Sulfometuron-methyl (BioDeep_00000008412)

 

Secondary id: BioDeep_00001868097

human metabolite blood metabolite


代谢物信息卡片


methyl 2-({[(4,6-dimethylpyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate

化学式: C15H16N4O5S (364.0841)
中文名称: 甲嘧磺隆
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=NC(=N1)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC)C
InChI: InChI=1S/C15H16N4O5S/c1-9-8-10(2)17-14(16-9)18-15(21)19-25(22,23)12-7-5-4-6-11(12)13(20)24-3/h4-8H,1-3H3,(H2,16,17,18,19,21)

描述信息

D010575 - Pesticides > D006540 - Herbicides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals

同义名列表

7 个代谢物同义名

methyl 2-({[(4,6-dimethylpyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate; sulfometuron-methyl [ANSI]; Sulphometuron-methyl; Sulphometuron methyl; sulfometuron-methyl; sulfometuron methyl; Sulfometuron methyl



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ARHGAP45, BCL2, CASP3, CASP9, HAND1, MYD88, RELA, SCGB1A1, TLR4, ZMYND8
Endosome membrane 2 MYD88, TLR4
Endoplasmic reticulum membrane 1 BCL2
Nucleus 9 BCL2, CASP3, CASP9, CYC1, HAND1, MYD88, NDUFA9, RELA, ZMYND8
cytosol 7 ARHGAP45, BCL2, CASP3, CASP9, MYD88, PGK1, RELA
mitochondrial membrane 1 NDUFA9
nucleoplasm 5 ATP2B1, CASP3, HAND1, RELA, ZMYND8
RNA polymerase II transcription regulator complex 1 HAND1
Cell membrane 2 ATP2B1, TLR4
ruffle membrane 1 ARHGAP45
Multi-pass membrane protein 2 ATP2B1, ATP4A
Synapse 1 ATP2B1
cell surface 3 MYD88, TLR4, TNR
dendritic shaft 1 ZMYND8
glutamatergic synapse 4 ATP2B1, CASP3, RELA, TNR
mitochondrial inner membrane 2 CYC1, NDUFA9
neuronal cell body 1 CASP3
presynaptic membrane 1 ATP2B1
plasma membrane 5 ARHGAP45, ATP2B1, ATP4A, MYD88, TLR4
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ARHGAP45, ATP2B1, ATP4A, BCL2, CYC1, PGK1, TLR4
apical plasma membrane 1 ATP4A
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 ATP2B1, CPVL, PGK1, SCGB1A1
endoplasmic reticulum 1 BCL2
extracellular space 6 ATP4A, CXCL8, IL10, PGK1, SCGB1A1, TNR
perinuclear region of cytoplasm 1 TLR4
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 4 BCL2, CASP9, CYC1, NDUFA9
protein-containing complex 3 BCL2, CASP9, MYD88
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR4
Secreted 3 CXCL8, IL10, SCGB1A1
extracellular region 5 ARHGAP45, CXCL8, IL10, SCGB1A1, TNR
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CYC1
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 NDUFA9
mitochondrial matrix 1 NDUFA9
transcription regulator complex 1 RELA
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TLR4
Secreted, extracellular space, extracellular matrix 1 TNR
dendritic spine 1 ZMYND8
nucleolus 2 HAND1, ZMYND8
Early endosome 1 TLR4
Apical cell membrane 1 ATP4A
Cell projection, ruffle membrane 1 ARHGAP45
Mitochondrion inner membrane 1 CYC1
Membrane raft 2 PGK1, TNR
pore complex 1 BCL2
collagen-containing extracellular matrix 1 TNR
secretory granule 1 SCGB1A1
lateral plasma membrane 1 ATP2B1
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
chromatin 3 HAND1, RELA, ZMYND8
cell projection 1 ATP2B1
phagocytic cup 1 TLR4
Chromosome 1 ZMYND8
Nucleus, nucleolus 1 HAND1
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 SCGB1A1
Nucleus, nucleoplasm 1 HAND1
Presynaptic cell membrane 1 ATP2B1
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
respiratory chain complex I 1 NDUFA9
secretory granule lumen 1 ARHGAP45
azurophil granule lumen 1 ARHGAP45
immunological synapse 1 ATP2B1
perineuronal net 1 TNR
apoptosome 1 CASP9
respiratory chain complex III 1 CYC1
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
death-inducing signaling complex 1 CASP3
extrinsic component of plasma membrane 1 MYD88
site of DNA damage 1 ZMYND8
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
NF-kappaB p50/p65 complex 1 RELA
potassium:proton exchanging ATPase complex 1 ATP4A
tenascin complex 1 TNR
NF-kappaB complex 1 RELA
caspase complex 1 CASP9


文献列表

  • Hao Zhang, Chun-Yang Liu, Xin Zhang, Hui-Ying Yang, Jie Sun, Cheng-Bin Liu, Na Li. The key sulfometuron-methyl degrading bacteria isolation based on soil bacterial phylogenetic molecular ecological networks and application for bioremediation of contaminated soil by immobilization. Ecotoxicology and environmental safety. 2022 Jun; 238(?):113605. doi: 10.1016/j.ecoenv.2022.113605. [PMID: 35561546]
  • Juliana Stéfani Jabur De Assis, Valdemar Luiz Tornisielo, Fabricia Cristina Dos Reis, Bianca A B Martins, Roberto Estevão Bragion Toledo, Ricardo Victória Filho. Absorption and translocation of sulfometuron-methyl in sugarcane (Saccharum officinarum L.) at different growth stages. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2018; 53(11):746-750. doi: 10.1080/03601234.2018.1480162. [PMID: 29883252]
  • Yu-Ting Lee, Chang-Jun Cui, Eve W L Chow, Nason Pue, Thierry Lonhienne, Jian-Guo Wang, James A Fraser, Luke W Guddat. Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of medicinal chemistry. 2013 Jan; 56(1):210-9. doi: 10.1021/jm301501k. [PMID: 23237384]
  • Omer Grundman, Inna Khozin-Goldberg, Dina Raveh, Zvi Cohen, Maria Vyazmensky, Sammy Boussiba, Michal Shapira. Cloning, mutagenesis, and characterization of the microalga Parietochloris incisa acetohydroxyacid synthase, and its possible use as an endogenous selection marker. Biotechnology and bioengineering. 2012 Sep; 109(9):2340-8. doi: 10.1002/bit.24515. [PMID: 22488216]
  • Thomas Pfleeger, David Olszyk, E Henry Lee, Milton Plocher. Comparing effects of low levels of herbicides on greenhouse- and field-grown potatoes (Solanum tuberosum L.), soybeans (Glycine max L.), and peas (Pisum sativum L.). Environmental toxicology and chemistry. 2011 Feb; 30(2):455-68. doi: 10.1002/etc.394. [PMID: 21038430]
  • Thomas Pfleeger, David Olszyk, Milton Plocher, Solomon Yilma. Effects of low concentrations of herbicides on full-season, field-grown potatoes. Journal of environmental quality. 2008 Nov; 37(6):2070-82. doi: 10.2134/jeq2007.0376. [PMID: 18948460]
  • Conor Bidelspach, David Olszyk, Thomas Pfleeger. Can artificial soil be used in the vegetative vigor test for U.S. pesticide registration?. Integrated environmental assessment and management. 2008 Oct; 4(4):409-15. doi: 10.1897/ieam_2007-068.1. [PMID: 18563958]
  • Zhiqiang Pan, Ameeta K Agarwal, Tao Xu, Qin Feng, Scott R Baerson, Stephen O Duke, Agnes M Rimando. Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol. BMC medical genomics. 2008 Mar; 1(?):7. doi: 10.1186/1755-8794-1-7. [PMID: 18366703]
  • David Olszyk, Thomas Pfleeger, E Henry Lee, Connie Burdick, George King, Milton Plocher, Jeffrey Kern. Selecting and evaluating native plants for region-specific phytotoxicity testing. Integrated environmental assessment and management. 2008 Jan; 4(1):105-17. doi: 10.1897/ieam_2007-044.1. [PMID: 17973566]
  • Tyrone B Hayes, Paola Case, Sarah Chui, Duc Chung, Cathryn Haeffele, Kelly Haston, Melissa Lee, Vien Phoung Mai, Youssra Marjuoa, John Parker, Mable Tsui. Pesticide mixtures, endocrine disruption, and amphibian declines: are we underestimating the impact?. Environmental health perspectives. 2006 Apr; 114 Suppl 1(?):40-50. doi: 10.1289/ehp.8051. [PMID: 16818245]
  • Jennifer A McCourt, Siew Siew Pang, Jack King-Scott, Luke W Guddat, Ronald G Duggleby. Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase. Proceedings of the National Academy of Sciences of the United States of America. 2006 Jan; 103(3):569-73. doi: 10.1073/pnas.0508701103. [PMID: 16407096]
  • Jennifer A McCourt, Siew Siew Pang, Luke W Guddat, Ronald G Duggleby. Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry. 2005 Feb; 44(7):2330-8. doi: 10.1021/bi047980a. [PMID: 15709745]
  • Yuhua Zhang, J Richard Dickinson, Matthew J Paul, Nigel G Halford. Molecular cloning of an arabidopsis homologue of GCN2, a protein kinase involved in co-ordinated response to amino acid starvation. Planta. 2003 Aug; 217(4):668-75. doi: 10.1007/s00425-003-1025-4. [PMID: 12905023]
  • J L Michael. Environmental fate and impacts of sulfometuron on watersheds in the southern United States. Journal of environmental quality. 2003 Mar; 32(2):456-65. doi: 10.2134/jeq2003.4560. [PMID: 12708668]
  • Yael Golda Mishael, Tomas Undabeytia, Onn Rabinovitz, Baruch Rubin, Shlomo Nir. Slow-release formulations of sulfometuron incorporated in micelles adsorbed on montmorillonite. Journal of agricultural and food chemistry. 2002 May; 50(10):2864-9. doi: 10.1021/jf011497e. [PMID: 11982412]
  • Miri Lapidot, Dina Raveh, Alex Sivan, Shoshana Malis Arad, Michal Shapira. Stable chloroplast transformation of the unicellular red alga Porphyridium species. Plant physiology. 2002 May; 129(1):7-12. doi: 10.1104/pp.011023. [PMID: 12011332]
  • Joy L Kovar, Jun Zhang, Roel P Funke, Donald P Weeks. Molecular analysis of the acetolactate synthase gene of Chlamydomonas reinhardtii and development of a genetically engineered gene as a dominant selectable marker for genetic transformation. The Plant journal : for cell and molecular biology. 2002 Jan; 29(1):109-17. doi: 10.1046/j.1365-313x.2002.01193.x. [PMID: 12060231]
  • M H Jia, R A Larossa, J M Lee, A Rafalski, E Derose, G Gonye, Z Xue. Global expression profiling of yeast treated with an inhibitor of amino acid biosynthesis, sulfometuron methyl. Physiological genomics. 2000 Aug; 3(2):83-92. doi: 10.1152/physiolgenomics.2000.3.2.83. [PMID: 11015603]
  • J A Grandoni, P T Marta, J V Schloss. Inhibitors of branched-chain amino acid biosynthesis as potential antituberculosis agents. The Journal of antimicrobial chemotherapy. 1998 Oct; 42(4):475-82. doi: 10.1093/jac/42.4.475. [PMID: 9818746]