(R)-Pronuciferine (BioDeep_00000007494)

 

Secondary id: BioDeep_00001869235

human metabolite Endogenous


代谢物信息卡片


10,11-dimethoxy-5-methyl-5-azaspiro[cyclohexane-1,2-tricyclo[6.3.1.0⁴,¹²]dodecane]-1(12),2,5,8,10-pentaen-4-one

化学式: C19H21NO3 (311.1521)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c2c3c(cc1OC)CCN([C@@H]3C[C@@]12C=CC(=O)C=C1)C)OC
InChI: InChI=1S/C19H21NO3/c1-20-9-6-12-10-15(22-2)18(23-3)17-16(12)14(20)11-19(17)7-4-13(21)5-8-19/h4-5,7-8,10,14H,6,9,11H2,1-3H3

描述信息

Alkaloid from Nelumbo nucifera (East India lotus). (R)-Pronuciferine is found in many foods, some of which are poppy, coffee and coffee products, sacred lotus, and cherimoya.
(R)-Pronuciferine is found in cherimoya. (R)-Pronuciferine is an alkaloid from Nelumbo nucifera (East India lotus

同义名列表

9 个代谢物同义名

10,11-dimethoxy-5-methyl-5-azaspiro[cyclohexane-1,2-tricyclo[6.3.1.0⁴,¹²]dodecane]-1(12),2,5,8,10-pentaen-4-one; N,O-Dimethylcrotonosine; N-Methylstepharine; (+)-Pronuciferine; (R)-Pronuciferine; pronuciferine; Milthanthine; Pronuciferin; (+)-Pronuciferine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AHR, BDNF, CASP3, CASP7, CYP1A1, CYP3A4, RAC1, VAV3
Peripheral membrane protein 4 CYP1A1, CYP1B1, CYP21A2, CYP27A1
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 10 CYP1A1, CYP1B1, CYP21A2, CYP26A1, CYP3A4, CYP4F8, CYP4V2, CYP4Z1, CYP7A1, RAC1
Mitochondrion membrane 1 CYP27A1
Nucleus 4 AHR, CASP3, CASP7, RAC1
cytosol 6 AHR, CASP3, CASP7, RAC1, SLC2A4, VAV3
dendrite 2 BDNF, RAC1
trans-Golgi network 2 RAC1, SLC2A4
nucleoplasm 3 AHR, CASP3, CASP7
Cell membrane 4 RAC1, SLC2A4, SLC6A4, TNF
Lipid-anchor 1 RAC1
Cytoplasmic side 1 RAC1
lamellipodium 1 RAC1
ruffle membrane 1 RAC1
Multi-pass membrane protein 2 SLC2A4, SLC6A4
Synapse 2 RAC1, SLC6A4
cell cortex 1 RAC1
cell surface 1 TNF
glutamatergic synapse 2 CASP3, RAC1
Golgi membrane 1 INS
mitochondrial inner membrane 2 CYP1A1, CYP27A1
neuronal cell body 2 CASP3, TNF
postsynapse 1 RAC1
presynaptic membrane 1 SLC6A4
sarcolemma 1 SLC2A4
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 CASP7
Presynapse 2 SLC2A4, SLC6A4
plasma membrane 5 RAC1, SLC2A4, SLC6A4, TNF, VAV3
Membrane 8 BDNF, CYP1B1, CYP21A2, CYP3A4, CYP4F8, RAC1, SLC2A4, SLC6A4
axon 1 BDNF
extracellular exosome 2 RAC1, SLC2A4
extracellular space 4 BDNF, CASP7, INS, TNF
perinuclear region of cytoplasm 2 BDNF, SLC2A4
mitochondrion 3 CYP1A1, CYP1B1, CYP27A1
protein-containing complex 1 AHR
intracellular membrane-bounded organelle 4 CYP1A1, CYP1B1, CYP3A4, CYP7A1
Microsome membrane 8 CYP1A1, CYP1B1, CYP21A2, CYP26A1, CYP3A4, CYP4F8, CYP4Z1, CYP7A1
postsynaptic density 1 CASP3
Secreted 3 BDNF, INS, RAC1
extracellular region 4 BDNF, INS, RAC1, TNF
Single-pass membrane protein 4 CYP21A2, CYP4F8, CYP4V2, CYP7A1
mitochondrial matrix 1 CYP27A1
transcription regulator complex 1 AHR
external side of plasma membrane 2 SLC2A4, TNF
multivesicular body 1 SLC2A4
dendritic spine 1 RAC1
T-tubule 1 SLC2A4
cytoplasmic vesicle 1 RAC1
clathrin-coated pit 1 SLC2A4
recycling endosome 1 TNF
Single-pass type II membrane protein 2 CYP4Z1, TNF
postsynaptic membrane 1 SLC6A4
Cell projection, lamellipodium 1 RAC1
Cytoplasm, perinuclear region 1 SLC2A4
Mitochondrion inner membrane 2 CYP1A1, CYP27A1
Membrane raft 3 SLC2A4, SLC6A4, TNF
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 2 RAC1, SLC6A4
sarcoplasmic reticulum 1 SLC2A4
Cell projection, neuron projection 1 SLC6A4
neuron projection 1 SLC6A4
chromatin 1 AHR
phagocytic cup 1 TNF
cytoskeleton 1 RAC1
cytoplasmic ribonucleoprotein granule 1 RAC1
Secreted, extracellular space 1 CASP7
Recycling endosome membrane 1 RAC1
Endomembrane system 2 SLC2A4, SLC6A4
endosome lumen 1 INS
aryl hydrocarbon receptor complex 1 AHR
Cytoplasmic vesicle membrane 1 SLC2A4
Cell projection, dendrite 1 RAC1
Melanosome 1 RAC1
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
secretory granule lumen 1 INS
secretory granule membrane 1 RAC1
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 BDNF, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 VAV3
vesicle membrane 1 SLC2A4
ficolin-1-rich granule membrane 1 RAC1
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
NADPH oxidase complex 1 RAC1
insulin-responsive compartment 1 SLC2A4
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
nuclear aryl hydrocarbon receptor complex 1 AHR
serotonergic synapse 1 SLC6A4
cytosolic aryl hydrocarbon receptor complex 1 AHR
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Michael E Pyne, Nicholas D Gold, Vincent J J Martin. Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera). Metabolic engineering. 2023 Mar; ?(?):. doi: 10.1016/j.ymben.2023.03.010. [PMID: 37004909]
  • Mamiko Yano, Souichi Nakashima, Yoshimi Oda, Seikou Nakamura, Hisashi Matsuda. BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells. Journal of natural medicines. 2020 Jan; 74(1):212-218. doi: 10.1007/s11418-019-01368-7. [PMID: 31707550]
  • Omer Bayazeid, Cemil Can Eylem, Tuba Reçber, Funda Nuray Yalçın, Sedef Kır, Emirhan Nemutlu. An LC-ESI-MS/MS method for the simultaneous determination of pronuciferine and roemerine in some Papaver species. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Oct; 1096(?):223-227. doi: 10.1016/j.jchromb.2018.08.020. [PMID: 30189375]
  • Chengjun Ma, Gang Li, Yanfeng He, Bo Xu, Xiangquan Mi, Honglun Wang, Zhenhua Wang. Pronuciferine and nuciferine inhibit lipogenesis in 3T3-L1 adipocytes by activating the AMPK signaling pathway. Life sciences. 2015 Sep; 136(?):120-5. doi: 10.1016/j.lfs.2015.07.001. [PMID: 26164185]
  • Jong Hoon Ahn, Eun Sil Kim, Chul Lee, Soonok Kim, Soo-Hyun Cho, Bang Yeon Hwang, Mi Kyeong Lee. Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects. Bioorganic & medicinal chemistry letters. 2013 Jun; 23(12):3604-8. doi: 10.1016/j.bmcl.2013.04.013. [PMID: 23642481]
  • Seikou Nakamura, Souichi Nakashima, Genzo Tanabe, Yoshimi Oda, Nami Yokota, Katsuyoshi Fujimoto, Takahiro Matsumoto, Rika Sakuma, Tomoe Ohta, Keiko Ogawa, Shino Nishida, Hisako Miki, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa. Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells. Bioorganic & medicinal chemistry. 2013 Feb; 21(3):779-87. doi: 10.1016/j.bmc.2012.11.038. [PMID: 23270663]
  • Pi Cheng, Yun-bao Ma, Shu-ying Yao, Quan Zhang, En-jun Wang, Meng-hong Yan, Xue-mei Zhang, Feng-xue Zhang, Ji-jun Chen. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. Bioorganic & medicinal chemistry letters. 2007 Oct; 17(19):5316-20. doi: 10.1016/j.bmcl.2007.08.027. [PMID: 17723297]