Fosphenytoin (BioDeep_00000006615)
Secondary id: BioDeep_00001868067
human metabolite blood metabolite
代谢物信息卡片
(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate
化学式: C16H15N2O6P (362.0668)
中文名称: 磷苯妥英
谱图信息:
最多检出来源 Homo sapiens(blood) 19.51%
分子结构信息
SMILES: C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)(O)O)C3=CC=CC=C3
InChI: InChI=1S/C16H15N2O6P/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23/h1-10H,11H2,(H,17,20)(H2,21,22,23)
描述信息
Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AB - Hydantoin derivatives
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
D049990 - Membrane Transport Modulators
同义名列表
12 个代谢物同义名
(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate; [(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methoxy]phosphonic acid; 3-(Hydroxymethyl)phenytoin disodium phosphate; 3-(Hydroxymethyl)phenytoin phosphate ester; (3-Phosphoryloxymethyl)phenytoin; Fosphenytoin, disodium salt; Fosphenytoin sodium; Fosphenytoin; Prodilantin; Cerebyx; HMPDP; Fosphenytoin
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:5165
- KEGG: C07840
- KEGGdrug: D07993
- PubChem: 56339
- HMDB: HMDB0015417
- Metlin: METLIN4050
- DrugBank: DB01320
- ChEMBL: CHEMBL1201336
- Wikipedia: Fosphenytoin
- chemspider: 50839
- CAS: 93390-81-9
- PMhub: MS000019683
- PubChem: 10042
- NIKKAJI: J540.502E
- RefMet: Fosphenytoin
- KNApSAcK: 5165
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Fosphenytoin (Antiarrhythmic) Action Pathway:
Adenosine triphosphate + Calcium + Water ⟶ Adenosine diphosphate + Calcium + Phosphate - Fosphenytoin (Antiarrhythmic) Metabolism Pathway:
Fosphenytoin ⟶ Phenytoin
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shusaku Noro, Yoshinobu Seo, Kaori Honjo, Masahiro Okuma, Bunsho Asayama, Yuki Amano, Masanori Kyono, Kazuya Sako, Hirohiko Nakamura. Intravenous fosphenytoin therapy for rescue of acute trigeminal neuralgia crisis in patients awaiting neurosurgical procedures: A cross-sectional study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2021 Dec; 94(?):59-64. doi:
10.1016/j.jocn.2021.09.040. [PMID: 34863463] - Abhishek G Sathe, Usha Mishra, Vijay Ivaturi, Richard C Brundage, James C Cloyd, Jordan J Elm, James M Chamberlain, Robert Silbergleit, Jaideep Kapur, Daniel H Lowenstein, Shlomo Shinnar, Hannah R Cock, Nathan B Fountain, Lynn Babcock, Lisa D Coles. Early Exposure of Fosphenytoin, Levetiracetam, and Valproic Acid After High-Dose Intravenous Administration in Young Children With Benzodiazepine-Refractory Status Epilepticus.
Journal of clinical pharmacology.
2021 06; 61(6):763-768. doi:
10.1002/jcph.1801. [PMID: 33336359] - S Nishida, Y Hayashi, K Hirai, A Takekoshi, Y Yamada, R Kobayashi, S Shimizu, T Niwa, H Hayashi, T Shimohata, T Sugiyama, A Suzuki. Effect of therapeutic plasma exchange on phenytoin plasma concentration in patients receiving intravenous fosphenytoin therapy.
Die Pharmazie.
2020 10; 75(10):488-490. doi:
10.1691/ph.2020.0525. [PMID: 33305722] - Kavita Srivastava, Shirish Bhartiya, Vrushabh Gavli, Rahul Patil, Surekha Rajadhyaksha. Efficacy, Tolerability and Serum Phenytoin Levels after Intravenous Fosphenytoin Loading Dose in Children with Status Epilepticus.
Indian pediatrics.
2020 03; 57(3):218-221. doi:
10.1007/s13312-020-1754-5. [PMID: 32198860] - Kanae Higuchi, Daiki Yamashita, Yushi Kashihara, Makoto Kakara, Takeshi Hirota, Masaaki Hirakawa, Ichiro Ieiri. Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients.
Therapeutic drug monitoring.
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2015 Jun; 56(6):888-94. doi:
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2013 Jun; 38(2):139-48. doi:
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