quetiapine (BioDeep_00000406004)

natural product Volatile Flavor Compounds

代谢物信息卡片

quetiapine

化学式: C21H25N3O2S (383.166739)
中文名称: 喹硫平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1ccc2c(c1)C(=Nc1ccccc1S2)N1CCN(CC1)CCOCCO
InChI: InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2

描述信息

N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AH - Diazepines, oxazepines, thiazepines and oxepines
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

同义名列表

3 个代谢物同义名

quetiapine; ICI204636; Quetiapine

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:8707
KEGG: C07397
KEGGdrug: D08456
PubChem: 5002
DrugBank: DB01224
ChEMBL: CHEMBL716
MeSH: Quetiapine Fumarate
CAS: 111974-69-7
MoNA: CCMSLIB00000081589
MoNA: CCMSLIB00000081590
MoNA: FiehnHILIC002288
MoNA: FiehnHILIC000722
PubChem: 9601
NIKKAJI: J386.371I
RefMet: Quetiapine
medchemexpress: HY-14544
KNApSAcK: 8707

分类词条

Dibenzothiazepines

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review. Medicine. 2024 Mar; 103(11):e37612. doi: 10.1097/md.0000000000037612. [PMID: 38489675]
Bruna Bernar Dias, Fernando Carreño, Victória Etges Helfer, Laura Ben Olivo, Keli Jaqueline Staudt, Karina Paese, Fabiano Barreto, Fabíola Schons Meyer, Ana Paula Herrmann, Sílvia Stanisçuaski Guterres, Stela Maris Kuze Rates, Bibiana Verlindo de Araújo, Iñaki F Trocóniz, Teresa Dalla Costa. Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats. CPT: pharmacometrics & systems pharmacology. 2024 Jan; ?(?):. doi: 10.1002/psp4.13107. [PMID: 38282365]
Meihua Lin, Yu Zhang, Duo Lv, Nana Xu, Xi Yang, Xueling Liu, Caixia Yan, Meijia Wu, Jiejing Kai, Shaohua Hu, Qingwei Zhao. The impact of CYP3A5*3 on oral quetiapine: A population pharmacokinetic model in Chinese bipolar disorder patients. Journal of affective disorders. 2024 Jan; 351(?):309-313. doi: 10.1016/j.jad.2024.01.170. [PMID: 38262522]
Lin Yang, Jinyuan Zhang, Jing Yu, Ze Yu, Xin Hao, Fei Gao, Chunhua Zhou. Predicting plasma concentration of quetiapine in patients with depression using machine learning techniques based on real-world evidence. Expert review of clinical pharmacology. 2023 Jul; 16(8):741-750. doi: 10.1080/17512433.2023.2238604. [PMID: 37466101]
Yupei Hao, Jinyuan Zhang, Chunhua Zhou, Lin Yang, Ze Yu, Xin Hao, Xiaolu Pang, Jing Yu. A Machine Learning Model For Predicting Blood Concentration of Quetiapine in Patients With Schizophrenia and Depression Based on Real-World Data. British journal of clinical pharmacology. 2023 Apr; ?(?):. doi: 10.1111/bcp.15734. [PMID: 37005382]
Mikkel Højlund, Henrik Støvring, Kjeld Andersen, Christoph U Correll, Jesper Hallas. Impact of low-dose quetiapine-use on glycosylated hemoglobin, triglyceride and cholesterol levels. Acta psychiatrica Scandinavica. 2023 01; 147(1):105-116. doi: 10.1111/acps.13515. [PMID: 36281759]
He Xu, Ge Liu, Jixing Gong, Ying Zhang, Shanshan Gu, Zhongjun Wan, Pengcheng Yang, Yage Nie, Yinghan Wang, Zhan-Peng Huang, Guanzheng Luo, Zhongyan Chen, Donghui Zhang, Nan Cao. Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart Tissues. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 10; 9(30):e2203388. doi: 10.1002/advs.202203388. [PMID: 36055796]
Reeha Sharon, Theis Lange, Mia Aakjær, Sarah Brøgger Kristiansen, Morten Baltzer Houlind, Morten Andersen. Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults: a Danish population-based cohort study. European journal of clinical pharmacology. 2022 Aug; 78(8):1341-1349. doi: 10.1007/s00228-022-03339-6. [PMID: 35639132]
Arnim Johannes Gaebler, Michelle Finner-Prével, Sarah Lammertz, Sabrina Schaffrath, Patrick Eisner, Felix Stöhr, Erik Röcher, Lina Winkler, Peter Kaleta, Laura Lenzen, Marc Augustin, Jana Hovancakova, Lara Schwemmer, Eva Stormanns, Fatih Keskin, Frederik Hendricks, Michael Paulzen, Gerhard Gründer, Frank Schneider, Klaus Mathiak. The negative impact of vitamin D on antipsychotic drug exposure may counteract its potential benefits in schizophrenia. British journal of clinical pharmacology. 2022 07; 88(7):3193-3200. doi: 10.1111/bcp.15223. [PMID: 35380747]
Seema Zargar, Tanveer A Wani, Nawaf A Alsaif, Arwa Ishaq A Khayyat. A Comprehensive Investigation of Interactions between Antipsychotic Drug Quetiapine and Human Serum Albumin Using Multi-Spectroscopic, Biochemical, and Molecular Modeling Approaches. Molecules (Basel, Switzerland). 2022 Apr; 27(8):. doi: 10.3390/molecules27082589. [PMID: 35458787]
Jennifer Fontaine, Evelyn Chin, Jean-François Provencher, Anthony Rainone, Dana Wazzan, Carmella Roy, Soham Rej, Marie Lordkipanidze, Vincent Dagenais-Beaulé. Assessing cardiometabolic parameter monitoring in inpatients taking a second-generation antipsychotic: The CAMI-SGA study - a cross-sectional study. BMJ open. 2022 04; 12(4):e055454. doi: 10.1136/bmjopen-2021-055454. [PMID: 35414553]
Maya Kuperberg, Ole Köhler-Forsberg, Alec P Shannon, Nevita George, Sophie Greenebaum, Charles L Bowden, Joseph R Calabrese, Michael Thase, Richard C Shelton, Melvin McInnis, Thilo Deckersbach, Mauricio Tohen, James H Kocsis, Terence A Ketter, Edward S Friedman, Dan V Iosifescu, Michael J Ostacher, Louisa G Sylvia, Susan L McElroy, Andrew A Nierenberg. Cardiometabolic risk markers during mood-stabilizing treatment: Correlation with drug-specific effects, depressive symptoms and treatment response. Journal of affective disorders. 2022 03; 300(?):41-49. doi: 10.1016/j.jad.2021.12.047. [PMID: 34952123]
Cintia R Prokopez, Romina Farinola, Miguel Vallejos, Lorena S Lopredo, Luciano E Sfriso, Luciana C Chiapella, Claudio Arce, Ricardo M Corral, Manuel J Cuesta, Martín Alomo. Olanzapine, risperidone and quetiapine: Do these atypical antipsychotics have a protective effect for SARS-CoV-2?. Schizophrenia research. 2022 03; 241(?):140-141. doi: 10.1016/j.schres.2022.01.035. [PMID: 35123336]
Y Zhang, F Teng, L L Liu, X L Cai, N Zhang, G Q Li. [Acute respiratory distress syndrome caused by quetiapine poisoning: a case report]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2022 Feb; 40(2):145-148. doi: 10.3760/cma.j.cn121094-20210203-00078. [PMID: 35255585]
Tai-Ling Liu, Li-Shan Fang, Jing-Ru Liou, Jia-Shan Dai, Yen-Ling Chen. Determination of quetiapine and its metabolites in plasma by field-enhanced sample stacking. Journal of food and drug analysis. 2021 12; 29(4):709-716. doi: 10.38212/2224-6614.3378. [PMID: 35649137]
Ditte Rudå, Karsten Gjessing Jensen, Marie Stentebjerg Decara, Dea Gowers Klauber, Birgitte Fagerlund, Jens Richardt Møllegaard, Kristian Linnet, Thomas Werge, Christoph U Correll, Anders Fink-Jensen, Gesche Jürgens, Anne Katrine Pagsberg. CYP2D6 Genotyping and Antipsychotic-Associated Extrapyramidal Adverse Effects in a Randomized Trial of Aripiprazole Versus Quetiapine Extended Release in Children and Adolescents, Aged 12-17 Years, With First Episode Psychosis. Journal of clinical psychopharmacology. 2021 Nov; 41(6):667-672. doi: 10.1097/jcp.0000000000001490. [PMID: 34735099]
Jayantee Kalita, Vijay Kumar, Vasudev Parashar, Usha K Misra. Neuropsychiatric Manifestations of Wilson Disease: Correlation with MRI and Glutamate Excitotoxicity. Molecular neurobiology. 2021 Nov; 58(11):6020-6031. doi: 10.1007/s12035-021-02525-4. [PMID: 34435331]
Céline Dubath, Marianna Piras, Mehdi Gholam, Nermine Laaboub, Claire Grosu, Othman Sentissi, Franziska Gamma, Alessandra Solida, Armin von Gunten, Philippe Conus, Chin B Eap. Effect of Quetiapine, from Low to High Dose, on Weight and Metabolic Traits: Results from a Prospective Cohort Study. Pharmacopsychiatry. 2021 Nov; 54(6):279-286. doi: 10.1055/a-1525-2820. [PMID: 34388836]
Mohsen Khosravi. Letter to the editor: Quetiapine safety in ICU delirium management among SARS-CoV-2-infected patients. Journal of psychosomatic research. 2021 10; 149(?):110598. doi: 10.1016/j.jpsychores.2021.110598. [PMID: 34411965]
Beatriz Torroba Sanz, Elena Mendez Martínez, Elena Cacho Asenjo, Irene Aquerreta Gonzalez. Permanent renal sequelae secondary to drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by quetiapine. European journal of hospital pharmacy : science and practice. 2021 09; 28(5):285-288. doi: 10.1136/ejhpharm-2019-002149. [PMID: 34426483]
Yuan-Yuan Zhang, Xie-Hai Zhou, Feng Shan, Jun Liang. Infection is associated with elevated serum concentrations of antipsychotic drugs. International clinical psychopharmacology. 2021 09; 36(5):264-267. doi: 10.1097/yic.0000000000000366. [PMID: 34030168]
Katerina Ragazou, Rallis Lougkovois, Vassiliki Katseli, Christos Kokkinos. Fully Integrated 3D-Printed Electronic Device for the On-Field Determination of Antipsychotic Drug Quetiapine. Sensors (Basel, Switzerland). 2021 Jul; 21(14):. doi: 10.3390/s21144753. [PMID: 34300495]
Luis Fernando Zavala-Jonguitud, Carla Cristina Pérez-García. Delirium triggered by COVID-19 vaccine in an elderly patient. Geriatrics & gerontology international. 2021 Jun; 21(6):540. doi: 10.1111/ggi.14163. [PMID: 33829614]
Kouji Fukuyama, Motohiro Okada. Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43. International journal of molecular sciences. 2021 May; 22(11):. doi: 10.3390/ijms22115623. [PMID: 34070699]
Kazuhito Nomura, Sonoko Sakawaki, Eiji Sakawaki, Ayumu Yamaoka, Wakiko Aisaka, Hiroyuki Okamoto, Yoshihiro Takeyama, Shuji Uemura, Eichi Narimatsu. Successful diagnosis and treatment of pulmonary aspergillosis-related malignant catatonia using propofol and quetiapine: A case report. Medicine. 2021 May; 100(19):e25967. doi: 10.1097/md.0000000000025967. [PMID: 34106671]
Liang Zheng, Shiwei Tang, Rui Tang, Miao Xu, Xuehua Jiang, Ling Wang. Dose Adjustment of Quetiapine and Aripiprazole for Pregnant Women Using Physiologically Based Pharmacokinetic Modeling and Simulation. Clinical pharmacokinetics. 2021 05; 60(5):623-635. doi: 10.1007/s40262-020-00962-3. [PMID: 33251573]
Miki Takahashi, Akihito Deguchi, Hiromu Nishihara, Mea Asou, Tomohiko Asakawa, Makoto Araki. Quetiapine-induced thrombotic microangiopathy in a patient on maintenance dialysis. CEN case reports. 2021 05; 10(2):159-164. doi: 10.1007/s13730-020-00536-z. [PMID: 32981026]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Koji Otsuki, Muneto Izuhara, Shoko Miura, Satoko Yamashita, Michiharu Nagahama, Maiko Hayashida, Sadayuki Hashioka, Tsuyoshi Miyaoka, Yukie Hotta, Yasuhiko Shimizu, Masatoshi Inagaki. Psychosis in a primary hyperparathyroidism patient with mild hypercalcemia: A case report. Medicine. 2021 Mar; 100(12):e25248. doi: 10.1097/md.0000000000025248. [PMID: 33761720]
Shayanth Manche Gowda, S Madhupreetha, Vijay Kumar Kg. Quetiapine for the Management of Tardive Dyskinesia in Schizoaffective Disorder Comorbid With Diabetes Mellitus and Chronic Kidney Disease. The primary care companion for CNS disorders. 2021 Feb; 23(1):. doi: 10.4088/pcc.20l02618. [PMID: 34000133]
Burak Çakır, Şermin Yalın Sapmaz, Hasan Kandemir. Use of Antipsychotics: The Experiences, Views, and Monitoring Practices of Child and Adolescent Psychiatrists in Turkey. Journal of child and adolescent psychopharmacology. 2021 02; 31(1):73-78. doi: 10.1089/cap.2020.0078. [PMID: 32614261]
Shweta Agarwal, S L HariKumar, Poonam Negi, Navneet Upadhyay, Rajeev Garg. Quetiapine Fumarate Loaded Nanostructured Lipid Carrier for Enhancing Oral Bioavailability: Design, Development and Pharmacokinetic Assessment. Current drug delivery. 2021; 18(2):184-198. doi: 10.2174/1567201817999200728135119. [PMID: 32723273]
John Kendrick, Ruth Stow, Neil Ibbotson, Georgina Adjin-Tettey, Beverley Murphy, Glynn Bailey, James Miller, Hans Helleberg, Mette Finderup Grove, Kirstine Øvlisen, Jesper Juhl Hansen. A novel welfare and scientific approach to conducting dog metabolism studies allowing dogs to be pair housed. Laboratory animals. 2020 Dec; 54(6):588-598. doi: 10.1177/0023677220905330. [PMID: 32063096]
Priyadeep Bhutani, Prabhakar K Rajanna, Atish T Paul. Impact of quercetin on pharmacokinetics of quetiapine: insights from in-vivo studies in wistar rats. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Dec; 50(12):1483-1489. doi: 10.1080/00498254.2020.1792002. [PMID: 32623931]
Joseph W Lowdon, Kasper Eersels, Rocio Arreguin-Campos, Manlio Caldara, Benjamin Heidt, Renato Rogosic, Kathia L Jimenez-Monroy, Thomas J Cleij, Hanne Diliën, Bart van Grinsven. A Molecularly Imprinted Polymer-based Dye Displacement Assay for the Rapid Visual Detection of Amphetamine in Urine. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225222. [PMID: 33182534]
Cui-Hong Zhou, Shan-Shan Xue, Fen Xue, Ling Liu, Jun-Chang Liu, Quan-Rui Ma, Jun-Hui Qin, Qing-Rong Tan, Hua-Ning Wang, Zheng-Wu Peng. The impact of quetiapine on the brain lipidome in a cuprizone-induced mouse model of schizophrenia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Nov; 131(?):110707. doi: 10.1016/j.biopha.2020.110707. [PMID: 32905942]
Kirsten E Schoonover, Laura J McMeekin, Charlene B Farmer, Neelu E Varghese, Stacy L Queern, Suzanne E Lapi, Rita M Cowell, Rosalinda C Roberts. Interactions between knockout of schizophrenia risk factor Dysbindin-1 and copper metabolism in mice. Brain research bulletin. 2020 11; 164(?):339-349. doi: 10.1016/j.brainresbull.2020.07.024. [PMID: 32795490]
Fernando Carreño, Victória Etges Helfer, Keli Jaqueline Staudt, Laura Bem Olivo, Fabiano Barreto, Ana Paula Herrmann, Stela Maris Kuze Rates, Teresa Dalla Costa. Quantification of neurotransmitters in microdialysate samples following quetiapine dosing to schizophrenia phenotyped rats using a validated LC-MS/MS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Oct; 1155(?):122282. doi: 10.1016/j.jchromb.2020.122282. [PMID: 32771966]
Javier Vázquez-Bourgon, Miguel Ibáñez Alario, Jacqueline Mayoral-van Son, Marcos Gómez Revuelta, Rosa Ayesa Arriola, María Juncal Ruiz, Víctor Ortiz-García de la Foz, Benedicto Crespo Facorro. A 3-year prospective study on the metabolic effect of aripiprazole, quetiapine and ziprasidone: A pragmatic clinical trial in first episode psychosis patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2020 10; 39(?):46-55. doi: 10.1016/j.euroneuro.2020.08.009. [PMID: 32891516]
Fernando Carreño, Victória Eteges Helfer, Keli Jaqueline Staudt, Laura Bem Olivo, Karina Paese, Fabíola Schons Meyer, Ana Paula Herrmann, Sílvia Stanisçuaski Guterres, Stela Mari Kuze Rates, Iñaki Trocóniz, Teresa Dalla Costa. Semi-Mechanistic Pharmacokinetic Modeling of Lipid Core Nanocapsules: Understanding Quetiapine Plasma and Brain Disposition in a Neurodevelopmental Animal Model of Schizophrenia. The Journal of pharmacology and experimental therapeutics. 2020 10; 375(1):49-58. doi: 10.1124/jpet.120.000109. [PMID: 32719070]
Samir Aruachán, Sergio Morales, Sandra Milena Caicedo. Hyponatraemia Associated with the Use of Quetiapine: Case Report. Revista Colombiana de psiquiatria (English ed.). 2020 Oct; 49(4):297-300. doi: 10.1016/j.rcp.2019.03.002. [PMID: 33328024]
Michelle A Hieger, Nicole E Peters. Lipid Emulsion Therapy for Quetiapine Overdose. American journal of therapeutics. 2020 Sep; 27(5):e518-e519. doi: 10.1097/mjt.0000000000000969. [PMID: 32769389]
Mohamed Adil Shah Khoodoruth, Adeel Ahmad Khan. Anabolic steroids-induced delirium: A case report. Medicine. 2020 Aug; 99(33):e21639. doi: 10.1097/md.0000000000021639. [PMID: 32872027]
Risa Fukushi, Yuki Nomura, Masataka Katashima, Kanji Komatsu, Yuichiro Sato, Akitsugu Takada. Approach to Evaluating QT Prolongation of Quetiapine Fumarate in Late Stage of Clinical Development Using Concentration-QTc Modeling and Simulation in Japanese Patients With Bipolar Disorder. Clinical therapeutics. 2020 08; 42(8):1483-1493.e1. doi: 10.1016/j.clinthera.2020.06.002. [PMID: 32792252]
Sayed M Derayea, Amal B Ahmed, Nada S Abdelwahab, Maha M Abdelrahman, Mahmoud A Omar. Innovative spectrofluorometric protocol based on micro-environment improvement for determination of Quetiapine in dosage forms and rat plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jun; 233(?):118196. doi: 10.1016/j.saa.2020.118196. [PMID: 32160581]
Risa Fukushi, Yuki Nomura, Masataka Katashima, Kanji Komatsu, Yuichiro Sato, Akitsugu Takada. Population Pharmacokinetics Analysis of Quetiapine Extended-release Formulation in Japanese Patients with Bipolar Depression. Clinical therapeutics. 2020 06; 42(6):1067-1076.e2. doi: 10.1016/j.clinthera.2020.04.006. [PMID: 32518042]
Raj K S Badhan, Hannah Macfarlane. Quetiapine dose optimisation during gestation: a pharmacokinetic modelling study. The Journal of pharmacy and pharmacology. 2020 May; 72(5):670-681. doi: 10.1111/jphp.13236. [PMID: 32012278]
Anna Zenno, Ellen Leschek. Quetiapine-Induced Central Hypothyroidism. Journal of the American Academy of Child and Adolescent Psychiatry. 2020 05; 59(5):575-576. doi: 10.1016/j.jaac.2020.01.018. [PMID: 32036034]
Hui Yan, Jiao-Jiao Ji, Ping Xiang, Min Shen. Characteristics of quetiapine and 7-hydroxyquetiapine in hair roots and blood after a single dose of quetiapine. Forensic science international. 2020 Apr; 309(?):110189. doi: 10.1016/j.forsciint.2020.110189. [PMID: 32109844]
Fernando Carreño, Victória Etges Helfer, Keli Jaqueline Staudt, Karina Paese, Fabíola Schons Meyer, Ana Paula Herrmann, Sílvia Stanisçuaski Guterres, Stela Maris Kuze Rates, Teresa Dalla Costa. Quetiapine lipid core nanocapsules restore prepulse inhibition deficits in a neurodevelopmental model of schizophrenia in male and female rats. Schizophrenia research. 2020 04; 218(?):173-179. doi: 10.1016/j.schres.2020.01.007. [PMID: 31973996]
T Bschor, C Baethge, H Grunze, U Lewitzka, H Scherk, E Severus, M Bauer. [German S3 guidelines on bipolar disorders-first update 2019 : What is new in pharmacotherapy?]. Der Nervenarzt. 2020 Mar; 91(3):216-221. doi: 10.1007/s00115-019-00852-5. [PMID: 31932883]
Ali Motaharian, Kobra Naseri, Omid Mehrpour, Shahram Shoeibi. Electrochemical determination of atypical antipsychotic drug quetiapine using nano-molecularly imprinted polymer modified carbon paste electrode. Analytica chimica acta. 2020 Feb; 1097(?):214-221. doi: 10.1016/j.aca.2019.11.020. [PMID: 31910962]
Claudia Vignali, Francesca Freni, Camilla Magnani, Matteo Moretti, Chiara Siodambro, Angelo Groppi, Antonio Marco Maria Osculati, Luca Morini. Distribution of quetiapine and metabolites in biological fluids and tissues. Forensic science international. 2020 Feb; 307(?):110108. doi: 10.1016/j.forsciint.2019.110108. [PMID: 31877542]
Daniel da Mota Castelo Branco, Noely Camila Tavares Cavalcanti Bedor, Carolina Santos Silva, Danilo César Galindo Bedor, Maria Fernanda Pimentel, Davi Pereira de Santana. Quality by design applied to olanzapine and quetiapine LC-MS/MS bioanalysis. Journal of chromatographic science. 2020 Jan; 58(2):117-126. doi: 10.1093/chromsci/bmz083. [PMID: 31950982]
Shweta Agarwal, Rayasa S Ramachandra Murthy, Sasidharan Leelakumari Harikumar, Rajeev Garg. Quality by Design Approach for Development and Characterisation of Solid Lipid Nanoparticles of Quetiapine Fumarate. Current computer-aided drug design. 2020; 16(1):73-91. doi: 10.2174/1573409915666190722122827. [PMID: 31429691]
Maike Scherf-Clavel, Anne Weidner, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Pathological Concentration of C-reactive Protein is Correlated to Increased Concentrations of Quetiapine, But Not of Risperidone, Olanzapine and Aripiprazole in a Naturalistic Setting. Pharmacopsychiatry. 2020 Jan; 53(1):30-35. doi: 10.1055/a-0869-8053. [PMID: 30913567]
Karsten Gjessing Jensen, Christoph U Correll, Ditte Rudå, Dea Gowers Klauber, Marie Stentebjerg Decara, Birgitte Fagerlund, Jens Richardt Møllegaard Jepsen, Frank Eriksson, Anders Fink-Jensen, Anne Katrine Pagsberg. Cardiometabolic Adverse Effects and Its Predictors in Children and Adolescents With First-Episode Psychosis During Treatment With Quetiapine-Extended Release Versus Aripiprazole: 12-Week Results From the Tolerance and Effect of Antipsychotics in Children and Adolescents With Psychosis (TEA) Trial. Journal of the American Academy of Child and Adolescent Psychiatry. 2019 11; 58(11):1062-1078. doi: 10.1016/j.jaac.2019.01.015. [PMID: 30858012]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Dorota Żelaszczyk, Magdalena Jakubczyk, Karolina Pytka, Anna Rapacz, Maria Walczak, Paulina Janiszewska, Katarzyna Pańczyk, Paweł Żmudzki, Karolina Słoczyńska, Henryk Marona, Anna M Waszkielewicz. Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system. Bioorganic & medicinal chemistry letters. 2019 11; 29(21):126679. doi: 10.1016/j.bmcl.2019.126679. [PMID: 31537425]
Zyad J Carr, Lauren Miller, Victor Ruiz-Velasco, Allen R Kunselman, Kunal Karamchandani. In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2019 09; 14(3):383-390. doi: 10.1007/s11481-019-09857-y. [PMID: 31119596]
Sue Lee, Amanda Morris, Sarah Kim, Fanny Li, Laura Baumgartner. Impact of Quetiapine Therapy on QTc Prolongation in Critically Ill Patients. The Annals of pharmacotherapy. 2019 07; 53(7):705-710. doi: 10.1177/1060028019829494. [PMID: 30704263]
Gayatri Seewoogoolam, George Miller, Beryl Tan. Compartment syndrome of the deltoid and pectoralis major in a young man following quetiapine use. ANZ journal of surgery. 2019 07; 89(7-8):E335-E336. doi: 10.1111/ans.14468. [PMID: 29569829]
Erlend Skaga, Ida Ø Skaga, Zanina Grieg, Cecilie J Sandberg, Iver A Langmoen, Einar O Vik-Mo. The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy. Journal of cancer research and clinical oncology. 2019 Jun; 145(6):1495-1507. doi: 10.1007/s00432-019-02920-4. [PMID: 31028540]
Rhome L Hughes. Fatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction. Forensic science, medicine, and pathology. 2019 03; 15(1):110-113. doi: 10.1007/s12024-018-0049-9. [PMID: 30498933]
Maike Scherf-Clavel, Lydia Samanski, Leif G Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2. International clinical psychopharmacology. 2019 03; 34(2):93-100. doi: 10.1097/yic.0000000000000250. [PMID: 30557209]
Helena Gustafsson, Diana Karpman. [A case of quetiapine-induced congenital thrombotic thrombocytopenic purpura, atypical phenotype diagnosed in adulthood]. Lakartidningen. 2019 Feb; 116(?):. doi: NULL. [PMID: 31192374]
Luiz G M Beloti, Luis F C Miranda, Maria Eugênia C Queiroz. Butyl Methacrylate-Co-Ethylene Glycol Dimethacrylate Monolith for Online in-Tube SPME-UHPLC-MS/MS to Determine Chlopromazine, Clozapine, Quetiapine, Olanzapine, and Their Metabolites in Plasma Samples. Molecules (Basel, Switzerland). 2019 Jan; 24(2):. doi: 10.3390/molecules24020310. [PMID: 30654481]
Xiaomei Huang, Suhua Zhang, Yanxia Ma, Heng Yang, Chuan He, Rufang Tian, Han Mei, Lipeng Liu, Bikui Zhang. Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles. Drug design, development and therapy. 2019; 13(?):255-264. doi: 10.2147/dddt.s182965. [PMID: 30643391]
Xiujuan Chen, Chen Liang, Lijun Cui, Jian Le, Zheyuan Qian, Runsheng Zhang, Zhanying Hong, Yifeng Chai. A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study. Journal of food and drug analysis. 2019 01; 27(1):323-331. doi: 10.1016/j.jfda.2018.07.003. [PMID: 30648587]
Hong Shen, Danyang Wu, Shanshan Wang, Mengjie Zhao, Wenbo Sun, Xiaozhou Zhu, Ning Zhang, Hui Yao, Qing Cui, Hong Xiao. Atypical Antipsychotic Administration in Schizophrenic Patients Leads to Elevated Lipoprotein-Associated Phospholipase A2 Levels and Increased Cardiovascular Risk: A Retrospective Cohort Study. Basic & clinical pharmacology & toxicology. 2018 Dec; 123(6):756-765. doi: 10.1111/bcpt.13079. [PMID: 29938908]
Muhammad Akhlaq, Faiza Maryam, Abdelhamid Elaissari, Hashmat Ullah, Muhammad Adeel, Abid Hussain, Muhammad Ramzan, Obaid Ullah, Muhammad Zeeshan Danish, Shehla Iftikhar, Nighat Aziz. Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia. Drug delivery. 2018 Nov; 25(1):916-927. doi: 10.1080/10717544.2018.1458922. [PMID: 29649903]
Gopinadh Bhyrapuneni, Jagadeesh Babu Thentu, Veera Raghava Choudary Palacharla, Nageswararao Muddana, Raghupathi Reddy Aleti, Devender Reddy Ajjala, Ramakrishna Nirogi. A definite measure of occupancy exposures, seeking with non-radiolabeled in vivo 5-HT2A receptor occupancy and in vitro free fractions. Journal of receptor and signal transduction research. 2018 Aug; 38(4):359-366. doi: 10.1080/10799893.2018.1531888. [PMID: 30481094]
Parvaneh Yazdani-Brojeni, Reo Tanoshima, Nobuko Taguchi, Facundo Garcia-Bournissen, Izhar Wallach, Myla E Moretti, Zulfikarali Verjee, Shinya Ito. Quetiapine Excretion Into Human Breast Milk. Journal of clinical psychopharmacology. 2018 Aug; 38(4):362-364. doi: 10.1097/jcp.0000000000000905. [PMID: 29912789]
Bryce Kayhart, Maria I Lapid, Sarah Nelson, Julie L Cunningham, Virginia H Thompson, Jonathan G Leung. A Lack of Systemic Absorption Following the Repeated Application of Topical Quetiapine in Healthy Adults. The American journal of hospice & palliative care. 2018 Aug; 35(8):1076-1080. doi: 10.1177/1049909117753828. [PMID: 29343085]
Michael Paulzen, Georgios Schoretsanitis, Christoph Hiemke, Gerhard Gründer, Ekkehard Haen, Marc Augustin. Reduced clearance of venlafaxine in a combined treatment with quetiapine. Progress in neuro-psychopharmacology & biological psychiatry. 2018 07; 85(?):116-121. doi: 10.1016/j.pnpbp.2018.04.014. [PMID: 29702137]
Haruhi Yamada, Yukiko Katsumori, Miki Kawano, Shumpei Mori, Ryo Takeshige, Jun Mukai, Hiroshi Imada, Hiroyuki Shimoura, Hachidai Takahashi, Tadasu Horai, Yutaka Okita, Ken-Ichi Hirata. Quetiapine-related Acute Kidney Injury Requiring Transient Continuous Hemodiafiltration. Internal medicine (Tokyo, Japan). 2018 Jun; 57(12):1763-1767. doi: 10.2169/internalmedicine.0170-17. [PMID: 29434130]
Constain H Salamanca, Cristhian J Yarce, Roger A Moreno, Vanessa Prieto, Juanita Recalde. Natural gum-type biopolymers as potential modified nonpolar drug release systems. Carbohydrate polymers. 2018 Jun; 189(?):31-38. doi: 10.1016/j.carbpol.2018.02.011. [PMID: 29580414]
Katharina Ebert, Elena Maurice, Richard Lukačin, Christian Fleischhaker, Eberhard Schulz, Dieter Ebert, Hans-Willi Clement. Serum and Saliva Concentrations of Venlafaxine, O-Desmethylvenlafaxine, Quetiapine, and Citalopram in Psychiatric Patients. Therapeutic drug monitoring. 2018 06; 40(3):351-355. doi: 10.1097/ftd.0000000000000508. [PMID: 29746434]
C Rafaniello, M Sessa, F F Bernardi, M Pozzi, S Cheli, D Cattaneo, S Baldelli, M Molteni, R Bernardini, F Rossi, E Clementi, C Bravaccio, S Radice, A Capuano. The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions. The pharmacogenomics journal. 2018 05; 18(3):422-430. doi: 10.1038/tpj.2017.38. [PMID: 28719598]
Islam M Mostafa, Mahmoud A Omar, Dalia M Nagy, Sayed M Derayea. Analysis of quetiapine in human plasma using fluorescence spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 May; 196(?):196-201. doi: 10.1016/j.saa.2018.02.019. [PMID: 29448172]
Wenxin Chen, Monica Cepoiu-Martin, Antonia Stang, Diane Duncan, Chris Symonds, Lara Cooke, Tamara Pringsheim. Antipsychotic Prescribing and Safety Monitoring Practices in Children and Youth: A Population-Based Study in Alberta, Canada. Clinical drug investigation. 2018 May; 38(5):449-455. doi: 10.1007/s40261-018-0626-4. [PMID: 29453686]
S Otte, B Fischer, F Sayk. [Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication]. Medizinische Klinik, Intensivmedizin und Notfallmedizin. 2018 05; 113(4):305-308. doi: 10.1007/s00063-017-0330-9. [PMID: 28785811]
Julia Korell, Bruce Green, Allan Rae, Bart Remmerie, An Vermeulen. Determination of plasma concentration reference ranges for oral aripiprazole, olanzapine, and quetiapine. European journal of clinical pharmacology. 2018 May; 74(5):593-599. doi: 10.1007/s00228-018-2419-3. [PMID: 29392351]
Michael Paulzen, Tamme W Goecke, Maxim Kuzin, Marc Augustin, Gerhard Gründer, Georgios Schoretsanitis. Pregnancy exposure to quetiapine - Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood and obstetrical outcomes. Schizophrenia research. 2018 05; 195(?):252-257. doi: 10.1016/j.schres.2017.09.043. [PMID: 28965779]
Anna Dietrich-Muszalska, Jolanta Kolińska-Łukaszuk. Comparative effects of aripiprazole and selected antipsychotic drugs on lipid peroxidation in plasma. Psychiatry and clinical neurosciences. 2018 May; 72(5):329-336. doi: 10.1111/pcn.12631. [PMID: 29280533]
Pengcheng Xu, Min Zhang, Xueer Wang, Yuan Yan, Yinghua Chen, Wei Wu, Lu Zhang, Lin Zhang. Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage. International journal of molecular sciences. 2018 Mar; 19(4):. doi: 10.3390/ijms19040953. [PMID: 29570608]
Orwa Dandash, Murat Yücel, Rothanthi Daglas, Christos Pantelis, Patrick McGorry, Michael Berk, Alex Fornito. Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania. Translational psychiatry. 2018 03; 8(1):59. doi: 10.1038/s41398-018-0108-8. [PMID: 29507281]
K K Fjukstad, A Engum, S Lydersen, I Dieset, N Eiel Steen, O A Andreassen, O Spigset. Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics. European psychiatry : the journal of the Association of European Psychiatrists. 2018 02; 48(?):71-78. doi: 10.1016/j.eurpsy.2017.04.001. [PMID: 29331603]
Victoria López-Corominas, Nuria Gilabert Iriondo, Isabel Gomila Muñiz, Bernardino Barceló Martín. Double false result in a drug screen after accidental pediatric poisoning. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2018 02; 30(1):64-65. doi: NULL. [PMID: 29437315]
Lakshmi N Yatham, Vesna Sossi, Yu-Shin Ding, Nasim Vafai, Shyam Sundar Arumugham, Taj Dhanoa, Raymond W Lam, David J Bond, Joseph H Puyat. A Positron Emission Tomography Study of Norepinephrine Transporter Occupancy and Its Correlation with Symptom Response in Depressed Patients Treated with Quetiapine XR. The international journal of neuropsychopharmacology. 2018 02; 21(2):108-113. doi: 10.1093/ijnp/pyx066. [PMID: 29016993]
Yahdiana Harahap, Budi Prasaja, Windy Lusthom, Lia Yumi Yusvita, Theresia Sinandang, Hardiyanti. A bioequivalence study of quetiapine 25 mg film-coated tablets in healthy Indonesian subjects . International journal of clinical pharmacology and therapeutics. 2018 Jan; 56(1):38-42. doi: 10.5414/cp202975. [PMID: 29198307]
Mohd Yasir, Praveen Kumar Gaur, Dinesh Puri, Preeti Shehkar, Shanmugam Sadish Kumar. Solid Lipid Nanoparticles Approach for Lymphatic Targeting Through Intraduodenal Delivery of Quetiapine Fumarate. Current drug delivery. 2018; 15(6):818-828. doi: 10.2174/1567201814666170525121049. [PMID: 28545354]
E Baptist, I C de Graaf, M Bannink. [Delirium as a late onset manifestation of quetiapine intoxication]. Tijdschrift voor psychiatrie. 2018 ; 60(8):548-551. doi: NULL. [PMID: 30132584]
Javier Vázquez-Bourgon, Rocío Pérez-Iglesias, Víctor Ortiz-García de la Foz, Paula Suárez Pinilla, Álvaro Díaz Martínez, Benedicto Crespo-Facorro. Long-term metabolic effects of aripiprazole, ziprasidone and quetiapine: a pragmatic clinical trial in drug-naïve patients with a first-episode of non-affective psychosis. Psychopharmacology. 2018 01; 235(1):245-255. doi: 10.1007/s00213-017-4763-x. [PMID: 29075885]
Anne Clark-Raymond, Edwin Meresh, Debra Hoppensteadt, Jawed Fareed, James Sinacore, Brittany Garlenski, Angelos Halaris. Vascular endothelial growth factor: Potential predictor of treatment response in major depression. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2017 12; 18(8):575-585. doi: 10.3109/15622975.2015.1117655. [PMID: 26726958]
Miloslav Kopecek, Petr Potmesil. How long does the pharmacokinetic interaction between carbamazepine and quetiapine last after carbamazepine withdrawal?. Neuro endocrinology letters. 2017 Dec; 38(7):475-478. doi: . [PMID: 29369597]
I Castberg, A A Westin, E Skogvoll, O Spigset. Effects of age and gender on the serum levels of clozapine, olanzapine, risperidone, and quetiapine. Acta psychiatrica Scandinavica. 2017 11; 136(5):455-464. doi: 10.1111/acps.12794. [PMID: 28865402]
Mi Hwa Heo, Jin Young Kim, Ilseon Hwang, Eunyoung Ha, Keon Uk Park. Analgesic effect of quetiapine in a mouse model of cancer-induced bone pain. The Korean journal of internal medicine. 2017 Nov; 32(6):1069-1074. doi: 10.3904/kjim.2015.377. [PMID: 28103434]
Caroline Gjestad, Tore Haslemo, Ole A Andreassen, Espen Molden. 4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. British journal of clinical pharmacology. 2017 Nov; 83(11):2398-2405. doi: 10.1111/bcp.13341. [PMID: 28585378]