2020 Jul; 33(4):1593-1597. doi: . [PMID: 33583792]
  • Navneet Kishore, Pradeep Kumar, Karuna Shanker, Akhilesh Kumar Verma. Human disorders associated with inflammation and the evolving role of natural products to overcome. European journal of medicinal chemistry. 2019 Oct; 179(?):272-309. doi: 10.1016/j.ejmech.2019.06.034. [PMID: 31255927]
  • Young Seon Cho, Woo Seok Song, Sang Ho Yoon, Kyeong-Yeol Park, Myoung-Hwan Kim. Syringaresinol suppresses excitatory synaptic transmission and picrotoxin-induced epileptic activity in the hippocampus through presynaptic mechanisms. Neuropharmacology. 2018 03; 131(?):68-82. doi: 10.1016/j.neuropharm.2017.12.014. [PMID: 29225041]
  • Ying-Ying Song, Ying Liu, Yong-Ming Yan, Xi-Feng Lu, Yong-Xian Cheng. Phenolic Compounds from Belamcanda chinensis Seeds. Molecules (Basel, Switzerland). 2018 Mar; 23(3):. doi: 10.3390/molecules23030580. [PMID: 29510567]
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  • Eun Jin Mo, Jong Hoon Ahn, Yang Hee Jo, Seon Beom Kim, Bang Yeon Hwang, Mi Kyeong Lee. Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum. Molecules (Basel, Switzerland). 2017 Aug; 22(8):. doi: 10.3390/molecules22081349. [PMID: 28805750]
  • Si-Young Cho, Juewon Kim, Ji Hae Lee, Ji Hyun Sim, Dong-Hyun Cho, Il-Hong Bae, Hyunbok Lee, Min A Seol, Hyun Mu Shin, Tae-Joo Kim, Dae-Yong Kim, Su-Hyung Lee, Song Seok Shin, Sin-Hyeog Im, Hang-Rae Kim. Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice. Scientific reports. 2016 12; 6(?):39026. doi: 10.1038/srep39026. [PMID: 27976725]
  • Yan-xi Chang, Bao-quan Bao, Xuan Zhang, J I Rimubatu, Ping Zhang. [Chemical Constituents from A Taditional Mongolian Medicine Clematis aethusifolia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jul; 39(7):1545-9. doi: . [PMID: 30203953]
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  • Qiang Wei, Zhen Qiu, Fei Xu, Qian-rong Li, Hao Yin. [Chemical Components from Leaves of Fatsia japonica and Their Antitumor Activities in vitro]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Apr; 38(4):745-50. doi: . [PMID: 26672339]
  • Hyun Woo Park, Si Young Cho, Hyun Hee Kim, Bong Sik Yun, Jeong Un Kim, Sang Jun Lee, Jiyong Park. Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem. Bioorganic & medicinal chemistry letters. 2015 Jan; 25(2):307-9. doi: 10.1016/j.bmcl.2014.11.045. [PMID: 25479772]
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  • Manh Heun Kim, Jun Hye Jang, Myeong Hwan Oh, Jun Hyeok Heo, Min Won Lee. The comparison of DPPH-scavenging capacity and anti-inflammatory effects of phenolic compounds isolated from the stems of Stewartia koreana Nakai. Natural product research. 2014; 28(17):1409-12. doi: 10.1080/14786419.2014.905560. [PMID: 24749670]
  • Laila Meija, Paivi Söderholm, Adile Samaletdin, Gita Ignace, Inese Siksna, Rafaels Joffe, Aivars Lejnieks, Vilnis Lietuvietis, Indrikis Krams, Herman Adlercreutz. Dietary intake and major sources of plant lignans in Latvian men and women. International journal of food sciences and nutrition. 2013 Aug; 64(5):535-43. doi: 10.3109/09637486.2013.765835. [PMID: 23373826]
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