glimepiride (BioDeep_00000398877)
Main id: BioDeep_00000001991
natural product
代谢物信息卡片
cis-Glimepiride
化学式: C24H34N4O5S (490.225)
中文名称: 顺式格列美脲, 格列美脲
谱图信息:
最多检出来源 Homo sapiens(general) 2.42%
分子结构信息
SMILES: C1=C(C=CC(=C1)S(NC(N[C@@H]2CC[C@H](CC2)C)=O)(=O)=O)CCNC(N3CC(=C(C3=O)CC)C)=O
InChI: InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
描述信息
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BB - Sulfonylureas
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C97936 - Sulfonylurea Antidiabetic Agent
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D007004 - Hypoglycemic Agents
CONFIDENCE standard compound; INTERNAL_ID 2355
CONFIDENCE standard compound; INTERNAL_ID 8512
同义名列表
3 个代谢物同义名
数据库引用编号
40 个数据库交叉引用编号
- ChEBI: CHEBI:92609
- ChEBI: CHEBI:5383
- KEGG: C07669
- KEGGdrug: D00593
- PubChem: 3476
- DrugBank: DB00222
- ChEMBL: CHEMBL149223
- ChEMBL: CHEMBL1481
- CAS: 684286-46-2
- CAS: 261361-60-8
- CAS: 93479-97-1
- MoNA: AU235560
- MoNA: AU235559
- MoNA: AU235558
- MoNA: AU235557
- MoNA: AU235506
- MoNA: AU235505
- MoNA: AU235504
- MoNA: AU235503
- MoNA: AU235502
- MoNA: AU235501
- MoNA: WA000804
- MoNA: WA000803
- MoNA: WA000802
- MoNA: WA000801
- MoNA: WA000800
- MoNA: WA000799
- MoNA: FiehnHILIC002716
- MoNA: FiehnHILIC001958
- MoNA: FiehnHILIC001208
- MoNA: FiehnHILIC000380
- MoNA: SM851253
- MoNA: SM851202
- MoNA: CCMSLIB00000078108
- MoNA: CCMSLIB00000078107
- PubChem: 9871
- PDB-CCD: GMR
- NIKKAJI: J35.096F
- RefMet: Glimepiride
- KNApSAcK: 5383
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Diski Wahyu Wijianto, Arifah Sri Wahyuni, Rizkiananda Wardani, Ambar Yunita Nugraheni, Fazleen Izzany Abu Bakar. Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells.
Pakistan journal of pharmaceutical sciences.
2024 Mar; 37(2):307-314. doi:
". [PMID: 38767097] - Neda Rasouli, Naji Younes, Alokananda Ghosh, Jeanine Albu, Robert M Cohen, Ralph A DeFronzo, Elsa Diaz, Laure Sayyed Kassem, José A Luchsinger, Janet B McGill, William I Sivitz, William V Tamborlane, Kristina M Utzschneider, Steven E Kahn. Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Diabetes care.
2024 Jan; ?(?):. doi:
10.2337/dc23-1070. [PMID: 38211595] - M Sue Kirkman, Mark Tripputi, Heidi Krause-Steinrauf, Ionut Bebu, Hiba AbouAssi, Henry Burch, Elizabeth Duran-Valdez, Hermes Florez, W Timothy Garvey, Daniel S Hsia, Maamoun Salam, Rodica Pop-Busui. Comparative Effects of Randomized Second-line Therapy for Type 2 Diabetes on a Composite Outcome Incorporating Glycemic Control, Body Weight, and Hypoglycemia: An Analysis of Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Diabetes care.
2024 Jan; ?(?):. doi:
10.2337/dc23-1332. [PMID: 38194519] - Rehab H Werida, Aalaa Ramzy, Youssri Nassief Ebrahim, Maged Wasfy Helmy. Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial.
BMC endocrine disorders.
2023 Nov; 23(1):259. doi:
10.1186/s12902-023-01511-2. [PMID: 38001474] - Deepankar Rath, Biswakanth Kar, Gurudutta Pattnaik, Pallishree Bhukta. Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats.
Current diabetes reviews.
2023 08; ?(?):. doi:
10.2174/1573399820666230817154835. [PMID: 37592777] - Deborah J Wexler, Ian H de Boer, Alokananda Ghosh, Naji Younes, Ionut Bebu, Silvio E Inzucchi, Janet B McGill, Sunder Mudaliar, David Schade, Michael W Steffes, William V Tamborlane, Meng H Tan, Faramarz Ismail-Beigi. Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
JAMA internal medicine.
2023 May; ?(?):. doi:
10.1001/jamainternmed.2023.1487. [PMID: 37213109] - Jelena Stojanovic, Marina Andjelic-Jelic, Miljanka Vuksanovic, Milica Marjanovic-Petkovic, Biljana Jojic, Marko Stojanovic, Teodora Beljic-Zivkovic. The effects of early short-term insulin treatment vs. glimepiride on beta cell function in newly diagnosed type 2 diabetes with HbA1c above 9.
Turkish journal of medical sciences.
2023 Apr; 53(2):552-562. doi:
10.55730/1300-0144.5616. [PMID: 37476884] - Gokul Sudhakaran, Ravi Rajesh, Ajay Guru, B Haridevamuthu, Raghul Murugan, Nattamai Bhuvanesh, Mohammad Ahmad Wadaan, Shalid Mahboob, Annie Juliet, Pushparathinam Gopinath, Jesu Arockiaraj. Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels.
Toxicology and applied pharmacology.
2022 11; 454(?):116229. doi:
10.1016/j.taap.2022.116229. [PMID: 36089001] - Hae Jin Kim, In Kyung Jeong, Kyu Yeon Hur, Soo-Kyung Kim, Jung Hyun Noh, Sung Wan Chun, Eun Seok Kang, Eun-Jung Rhee, Sung Hee Choi. Comparison of Efficacy of Glimepiride, Alogliptin, and Alogliptin-Pioglitazone as the Initial Periods of Therapy in Patients with Poorly Controlled Type 2 Diabetes Mellitus: An Open-Label, Multicenter, Randomized, Controlled Study.
Diabetes & metabolism journal.
2022 09; 46(5):689-700. doi:
10.4093/dmj.2021.0183. [PMID: 35295073] - Narendra Kumar Pandey, Sachin Kumar Singh, Bimlesh Kumar, Monica Gulati, Sukriti Vishwas, Rubiya Khursheed, Harish Dureja, Dinesh Kumar Chellappan, Niraj Kumar Jha, Ankur Sharma, Saurabh Kumar Jha, Piyush Kumar Gupta, Saurabh Gupta, Gaurav Gupta, Parteek Prasher, Kamal Dua. Expanding arsenal against diabetes mellitus through nanoformulations loaded with glimepiride and simvastatin: A comparative study.
Environmental science and pollution research international.
2022 Jul; 29(34):51976-51988. doi:
10.1007/s11356-022-19371-z. [PMID: 35254621] - M Miura, S Tanaka, M Ikeda, J Kawakami, H Watanabe, N Namiki, S Uchida. Increased plasma drug concentration and decreased additional insulin secretion following oral administration of glimepiride in Spontaneously Diabetic Torii rats.
Die Pharmazie.
2022 01; 77(1):6-8. doi:
10.1691/ph.2022.1950. [PMID: 35045918] - Marcel H A Muskiet, Lennart Tonneijck, Mark M Smits, Mark H H Kramer, D Margriet Ouwens, Bolette Hartmann, Jens J Holst, A H Jan Danser, Jaap A Joles, Daniël H van Raalte. Postprandial renal haemodynamic effects of the dipeptidyl peptidase-4 inhibitor linagliptin versus the sulphonylurea glimepiride in adults with type 2 diabetes (RENALIS): A predefined substudy of a randomized, double-blind trial.
Diabetes, obesity & metabolism.
2022 01; 24(1):115-124. doi:
10.1111/dom.14557. [PMID: 34580975] - J Jendle, T Hyötyläinen, M Orešič, T Nyström. Pharmacometabolomic profiles in type 2 diabetic subjects treated with liraglutide or glimepiride.
Cardiovascular diabetology.
2021 12; 20(1):237. doi:
10.1186/s12933-021-01431-2. [PMID: 34920733] - Beere Nagaraju, K V Anilkumar. Pharmacodynamic and pharmacokinetic interaction of losartan with glimepiride-metformin combination in rats and rabbits.
Indian journal of pharmacology.
2021 Nov; 53(6):465-470. doi:
10.4103/ijp.ijp_845_19. [PMID: 34975134] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - H N Chakravarti, A Nag. Efficacy and safety of hydroxychloroquine as add-on therapy in uncontrolled type 2 diabetes patients who were using two oral antidiabetic drugs.
Journal of endocrinological investigation.
2021 Mar; 44(3):481-492. doi:
10.1007/s40618-020-01330-5. [PMID: 32594451] - Michael Ikechukwu Oraebosi, Temidayo Olutoyin Olurishe, Sherifat Bola Anafi, Mohammed Bisalla. Chronopharmacology of the alpha-lipoic acid/nifedipine/glimepiride combination in the amelioration of retinopathy in rats.
Chronobiology international.
2021 03; 38(3):443-450. doi:
10.1080/07420528.2020.1866004. [PMID: 33356611] - Mazhar Hussain, Asim Elahi, Abid Hussain, Javed Iqbal, Lubna Akhtar, Abdul Majid. Sodium-Glucose Cotransporter-2 (SGLT-2) Attenuates Serum Uric Acid (SUA) Level in Patients with Type 2 Diabetes.
Journal of diabetes research.
2021; 2021(?):9973862. doi:
10.1155/2021/9973862. [PMID: 34239940] - Vasile-Ion Iancu, Roxana-Elena Scutariu, Florentina-Laura Chiriac, Gabriel-Lucian Radu. Sensitive detection of antidiabetic compounds and one degradation product in wastewater samples by a new SPE-LC-MS/MS method.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2021; 56(3):310-323. doi:
10.1080/10934529.2021.1873671. [PMID: 33471573] - Rania G Abdel-Latif, Amira F Ahmed, Gehan H Heeba. Low-dose lixisenatide protects against early-onset nephropathy induced in diabetic rats.
Life sciences.
2020 Dec; 263(?):118592. doi:
10.1016/j.lfs.2020.118592. [PMID: 33065146] - Rehab Werida, Mahmoud Kabel, Gamal Omran, Ahmed Shokry, Tarek Mostafa. Comparative clinical study evaluating the effect of adding Vildagliptin versus Glimepiride to ongoing Metformin therapy on diabetic patients with symptomatic coronary artery disease.
Diabetes research and clinical practice.
2020 Dec; 170(?):108473. doi:
10.1016/j.diabres.2020.108473. [PMID: 33002553] - Marcel H A Muskiet, Lennart Tonneijck, Mark M Smits, Mark H H Kramer, D Margriet Ouwens, Bolette Hartmann, Jens J Holst, Daan J Touw, A H Jan Danser, Jaap A Joles, Daniël H van Raalte. Effects of DPP-4 Inhibitor Linagliptin Versus Sulfonylurea Glimepiride as Add-on to Metformin on Renal Physiology in Overweight Patients With Type 2 Diabetes (RENALIS): A Randomized, Double-Blind Trial.
Diabetes care.
2020 11; 43(11):2889-2893. doi:
10.2337/dc20-0902. [PMID: 32900785] - M R Jasmine, Nivedita Nanda, Jayaprakash Sahoo, S Velkumary, G K Pal. Increased osteoprotegerin level is associated with impaired cardiovagal modulation in type-2 diabetic patients treated with oral antidiabetic drugs.
BMC cardiovascular disorders.
2020 10; 20(1):453. doi:
10.1186/s12872-020-01729-1. [PMID: 33081726] - Alexander S Christensen, Sofie Hædersdal, Julie Støy, Heidi Storgaard, Ulla Kampmann, Julie L Forman, Marta Seghieri, Jens J Holst, Torben Hansen, Filip K Knop, Tina Vilsbøll. Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA).
Diabetes care.
2020 09; 43(9):2025-2033. doi:
10.2337/dc20-0408. [PMID: 32661107] - Han-Ju Chien, Syu-Ming Lai, Wei-Chen Wang, Hung-Yu Lin, Yu-Min Juang, Ping-Shan Lai, Chien-Chen Lai. Preparation and comparison of Fe3O4@graphene oxide nanoclusters for analysis of glimepiride in urine by surface-assisted laser desorption/ionization time-of-flight mass spectrometry.
Analytical and bioanalytical chemistry.
2020 Jul; 412(17):4057-4065. doi:
10.1007/s00216-020-02611-x. [PMID: 32248396] - Jinglin Zhu, Yang Li, Yangjiayi Xiang, Ligang Zhou, Yan Li. Magnetic solid phase extraction followed with LC-MS/MS for determination of glimepiride in beagle dog plasma and its application to bioequivalence study.
Journal of pharmaceutical and biomedical analysis.
2020 May; 184(?):113180. doi:
10.1016/j.jpba.2020.113180. [PMID: 32092631] - Waheeda Nasreen, Suchitra Sarker, Md Abu Sufian, F A Dain Md Opo, Mohammad Shahriar, Rumana Akhter, Mohammad A Halim. A possible alternative therapy for type 2 diabetes using Myristica fragrans Houtt in combination with glimepiride: in vivo evaluation and in silico support.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2020 Mar; 75(3-4):103-112. doi:
10.1515/znc-2019-0134. [PMID: 32187019] - Dandan Zhou, Yunting Xu, Yedong Wang, Jiajun Li, Chunshan Gui, Hongjian Zhang. Interaction of Organic Anion Transporter 3-Mediated Uptake of Steviol Acyl Glucuronide, a Major Metabolite of Rebaudioside A, with Selected Drugs.
Journal of agricultural and food chemistry.
2020 Feb; 68(6):1579-1587. doi:
10.1021/acs.jafc.9b05808. [PMID: 31760750] - Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim, In Joo Kim. Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study.
Diabetes & metabolism journal.
2020 02; 44(1):67-77. doi:
10.4093/dmj.2018.0274. [PMID: 31339011] - Hyounggyoon Yoo, Yun Kim, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee. Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects.
Drug design, development and therapy.
2020; 14(?):5179-5187. doi:
10.2147/dddt.s275343. [PMID: 33262578] - Gehang Ju, Keyu Yan, Youwei Xu, Shilin Chen, Zhonghui Zheng, Wen Qiu. Evaluation of Bioequivalency and Pharmacokinetic Parameters for Two Formulations of Glimepiride 1-mg in Chinese Subjects.
Drug design, development and therapy.
2020; 14(?):2637-2644. doi:
10.2147/dddt.s249355. [PMID: 32753845] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Merita Emini-Sadiku, Nikica Car, Luljeta Begolli, Kristina Blaslov, Edmond Haliti, Elton Bahtiri. The differential influence of glimepiride and glibenclamide on insulin resistance and adiponectin levels in patients with type 2 diabetes.
Endocrine journal.
2019 Oct; 66(10):915-921. doi:
10.1507/endocrj.ej18-0493. [PMID: 31292311] - Jin-Woo Park, Kyoung-Ah Kim, Yun Jung Choi, Soo Hyun Yoon, Ji-Young Park. Effect of glimepiride on the pharmacokinetics of teneligliptin in healthy Korean subjects.
Journal of clinical pharmacy and therapeutics.
2019 Oct; 44(5):720-725. doi:
10.1111/jcpt.12848. [PMID: 31094010] - Liudmyla G Savchenko, Nataliia I Digtiar, Liudmyla G Selikhova, Elvira I Kaidasheva, Oksana A Shlykova, Liudmyla E Vesnina, Igor P Kaidashev. Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes.
Romanian journal of internal medicine = Revue roumaine de medecine interne.
2019 Sep; 57(3):233-240. doi:
10.2478/rjim-2019-0003. [PMID: 30901315] - Ismail O Ishola, Onyinyechi E Akataobi, Azeez A Alade, Olufunmilayo O Adeyemi. Glimepiride prevents paraquat-induced Parkinsonism in mice: involvement of oxidative stress and neuroinflammation.
Fundamental & clinical pharmacology.
2019 Jun; 33(3):277-285. doi:
10.1111/fcp.12434. [PMID: 30451327] - Eu Jeong Ku, Dong-Hwa Lee, Hyun Jeong Jeon, Tae Keun Oh. Empagliflozin versus dapagliflozin in patients with type 2 diabetes inadequately controlled with metformin, glimepiride and dipeptidyl peptide 4 inhibitors: A 52-week prospective observational study.
Diabetes research and clinical practice.
2019 May; 151(?):65-73. doi:
10.1016/j.diabres.2019.04.008. [PMID: 30954510] - Giovanni Sartore, Nino Cristiano Chilelli, Roberta Seraglia, Eugenio Ragazzi, Raffaella Marin, Marco Roverso, Chiara Cosma, Olga Vaccaro, Silvia Burlina, Annunziata Lapolla. Long-term effect of pioglitazone vs glimepiride on lipoprotein oxidation in patients with type 2 diabetes: a prospective randomized study.
Acta diabetologica.
2019 May; 56(5):505-513. doi:
10.1007/s00592-018-01278-2. [PMID: 30740640] - Vikas Kumar Dawra, David L Cutler, Susan Zhou, Rajesh Krishna, Haihong Shi, Yali Liang, Christine Alvey, Anne Hickman, Didier Saur, Steven G Terra, Vaishali Sahasrabudhe. Assessment of the Drug Interaction Potential of Ertugliflozin With Sitagliptin, Metformin, Glimepiride, or Simvastatin in Healthy Subjects.
Clinical pharmacology in drug development.
2019 04; 8(3):314-325. doi:
10.1002/cpdd.472. [PMID: 29786959] - Silvina Gallo, Bernard Charbonnel, Allison Goldman, Harry Shi, Susan Huyck, Amanda Darekar, Brett Lauring, Steven G Terra. Long-term efficacy and safety of ertugliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin monotherapy: 104-week VERTIS MET trial.
Diabetes, obesity & metabolism.
2019 04; 21(4):1027-1036. doi:
10.1111/dom.13631. [PMID: 30614616] - Yan Peng, Shu-Hong Chen, Xiao-Nan Liu, Qing-Yun Sun. Efficacy of different antidiabetic drugs based on metformin in the treatment of type 2 diabetes mellitus: A network meta-analysis involving eight eligible randomized-controlled trials.
Journal of cellular physiology.
2019 03; 234(3):2795-2806. doi:
10.1002/jcp.27097. [PMID: 30145806] - Yonghyun Kim, Eun Seok Kang, Hak Chul Jang, Dong Jun Kim, Taekeun Oh, Eun Sook Kim, Nan-Hee Kim, Kyung Mook Choi, Sung-Rae Kim, JiYoung You, Se-Jin Kim, Moon-Kyu Lee. Teneligliptin versus sitagliptin in Korean patients with type 2 diabetes inadequately controlled with metformin and glimepiride: A randomized, double-blind, non-inferiority trial.
Diabetes, obesity & metabolism.
2019 03; 21(3):631-639. doi:
10.1111/dom.13566. [PMID: 30362280] - Anca-Monica Strugaru, Julia Kazakova, Elena Butnaru, Ioana-Cezara Caba, Miguel Ángel Bello-López, Rut Fernández-Torres. Simultaneous determination of metformin and glimepiride in human serum by ultra high performance liquid chromatography quadrupole time of flight mass spectrometry detection.
Journal of pharmaceutical and biomedical analysis.
2019 Feb; 165(?):276-283. doi:
10.1016/j.jpba.2018.12.004. [PMID: 30572192] - Xiaojun Zhou, Rui Zhang, Zhiwei Zou, Xue Shen, Tianyue Xie, Chunmei Xu, Jianjun Dong, Lin Liao. Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat.
British journal of pharmacology.
2019 02; 176(3):478-490. doi:
10.1111/bph.14553. [PMID: 30471094] - Hadier M El-Sheikh, Sahar M El-Haggar, Tamer A Elbedewy. Comparative study to evaluate the effect of l-carnitine plus glimepiride versus glimepiride alone on insulin resistance in type 2 diabetic patients.
Diabetes & metabolic syndrome.
2019 Jan; 13(1):167-173. doi:
10.1016/j.dsx.2018.08.035. [PMID: 30641691] - Juan-Juan Li, Ping Zhang, Bing Fan, Xiu-Li Guo, Zhe-Shu Zheng. The efficacy of saxagliptin in T2DM patients with non-alcoholic fatty liver disease: preliminary data.
Revista da Associacao Medica Brasileira (1992).
2019 Jan; 65(1):33-37. doi:
10.1590/1806-9282.65.1.33. [PMID: 30758417] - André Luiz Machado Viana, Antonio Carlos Doriguetto, Olimpia Maria Martins Santos Viana, André Luís Morais Ruela, Jennifer Tavares Jacon Freitas, Bruno Ewerton Meireles Souto, Magali Benjamim de Araújo, Fernanda Borges de Araújo Paula. Pharmacokinetics and pharmacodynamics of glimepiride polymorphs.
International journal of pharmaceutics.
2018 Dec; 553(1-2):272-280. doi:
10.1016/j.ijpharm.2018.10.050. [PMID: 30359686] - Martin Ridderstråle, Julio Rosenstock, Knut R Andersen, Hans J Woerle, Afshin Salsali. Empagliflozin compared with glimepiride in metformin-treated patients with type 2 diabetes: 208-week data from a masked randomized controlled trial.
Diabetes, obesity & metabolism.
2018 12; 20(12):2768-2777. doi:
10.1111/dom.13457. [PMID: 29961998] - Rui Zhang, Xiaojun Zhou, Xue Shen, Tianyue Xie, Chunmei Xu, Zhiwei Zou, Jianjun Dong, Lin Liao. Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing KATP channel.
Molecular medicine (Cambridge, Mass.).
2018 09; 24(1):47. doi:
10.1186/s10020-018-0042-5. [PMID: 30180807] - Zhimin Huang, Juan Liu, Kaka Ng, Xuesi Wan, Lijuan Xu, Xiaoying He, Zhihong Liao, Yanbing Li. Glimepiride treatment in a patient with type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene.
Journal of diabetes investigation.
2018 Sep; 9(5):1075-1083. doi:
10.1111/jdi.12824. [PMID: 29469970] - N Shao, X-Y Yu, Y-M Yu, B-W Li, J Pan, W-H Wu, H-J Zhang, X-F Ma, M Hao, H-Y Kuang. Short-term combined treatment with exenatide and metformin is superior to glimepiride combined metformin in improvement of serum testosterone levels in type 2 diabetic patients with obesity.
Andrologia.
2018 Sep; 50(7):e13039. doi:
10.1111/and.13039. [PMID: 29740874] - W Timothy Garvey, Luc Van Gaal, Lawrence A Leiter, Ujjwala Vijapurkar, James List, Robert Cuddihy, Jimmy Ren, Michael J Davies. Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes.
Metabolism: clinical and experimental.
2018 08; 85(?):32-37. doi:
10.1016/j.metabol.2018.02.002. [PMID: 29452178] - John F Marcinak, Melvin S Munsaka, Paul B Watkins, Takashi Ohira, Neila Smith. Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience.
Drug safety.
2018 06; 41(6):625-640. doi:
10.1007/s40264-018-0642-6. [PMID: 29492878] - Tarek A Ahmed, Mohammad A A Suhail, Khaled M Hosny, Fathy I Abd-Allah. Clinical pharmacokinetic study for the effect of glimepiride matrix tablets developed by quality by design concept.
Drug development and industrial pharmacy.
2018 Jan; 44(1):66-81. doi:
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Scientific reports.
2017 11; 7(1):16384. doi:
10.1038/s41598-017-16728-0. [PMID: 29180715] - Amira Mohamed Mohsen, Mona Mahmoud AbouSamra, Shaimaa Ahmed ElShebiney. Enhanced oral bioavailability and sustained delivery of glimepiride via niosomal encapsulation: in-vitro characterization and in-vivo evaluation.
Drug development and industrial pharmacy.
2017 Aug; 43(8):1254-1264. doi:
10.1080/03639045.2017.1310224. [PMID: 28330377] - Gyuri Kim, Sewon Oh, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Moon-Kyu Lee. The efficacy and safety of adding either vildagliptin or glimepiride to ongoing metformin therapy in patients with type 2 diabetes mellitus.
Expert opinion on pharmacotherapy.
2017 Aug; 18(12):1179-1186. doi:
10.1080/14656566.2017.1353080. [PMID: 28714741] - Mehul Desai, Yshai Yavin, Dainius Balis, Don Sun, John Xie, William Canovatchel, Norm Rosenthal. Renal safety of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus.
Diabetes, obesity & metabolism.
2017 06; 19(6):897-900. doi:
10.1111/dom.12876. [PMID: 28083972] - Sang Soo Kim, In Joo Kim, Kwang Jae Lee, Jeong Hyun Park, Young Il Kim, Young Sil Lee, Sung Chang Chung, Sang Jin Lee. Efficacy and safety of sitagliptin/metformin fixed-dose combination compared with glimepiride in patients with type 2 diabetes: A multicenter randomized double-blind study.
Journal of diabetes.
2017 Apr; 9(4):412-422. doi:
10.1111/1753-0407.12432. [PMID: 27229178] - Akiko Hattori, Minoru Takemoto, Hirotake Tokuyama, Masaya Koshizaka, Koutaro Yokote. Sitagliptin but not alpha glucosidase inhibitor reduced the serum soluble CD163, a marker for activated macrophage, in individuals with type 2 diabetes mellitus.
Diabetes research and clinical practice.
2017 Apr; 126(?):138-143. doi:
10.1016/j.diabres.2017.02.010. [PMID: 28237860] - Shruti Surendran, David Paul, Ratna Sushmita, Lavanya Krishna, Nirbhay Kumar Tiwari, Sanjeev Giri, Nanjappan Satheeshkumar. A validated LC-MS/MS method for the estimation of glimepiride and pitavastatin in rat plasma: Application to drug interaction studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Mar; 1046(?):218-225. doi:
10.1016/j.jchromb.2017.01.009. [PMID: 28159531] - Kyeong Seon Park, SooHeon Kwak, Young Min Cho, Kyong Soo Park, Hak C Jang, Seong Yeon Kim, Hye Seung Jung. Vildagliptin reduces plasma stromal cell-derived factor-1α in patients with type 2 diabetes compared with glimepiride.
Journal of diabetes investigation.
2017 Mar; 8(2):218-226. doi:
10.1111/jdi.12572. [PMID: 27575011] - A P Dewani, A S Tripathi, P G Shelke, R L Bakal, D S Mohale, A V Chandewar. Development of Solid-Phase Extraction and HPLC Method for Simultaneous Estimation of Ilaprazole and Glimepiride in Rat Plasma: Application to Pharmacokinetic Studies.
Journal of chromatographic science.
2017 03; 55(3):327-333. doi:
10.1093/chromsci/bmw189. [PMID: 28069690] - Choon Ok Kim, Eun Sil Oh, Hohyun Kim, Min Soo Park. Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?.
Drug design, development and therapy.
2017; 11(?):503-512. doi:
10.2147/dddt.s129586. [PMID: 28260863] - Rabia Farooq, Shajrul Amin, M Hayat Bhat, Rawoof Malik, Hilal Ahmad Wani, Sabhiya Majid. Type 2 diabetes and metabolic syndrome - adipokine levels and effect of drugs.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2017 Jan; 33(1):75-78. doi:
10.1080/09513590.2016.1207165. [PMID: 27705028] - Shira Perl, William Cook, Cheryl Wei, Peter Ohman, Boaz Hirshberg. Effects of Glimepiride versus Saxagliptin on β-Cell Function and Hypoglycemia: A Post Hoc Analysis in Older Patients with Type 2 Diabetes Inadequately Controlled with Metformin.
Clinical therapeutics.
2016 Dec; 38(12):2578-2588. doi:
10.1016/j.clinthera.2016.10.006. [PMID: 27823868] - Tayyaba Sana, Bilal Aslam, Nosheen Aslam, Muhammad Mudassar Ashraf, Asma Ashraf, Tahir Aqeel Malik, Sammia Gul Niazi, Imtiaz Mahmood Tahir, Muhammad RiazurRehman, Hamad Ahmed. Therapeutic effect of atorvastatin on kidney functions and urinary excretion of Glimepiride in healthy adult human male subjects.
Pakistan journal of pharmaceutical sciences.
2016 Nov; 29(6 Suppl):2321-2326. doi:
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Molecules (Basel, Switzerland).
2016 Oct; 21(11):. doi:
10.3390/molecules21111446. [PMID: 27809246] - Bianca Hemmingsen, David Peick Sonne, Maria-Inti Metzendorf, Bernd Richter. Insulin secretagogues for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.
The Cochrane database of systematic reviews.
2016 Oct; 10(?):CD012151. doi:
10.1002/14651858.cd012151.pub2. [PMID: 27749986] - Mengchun Chen, Wenjie Song, Shuanghu Wang, Qiulei Chen, Peipei Pan, Tao Xu, Guoxin Hu, Zhiqiang Zheng. Simultaneous Determination of Bosentan, Glimepiride, HYBOS and M1 in Rat Plasma by UPLC-MS-MS and its Application to Pharmacokinetic Study.
Journal of chromatographic science.
2016 Aug; 54(7):1159-65. doi:
10.1093/chromsci/bmw003. [PMID: 27240565] - Zubair Ali, Muhammad Daniyal, Ismailov S I, Khan Usmanghani, Safila Naveed. Evaluation, efficacy and tolerability of GlucoNovax tablet in type 2 diabetic patients.
Pakistan journal of pharmaceutical sciences.
2016 Jul; 29(4 Suppl):1443-9. doi:
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Diabetes, obesity & metabolism.
2016 May; 18(5):475-82. doi:
10.1111/dom.12634. [PMID: 26799540] - Atsushi Tanaka, Teruo Inoue, Masafumi Kitakaze, Jun-Ichi Oyama, Masataka Sata, Isao Taguchi, Wataru Shimizu, Hirotaka Watada, Hirofumi Tomiyama, Junya Ako, Yasushi Sakata, Toshihisa Anzai, Masaaki Uematsu, Makoto Suzuki, Kazuo Eguchi, Akira Yamashina, Yoshihiko Saito, Yasunori Sato, Shinichiro Ueda, Toyoaki Murohara, Koichi Node. Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial.
Cardiovascular diabetology.
2016 Apr; 15(?):57. doi:
10.1186/s12933-016-0381-x. [PMID: 27044332] - Ryo Ito, Yoshiyuki Tsujihata, Masami Suzuki, Kazumasa Miyawaki, Kae Matsuda, Koji Takeuchi. Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas.
The Journal of pharmacology and experimental therapeutics.
2016 Apr; 357(1):217-27. doi:
10.1124/jpet.115.230730. [PMID: 26813930] - Tarek A Ahmed, Khalid M El-Say, Bader M Aljaeid, Usama A Fahmy, Fathy I Abd-Allah. Transdermal glimepiride delivery system based on optimized ethosomal nano-vesicles: Preparation, characterization, in vitro, ex vivo and clinical evaluation.
International journal of pharmaceutics.
2016 Mar; 500(1-2):245-54. doi:
10.1016/j.ijpharm.2016.01.017. [PMID: 26775063] - Bhagyashree Kamble, Ankur Gupta, Ismail Moothedath, Laxman Khatal, Shirish Janrao, Amol Jadhav, B Duraiswamy. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats.
Chemico-biological interactions.
2016 Feb; 245(?):30-8. doi:
10.1016/j.cbi.2015.12.008. [PMID: 26721197] - Robert Krysiak, Wojciech Gilowski, Bogusław Okopień. The effect of testosterone on cardiovascular risk factors in men with type 2 diabetes and late-onset hypogonadism treated with metformin or glimepiride.
Pharmacological reports : PR.
2016 Feb; 68(1):75-9. doi:
10.1016/j.pharep.2015.06.003. [PMID: 26721356] - S Tani, K Nagao, A Hirayama. Differences between Mitiglinide/Voglibose Fixed-dose Combination and Glimepiride in Modifying Low-density Lipoprotein Heterogeneity in Japanese Type-2 Diabetic Patients: A Pilot Study.
Drug research.
2016 Feb; 66(2):94-9. doi:
10.1055/s-0035-1549993. [PMID: 26011816] - N Kasahara, H Fukase, Y Ohba, T Saito, K Miyata, S Iida, Y Takano, S Ikeda, M Harigai, K Terao. A Pharmacokinetic/Pharmacodynamic Drug-Drug Interaction Study of Tofogliflozin (a New SGLT2 Inhibitor) and Selected Anti-Type 2 Diabetes Mellitus Drugs.
Drug research.
2016 Feb; 66(2):74-81. doi:
10.1055/s-0035-1549967. [PMID: 26158794] - Haiying Li, Tingting Pan, Ying Cui, Xiaxia Li, Jiefang Gao, Wenzhi Yang, Shigang Shen. Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique.
International journal of nanomedicine.
2016; 11(?):3777-88. doi:
10.2147/ijn.s105419. [PMID: 27540291] - Hiroshi Nomoto, Hideaki Miyoshi, Tomoo Furumoto, Koji Oba, Hiroyuki Tsutsui, Atsushi Inoue, Tatsuya Atsumi, Naoki Manda, Yoshio Kurihara, Shin Aoki. A Randomized Controlled Trial Comparing the Effects of Sitagliptin and Glimepiride on Endothelial Function and Metabolic Parameters: Sapporo Athero-Incretin Study 1 (SAIS1).
PloS one.
2016; 11(10):e0164255. doi:
10.1371/journal.pone.0164255. [PMID: 27711199] - Alok Shiomurti Tripathi, Papiya Mitra Mazumder, Anil Vilasrao Chandewar. Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in STZ-induced diabetic rats.
Journal of basic and clinical physiology and pharmacology.
2016 Jan; 27(1):57-62. doi:
10.1515/jbcpp-2015-0035. [PMID: 26295204] - Nobuhiro Tahara, Sho-Ichi Yamagishi, Munehisa Bekki, Norihiro Kodama, Tomohisa Nakamura, Yoichi Sugiyama, Tamami Oshige, Yuki Kumashiro, Akihiro Honda, Atsuko Tahara, Sachiyo Igata, Yoshihiro Fukumoto. Anagliptin, A Dipeptidyl Peptidase-4 Inhibitor Ameliorates Arterial Stiffness in Association with Reduction of Remnant-Like Particle Cholesterol and Alanine Transaminase Levels in Type 2 Diabetic Patients.
Current vascular pharmacology.
2016; 14(6):552-562. doi:
10.2174/1570161114666160625090212. [PMID: 27357182] - Francesco Giorgino, Marian Benroubi, Jui-Hung Sun, Alan G Zimmermann, Valeria Pechtner. Efficacy and Safety of Once-Weekly Dulaglutide Versus Insulin Glargine in Patients With Type 2 Diabetes on Metformin and Glimepiride (AWARD-2).
Diabetes care.
2015 Dec; 38(12):2241-9. doi:
10.2337/dc14-1625. [PMID: 26089386] - Li Li, Xing Zhang, Lei Wang, Zhenhai Chai, Xiuping Shen, Zongpeng Zhang, Changxiao Liu. A toxicology study to evaluate the embryotoxicity of metformin compared with the hypoglycemic drugs, the anticancer drug, the anti-epileptic drug, the antibiotic, and the cyclo-oxygenase (COX)-2 inhibitor.
Journal of diabetes.
2015 Nov; 7(6):839-49. doi:
10.1111/1753-0407.12251. [PMID: 25492223] - Alok Shiomurti Tripathi, Ajay Kumar Timiri, Papiya Mitra Mazumder, Anil Chandewar. Does glimepiride alter the pharmacokinetics of sildenafil citrate in diabetic nephropathy animals: investigating mechanism of interaction by molecular modeling studies.
Journal of molecular modeling.
2015 Oct; 21(10):276. doi:
10.1007/s00894-015-2823-x. [PMID: 26428531] - Rafael Simó, Bruno Guerci, Guntram Schernthaner, Baptist Gallwitz, Juan Rosas-Guzmàn, Francesco Dotta, Andreas Festa, Ming Zhou, Jacek Kiljański. Long-term changes in cardiovascular risk markers during administration of exenatide twice daily or glimepiride: results from the European exenatide study.
Cardiovascular diabetology.
2015 Sep; 14(?):116. doi:
10.1186/s12933-015-0279-z. [PMID: 26338040] - Memy Hegazy Hassan, Gamil Mohamed Abd-Allah. Effects of metformin plus gliclazide versus metformin plus glimepiride on cardiovascular risk factors in patients with type 2 diabetes mellitus.
Pakistan journal of pharmaceutical sciences.
2015 Sep; 28(5):1723-30. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2015 Sep; 83(?):146-50. doi:
10.1016/j.fct.2015.06.013. [PMID: 26115598] - Ryan Matsuda, Zhao Li, Xiwei Zheng, David S Hage. Analysis of multi-site drug-protein interactions by high-performance affinity chromatography: Binding by glimepiride to normal or glycated human serum albumin.
Journal of chromatography. A.
2015 Aug; 1408(?):133-44. doi:
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Diabetes, obesity & metabolism.
2015 Aug; 17(8):751-9. doi:
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Diabetologia.
2015 Aug; 58(8):1845-54. doi:
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Diabetes, obesity & metabolism.
2015 Jul; 17(7):630-8. doi:
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Diabetes research and clinical practice.
2015 Jul; 109(1):199-205. doi:
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Diabetes technology & therapeutics.
2015 Jul; 17(7):468-74. doi:
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Drugs & aging.
2015 Jun; 32(6):469-76. doi:
10.1007/s40266-015-0271-z. [PMID: 26041585] - Y-H Lee, C J Lee, H S Lee, E Y Choe, B-W Lee, C W Ahn, B-S Cha, H C Lee, B Balkau, E S Kang. Comparing kidney outcomes in type 2 diabetes treated with different sulphonylureas in real-life clinical practice.
Diabetes & metabolism.
2015 Jun; 41(3):208-15. doi:
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International journal of clinical practice.
2015 Mar; 69(3):292-304. doi:
10.1111/ijcp.12605. [PMID: 25683794] - Lawrence A Leiter, Kun-Ho Yoon, Pablo Arias, Gisle Langslet, John Xie, Dainius A Balis, Dawn Millington, Frank Vercruysse, William Canovatchel, Gary Meininger. Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study.
Diabetes care.
2015 Mar; 38(3):355-64. doi:
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