2,3-Butanediol (BioDeep_00000018434)

 

Secondary id: BioDeep_00000003073, BioDeep_00000405549, BioDeep_00000871766, BioDeep_00001868592

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


2,3-Butylene glycol, (r*,r*,)-(+-)-isomer

化学式: C4H10O2 (90.0681)
中文名称: (2R,3R)-(-)-2,3-丁二醇, (R,R)-2,3-丁二醇, 2,3-丁二醇, 2,3-丁二醇 (立体异构体的混合物)
谱图信息: 最多检出来源 Homo sapiens(blood) 15.34%

分子结构信息

SMILES: CC(C(C)O)O
InChI: InChI=1S/C4H10O2/c1-3(5)4(2)6/h3-6H,1-2H3

描述信息

2,3-Butanediol is an isomer of butanediol. The 2R,3R stereoisomer of 2,3-butanediol is produced by a variety of microorganisms, in a process known as butanediol fermentation. 2,3-Butanediol fermentation is the anaerobic fermentation of glucose with 2,3-butanediol as one of the end products. The overall stoichiometry of the reaction is 2 pyruvate + NADH --> 2CO2 + 2,3-butanediol. Butanediol fermentation is typical for Enterobacter species or microbes found in the gut. 2,3-butanediol has been identified in the sera of alcoholics and it may be a specific marker of alcohol abuse (PMID:6139706). In humans, 2,3-butanediol is oxidized to acetyl-CoA via acetoin. 2,3-Butanediol is also found in cocoa butter. 2,3-Butanediol can also be found in Bacillus, Klebsiella and Serratia (PMID:21272631).
2,3-Butanediol is one of the constitutional isomers of butanediol. The 2R,3R stereoisomer of 2,3-butanediol is produced by a variety of microorganisms, in a process known as butanediol fermentation. It is found in cocoa butter and in the roots of Ruta graveolens.
(2R,3R)-Butane-2,3-diol is an endogenous metabolite.
(2R,3R)-Butane-2,3-diol is an endogenous metabolite.
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources[1].
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources[1].

同义名列表

24 个代谢物同义名

2,3-Butylene glycol, (r*,r*,)-(+-)-isomer; 2,3-Butylene glycol, (S-(r*,r*))-isomer; 2,3-Butylene glycol, R-(r*,r*)-isomer; 2,3-Butylene glycol, (r*,r*)-isomer; 2,3-Butylene glycol, (r*,s*)-isomer; Sym-dimethylethylene glycol; (2R,3R)-(-)-2,3-Butanediol; Dimethylethylene glycol; Pseudobutylene glycol; (R,R)-2,3-Butanediol; 2,3-Dihydroxybutane; 2,3-Butylene glycol; (±)-2,3-Butanediol; Dimethylene glycol; D-2,3-Butane diol; Butane-2,3-diol; 2,3-butanediol; 2,3-Butanodiol; 2,3-Butandiol; (2R,3R)-Butane-2,3-diol; (R,R)-Butane-2,3-diol; (R,R)-2,3-butanediol; (R,R)-2,3-butanediol; 2,3-Butanediol



数据库引用编号

32 个数据库交叉引用编号

分类词条

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ACE, BDH2, PFDN5
Peripheral membrane protein 1 SORD
Mitochondrion membrane 1 SORD
Nucleus 4 ACR, MBD1, PDC, PFDN5
cytosol 5 ADCY9, BDH2, PDC, PFDN5, SORD
dendrite 1 ADCY9
mitochondrial membrane 1 SORD
nucleoplasm 1 MBD1
Cell membrane 3 ACE, ADCY6, ADCY9
Multi-pass membrane protein 3 ADCY6, ADCY7, ADCY9
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 BDH1
Cytoplasm, cytosol 1 PDC
Lysosome 2 ACE, GAA
endosome 1 ACE
plasma membrane 6 ACE, ADCY6, ADCY7, ADCY9, GAA, MUC5B
Membrane 7 ACE, ADCY6, ADCY7, ADCY9, BDH1, GAA, SORD
axon 1 ADCY9
extracellular exosome 5 ACE, BDH2, GAA, MUC5B, SORD
Lysosome membrane 1 GAA
extracellular space 4 ACE, GH1, MUC5B, SORD
lysosomal lumen 1 GAA
mitochondrion 1 BDH1
protein-containing complex 1 ACR
intracellular membrane-bounded organelle 4 BDH1, GAA, MBD1, MUC5B
Single-pass type I membrane protein 1 ACE
Secreted 3 ACE, GAA, GH1
extracellular region 5 ACE, ACR, GAA, GALP, GH1
Mitochondrion matrix 1 BDH1
mitochondrial matrix 1 BDH1
Cell projection, cilium 1 ADCY6
motile cilium 1 SORD
photoreceptor inner segment 1 PDC
photoreceptor outer segment 1 PDC
external side of plasma membrane 1 ACE
Golgi-associated vesicle 1 ACR
Mitochondrion inner membrane 1 BDH1
extracellular matrix 1 MUC5B
nuclear speck 1 MBD1
cilium 1 ADCY6
chromatin 1 MBD1
Chromosome 1 MBD1
Cell projection, cilium, photoreceptor outer segment 1 PDC
brush border membrane 1 ACE
Cell projection, cilium, flagellum 1 SORD
sperm midpiece 1 ACE
endosome lumen 1 GH1
Cell projection, stereocilium 1 ADCY6
stereocilium 1 ADCY6
tertiary granule membrane 1 GAA
Nucleus speckle 1 MBD1
intermediate filament cytoskeleton 1 PFDN5
basal plasma membrane 1 ACE
Golgi lumen 1 MUC5B
nuclear matrix 1 MBD1
azurophil granule membrane 1 GAA
Nucleus matrix 1 MBD1
[Isoform 2]: Nucleus 1 PDC
prefoldin complex 1 PFDN5
ficolin-1-rich granule membrane 1 GAA
growth hormone receptor complex 1 GH1
acrosomal matrix 1 ACR
autolysosome lumen 1 GAA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
matrix side of mitochondrial inner membrane 1 BDH1


文献列表

  • Tania N N Tanwee, Gina L Lipscomb, Jason L Vailionis, Ke Zhang, Ryan G Bing, Hailey C O'Quinn, Farris L Poole, Ying Zhang, Robert M Kelly, Michael W W Adams. Metabolic engineering of Caldicellulosiruptor bescii for 2,3-butanediol production from unpretreated lignocellulosic biomass and metabolic strategies for improving yields and titers. Applied and environmental microbiology. 2024 Jan; 90(1):e0195123. doi: 10.1128/aem.01951-23. [PMID: 38131671]
  • Ping Lu, Ruoxuan Bai, Ting Gao, Jiale Chen, Ke Jiang, Yalun Zhu, Ye Lu, Shuting Zhang, Fangxu Xu, Hongxin Zhao. Systemic metabolic engineering of Enterobacter aerogenes for efficient 2,3-butanediol production. Applied microbiology and biotechnology. 2024 Jan; 108(1):146. doi: 10.1007/s00253-023-12911-8. [PMID: 38240862]
  • Jikun Zhang, Jianzhi Zhao, Quanbin Fu, Haiyang Liu, Min Li, Zhongyue Wang, Wei Gu, Xueming Zhu, Rongshan Lin, Li Dai, Kai Liu, Chengqiang Wang. Metabolic engineering of Paenibacillus polymyxa for effective production of 2,3-butanediol from poplar hydrolysate. Bioresource technology. 2024 Jan; 392(?):130002. doi: 10.1016/j.biortech.2023.130002. [PMID: 37956945]
  • Jake N Gonzales, Tanner R Treece, Stephen P Mayfield, Ryan Simkovsky, Shota Atsumi. Utilization of lignocellulosic hydrolysates for photomixotrophic chemical production in Synechococcus elongatus PCC 7942. Communications biology. 2023 10; 6(1):1022. doi: 10.1038/s42003-023-05394-w. [PMID: 37813969]
  • Wang Yue, Yang Genji, Wu Bowen, Mi Yaozu, Zhou Yang, Ma Tian, Zang Hailian, Xi Chuanwu, Cheng Yi, Li Chunyan. Papermaking wastewater treatment coupled to 2,3-butanediol production by engineered psychrotrophic Raoultella terrigena. Journal of hazardous materials. 2023 09; 458(?):131994. doi: 10.1016/j.jhazmat.2023.131994. [PMID: 37418966]
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  • Ping Lu, Ting Gao, Ruoxuan Bai, Jiayao Yang, Yudong Xu, Wanying Chu, Ke Jiang, Jingya Zhang, Fangxu Xu, Hongxin Zhao. Regulation of carbon flux and NADH/NAD+ supply to enhance 2,3-butanediol production in Enterobacter aerogenes. Journal of biotechnology. 2022 Nov; 358(?):67-75. doi: 10.1016/j.jbiotec.2022.09.001. [PMID: 36087783]
  • Ae Ran Park, Jongmun Kim, Bora Kim, Areum Ha, Ji-Yeon Son, Chan Woo Song, Hyohak Song, Jin-Cheol Kim. Exogenous Bio-Based 2,3-Butanediols Enhanced Abiotic Stress Tolerance of Tomato and Turfgrass under Drought or Chilling Stress. Journal of microbiology and biotechnology. 2022 May; 32(5):582-593. doi: 10.4014/jmb.2201.01025. [PMID: 35484968]
  • Haifeng Sun, Xinyu Zuo, Qingqing Zhang, Jianping Gao, Guoyin Kai. Elicitation of (E)-2-Hexenal and 2,3-Butanediol on the Bioactive Compounds in Adventitious Roots of Astragalus membranaceus var. mongholicus. Journal of agricultural and food chemistry. 2022 Jan; 70(2):470-479. doi: 10.1021/acs.jafc.1c05813. [PMID: 34985895]
  • Wanying Chu, Ke Jiang, Ping Lu, Yudong Xu, Jiayao Yang, Xuan Wei, Li Li, Shuxin Liu, Yan Wu, Shenghou Wang, Hongxin Zhao. Metabolic regulation and optimization of oxygen supply enhance the 2,3-butanediol yield of the novel Klebsiella sp. isolate FSoil 024. Biotechnology journal. 2021 Nov; 16(11):e2100279. doi: 10.1002/biot.202100279. [PMID: 34390606]
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