flumazenil (BioDeep_00000398874)
Main id: BioDeep_00000001977
natural product
代谢物信息卡片
flumazenil
化学式: C15H14FN3O3 (303.1019)
中文名称: 氟吗西尼, 氟马西尼
谱图信息:
最多检出来源 Viridiplantae(blood) 8.33%
分子结构信息
SMILES: C1=C(C=C2C(=C1)N3C(CN(C2=O)C)=C(N=C3)C(=O)OCC)F
InChI: InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
描述信息
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D020011 - Protective Agents > D000931 - Antidotes
Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
同义名列表
4 个代谢物同义名
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:5103
- KEGG: C07825
- KEGGdrug: D00697
- PubChem: 3373
- DrugBank: DB01205
- ChEMBL: CHEMBL407
- MeSH: Flumazenil
- CAS: 78755-81-4
- MoNA: WA000548
- MoNA: WA000547
- MoNA: WA000546
- MoNA: WA000545
- MoNA: WA000544
- MoNA: WA000543
- MoNA: FiehnHILIC001940
- MoNA: FiehnHILIC000358
- MoNA: CCMSLIB00000078102
- PubChem: 10027
- PDB-CCD: FYP
- NIKKAJI: J23.594F
- RefMet: Flumazenil
- medchemexpress: HY-B0009
- KNApSAcK: 5103
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- E Tahmasebi, H Monsef-Esfahani, M Vazirian, P Sharafi-Badr, M Sharifzadeh, S N Sadati Lamardi. Anticonvulsant effects of Paeonia daurica subsp. macrophylla root extracts in pentylenetetrazol-induced seizure models in mice.
Neurologia.
2024 May; 39(4):329-339. doi:
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Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083457. [PMID: 37110691] - Shana Wuken, Junjun Li, Xiaoli Gao, Shungang Jiao, Xiaojing Ma, Suyile Chen, Pengfei Tu, Luqi Huang, Xingyun Chai. Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system.
Journal of ethnopharmacology.
2023 Jan; 301(?):115813. doi:
10.1016/j.jep.2022.115813. [PMID: 36220513] - Zahra Rahimian, SeyedHassan Sadrian, Mina Shahisavandi, Hadi Aligholi, Mohammad M Zarshenas, Alireza Abyar, Zahra Zeraatpisheh, Ali A Asadi-Pooya. Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia.
BioMed research international.
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Neurochemical research.
2022 Dec; 47(12):3792-3804. doi:
10.1007/s11064-022-03759-x. [PMID: 36287300] - Taiwo G Olubodun-Obadun, Ismail O Ishola, Benneth Ben-Azu, Olasunmbo Afolayan, Ekene Nwose, Ayorinde B James, Abayomi M Ajayi, Solomon Umukoro, Olufunmilayo O Adeyemi. Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Journal of food biochemistry.
2022 10; 46(10):e14342. doi:
10.1111/jfbc.14342. [PMID: 35851712] - Maria Goretti de Vasconcelos Silva, Daniele Rodrigues de Lima, Jackelyne Alves Monteiro, Francisco Ernani Alves Magalhães. Anxiolytic-like effect of chrysophanol from Senna cana stem in adult zebrafish (Danio rerio).
Natural product research.
2022 Sep; 36(17):4426-4430. doi:
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European journal of nuclear medicine and molecular imaging.
2022 03; 49(4):1232-1241. doi:
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Journal of ethnopharmacology.
2022 Jan; 282(?):114630. doi:
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Human & experimental toxicology.
2022 Jan; 41(?):9603271211062857. doi:
10.1177/09603271211062857. [PMID: 35018838] - Hope Douglas, Klaus Hopster, Michelle Cerullo, Charlotte Hopster-Iversen, Darko Stefanovski, Bernd Driessen. The effects of flumazenil on ventilatory and recovery characteristics in horses following midazolam-ketamine induction and isoflurane anaesthesia.
Equine veterinary journal.
2021 Nov; 53(6):1257-1267. doi:
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Journal of psychopharmacology (Oxford, England).
2021 Oct; 35(10):1277-1284. doi:
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Journal of ethnopharmacology.
2021 Jul; 275(?):114142. doi:
10.1016/j.jep.2021.114142. [PMID: 33910044] - Frédérik Rousseau-Blass, Alastair E Cribb, Francis Beaudry, Daniel Sj Pang. A Pharmacokinetic-Pharmacodynamic Study of Intravenous Midazolam and Flumazenil in Adult New Zealand White-Californian Rabbits (Oryctolagus cuniculus).
Journal of the American Association for Laboratory Animal Science : JAALAS.
2021 05; 60(3):319-328. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Valeria Itzel Reyes-Pérez, Vinicio Granados-Soto, Manuel Rangel-Grimaldo, Myrna Déciga-Campos, Rachel Mata. Pharmacological Analysis of the Anti-inflammatory and Antiallodynic Effects of Zinagrandinolide E from Zinnia grandiflora in Mice.
Journal of natural products.
2021 03; 84(3):713-723. doi:
10.1021/acs.jnatprod.0c00793. [PMID: 32870011] - Godfried Dougnon, Michiho Ito. Role of Ascaridole and p-Cymene in the Sleep-Promoting Effects of Dysphania ambrosioides Essential Oil via the GABAergic System in a ddY Mouse Inhalation Model.
Journal of natural products.
2021 01; 84(1):91-100. doi:
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Neural plasticity.
2021; 2021(?):5566890. doi:
10.1155/2021/5566890. [PMID: 34257639] - Nikolaos Pitsikas, Petros A Tarantilis. The GABAA-Benzodiazepine Receptor Antagonist Flumazenil Abolishes the Anxiolytic Effects of the Active Constituents of Crocus sativus L. Crocins in Rats.
Molecules (Basel, Switzerland).
2020 Nov; 25(23):. doi:
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NeuroImage.
2020 11; 221(?):117160. doi:
10.1016/j.neuroimage.2020.117160. [PMID: 32679251] - Nan Zhang, Mu Luo, Lei He, Lei Yao. Chemical Composition of Essential Oil from Flower of 'Shanzhizi' (Gardenia jasminoides Ellis) and Involvement of Serotonergic System in Its Anxiolytic Effect.
Molecules (Basel, Switzerland).
2020 Oct; 25(20):. doi:
10.3390/molecules25204702. [PMID: 33066512] - Touran Mahmoudi, Zahra Lorigooini, Mahmoud Rafieian-Kopaei, Mehran Arabi, Zahra Rabiei, Elham Bijad, Sedigheh Kazemi. Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat.
Behavioral and brain functions : BBF.
2020 Oct; 16(1):7. doi:
10.1186/s12993-020-00169-3. [PMID: 33023622] - Ana Carolina Mendes Hacke, Edmar Miyoshi, Jacqueline Aparecida Marques, Romaiana Picada Pereira. Anxiolytic properties of Cymbopogon citratus (DC.) stapf extract, essential oil and its constituents in zebrafish (Danio rerio).
Journal of ethnopharmacology.
2020 Oct; 260(?):113036. doi:
10.1016/j.jep.2020.113036. [PMID: 32473367] - Fereshteh Farajdokht, Armin Vosoughi, Mojtaba Ziaee, Mostafa Araj-Khodaei, Javad Mahmoudi, Saeed Sadigh-Eteghad. The role of hippocampal GABAA receptors on anxiolytic effects of Echium amoenum extract in a mice model of restraint stress.
Molecular biology reports.
2020 Sep; 47(9):6487-6496. doi:
10.1007/s11033-020-05699-7. [PMID: 32778988] - Ali Y Benkherouf, Nora Logrén, Tamara Somborac, Maaria Kortesniemi, Sanna L Soini, Baoru Yang, Outi M H Salo-Ahen, Oskar Laaksonen, Mikko Uusi-Oukari. Hops compounds modulatory effects and 6-prenylnaringenin dual mode of action on GABAA receptors.
European journal of pharmacology.
2020 Apr; 873(?):172962. doi:
10.1016/j.ejphar.2020.172962. [PMID: 32001220] - Xia Chen, Nuoer Sang, Kaicheng Song, Wen Zhong, Hongyun Wang, Ji Jiang, Yuguang Huang, Pei Hu. Psychomotor Recovery Following Remimazolam-induced Sedation and the Effectiveness of Flumazenil as an Antidote.
Clinical therapeutics.
2020 04; 42(4):614-624. doi:
10.1016/j.clinthera.2020.02.006. [PMID: 32178858] - Clara Alba-Betancourt, Amanda Sánchez-Recillas, Angel J Alonso-Castro, David Esquivel-Juárez, Juan R Zapata-Morales, Víctor Yáñez-Pérez, Daniel Álvarez-Camacho, Yessica E Medina-Rivera, Marco M González-Chávez, Deisy Gasca-Martínez, Rolffy Ortiz-Andrade. Antidiarrheal, vasorelaxant, and neuropharmacological actions of the diterpene tilifodiolide.
Drug development research.
2019 11; 80(7):981-991. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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Nutrients.
2019 Aug; 11(8):. doi:
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Clinical toxicology (Philadelphia, Pa.).
2019 03; 57(3):203-212. doi:
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Metabolic brain disease.
2018 10; 33(5):1533-1549. doi:
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Nuclear medicine communications.
2018 Sep; 39(9):825-833. doi:
10.1097/mnm.0000000000000875. [PMID: 29877992] - Zul Merali, Christian Cayer, Pamela Kent, Rui Liu, Victor Cal, Cory S Harris, John T Arnason. Sacred Maya incense, copal (Protium copal - Burseraceae), has antianxiety effects in animal models.
Journal of ethnopharmacology.
2018 Apr; 216(?):63-70. doi:
10.1016/j.jep.2018.01.027. [PMID: 29414121] - Samuel Daanaa, Wonder Kofi Mensah Abotsi, Eric Boakye-Gyasi, Eric Woode. Anticonvulsant effect of the hydroethanolic leaf extract of Psydrax subcordata (DC.) Bridson in murine models.
Journal of ethnopharmacology.
2018 Mar; 213(?):384-394. doi:
10.1016/j.jep.2017.11.028. [PMID: 29183747] - Gisele Claudine Nkamguie Nkantchoua, Jacqueline Stephanie Kameni Njapdounke, Jean Jules Fifen, Germain Sotoing Taiwe, Lucie Josiane Ojong, Antoine Kavaye Kandeda, Elisabeth Ngo Bum. Anticonvulsant effects of Senna spectabilis on seizures induced by chemicals and maximal electroshock.
Journal of ethnopharmacology.
2018 Feb; 212(?):18-28. doi:
10.1016/j.jep.2017.09.042. [PMID: 28986332] - Isadora Lopes Alves, David Vállez García, Andrea Parente, Janine Doorduin, Ana Maria Marques da Silva, Michel Koole, Rudi Dierckx, Antoon Willemsen, Ronald Boellaard. Parametric Imaging of [11C]Flumazenil Binding in the Rat Brain.
Molecular imaging and biology.
2018 02; 20(1):114-123. doi:
10.1007/s11307-017-1098-2. [PMID: 28631142] - H M Jang, S-E Jang, M J Han, D-H Kim. Anxiolytic-like effect of Bifidobacterium adolescentis IM38 in mice with or without immobilisation stress.
Beneficial microbes.
2018 Jan; 9(1):123-132. doi:
10.3920/bm2016.0226. [PMID: 28969445] - Quelen Iane Garlet, Luana da Costa Pires, Laura Hautrive Milanesi, Joseane Righes Marafiga, Bernardo Baldisserotto, Carlos Fernando Mello, Berta Maria Heinzmann. (+)-Dehydrofukinone modulates membrane potential and delays seizure onset by GABAa receptor-mediated mechanism in mice.
Toxicology and applied pharmacology.
2017 10; 332(?):52-63. doi:
10.1016/j.taap.2017.07.010. [PMID: 28733205] - Barbara Costa, Chiara Cavallini, Eleonora Da Pozzo, Sabrina Taliani, Federico Da Settimo, Claudia Martini. The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity.
ACS chemical neuroscience.
2017 07; 8(7):1448-1454. doi:
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Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2017 May; 27(3):369-372. doi:
10.1111/vec.12602. [PMID: 28427112] - Aurelija Jucaite, Zsolt Cselényi, Jaakko Lappalainen, Dennis J McCarthy, Chi-Ming Lee, Svante Nyberg, Katarina Varnäs, Per Stenkrona, Christer Halldin, Alan Cross, Lars Farde. GABAA receptor occupancy by subtype selective GABAAα2,3 modulators: PET studies in humans.
Psychopharmacology.
2017 Feb; 234(4):707-716. doi:
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Molecular pharmacology.
2016 Nov; 90(5):530-539. doi:
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Journal of evidence-based complementary & alternative medicine.
2016 Oct; 21(4):NP31-5. doi:
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Anesthesiology.
2016 07; 125(1):147-58. doi:
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Vojnosanitetski pregled.
2016 Feb; 73(2):146-51. doi:
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PloS one.
2016; 11(6):e0157700. doi:
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Clinical toxicology (Philadelphia, Pa.).
2016; 54(1):66-8. doi:
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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2016 Jan; 49(1):e4872. doi:
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The American journal of psychiatry.
2015 Nov; 172(11):1148-59. doi:
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Journal of ethnopharmacology.
2015 Aug; 172(?):288-96. doi:
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Journal of feline medicine and surgery.
2015 Aug; 17(8):711-8. doi:
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The Journal of pharmacology and experimental therapeutics.
2015 Jun; 353(3):517-28. doi:
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Drug research.
2015 Apr; 65(4):205-13. doi:
10.1055/s-0034-1376963. [PMID: 24886981] - Tomás Eduardo Ceremuga, Debra Valdivieso, Catherine Kenner, Amy Lucia, Keith Lathrop, Owen Stailey, Heather Bailey, Jonathan Criss, Jessica Linton, Jordan Fried, Andrew Taylor, Gina Padron, Arthur Don Johnson. Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat.
AANA journal.
2015 Apr; 83(2):91-8. doi:
". [PMID: 26016167] - Hiroaki Takemoto, Michiho Ito, Yoshihisa Asada, Yoshinori Kobayashi. Inhalation administration of the sesquiterpenoid aristolen-1(10)-en-9-ol from Nardostachys chinensis has a sedative effect via the GABAergic system.
Planta medica.
2015 Mar; 81(5):343-7. doi:
10.1055/s-0035-1545725. [PMID: 25798643] - Floris H P van Velden, Syahir M Mansor, Daniëlle M E van Assema, Bart N M van Berckel, Femke E Froklage, Shaonan Wang, Robert C Schuit, Marie-Claude Asselin, Adriaan A Lammertsma, Ronald Boellaard, Marc C Huisman. Comparison of HRRT and HR+ scanners for quantitative (R)-[11C]verapamil, [11C]raclopride and [11C]flumazenil brain studies.
Molecular imaging and biology.
2015 Feb; 17(1):129-39. doi:
10.1007/s11307-014-0766-8. [PMID: 25028091] - Clarissa G Heldwein, Lenise de L Silva, Eduarda Z Gai, Cassiela Roman, Thaylise V Parodi, Marilise E Bürger, Bernardo Baldisserotto, Érico M de M Flores, Berta M Heinzmann. S-(+)-Linalool from Lippia alba: sedative and anesthetic for silver catfish (Rhamdia quelen).
Veterinary anaesthesia and analgesia.
2014 Nov; 41(6):621-9. doi:
10.1111/vaa.12146. [PMID: 24628858] - Ibrahim Malami, Sanusi Wara Hassan, Alhassan Muhammad Alhassan, Tijjani Salihu Shinkafi, Ahmad Tijjani Umar, Shaayau Shehu. Report: Anxiolytic, sedative and toxicological effect of hydromethanolic stem bark extract of Maerua angolensis DC. in Wister rats.
Pakistan journal of pharmaceutical sciences.
2014 Sep; 27(5):1363-70. doi:
NULL. [PMID: 25176388] - Martha Mullally, Christian Cayer, Kari Kramp, Marco Otárola Rojas, Pablo Sanchez Vindas, Mario Garcia, Luis Poveda Alvarez, Tony Durst, Zul Merali, Vance L Trudeau, John T Arnason. Souroubea sympetala (Marcgraviaceae): a medicinal plant that exerts anxiolysis through interaction with the GABAA benzodiazepine receptor.
Canadian journal of physiology and pharmacology.
2014 Sep; 92(9):758-64. doi:
10.1139/cjpp-2014-0213. [PMID: 25140794] - Suengmok Cho, Minseok Yoon, Ae Nim Pae, Young-Ho Jin, Nam-Chul Cho, Yohko Takata, Yoshihiro Urade, Sojin Kim, Jin-Soo Kim, Hyejin Yang, Jiyoung Kim, Jinkyoung Kim, Jin-Kyu Han, Makoto Shimizu, Zhi-Li Huang. Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor.
Psychopharmacology.
2014 Jul; 231(14):2825-37. doi:
10.1007/s00213-014-3445-1. [PMID: 24488362] - Antonia Amanda Cardoso de Almeida, Rusbene Bruno Fonseca de Carvalho, Oskar Almeida Silva, Damião Pergentino de Sousa, Rivelilson Mendes de Freitas. Potential antioxidant and anxiolytic effects of (+)-limonene epoxide in mice after marble-burying test.
Pharmacology, biochemistry, and behavior.
2014 Mar; 118(?):69-78. doi:
10.1016/j.pbb.2014.01.006. [PMID: 24463201] - Claudio Zanettini, Charles P France, Lisa R Gerak. Quantitative pharmacological analyses of the interaction between flumazenil and midazolam in monkeys discriminating midazolam: Determination of the functional half life of flumazenil.
European journal of pharmacology.
2014 Jan; 723(?):405-9. doi:
10.1016/j.ejphar.2013.10.065. [PMID: 24216249] - Majid Asadi-Shekaari, Azam Eslami, Tajpari Kalantaripour, Siyavash Joukar. Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre.
2014; 23(6):538-42. doi:
10.1159/000365759. [PMID: 25196480] - Idris Ajayi Oyemitan, Christianah Abimbola Elusiyan, Moses Atanda Akanmu, Tiwalade Adewale Olugbade. Hypnotic, anticonvulsant and anxiolytic effects of 1-nitro-2-phenylethane isolated from the essential oil of Dennettia tripetala in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Nov; 20(14):1315-22. doi:
10.1016/j.phymed.2013.07.005. [PMID: 23920280] - Stephen L Thornton, Elezer Negus, Shaun D Carstairs. Pediatric zolpidem ingestion demonstrating zero-order kinetics treated with flumazenil.
Pediatric emergency care.
2013 Nov; 29(11):1204-6. doi:
10.1097/pec.0b013e3182aa139c. [PMID: 24196090] - Zhenhua Jin, Sojin Kim, Suengmok Cho, In-Ho Kim, Daeseok Han, Young-Ho Jin. Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons.
Planta medica.
2013 Oct; 79(15):1408-12. doi:
10.1055/s-0033-1350698. [PMID: 23975867] - Naren Gunja. The clinical and forensic toxicology of Z-drugs.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2013 Jun; 9(2):155-62. doi:
10.1007/s13181-013-0292-0. [PMID: 23404347] - Yasushi Koike, Tomoyuki Kawamata, Katsumi Yamamoto, Mikito Kawamata. [Improvement of consciousness by administration of flumazenil in a patient with unexpectedly delayed emergence from general anesthesia].
Masui. The Japanese journal of anesthesiology.
2013 Apr; 62(4):449-52. doi:
NULL. [PMID: 23697200] - Celso A R A Costa, Thaís C Cury, Bruna O Cassettari, Regina K Takahira, Jorge C Flório, Mirtes Costa. Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT(1A)-receptors and reduces cholesterol after repeated oral treatment.
BMC complementary and alternative medicine.
2013 Feb; 13(?):42. doi:
10.1186/1472-6882-13-42. [PMID: 23432968] - Alexander Jackson, Benedicte B Guilbert, Stuart D Plant, Julian Goggi, Mark R Battle, John L Woodcraft, Alessandra Gaeta, Clare L Jones, Denis R Bouvet, Paul A Jones, Dennis M O'Shea, Penny Hao Zheng, Samantha L Brown, Amanda L Ewan, William Trigg. The development of potential new fluorine-18 labelled radiotracers for imaging the GABA(A) receptor.
Bioorganic & medicinal chemistry letters.
2013 Feb; 23(3):821-6. doi:
10.1016/j.bmcl.2012.11.066. [PMID: 23265897] - Nahid Amini, Ryuji Nakao, Magnus Schou, Christer Halldin. Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28.
Analytical and bioanalytical chemistry.
2013 Feb; 405(4):1303-10. doi:
10.1007/s00216-012-6541-2. [PMID: 23180082] - Gbola Olayiwola, Otas Ukponmwan, Dayo Olawode. Sedative and anxiolytic effects of the extracts of the leaves of Stachytarpheta cayennensis in mice.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2013; 10(6):568-79. doi:
10.4314/ajtcam.v10i6.32. [PMID: 24311890] - Seungheon Lee, Dong Hyun Kim, Ji Hye Lee, Eun Seong Ko, Won Bo Oh, Yong Taek Seo, Young Pyo Jang, Jong Hoon Ryu, Ji Wook Jung. Involvement of histaminergic system in the anxiolytic-like activities of Morus alba leaves in mice.
Biological & pharmaceutical bulletin.
2013; 36(11):1692-9. doi:
10.1248/bpb.b13-00126. [PMID: 23965748] - Hyejin Yang, Young-Chul Lee, Kyoung-Sik Han, Harjinder Singh, Minseok Yoon, Ji-Hae Park, Chang-Won Cho, Suengmok Cho. Green and gold kiwifruit peel ethanol extracts potentiate pentobarbital-induced sleep in mice via a GABAergic mechanism.
Food chemistry.
2013 Jan; 136(1):160-3. doi:
10.1016/j.foodchem.2012.07.111. [PMID: 23017407] - Bingjin Li, Fang Tang, Liang Wang, Lei Liu, Jing Zhao, Yang Zhou, Yinuo Wang, Yunong Song, Yuxin Li, Ranji Cui. Anticonvulsant effects of Fuzi total alkaloid on pentylenetetrazole-induced seizure in mice.
Journal of pharmacological sciences.
2013; 123(2):195-8. doi:
10.1254/jphs.13057sc. [PMID: 24096829] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Chang-Rui Chen, Xu-Zhao Zhou, Yan-Jia Luo, Zhi-Li Huang, Yoshihiro Urade, Wei-Min Qu. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice.
Neuropharmacology.
2012 Nov; 63(6):1191-9. doi:
10.1016/j.neuropharm.2012.06.031. [PMID: 22771461] - Germain Sotoing Taïwe, Elisabeth Ngo Bum, Emmanuel Talla, Amadou Dawe, Fleur Clarisse Okomolo Moto, Gwladys Temkou Ngoupaye, Neteydji Sidiki, Bernard Dabole, Paul Désiré Djomeni Dzeufiet, Théophile Dimo, Michel De Waard. Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Journal of ethnopharmacology.
2012 Aug; 143(1):213-20. doi:
10.1016/j.jep.2012.06.026. [PMID: 22750453] - Pablinny Moreira Galdino, Marcus Vinícius Mariano Nascimento, Iziara Ferreira Florentino, Roberta Campos Lino, James Oluwagbamigbe Fajemiroye, Beatriz Abdallah Chaibub, José Realino de Paula, Thereza Christina Monteiro de Lima, Elson Alves Costa. The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2012 Aug; 38(2):276-84. doi:
10.1016/j.pnpbp.2012.04.012. [PMID: 22542869] - James Oluwagbamigbe Fajemiroye, Pablinny Moreira Galdino, Suzana Fereirra Alves, Joelma Abadia Marciano de Paula, José Realino de Paula, Paulo Cesár Ghedini, Elson Alves Costa. Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus.
Journal of ethnopharmacology.
2012 Jun; 141(3):872-7. doi:
10.1016/j.jep.2012.03.043. [PMID: 22472106] - Dubravka Švob Štrac, Dorotea Muck-Šeler, Nela Pivac. The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.
Croatian medical journal.
2012 Jun; 53(3):214-23. doi:
10.3325/cmj.2012.53.214. [PMID: 22661134] - Suengmok Cho, Ji-Hae Park, Ae Nim Pae, Daeseok Han, Dongsoo Kim, Nam-Chul Cho, Kyoung Tai No, Hyejin Yang, Minseok Yoon, Changho Lee, Makoto Shimizu, Nam-In Baek. Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol.
Bioorganic & medicinal chemistry.
2012 Jun; 20(11):3493-501. doi:
10.1016/j.bmc.2012.04.011. [PMID: 22543233] - C G Heldwein, L L Silva, P Reckziegel, F M C Barros, M E Bürger, B Baldisserotto, C A Mallmann, D Schmidt, B O Caron, B M Heinzmann. Participation of the GABAergic system in the anesthetic effect of Lippia alba (Mill.) N.E. Brown essential oil.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2012 May; 45(5):436-43. doi:
10.1590/s0100-879x2012007500052. [PMID: 22473320] - Ursula M H Klumpers, Ronald Boellaard, Dick J Veltman, Reina W Kloet, Witte J G Hoogendijk, Adriaan A Lammertsma. Parametric [11C]flumazenil images.
Nuclear medicine communications.
2012 Apr; 33(4):422-30. doi:
10.1097/mnm.0b013e3283505f7b. [PMID: 22293497] - Irinéia Paulina Baretta, Regiane Américo Felizardo, Vanessa Fávero Bimbato, Maísa Gonçalves Jorge dos Santos, Candida Aparecida Leite Kassuya, Arquimedes Gasparotto Junior, Cássia Regina da Silva, Sara Marchesan de Oliveira, Juliano Ferreira, Roberto Andreatini. Anxiolytic-like effects of acute and chronic treatment with Achillea millefolium L. extract.
Journal of ethnopharmacology.
2012 Mar; 140(1):46-54. doi:
10.1016/j.jep.2011.11.047. [PMID: 22155391] - Walter Ling, Steven Shoptaw, Maureen Hillhouse, Michelle A Bholat, Charles Charuvastra, Keith Heinzerling, David Chim, Jeffrey Annon, Patrick T Dowling, Geetha Doraimani. Double-blind placebo-controlled evaluation of the PROMETA™ protocol for methamphetamine dependence.
Addiction (Abingdon, England).
2012 Feb; 107(2):361-9. doi:
10.1111/j.1360-0443.2011.03619.x. [PMID: 22082089] - Yi Shen, A Kerstin Lindemeyer, Claudia Gonzalez, Xuesi M Shao, Igor Spigelman, Richard W Olsen, Jing Liang. Dihydromyricetin as a novel anti-alcohol intoxication medication.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Jan; 32(1):390-401. doi:
10.1523/jneurosci.4639-11.2012. [PMID: 22219299] - Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
10.1124/dmd.111.040758. [PMID: 21965623] - Suengmok Cho, Daeseok Han, Seon-Bong Kim, Minseok Yoon, Hyejin Yang, Young-Ho Jin, Jinho Jo, Hyeim Yong, Sang-Hoon Lee, You-Jin Jeon, Makoto Shimizu. Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed.
Bioscience, biotechnology, and biochemistry.
2012; 76(1):163-8. doi:
10.1271/bbb.110702. [PMID: 22232271] - Wesley Anderson, Mark Barrows, Fernando Lopez, Sara Rogers, Adriana Ortiz-Coffie, David Norman, Jonathan Hodges, Keith McDonald, Devon Barnes, Suzanne McCall, Johnson Arthur Don, Thomas E Ceremuga. Investigation of the anxiolytic effects of naringenin, a component of Mentha aquatica, in the male Sprague-Dawley rat.
Holistic nursing practice.
2012 Jan; 26(1):52-7. doi:
10.1097/hnp.0b013e31823c003a. [PMID: 22157509] - W Gordon Frankle, Raymond Y Cho, N Scott Mason, Chi-Min Chen, Michael Himes, Christopher Walker, David A Lewis, Chester A Mathis, Rajesh Narendran. [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.
PloS one.
2012; 7(2):e32443. doi:
10.1371/journal.pone.0032443. [PMID: 22384252] - Anna M Arroyo Plasencia, Lynn M Ballentine, James B Mowry, Louise W Kao. Benzodiazepine-associated atrioventricular block.
American journal of therapeutics.
2012 Jan; 19(1):e48-52. doi:
10.1097/mjt.0b013e3181dcf572. [PMID: 20535011] - E Bozogluer, H Madenoglu, R Aksu, C Bicer, C Yazici, A Boyaci. The effect of different doses of flumazenil on acetaminophen toxicity in rats.
Bratislavske lekarske listy.
2012; 113(9):525-8. doi:
10.4149/bll_2012_118. [PMID: 22979906] - Heather M Wright, Annie V Chen, Patricia A Talcott, Robert H Poppenga, Katrina L Mealey. Intravenous fat emulsion as treatment for ivermectin toxicosis in three dogs homozygous for the ABCB1-1Δ gene mutation.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2011 Dec; 21(6):666-72. doi:
10.1111/j.1476-4431.2011.00687.x. [PMID: 22316260] - Maribel Herrera-Ruiz, Adolfo González-Carranza, Alejandro Zamilpa, Enrique Jiménez-Ferrer, Maira Huerta-Reyes, Víctor M Navarro-García. The standardized extract of Loeselia mexicana possesses anxiolytic activity through the γ-amino butyric acid mechanism.
Journal of ethnopharmacology.
2011 Nov; 138(2):261-7. doi:
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British journal of pharmacology.
2011 Nov; 164(5):1534-46. doi:
10.1111/j.1476-5381.2011.01456.x. [PMID: 21518336] - Moses Graubard, Paul Rohdenberg, Timothy Jang. Short answer question case series: the perils of urine toxicology testing.
Emergency medicine journal : EMJ.
2011 Nov; 28(11):998-9. doi:
10.1136/emermed-2011-200276. [PMID: 21708959] - Yukihiko Shirayama, Katsumasa Muneoka, Makoto Fukumoto, Shigenori Tadokoro, Goro Fukami, Kenji Hashimoto, Masaomi Iyo. Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats.
Hippocampus.
2011 Oct; 21(10):1105-13. doi:
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