Paroxetine (BioDeep_00000397879)

Main id: BioDeep_00000002101

 


代谢物信息卡片


3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

化学式: C19H20FNO3 (329.1427)
中文名称: 帕罗西汀
谱图信息: 最多检出来源 Homo sapiens(urine) 10.56%

分子结构信息

SMILES: c1cc(ccc1[C@@H]1CCNC[C@H]1COc1ccc2c(c1)OCO2)F
InChI: InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2

描述信息

D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065690 - Cytochrome P-450 CYP2D6 Inhibitors
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AB - Selective serotonin reuptake inhibitors
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C94725 - Selective Serotonin Reuptake Inhibitor
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
CONFIDENCE standard compound; INTERNAL_ID 1526
CONFIDENCE standard compound; INTERNAL_ID 4079
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3611
Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs[1].

同义名列表

4 个代谢物同义名

Paroxetine; 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine; BRL29060; Paroxetine



数据库引用编号

51 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, AXIN2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, MVD, POMC
Peripheral membrane protein 1 CYP1B1
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 6 CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4
Nucleus 1 AXIN2
cytosol 3 AVP, AXIN2, MVD
dendrite 5 AVP, DRD2, HTR1A, HTR1B, HTR2A
centrosome 1 AXIN2
Cell membrane 8 ABCB1, DRD2, HTR1A, HTR1B, HTR2A, HTR3A, SLC6A2, SLC6A4
Cleavage furrow 1 HTR3A
Cell projection, axon 1 HTR2A
Multi-pass membrane protein 8 ABCB1, DRD2, HTR1A, HTR1B, HTR2A, HTR3A, SLC6A2, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 4 DRD2, HTR1A, HTR3A, SLC6A4
cell surface 2 ABCB1, SLC6A2
dendritic shaft 1 HTR2A
glutamatergic synapse 2 DRD2, HTR2A
Golgi membrane 2 DRD2, INS
neuronal cell body 1 HTR2A
postsynapse 1 HTR3A
presynaptic membrane 5 DRD2, HTR1B, HTR2A, SLC6A2, SLC6A4
Presynapse 2 HTR2A, SLC6A4
acrosomal vesicle 1 DRD2
plasma membrane 11 ABCB1, AXIN2, CYP2C19, CYP2C9, DRD2, HTR1A, HTR1B, HTR2A, HTR3A, SLC6A2, SLC6A4
synaptic vesicle membrane 2 DRD2, SLC6A2
Membrane 7 ABCB1, CYP1B1, CYP2D6, CYP3A4, HTR3A, SLC6A2, SLC6A4
apical plasma membrane 1 ABCB1
axon 3 DRD2, HTR2A, SLC6A2
caveola 1 HTR2A
extracellular exosome 1 ABCB1
endoplasmic reticulum 2 CYP2D6, HTR1B
extracellular space 4 AVP, IL10, INS, POMC
mitochondrion 2 CYP1B1, CYP2D6
intracellular membrane-bounded organelle 6 CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4
Microsome membrane 5 CYP1A2, CYP1B1, CYP2C9, CYP2D6, CYP3A4
Secreted 4 AVP, IL10, INS, POMC
extracellular region 4 AVP, IL10, INS, POMC
Single-pass membrane protein 1 CYP2D6
neuronal cell body membrane 1 SLC6A2
ciliary membrane 1 DRD2
dendritic spine 1 DRD2
perikaryon 1 DRD2
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 HTR2A
postsynaptic membrane 4 DRD2, HTR2A, HTR3A, SLC6A4
Apical cell membrane 1 ABCB1
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
GABA-ergic synapse 1 DRD2
secretory granule 2 AVP, POMC
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 1 HTR3A
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 HTR3A, SLC6A4
cilium 1 DRD2
non-motile cilium 1 DRD2
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
sperm flagellum 1 DRD2
Endomembrane system 1 SLC6A4
endosome lumen 1 INS
Membrane, caveola 1 HTR2A
cell body fiber 1 HTR2A
Cell projection, dendrite 2 HTR1A, HTR2A
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 AVP
neurofilament 1 HTR2A
calyx of Held 1 HTR1B
clathrin-coated endocytic vesicle membrane 1 AVP
external side of apical plasma membrane 1 ABCB1
dopaminergic synapse 1 DRD2
G protein-coupled receptor complex 1 DRD2
G protein-coupled serotonin receptor complex 2 HTR1B, HTR2A
serotonergic synapse 2 HTR1B, SLC6A4


文献列表

  • Xiaojie Liu, Mengyu Li, Chen Jian, Xuemei Qin. Characterization of 'microbiome-metabolome-immunity' in depressed rats with divergent responses to Paroxetine. Journal of affective disorders. 2024 May; 352(?):201-213. doi: 10.1016/j.jad.2024.02.017. [PMID: 38346646]
  • Fahad Pervaiz, Ayesha Saba, Haya Yasin, Manal Buabeid, Sobia Noreen, Abida Kalsoom Khan, Ghulam Murtaza. Fabrication of solid lipid nanoparticles-based patches of paroxetine and their ex-vivo permeation behaviour. Artificial cells, nanomedicine, and biotechnology. 2023 Dec; 51(1):108-119. doi: 10.1080/21691401.2023.2179631. [PMID: 36855254]
  • Li-Lin Jiang, Yu-Lin Wu, Ye Mo, Ling Gou, Mei-Ling Chen, Yan Wang, Qing-Min Zang, De-Qi Jiang. The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis. Medicine. 2023 Aug; 102(34):e34687. doi: 10.1097/md.0000000000034687. [PMID: 37653795]
  • Dat T N Ngo, Tho H Ho, Lam K Huynh, Trang T Nguyen. The interplay of membrane fluidity, acyl chain order and area per lipid on the partitioning of two antidepressants paroxetine and sertraline. Soft matter. 2023 Jul; ?(?):. doi: 10.1039/d3sm00462g. [PMID: 37435937]
  • Xu Chen, Jiu-Xi Chen, Xue-Yan Han, Yang Zhao, Jing Cao, Xiu-Zhen Jiao, Hong-Mei Liu, Chun-Li Guo, Shuo Meng, Shuai Liang, Jiang-Xia Qi, Dong Chen, Ming-Xia Li, Yun-Xia Jiao, Ting-Ting Wang, Xia Hong. Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin (Heart)-Pi (Spleen) Deficiency Syndrome: A Multi-centre Randomized Controlled Study. Chinese journal of integrative medicine. 2023 Apr; 29(4):299-307. doi: 10.1007/s11655-022-3685-6. [PMID: 36301455]
  • Queen Saikia, Ajit Hazarika, Jogen Chandra Kalita. Isoliquiritigenin ameliorates paroxetine-induced sexual dysfunction in male albino mice. Reproductive toxicology (Elmsford, N.Y.). 2023 Feb; 117(?):108341. doi: 10.1016/j.reprotox.2023.108341. [PMID: 36740106]
  • O Godin, B Pignon, A Szoke, L Boyer, B Aouizerate, B Schorr, M André, D Capdevielle, I Chereau, N Coulon, R Dassing, C Dubertret, B Etain, S Leignier, P M Llorca, J Mallet, D Misdrahi, C Passerieux, R Rey, M Urbach, F Schürhoff, M Leboyer, G Fond. 3-year incidence and predictors of metabolic syndrome in schizophrenia in the national FACE-SZ cohort. Progress in neuro-psychopharmacology & biological psychiatry. 2023 01; 120(?):110641. doi: 10.1016/j.pnpbp.2022.110641. [PMID: 36122839]
  • Jun Shao, Bo Li, Ai-Hong Yuan, Xiu-Qiang Hu, Jie Guo, Ming-Xing Ren, Jun Yang. [Huayu Tongluo moxibustion combined with intradermal needling in patients with mild to moderate depression after cerebral infarction]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2022 Nov; 42(11):1211-5. doi: 10.13703/j.0255-2930.20220424-k0004. [PMID: 36397216]
  • Ayokunle O Ademosun, Ganiyu Oboh, Adeniyi A Adebayo, Tosin A Olasehinde, Olamide W Fasakin. Grapefruit peel extract mitigates paroxetine-induced erectile dysfunction in rats through stimulation of erectile response, antioxidant status, and inhibition of key enzymes related with impaired penile erection. Journal of food biochemistry. 2022 11; 46(11):e14193. doi: 10.1111/jfbc.14193. [PMID: 35460094]
  • Xu He, Ruihuan Zhang, Zhe Li, Zhen Yao, Xiaoxia Xie, Ruoxue Bai, Lan Li, Xu Zhang, Sha Zhang, Yan Shen, Shaowei Li, Zhenliang Hui, Rongrong Liu, Jun Chen. Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double-blind, placebo-controlled trial. Journal of pineal research. 2022 Nov; 73(4):e12832. doi: 10.1111/jpi.12832. [PMID: 36073608]
  • Sunday Idowu Oyeleye, Tosin Abiola Olasehinde, Ibrahim Pelumi Odumosu, Ganiyu Oboh. Plantain peels restore sexual performance, hormonal imbalance, and modulate nitric oxide production and key enzymes of penile function in paroxetine-sexually impaired male rats. Journal of food biochemistry. 2022 11; 46(11):e14261. doi: 10.1111/jfbc.14261. [PMID: 35609010]
  • Wen-Qing Mu, Guang Xu, Jia Zhao, Yuan-Yuan Chen, Zhao-Fang Bai, Xiao-He Xiao. [Preventive and therapeutic effect of bioactive component of licorice on antidepressant-induced liver injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Nov; 47(22):6146-6154. doi: 10.19540/j.cnki.cjcmm.20220608.402. [PMID: 36471939]
  • Sheng Han, Heng Li, Weixiong Chen, Li Yang, Xiankun Tong, Jianping Zuo, Youhong Hu. Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold. European journal of medicinal chemistry. 2022 Oct; 240(?):114608. doi: 10.1016/j.ejmech.2022.114608. [PMID: 35872393]
  • Mengjie Zeng, Aimin Gong, Zhiquan Wu. Paroxetine combined with traditional chinese medicine prescriptions in the treatment of postpartum depression: A systematic review of randomized controlled trials. Frontiers in neuroendocrinology. 2022 10; 67(?):101019. doi: 10.1016/j.yfrne.2022.101019. [PMID: 35926637]
  • Olalekan Bukunmi Ogunro, Musa Toyin Yakubu. Fadogia agrestis (Schweinf. Ex Hiern) Stem Extract Restores Selected Biomolecules of Erectile Dysfunction in the Testicular and Penile Tissues of Paroxetine-Treated Wistar Rats. Reproductive sciences (Thousand Oaks, Calif.). 2022 Aug; ?(?):. doi: 10.1007/s43032-022-01050-6. [PMID: 35969364]
  • Zubeyde Ercan, Meryem Sedef Dogru, Nazife Ulker Ertugrul, Ahmet Yardimci, Sinan Canpolat. Beneficial effects of irisin in experimental paroxetine-induced hyperprolactinemia. Endocrine. 2022 05; 76(2):419-425. doi: 10.1007/s12020-022-03010-1. [PMID: 35226247]
  • Cheng-Gao Zhou, Zhi-Nan Xiang, Ning Zhao, Xing Sun, Zhuo-Fan Hu, Jia-Le Wu, Ru-Feng Xia, Chen Chen, Jun-Cheng Su, Jia-Chun Chen, Luo-Sheng Wan. Jatrophane Diterpenoids with Kv1.3 Ion Channel Inhibitory Effects from Euphorbia helioscopia. Journal of natural products. 2022 04; 85(4):815-827. doi: 10.1021/acs.jnatprod.1c00879. [PMID: 35245067]
  • Fahad Aldosary, Sandhaya Norris, Philippe Tremblay, Jonathan S James, James C Ritchie, Pierre Blier. Differential Potency of Venlafaxine, Paroxetine, and Atomoxetine to Inhibit Serotonin and Norepinephrine Reuptake in Patients With Major Depressive Disorder. The international journal of neuropsychopharmacology. 2022 04; 25(4):283-292. doi: 10.1093/ijnp/pyab086. [PMID: 34958348]
  • Kateryna Murlanova, Netanela Cohen, Anna Pinkus, Liudmila Vinnikova, Mikhail Pletnikov, Michael Kirby, Jonathan Gorelick, Elyashiv Drori, Albert Pinhasov. Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract. Scientific reports. 2022 03; 12(1):3647. doi: 10.1038/s41598-022-04840-9. [PMID: 35256610]
  • Sinan Canpolat, Nazife Ulker, Ahmet Yardimci, Emre Tancan, Elif Sahin, Serap Ozer Yaman, Ozgur Bulmuş, Ahmet Alver, Mete Ozcan. Irisin ameliorates male sexual dysfunction in paroxetine-treated male rats. Psychoneuroendocrinology. 2022 02; 136(?):105597. doi: 10.1016/j.psyneuen.2021.105597. [PMID: 34861466]
  • Qi Jin, Jie Li, Guang-Yao Chen, Zi-Yu Wu, Xiao-Yu Liu, Yi Liu, Lin Chen, Xin-Yi Wu, Yan Liu, Xin Zhao, Yue-Han Song. Network and Experimental Pharmacology to Decode the Action of Wendan Decoction Against Generalized Anxiety Disorder. Drug design, development and therapy. 2022; 16(?):3297-3314. doi: 10.2147/dddt.s367871. [PMID: 36193286]
  • Mithula Sivasaravanaparan, Louise Ørum Olesen, Maurizio Severino, Christian Ulrich von Linstow, Kate Lykke Lambertsen, Jan Bert Gramsbergen, Jørgen Hasselstrøm, Athanasios Metaxas, Ove Wiborg, Bente Finsen. Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice. Journal of Alzheimer's disease : JAD. 2022; 87(2):685-699. doi: 10.3233/jad-220019. [PMID: 35342093]
  • Jialing Zhang, Jiping Zhang, Zhinan Zhang, Yu Zheng, Zheng Zhong, Zengyu Yao, Xiaowen Cai, Lixing Lao, Yong Huang, Shanshan Qu. Dopaminergic signaling in prefrontal cortex contributes to the antidepressant effect of electroacupuncture: An iTRAQ-based proteomics analysis in a rat model of CUMS. Anatomical record (Hoboken, N.J. : 2007). 2021 11; 304(11):2454-2469. doi: 10.1002/ar.24732. [PMID: 34523244]
  • Zihong Liang, Yanbo Jia, Lizhen Zhao, Runxiu Zhu, Xuemei He, Bagen Tong, Fan Yang, Lixia Hao, Pengfei Cui, Jun Yuan. Agomelatine might be more appropriate for elderly, depressed, type 2 diabetes mellitus patients than paroxetine/fluoxetine. Aging. 2021 10; 13(19):22934-22946. doi: 10.18632/aging.203586. [PMID: 34610580]
  • Anindita Bhattacharjee, Santosh Kumar Prajapati, Sairam Krishnamurthy. Supplementation of taurine improves ionic homeostasis and mitochondrial function in the rats exhibiting post-traumatic stress disorder-like symptoms. European journal of pharmacology. 2021 Oct; 908(?):174361. doi: 10.1016/j.ejphar.2021.174361. [PMID: 34297965]
  • Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Eva Falvo, Donatella Caruso, Roberto C Melcangi. Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis. Psychoneuroendocrinology. 2021 10; 132(?):105364. doi: 10.1016/j.psyneuen.2021.105364. [PMID: 34325207]
  • Shannon C Waye, O Chandani Dinesh, Sm Nageeb Hasan, Joshua D Conway, Roger Raymond, José N Nobrega, Jacqueline Blundell, Francis Rodriguez Bambico. Antidepressant action of transcranial direct current stimulation in olfactory bulbectomised adolescent rats. Journal of psychopharmacology (Oxford, England). 2021 Aug; 35(8):1003-1016. doi: 10.1177/02698811211000765. [PMID: 33908307]
  • Magdalena Kowalska, Łukasz Fijałkowski, Alicja Nowaczyk. Assessment of Paroxetine Molecular Interactions with Selected Monoamine and γ-Aminobutyric Acid Transporters. International journal of molecular sciences. 2021 Jun; 22(12):. doi: 10.3390/ijms22126293. [PMID: 34208199]
  • Lucia Carboni, Bruno Delafont, Elena Ivanchenko, Emiliangelo Ratti, Susan M Learned, Robert Alexander, Enrico Domenici. Folate metabolism biomarkers from two randomised placebo-controlled clinical studies with paroxetine and venlafaxine. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2021 04; 22(4):315-321. doi: 10.1080/15622975.2020.1805509. [PMID: 32787676]
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