Sucralose (BioDeep_00000397916)
Main id: BioDeep_00000003322
BioNovoGene_Lab2019
代谢物信息卡片
Sucralose
化学式: C12H19Cl3O8 (396.0145)
中文名称: 三氯蔗糖, 三氯蔗糖；蔗糖素；羟糖氯
谱图信息:
最多检出来源 Viridiplantae(not specific) 5.66%
分子结构信息
SMILES: C(C1C(C(C(C(O1)OC2(C(C(C(O2)CCl)O)O)CCl)O)O)Cl)O
InChI: InChI=1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:32159
- KEGG: C12285
- PubChem: 71485
- ChEMBL: CHEMBL3185084
- CAS: 56038-13-2
- MoNA: MoNA038228
- MoNA: MoNA035203
- MoNA: MoNA035202
- MoNA: MoNA035201
- MoNA: MoNA033019
- MoNA: MoNA033015
- MoNA: MoNA033012
- MoNA: TUE00667
- MoNA: TUE00666
- MoNA: TUE00665
- MoNA: TUE00662
- MoNA: TUE00661
- PubChem: 14429
- PDB-CCD: 40J
- NIKKAJI: J247.962A
- RefMet: Sucralose
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-831
- KNApSAcK: 32159
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shuang Qiao, Wendy Huang, Darina Kuzma, Aleshia Kormendi. Acesulfame and other artificial sweeteners in a wastewater treatment plant in Alberta, Canada: Occurrence, degradation, and emission.
Chemosphere.
2024 May; 356(?):141893. doi:
10.1016/j.chemosphere.2024.141893. [PMID: 38582168] - Liang Chi, YifeiYang, Xiaoming Bian, Bei Gao, Pengcheng Tu, Hongyu Ru, Kun Lu. Chronic sucralose consumption inhibits farnesoid X receptor signaling and perturbs lipid and cholesterol homeostasis in the mouse livers, potentially by altering gut microbiota functions.
The Science of the total environment.
2024 Apr; 919(?):169603. doi:
10.1016/j.scitotenv.2023.169603. [PMID: 38272087] - Xinyi Wu, Le Cui, Haoquan Wang, Jinhong Xu, Zhaozhao Zhong, Xibei Jia, Jiaqi Wang, Huahua Zhang, Yanteng Shi, Yuhang Tang, Qianhui Yang, Qiongdan Liang, Yujing Zhang, Jing Li, Xiaohong Jiang. Impact of dietary sucralose and sucrose-sweetened water intake on lipid and glucose metabolism in male mice.
European journal of nutrition.
2023 Feb; 62(1):199-211. doi:
10.1007/s00394-022-02980-2. [PMID: 35933635] - Karla Colín-García, Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez-Oliván, Hariz Islas-Flores, Sandra García-Medina, Marcela Galar-Martínez. Acute exposure to environmentally relevant concentrations of sucralose disrupts embryonic development and leads to an oxidative stress response in Danio rerio.
The Science of the total environment.
2022 Jul; 829(?):154689. doi:
10.1016/j.scitotenv.2022.154689. [PMID: 35314215] - Vicente Agulló, Cristina García-Viguera, Raúl Domínguez-Perles. The use of alternative sweeteners (sucralose and stevia) in healthy soft-drink beverages, enhances the bioavailability of polyphenols relative to the classical caloric sucrose.
Food chemistry.
2022 Feb; 370(?):131051. doi:
10.1016/j.foodchem.2021.131051. [PMID: 34530345] - Mohan Zhang, Shuai Chen, Yuhua Dai, Ting Duan, Yuying Xu, Xiaolin Li, Jun Yang, Xinqiang Zhu. Aspartame and sucralose extend the lifespan and improve the health status of C. elegans.
Food & function.
2021 Oct; 12(20):9912-9921. doi:
10.1039/d1fo01579f. [PMID: 34486601] - Pilar Zafrilla, Hedyeh Masoodi, Begoña Cerdá, Cristina García-Viguera, Débora Villaño. Biological effects of stevia, sucralose and sucrose in citrus-maqui juices on overweight subjects.
Food & function.
2021 Sep; 12(18):8535-8543. doi:
10.1039/d1fo01160j. [PMID: 34323244] - Alexandra G Yunker, Jasmin M Alves, Shan Luo, Brendan Angelo, Alexis DeFendis, Trevor A Pickering, John R Monterosso, Kathleen A Page. Obesity and Sex-Related Associations With Differential Effects of Sucralose vs Sucrose on Appetite and Reward Processing: A Randomized Crossover Trial.
JAMA network open.
2021 09; 4(9):e2126313. doi:
10.1001/jamanetworkopen.2021.26313. [PMID: 34581796] - Emmanuella Enuwosa, Lata Gautam, Linda King, Havovi Chichger. Saccharin and Sucralose Protect the Glomerular Microvasculature In Vitro against VEGF-Induced Permeability.
Nutrients.
2021 Aug; 13(8):. doi:
10.3390/nu13082746. [PMID: 34444906] - Cheng Qian, Yicheng Qi, Rilu Feng, Mei Yang, Minchun Zhang, Wei Liu, Christopher K Rayner, Jing Ma. Sucralose can improve glucose tolerance and upregulate expression of sweet taste receptors and glucose transporters in an obese rat model.
European journal of nutrition.
2021 Jun; 60(4):1809-1817. doi:
10.1007/s00394-020-02375-1. [PMID: 32860125] - Zunji Shi, Gui Chen, Zheng Cao, Fang Wu, Hehua Lei, Chuan Chen, Yuchen Song, Caixiang Liu, Jinquan Li, Jinlin Zhou, Yujing Lu, Limin Zhang. Gut Microbiota and Its Metabolite Deoxycholic Acid Contribute to Sucralose Consumption-Induced Nonalcoholic Fatty Liver Disease.
Journal of agricultural and food chemistry.
2021 Apr; 69(13):3982-3991. doi:
10.1021/acs.jafc.0c07467. [PMID: 33755449] - Vicente Agulló, Raúl Domínguez-Perles, Cristina García-Viguera. Sweetener influences plasma concentration of flavonoids in humans after an acute intake of a new (poly)phenol-rich beverage.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2021 03; 31(3):930-938. doi:
10.1016/j.numecd.2020.11.016. [PMID: 33546941] - Jianhui Zhu, Jiaxin Liu, Zhengyi Li, Ranhui Xi, Yuqing Li, Xian Peng, Xin Xu, Xin Zheng, Xuedong Zhou. The Effects of Nonnutritive Sweeteners on the Cariogenic Potential of Oral Microbiome.
BioMed research international.
2021; 2021(?):9967035. doi:
10.1155/2021/9967035. [PMID: 34258285] - Samar Y Ahmad, James Friel, Dylan Mackay. The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial.
Nutrients.
2020 Nov; 12(11):. doi:
10.3390/nu12113408. [PMID: 33171964] - Meghan B Azad, Alyssa Archibald, Mateusz M Tomczyk, Alanna Head, Kyle G Cheung, Russell J de Souza, Allan B Becker, Piushkumar J Mandhane, Stuart E Turvey, Theo J Moraes, Malcolm R Sears, Padmaja Subbarao, Vernon W Dolinsky. Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells.
International journal of obesity (2005).
2020 10; 44(10):2137-2148. doi:
10.1038/s41366-020-0575-x. [PMID: 32366959] - Atanasio Pandiella-Alonso, Elena Díaz-Rodríguez, Eduardo Sanz. Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review.
Nutrients.
2020 Aug; 12(9):. doi:
10.3390/nu12092661. [PMID: 32878230] - Alonso Romo-Romo, Carlos A Aguilar-Salinas, M Guadalupe López-Carrasco, Luz E Guillén-Pineda, Griselda X Brito-Córdova, Rita A Gómez-Díaz, Francisco J Gómez-Pérez, Paloma Almeda-Valdes. Sucralose Consumption over 2 Weeks in Healthy Subjects Does Not Modify Fasting Plasma Concentrations of Appetite-Regulating Hormones: A Randomized Clinical Trial.
Journal of the Academy of Nutrition and Dietetics.
2020 08; 120(8):1295-1304. doi:
10.1016/j.jand.2020.03.018. [PMID: 32711853] - Xin Dai, Zixuan Guo, Danfeng Chen, Lu Li, Xueli Song, Tianyu Liu, Ge Jin, Yun Li, Yi Liu, Aihemaiti Ajiguli, Cheng Yang, Bangmao Wang, Hailong Cao. Maternal sucralose intake alters gut microbiota of offspring and exacerbates hepatic steatosis in adulthood.
Gut microbes.
2020 07; 11(4):1043-1063. doi:
10.1080/19490976.2020.1738187. [PMID: 32228300] - Nallely Bueno-Hernández, Marcela Esquivel-Velázquez, Raúl Alcántara-Suárez, Angélica Y Gómez-Arauz, Aranza J Espinosa-Flores, Karen L de León-Barrera, Viridiana M Mendoza-Martínez, Gabriela A Sánchez Medina, Mireya León-Hernández, Alejandra Ruiz-Barranco, Galileo Escobedo, Guillermo Meléndez. Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial.
Nutrition journal.
2020 04; 19(1):32. doi:
10.1186/s12937-020-00549-5. [PMID: 32284053] - Gerardo Heredia-García, Leobardo Manuel Gómez-Oliván, José Manuel Orozco-Hernández, Marlenee Luja-Mondragón, Hariz Islas-Flores, Nely SanJuan-Reyes, Marcela Galar-Martínez, Sandra García-Medina, Octavio Dublán-García. Alterations to DNA, apoptosis and oxidative damage induced by sucralose in blood cells of Cyprinus carpio.
The Science of the total environment.
2019 Nov; 692(?):411-421. doi:
10.1016/j.scitotenv.2019.07.165. [PMID: 31351285] - Susan S Schiffman, H Troy Nagle. Revisited: Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Oct; 132(?):110692. doi:
10.1016/j.fct.2019.110692. [PMID: 31351100] - Simone Garzon, Antonio Simone Laganà, Giovanni Monastra. Risk of reduced intestinal absorption of myo-inositol caused by D-chiro-inositol or by glucose transporter inhibitors.
Expert opinion on drug metabolism & toxicology.
2019 Sep; 15(9):697-703. doi:
10.1080/17425255.2019.1651839. [PMID: 31382802] - Kelly A Higgins, Richard D Mattes. A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity.
The American journal of clinical nutrition.
2019 05; 109(5):1288-1301. doi:
10.1093/ajcn/nqy381. [PMID: 30997499] - Nomcebo Mchunu, Chika Ifeanyi Chukwuma, Mohammed Auwal Ibrahim, Olajumoke A Oyebode, Siphiwe Ndumiso Dlamini, Md Shahidul Islam. Commercially available non-nutritive sweeteners modulate the antioxidant status of type 2 diabetic rats.
Journal of food biochemistry.
2019 03; 43(3):e12775. doi:
10.1111/jfbc.12775. [PMID: 31353552] - Angélica Y Gómez-Arauz, Nallely Bueno-Hernández, Leon F Palomera, Raúl Alcántara-Suárez, Karen L De León, Lucía A Méndez-García, Miguel Carrero-Aguirre, Aaron N Manjarrez-Reyna, Camilo P Martínez-Reyes, Marcela Esquivel-Velázquez, Alejandra Ruiz-Barranco, Neyla Baltazar-López, Sergio Islas-Andrade, Galileo Escobedo, Guillermo Meléndez. A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults.
Journal of immunology research.
2019; 2019(?):6105059. doi:
10.1155/2019/6105059. [PMID: 31183389] - Qing Shi, Xuemei Zhu, Jue Zhou, Lianlian Chen. Low intake of digestible carbohydrates ameliorates the duodenal absorption of carbohydrates in mice with glucose metabolic disorders induced by sucralose.
Food & function.
2018 Dec; 9(12):6236-6244. doi:
10.1039/c8fo02029a. [PMID: 30402638] - Amornpan Lertrit, Sasinee Srimachai, Sunee Saetung, Suwannee Chanprasertyothin, La-Or Chailurkit, Chatvara Areevut, Pornalat Katekao, Boonsong Ongphiphadhanakul, Chutintorn Sriphrapradang. Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, double-blind, placebo-controlled trial.
Nutrition (Burbank, Los Angeles County, Calif.).
2018 11; 55-56(?):125-130. doi:
10.1016/j.nut.2018.04.001. [PMID: 30005329] - Joanna Doummar, Michel Aoun. Assessment of the origin and transport of four selected emerging micropollutants sucralose, Acesulfame-K, gemfibrozil, and iohexol in a karst spring during a multi-event spring response.
Journal of contaminant hydrology.
2018 08; 215(?):11-20. doi:
10.1016/j.jconhyd.2018.06.003. [PMID: 29983209] - Janina A Krumbeck, Heather E Rasmussen, Robert W Hutkins, Jennifer Clarke, Krista Shawron, Ali Keshavarzian, Jens Walter. Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics.
Microbiome.
2018 06; 6(1):121. doi:
10.1186/s40168-018-0494-4. [PMID: 29954454] - Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu, Dilek Taskiran. Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study.
Journal of biochemical and molecular toxicology.
2018 Jun; 32(6):e22053. doi:
10.1002/jbt.22053. [PMID: 29660801] - Ewelina Pałkowska-Goździk, Anna Bigos, Danuta Rosołowska-Huszcz. Type of sweet flavour carrier affects thyroid axis activity in male rats.
European journal of nutrition.
2018 Mar; 57(2):773-782. doi:
10.1007/s00394-016-1367-x. [PMID: 28040879] - Kristina I Rother, Allison C Sylvetsky, Peter J Walter, H Martin Garraffo, David A Fields. Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.
Journal of pediatric gastroenterology and nutrition.
2018 03; 66(3):466-470. doi:
10.1097/mpg.0000000000001817. [PMID: 29077645] - Ernestina Hernández García, Norma Osnaya Brizuela, Armando Valenzuela Peraza, David Calderón Guzmán, Maribel Ortiz Herrera, Hugo Juárez Olguín, Gerardo Barragán Mejía, Daniel Santamaría Del Ángel, Alberto Rojas Ochoa. Biochemical and histological changes produced by sweeteners and cytarabine in the brain of young rats.
Nutricion hospitalaria.
2018 Feb; 35(1):194-200. doi:
10.20960/nh.1245. [PMID: 29565169] - Volker Bornemann, Stephen C Werness, Lauren Buslinger, Susan S Schiffman. Intestinal Metabolism and Bioaccumulation of Sucralose In Adipose Tissue In The Rat.
Journal of toxicology and environmental health. Part A.
2018; 81(18):913-923. doi:
10.1080/15287394.2018.1502560. [PMID: 30130461] - Ling Ma, Yarui Liu, Jiayao Xu, Hongwen Sun, Hao Chen, Yiming Yao, Peng Zhang, Fengju Shen, Aldredo C Alder. Mass loading of typical artificial sweeteners in a pig farm and their dissipation and uptake by plants in neighboring farmland.
The Science of the total environment.
2017 Dec; 605-606(?):735-744. doi:
10.1016/j.scitotenv.2017.06.027. [PMID: 28675883] - Jaapna Dhillon, Janice Y Lee, Richard D Mattes. The cephalic phase insulin response to nutritive and low-calorie sweeteners in solid and beverage form.
Physiology & behavior.
2017 Nov; 181(?):100-109. doi:
10.1016/j.physbeh.2017.09.009. [PMID: 28899680] - Caomhan Logue, Le Roy C Dowey, J J Strain, Hans Verhagen, Stephen McClean, Alison M Gallagher. Application of Liquid Chromatography-Tandem Mass Spectrometry To Determine Urinary Concentrations of Five Commonly Used Low-Calorie Sweeteners: A Novel Biomarker Approach for Assessing Recent Intakes?.
Journal of agricultural and food chemistry.
2017 Jun; 65(22):4516-4525. doi:
10.1021/acs.jafc.7b00404. [PMID: 28506059] - Takashi Uebanso, Ai Ohnishi, Reiko Kitayama, Ayumi Yoshimoto, Mutsumi Nakahashi, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi. Effects of Low-Dose Non-Caloric Sweetener Consumption on Gut Microbiota in Mice.
Nutrients.
2017 Jun; 9(6):. doi:
10.3390/nu9060560. [PMID: 28587159] - Allison C Sylvetsky, Peter J Walter, H Martin Garraffo, Kim Robien, Kristina I Rother. Widespread sucralose exposure in a randomized clinical trial in healthy young adults.
The American journal of clinical nutrition.
2017 04; 105(4):820-823. doi:
10.3945/ajcn.116.144402. [PMID: 28228424] - Morgan Barker, Anthony Kennedy. Disruption of gel phase lipid packing efficiency by sucralose studied with merocyanine 540.
Colloids and surfaces. B, Biointerfaces.
2017 Apr; 152(?):214-219. doi:
10.1016/j.colsurfb.2017.01.026. [PMID: 28113123] - Cherisse Amy-Sagers, Keith Reinhardt, Danelle M Larson. Ecotoxicological assessments show sucralose and fluoxetine affect the aquatic plant, Lemna minor.
Aquatic toxicology (Amsterdam, Netherlands).
2017 Apr; 185(?):76-85. doi:
10.1016/j.aquatox.2017.01.008. [PMID: 28192727] - Sandra Steensels, Leen Cools, Bert Avau, Laurien Vancleef, Ricard Farré, Kristin Verbeke, Inge Depoortere. Supplementation of oligofructose, but not sucralose, decreases high-fat diet induced body weight gain in mice independent of gustducin-mediated gut hormone release.
Molecular nutrition & food research.
2017 03; 61(3):. doi:
10.1002/mnfr.201600716. [PMID: 27800650] - Karinne Saucedo-Vence, Armando Elizalde-Velázquez, Octavio Dublán-García, Marcela Galar-Martínez, Hariz Islas-Flores, Nely SanJuan-Reyes, Sandra García-Medina, María Dolores Hernández-Navarro, Leobardo Manuel Gómez-Oliván. Toxicological hazard induced by sucralose to environmentally relevant concentrations in common carp (Cyprinus carpio).
The Science of the total environment.
2017 Jan; 575(?):347-357. doi:
10.1016/j.scitotenv.2016.09.230. [PMID: 27744200] - Rongyan Li, Jiadong Zheng, Mingshan Jiang, Yuanli Liu, Xiaofa Qin, Xiuhong Wang. Increased Digestive Proteases and Decreased β-Glucuronidase in Feces of Rats Treated with Sucralose and Saccharin-Another Critical Evidence That These Dietary Chemicals May Be Important Causative Factors for Inflammatory Bowel Disease.
Inflammatory bowel diseases.
2016 08; 22(8):E29-30. doi:
10.1097/mib.0000000000000859. [PMID: 27416049] - Wenwu Yan, Nani Wang, Peimin Zhang, Jiajie Zhang, Shuchao Wu, Yan Zhu. Simultaneous determination of sucralose and related compounds by high-performance liquid chromatography with evaporative light scattering detection.
Food chemistry.
2016 Aug; 204(?):358-364. doi:
10.1016/j.foodchem.2016.02.099. [PMID: 26988513] - Yi-Hsing Hsiao, Chia-Hsien Hsu, Chihchen Chen. A High-Throughput Automated Microfluidic Platform for Calcium Imaging of Taste Sensing.
Molecules (Basel, Switzerland).
2016 Jul; 21(7):. doi:
10.3390/molecules21070896. [PMID: 27399663] - Nadine Srour, Hamza Daroub, Imad Toufeili, Ammar Olabi. Developing a carob-based milk beverage using different varieties of carob pods and two roasting treatments and assessing their effect on quality characteristics.
Journal of the science of food and agriculture.
2016 Jul; 96(9):3047-57. doi:
10.1002/jsfa.7476. [PMID: 26416256] - Samantha D Splitt, Douglas D Risser. The non-metabolizable sucrose analog sucralose is a potent inhibitor of hormogonium differentiation in the filamentous cyanobacterium Nostoc punctiforme.
Archives of microbiology.
2016 Mar; 198(2):137-47. doi:
10.1007/s00203-015-1171-7. [PMID: 26576759] - Soffritti M, Padovani M, Tibaldi E, Falcioni L, Manservisi F, Lauriola M, Bua L, Manservigi M, Belpoggi F. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice.
International journal of occupational and environmental health.
2016 01; 22(1):7-17. doi:
10.1080/10773525.2015.1106075. [PMID: 27078173] - Ngoc Han Tran, Jie Gan, Viet Tung Nguyen, Huiting Chen, Luhua You, Ankur Duarah, Lifeng Zhang, Karina Yew-Hoong Gin. Sorption and biodegradation of artificial sweeteners in activated sludge processes.
Bioresource technology.
2015 Dec; 197(?):329-38. doi:
10.1016/j.biortech.2015.08.083. [PMID: 26342347] - J B Rodrigues, J A Paixão, A G Cruz, H M A Bolini. Chocolate Milk with Chia Oil: Ideal Sweetness, Sweeteners Equivalence, and Dynamic Sensory Evaluation Using a Time-Intensity Methodology.
Journal of food science.
2015 Dec; 80(12):S2944-9. doi:
10.1111/1750-3841.13120. [PMID: 26523944] - Bosi Yuan, Shuping Zhou, Youke Lu, Jiong Liu, Xinxin Jin, Haijun Wan, Fangyu Wang. Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis.
Gut and liver.
2015 Nov; 9(6):734-40. doi:
10.5009/gnl14155. [PMID: 25717051] - Kristina I Rother, Allison C Sylvetsky, S S Schiffman. Non-nutritive sweeteners in breast milk: perspective on potential implications of recent findings.
Archives of toxicology.
2015 Nov; 89(11):2169-71. doi:
10.1007/s00204-015-1611-9. [PMID: 26462668] - Radamés Alemón-Medina, Juan Luis Chávez-Pacheco, Liliana Rivera-Espinosa, Blanca Ramírez-Mendiola, Raquel García-Álvarez, Cynthia Sámano-Salazar, Víctor Manuel Dávila-Borja. Extemporaneous Formulations of Metformin for Pediatric Endocrinology: Physicochemical Integrity, Cytotoxicity of Sweeteners, and Quantitation of Plasma Levels.
Clinical therapeutics.
2015 Aug; 37(8):1689-702. doi:
10.1016/j.clinthera.2015.05.502. [PMID: 26092088] - Andrea Matros, Darin Peshev, Manuela Peukert, Hans-Peter Mock, Wim Van den Ende. Sugars as hydroxyl radical scavengers: proof-of-concept by studying the fate of sucralose in Arabidopsis.
The Plant journal : for cell and molecular biology.
2015 Jun; 82(5):822-39. doi:
10.1111/tpj.12853. [PMID: 25891826] - Sudha Rani Batchu, Cesar E Ramirez, Piero R Gardinali. Rapid ultra-trace analysis of sucralose in multiple-origin aqueous samples by online solid-phase extraction coupled to high-resolution mass spectrometry.
Analytical and bioanalytical chemistry.
2015 May; 407(13):3717-25. doi:
10.1007/s00216-015-8593-6. [PMID: 25772563] - Lee Chen, Nimesh Shukla, Inha Cho, Erin Cohn, Erika A Taylor, Christina M Othon. Sucralose Destabilization of Protein Structure.
The journal of physical chemistry letters.
2015 Apr; 6(8):1441-6. doi:
10.1021/acs.jpclett.5b00442. [PMID: 26263149] - Allison C Sylvetsky, Alexandra L Gardner, Viviana Bauman, Jenny E Blau, H Martin Garraffo, Peter J Walter, Kristina I Rother. Nonnutritive Sweeteners in Breast Milk.
Journal of toxicology and environmental health. Part A.
2015; 78(16):1029-32. doi:
10.1080/15287394.2015.1053646. [PMID: 26267522] - Armorel Diane van Eyk. The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells.
Drug and chemical toxicology.
2015; 38(3):318-27. doi:
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Journal of clinical gastroenterology.
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